Szymkowicz, E., Cardone, P., Gosseries, O., Laureys, S., & Thibaut, A. (in press). Neurophysiology and traumatic brain injury. In P. Jenkins & N. Agrawal (Eds.), The Oxford Textbook of Traumatic Brain Injury. Oxford, United Kingdom: Oxford University Press.
Neurophysiological techniques, such as electroencephalography, provide valuable information to ai...
Editorial reviewed
Chen, Y., Xiao, X., Dong, Z., Ding, J., Cruz, S., Zhang, M., Lu, Y., Ding, N., Aubinet, C., Laureys, S., & Di, H. (2025). Clinical diagnostic and prognostic value of residual language learning ability in patients with disorders of consciousness. Journal of Neuroscience, 1684242025. doi:10.1523/JNEUROSCI.1684-24.2025
Recent research suggests that the detection of preserved cognitive function can assist in the dia...
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Barra, A., Huerta-Gutierrez, R., Annen, J., Martens, G., Laureys, S., Llorens, R., Kurth, T., & Thibaut, A. (2025). Characterization of responders to transcranial direct current stimulation in disorders of consciousness: A retrospective study of 8 clinical trials. Neurotherapeutics, 00587. doi:10.1016/j.neurot.2025.e00587
Peer Reviewed verified by ORBi
Cecconi, B., Bonhomme, V., Laureys, S., Gosseries, O., Boly, M., & Annen, J. (20 March 2025). Experimental approaches to study sensory disconnection in humans during sleep and anesthesia. Current Opinion in Behavioral Sciences, 63, 101505. doi:10.1016/j.cobeha.2025.101505
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Mikolić, A., van Klaveren, D., Jost, M., Maas, A. I., Shi, S., Silverberg, N. D., Wilson, L., Lingsma, H. F., Steyerberg, E. W., CENTER-TBI Participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Luisa Azzolini, M. (Other coll.), ... Zoerle, T. (Other coll.). (15 January 2025). Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study. BMJ Mental Health, 28 (1). doi:10.1136/bmjment-2024-301181
BACKGROUND: Traumatic brain injury (TBI) is associated with an increased risk of major depressiv...
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Sala, A., Gosseries, O., Laureys, S., & Annen, J. (2025). Advances in neuroimaging in disorders of consciousness. In Handbook of Clinical Neurology: Coma, Stupor, and Related Disorders of Consciousness. Elsevier. doi:10.1016/B978-0-443-13408-1.00008-7
Disorders of consciousness (DoC) are a heterogeneous spectrum of clinical conditions, including c...
Editorial reviewed
Vitello, M., Thibaut, A., Laureys, S., & Gosseries, O. (2025). Non-pharmacologic interventions in disorders of consciousness. In P. Kaplan & R. Geocadin, Stupor, Coma, and Related Disorders of Consciousness. Elsevier. doi:10.1016/B978-0-443-13408-1.00007-5
Peer reviewed
Li, M., Cecconi, B., Gosseries, O., Cheng, L., Yan, Y., Li, Y., Laureys, S., & Di, H. (December 2024). Exploring end-of-life decision-making in China for disorders of consciousness. Annals of Medicine, 56 (1), 2423794. doi:10.1080/07853890.2024.2423794
[en] OBJECTIVES: We aim to investigate the ethical attitudes of the Chinese population toward wit...
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Sanz, L., Lejeune, N., Szymkowicz, E., Bonin, E., Panda, R., Sala, A., Thibaut, A., Huerta-Gutierrez, R., Dardenne, N., Dikenstein, D., Van Goethem, S., Ledoux, D., Hustinx, R., Stender, J., Farber, N. M., Zafonte, R. D., Schiff, N. D., Laureys, S., & Gosseries, O. (December 2024). Apomorphine for prolonged disorders of consciousness: a multimodal open-label study. EClinicalMedicine, 78, 102925. doi:10.1016/j.eclinm.2024.102925
[en] BACKGROUND: Apomorphine is a dopaminergic candidate therapy to improve recovery in patients ...
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Ooms, F., Annen, J., Panda, R., Cecconi, B., Surlemont, B., & Laureys, S. (November 2024). Entrepreneurial neuroanatomy: Exploring gray matter volume in habitual entrepreneurs. Journal of Business Venturing Insights, 22, 00480. doi:10.1016/j.jbvi.2024.e00480
This pilot study embarks on a journey to uncover the potential anatomical nuances in the brains o...
Peer reviewed
Kumar Govindaiah, P., Adarsh, A., Panda, R., Gosseries, O., MALAISE, N., Salamun, I., Tshibanda, L., Laureys, S., Bonhomme, V., Faymonville, M.-E., Vanhaudenhuyse, A., & Bicego, A. Y. (23 October 2024). Exploring Electrophysiological Responses to Hypnosis in Patients with Fibromyalgia. Brain Sciences, 14 (11), 1047. doi:10.3390/brainsci14111047
Background/Objectives: Hypnosis shows great potential for managing patients suffering from fibrom...
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van der Lande, G., Casas-Torremocha, D., Manasanch, A., Dalla Porta, L., Gosseries, O., Alnagger, N., Barra, A., Mejías, J. F., Panda, R., Riefolo, F., Thibaut, A., Bonhomme, V., Thirion, B., Clasca, F., Gorostiza, P., Sanchez-Vives, M. V., Deco, G., Laureys, S., Zamora-López, G., & Annen, J. (11 October 2024). Brain state identification and neuromodulation to promote recovery of consciousness. Brain Communications, 6 (5), 362. doi:10.1093/braincomms/fcae362
Experimental and clinical studies of consciousness identify brain states (i.e. quasi-stable funct...
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Staquet, C., Vanhaudenhuyse, A., Kandeepan, S., Sanders, R. D., Ribeiro de Paula, D., Brichant, J.-F., Laureys, S., Bonhomme, V., & Soddu, A. (01 October 2024). Changes in Intrinsic Connectivity Networks Topology Across Levels of Dexmedetomidine-Induced Alteration of Consciousness. Anesthesia and Analgesia, 139 (4), 798 - 811. doi:10.1213/ANE.0000000000006799
[en] BACKGROUND: Human consciousness is generally thought to emerge from the activity of intrinsi...
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Martial, C.* , Piarulli, A.* , Gosseries, O., CASSOL, H., Ledoux, D., Charland-Verville, V.* , & Laureys, S.*. (September 2024). EEG signature of near-death-like experiences during syncope-induced periods of unresponsiveness. NeuroImage, 298, 120759. doi:10.1016/j.neuroimage.2024.120759
During fainting, disconnected consciousness may emerge in the form of dream-like experiences. Cha...
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Bodien, Y. G., Allanson, J., Cardone, P., BONHOMME, A., Carmona, J., Chatelle, C., Chennu, S., Conte, M., Dehaene, S., Finoia, P., Heinonen, G., Hersh, J. E., Kamau, E., Lawrence, P. K., Lupson, V. C., Meydan, A., Rohaut, B., Sanders, W. R., Sitt, J. D., ... Schiff, N. D. (15 August 2024). Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal of Medicine, 391 (7), 598 - 608. doi:10.1056/NEJMoa2400645
[en] BACKGROUND: Patients with brain injury who are unresponsive to commands may perform cognitiv...
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Aubinet, C., Vanhaudenhuyse, A., Laureys, S., & Demertzi, A. (2024). The Self in Disorders of Consciousness. In Phenomenological Neuropsychiatry. Springer International Publishing. doi:10.1007/978-3-031-38391-5_16
Editorial reviewed
Herr, R.* , Regnier, A.* , Belorgeot, M.* , Mélotte, E., Simon, J., Sanz, L., Lejeune, N., Chavet, V., PALUSZKIEWICZ, J., Pellas, F., Chevallier, J.-B., Laureys, S., Kaux, J.-F., & Gosseries, O. (31 May 2024). Swallowing Assessment in Post-Comatose Patients: A Feasibility Study on the SWADOC Tool. Journal of Clinical Medicine, 13 (11), 3268. doi:10.3390/jcm13113268
Background: After a severe brain injury and a coma, patients may develop disorders of consciousne...
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Dagnino, P. C., Escrichs, A., López-González, A., Gosseries, O., Annen, J., Sanz Perl, Y., Kringelbach, M. L., Laureys, S., & Deco, G. (May 2024). Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation. PLoS Computational Biology, 20 (5), 1011350. doi:10.1371/journal.pcbi.1011350
A fundamental challenge in neuroscience is accurately defining brain states and predicting how an...
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Howe, E. I., Andelic, N., Brunborg, C., Zeldovich, M., Helseth, E., Skandsen, T., Olsen, A., Fure, S. C. R., Theadom, A., Rauen, K., Madsen, B. Å., Jacobs, B., van der Naalt, J., Tartaglia, M. C., Einarsen, C. E., Storvig, G., Tronvik, E., Tverdal, C., von Steinbüchel, N., ... TommasoZoerle (Other coll.). (25 March 2024). Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI. Journal of Headache and Pain, 25 (1), 44. doi:10.1186/s10194-024-01751-0
BACKGROUND: Headache is a prevalent and debilitating symptom following traumatic brain injury (T...
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Zheng, J., Ouyang, Y., Zhang, K., Wang, Z., Younsi, A., Alhalabi, O., Fu, H., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain, Rosand, J. (Other coll.), Correia, M. (Other coll.), Gagliardo, P. (Other coll.), Vespa, P. M. (Other coll.), Stevens, R. (Other coll.), Furmanov, A. (Other coll.), Brazinova, A. (Other coll.), Ghuysen, A. (Other coll.), Lagares, A. (Other coll.), Kowark, A. (Other coll.), Castaño-León, A. M. (Other coll.), ... Winzeck, S. (Other coll.). (04 March 2024). Early vs Late Fixation of Extremity Fractures Among Adults With Traumatic Brain Injury. JAMA Network Open, 7 (3), 241556. doi:10.1001/jamanetworkopen.2024.1556
IMPORTANCE: The optimal timing for fixation of extremity fractures after traumatic brain injury ...
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Ooms, F., Annen, J., Panda, R., Meunier, P., Tshibanda, L., Laureys, S., Pollack, J. M., & Surlemont, B. (March 2024). Advancing (Neuro)Entrepreneurship Cognition Research Through Resting-State fMRI: A Methodological Brief. Entrepreneurship: Theory and Practice, 48 (2), 719-741. doi:10.1177/10422587231170217
Despite many calls, functional brain magnetic resonance imaging (fMRI) studies are relatively rar...
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Robba, C., Graziano, F., Picetti, E., Åkerlund, C., Addis, A., Pastore, G., Sivero, M., Rebora, P., Galimberti, S., Stocchetti, N., Maas, A., Menon, D. K., Citerio, G., CENTER-TBI Participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), ... Zoerle, T. (Other coll.). (March 2024). Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes-an analysis of CENTER-TBI data. Intensive Care Medicine, 50 (3), 371-384. doi:10.1007/s00134-024-07324-8
PURPOSE: We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on br...
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Regnier, A., Mélotte, E., Aubinet, C., Alnagger, N., Fischer, D., Lagier, A., Thibaut, A., Laureys, S., Kaux, J.-F., & Gosseries, O. (08 January 2024). Swallowing dysfunctions in patients with disorders of consciousness: Evidence from neuroimaging data, assessment, and management. NeuroRehabilitation, 54 (1), 91-107. doi:10.3233/NRE-230135
Following severe brain injuries, a subset of patients may remain in an altered state of conscious...
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Ntikas, M., Stewart, W., Ietswaart, M., Hunter, A. M., Maas, A. I. R., Menon, D. K., Wilson, L., CENTER-TBI participants and, I., Ackerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), Barzó, P. (Other coll.), ... Zoerle, T. (Other coll.). (02 January 2024). Contrasting Characteristics and Outcomes of Sports-Related and Non-Sports-Related Traumatic Brain Injury. JAMA Network Open, 7 (1), 2353318. doi:10.1001/jamanetworkopen.2023.53318
IMPORTANCE: Exposure to traumatic brain injury (TBI) has raised widespread concern over particip...
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Åkerlund, C. A. I., Holst, A., Bhattacharyay, S., Stocchetti, N., Steyerberg, E., Smielewski, P., Menon, D. K., Ercole, A., Nelson, D. W., CENTER-TBI participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), ... Zoerle, T. (Other coll.). (January 2024). Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study. The Lancet Neurology, 23 (1), 71-80. doi:10.1016/S1474-4422(23)00358-7
BACKGROUND: Patients with traumatic brain injury are a heterogeneous population, and the most se...
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Cecconi, B., Montupil, J., Mortaheb, S., Panda, R., Sanders, R. D., Phillips, C., Alnagger, N., Remacle, E., DEFRESNE, A., Boly, M., Bahri, M. A., Lamalle, L., Laureys, S., Gosseries, O., Bonhomme, V., & Annen, J. (2024). Study protocol: Cerebral characterization of sensory gating in disconnected dreaming states during propofol anesthesia using fMRI. Frontiers in Neuroscience, 18, 1306344. doi:10.3389/fnins.2024.1306344
[en] BACKGROUND: Disconnected consciousness describes a state in which subjective experience (i.e...
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Farisco, M., Formisano, R., Gosseries, O., Kato, Y., Koboyashi, S., Laureys, S., Lejeune, N., Martial, C., Matar, A., Morrisey, A.-M., Schnakers, C., Yakufujiang, M., Yamaki, T., Veeramuthu, V., Zandalasini, M., Zasler, N., Magliacano, A., Estraneo, A., & IBIA Special Interest Group on DoCs. (January 2024). Correction to: International survey on the implementation of the European and American guidelines on disorders of consciousness. Journal of Neurology, 271 (1), 408 - 409. doi:10.1007/s00415-023-12083-5
In the original version of this article, the affiliation detail for author Anna Estraneo was inco...
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Farisco, M., Formisano, R., Gosseries, O., Kato, Y., Koboyashi, S., Laureys, S., Lejeune, N., Martial, C., Matar, A., Morrisey, A.-M., Schnakers, C., Yakufujiang, M., Yamaki, T., Veeramuthu, V., Zandalasini, M., Zasler, N., Magliacano, A., Estraneo, A., & IBIA Special Interest Group on DoCs. (2024). International survey on the implementation of the European and American guidelines on disorders of consciousness. Journal of Neurology. doi:10.1007/s00415-023-11956-z
Diagnostic, prognostic, and therapeutic procedures for patients with prolonged disorders of consc...
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Ihalainen, R., Annen, J., Gosseries, O., Cardone, P., Panda, R., Martial, C., Thibaut, A., Laureys, S., & Chennu, S. (2024). Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness. PLoS ONE. doi:10.1371/journal.pone.0298110
Peer Reviewed verified by ORBi
Kumar, G. P., Panda, R., Sharma, K., Adarsh, A., Annen, J., Martial, C., Faymonville, M.-E., Laureys, S., Sombrun, C., Ganesan, R. A., Vanhaudenhuyse, A., & Gosseries, O. (2024). Changes in high-order interaction measures of synergy and redundancy during non-ordinary states of consciousness induced by meditation, hypnosis, and auto-induced cognitive trance. NeuroImage, 293, 120623. doi:10.1016/j.neuroimage.2024.120623
High-order interactions are required across brain regions to accomplish specific cognitive functi...
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Li, Y., Chen, Y., Martial, C., Shen, M., CASSOL, H., Zhou, X., Yu, J., Ni, C., lI, M., Hu, N., Gosseries, O., Laureys, S., & Di, H. (2024). Chinese translation and validation of the Near-Death Experience Content (NDE-C) scale. Frontiers in Psychiatry. doi:10.3389/fpsyt.2023.1201416
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Salmon, E., Feyers, D., Bastin, C., Genon, S., Jedidi, H., Bahri, M. A., Laureys, S., & Collette, F. (2024). Self in dementia. In A. L. Mishara, M. Moskalewicz, M. A. Schwartz, ... A. Kranjec, Phenomenological Neuropsychiatry. How Patient Experience Bridges the Clinic with Clinical Neuroscience (pp. 253-264). United States - New York: Springer. doi:10.1007/978-3-031-38391-5_18
Peer reviewed
Schiller, D., Yu, A. N. C., Alia-Klein, N., Becker, S., Cromwell, H. C., Dolcos, F., Eslinger, P. J., Frewen, P., Kemp, A. H., Pace-Schott, E. F., Raber, J., Silton, R. L., Stefanova, E., Williams, J. H. G., Abe, N., Aghajani, M., Albrecht, F., Alexander, R., Anders, S., ... Leonie, L. (2024). The Human Affectome. Neuroscience and Biobehavioral Reviews, 105450. doi:10.1016/j.neubiorev.2023.105450
Over the last decades, the interdisciplinary field of the affective sciences has seen proliferati...
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Vitello, M., Regnier, A., Gosseries, O., Laureys, S., & Thibaut, A. (2024). Prolonged Impairments of Consciousness. In Encyclopedia of the Neurological Sciences. Elsevier.
Editorial reviewed
Yan, Y.* , Li, M.* , Cai, T., Wang, X., Dong, T., Hu, X., Laureys, S., Gosseries, O., Grégoire, C., & Di, H. (2024). Mood Assessments of Family Caregivers of Patients with Severe Brain Injury in China. Quality of Life Research. doi:10.1007/s11136-023-03539-2
Peer Reviewed verified by ORBi
Szymkowicz, E.* , Neumann, O.* , Sanz, L.* , Gosseries, O., Thibaut, A., Cavaliere, C., Laureys, S.* , & Liepert, J.*. (December 2023). Recovery of Acute Leukoencephalopathy Documented by Neuroimaging: A Case Report. Neurology: Clinical Practice, 13 (6), 200203. doi:10.1212/CPJ.0000000000200203
[en] OBJECTIVES: We describe an atypical delayed neurologic recovery from coma and unresponsive w...
Peer reviewed
Edlow, B. L., Boerwinkle, V. L., Annen, J., Boly, M., Gosseries, O., Laureys, S., Mukherjee, P., Puybasset, L., Stevens, R. D., Threlkeld, Z. D., Newcombe, V. F. J., Fernandez-Espejo, D., & and the Curing Coma Campaign and its Contributing Members. (2023). Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging. Neurocritical Care. doi:10.1007/s12028-023-01842-x
Peer Reviewed verified by ORBi
Oswald, V.* , Vanhaudenhuyse, A.* , Annen, J., Martial, C., Bicego, A. Y., Rousseaux, F., Sombrun, C., Harel, Y., Faymonville, M.-E., Laureys, S., Jerbi, K., & Gosseries, O. (22 September 2023). Autonomic nervous system modulation during self-induced non-ordinary states of consciousness. Scientific Reports, 13 (1), 15811. doi:10.1038/s41598-023-42393-7
Self-induced cognitive trance (SICT) is a voluntary non-ordinary state of consciousness character...
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Zeldovich, M., Bockhop, F., Covic, A., Mueller, I., Polinder, S., Mikolic, A., van der Vlegel, M., von Steinbuechel, N., CENTER-TBI participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), ... Zoerle, T. (Other coll.). (08 September 2023). Factorial validity and comparability of the six translations of the Rivermead Post-Concussion Symptoms Questionnaire translations: results from the CENTER-TBI study. Journal of Patient-Reported Outcomes, 7 (1), 90. doi:10.1186/s41687-023-00632-5
BACKGROUND: Comparison of patient-reported outcomes in multilingual studies requires evidence of...
Peer Reviewed verified by ORBi
Assadzadeh, S.* , Annen, J.* , Sanz, L., Barra, A., Bonin, E., Thibaut, A., Boly, M., Laureys, S., Gosseries, O.* , & Robinson, P. A.*. (01 September 2023). Method for quantifying arousal and consciousness in healthy states and severe brain injury via EEG-based measures of corticothalamic physiology. Journal of Neuroscience Methods, 398, 109958. doi:10.1016/j.jneumeth.2023.109958
[en] BACKGROUND: Characterization of normal arousal states has been achieved by fitting predictio...
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van Essen, T. A., van Erp, I. A. M., Lingsma, H. F., Pisică, D., Yue, J. K., Singh, R. D., van Dijck, J. T. J. M., Volovici, V., Younsi, A., Kolias, A., Peppel, L. D., Heijenbrok-Kal, M., Ribbers, G. M., Menon, D. K., Hutchinson, P. J. A., Manley, G. T., Depreitere, B., Steyerberg, E. W., Maas, A. I. R., ... Zoerle, T. (Other coll.). (September 2023). Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study. EClinicalMedicine, 63, 102161. doi:10.1016/j.eclinm.2023.102161
BACKGROUND: Limited evidence existed on the comparative effectiveness of decompressive craniecto...
Peer Reviewed verified by ORBi
Edlow, B. L., Boerwinkle, V. L., Annen, J., Boly, M., Gosseries, O., Laureys, S., Mukherjee, P., Puybasset, L., Stevens, R. D., Threlkeld, Z. D., Newcombe, V. F. J., Fernandez-Espejo, D., & and the Curing Coma Campaign and  its Contributing Members. (2023). Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging. Neurocritical Care. doi:10.1007/s12028-023-01794-2
[en] BACKGROUND: Over the past 5 decades, advances in neuroimaging have yielded insights into the...
Peer Reviewed verified by ORBi
Cardone, P.* , Bodart, O.* , KIRSCH, M., Sanfilippo, J., Virgillito, A., Martial, C., Simon, J., Wannez, S., Sanders, R. D., Laureys, S., Massimini, M., Vandewalle, G., Bonhomme, V.* , & Gosseries, O.*. (2023). Depth of sedation with dexmedetomidine increases transcranial magnetic stimulation-evoked potential amplitude non-linearly. British Journal of Anaesthesia. doi:10.1016/j.bja.2023.05.030
Peer Reviewed verified by ORBi
Ooms, F., Surlemont, B., Annen, J., Panda, R., & Laureys, S. (August 2023). The Habitual Entrepreneur Brain – A Voxel Based Morphometry Study. Academy of Management Proceedings, 2023 (1). doi:10.5465/amproc.2023.142bp
Peer reviewed
Woodrow, R. E., Winzeck, S., Luppi, A. I., Kelleher-Unger, I. R., Spindler, L. R. B., Wilson, J. T. L., Newcombe, V. F. J., Coles, J. P., CENTER-TBI MRI Substudy Participants and, I., Menon, D. K., Stamatakis, E. A., Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Azouvi, P. (Other coll.), Bellander, B.-M. (Other coll.), Benali, H. (Other coll.), Buki, A. (Other coll.), ... Zoerle, T. (Other coll.). (01 August 2023). Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury. Brain: a Journal of Neurology, 146 (8), 3484-3499. doi:10.1093/brain/awad056
Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are dif...
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Annen, J., Frasso, G., van der Lande, G., Bonin, E., Vitello, M., Panda, R., Sala, A., Cavaliere, C., Raimondo, F., Bahri, M. A., Schiff, N. D., Gosseries, O., Thibaut, A., & Laureys, S. (26 July 2023). Cerebral electrometabolic coupling in disordered and normal states of consciousness. Cell Reports, 42 (8), 112854. doi:10.1016/j.celrep.2023.112854
We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalog...
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Thibaut, A., Fregni, F., Estraneo, A., Fiorenza, S., Noe, E., Llorens, R., Ferri, J., Formisano, R., Morone, G., Bender, A., Rosenfelder, M., Lamberti, G., Kodratyeva, E., Kondratyev, S., Legostaeva, L., Suponeva, N., Krewer, C., Müller, F., Dardenne, N., ... IBIA DOC-SIG. (2023). Sham-controlled randomized multicentre trial of transcranial direct current stimulation for prolonged disorders of consciousness. European Journal of Neurology. doi:10.1111/ene.15974
[en] BACKGROUND AND PURPOSE: Transcranial direct current stimulation (tDCS) has been shown to imp...
Peer Reviewed verified by ORBi
Riemann, L., Mikolic, A., Maas, A., Unterberg, A., Younsi, A., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain, Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Luisa Azzolini, M. (Other coll.), Bartels, R. (Other coll.), Barzó, P. (Other coll.), Beauvais, R. (Other coll.), Beer, R. (Other coll.), ... Zoerle, T. (Other coll.). (June 2023). Computed Tomography Lesions and Their Association With Global Outcome in Young People With Mild Traumatic Brain Injury. Journal of Neurotrauma, 40 (11-12), 1243-1254. doi:10.1089/neu.2022.0055
Mild traumatic brain injury (mTBI) can be accompanied by structural damage to the brain. Here, w...
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Panda, R.* , López-González, A.* , Gilson, M., Gosseries, O., Thibaut, A., Frasso, G., Cecconi, B., Escrichs, A., Coma Science Group Collaborators, Deco, G., Laureys, S., Zamora-López, G.* , & Annen, J.*. (2023). Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness. Human Brain Mapping. doi:10.1002/hbm.26386
The study of the brain's dynamical activity is opening a window to help the clinical assessment o...
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Bicego, A. Y., CASSOL, H., Jessica Simon, Fritz, P., Simona Abagnale, Vanhaudenhuyse, A., Laureys, S., & Martial, C. (2023). Personality traits and pattern of beliefs of near-death(-like) experiencers. Frontiers in Neuroscience. doi:10.3389/fnhum.2023.1124739
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Colombo, M. A.* , Comanducci, A.* , Casarotto, S., Derchi, C.-C., Annen, J., Viganò, A., Mazza, A., Trimarchi, P. D., Boly, M., Fecchio, M., Bodart, O., Navarro, J., Laureys, S., Gosseries, O., Massimini, M., Sarasso, S., & Rosanova, M. (2023). Beyond alpha power: EEG spatial and spectral gradients robustly stratify disorders of consciousness. Cerebral Cortex. doi:10.1093/cercor/bhad031
Neurophysiological markers can overcome the limitations of behavioural assessments of Disorders o...
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Bonin, E., Lejeune, N., Szymkowicz, E., Bonhomme, V., Martial, C., Gosseries, O., Laureys, S., & Thibaut, A. (20 March 2023). Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review. Frontiers in Systems Neuroscience, 17, 1112206. doi:10.3389/fnsys.2023.1112206
The assessment and management of pain and nociception is very challenging in patients unable to c...
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Alnagger, N., Cardone, P., Martial, C., Laureys, S., Annen, J., & Gosseries, O. (14 February 2023). The current and future contribution of neuroimaging to the understanding of disorders of consciousness. Presse Médicale, 52 (2), 104163. doi:10.1016/j.lpm.2022.104163
Patients with disorders of consciousness (DoC) represent a group of severely brain-injured patien...
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Gosseries, O.* , Schnakers, C.* , Vanhaudenhuyse, A., Martial, C., Aubinet, C., Charland-Verville, V., Thibaut, A., Annen, J., Ledoux, D., Laureys, S., & Grégoire, C. (11 February 2023). Needs and quality of life in caregivers of patients with prolonged disorders of consciousness. Brain Sciences, 13 (2), 308. doi:10.3390/brainsci13020308
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Mélotte, E., Maudoux, A., Panda, R., Kaux, J.-F., Lagier, A., Herr, R., Belorgeot, M., LAUREYS, S., & Gosseries, O. (February 2023). Links Between Swallowing and Consciousness: A Narrative Review. Dysphagia, 38 (1), 42-64. doi:10.1007/s00455-022-10452-2
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Timmermann, C.* , Bauer, P. R.* , Gosseries, O.* , Vanhaudenhuyse, A.* , Vollenweider, F., Laureys, S., Singer, T., Mind and Life Europe (MLE) ENCECON Research Group, Antonova, E.* , & Lutz, A.*. (February 2023). A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation, and psychedelics. Trends in Cognitive Sciences, 27 (2), 139 - 159. doi:10.1016/j.tics.2022.11.006
No contemporary unifying framework has been provided for the study of non-ordinary states of cons...
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Jillings, S., Pechenkova, E., Tomilovskaya Elena, Rukavishnikov, I., Jeurissen, B., Van Ombergen, A., Nosikova, I., Rumshiskaya, A., Annen, J., De Laet, C., Schoenmaeker, C., Sijbers, J., Petrovichev, V., Sunaert, S., Parizel, P. M., Sinitsyn, V., zu Eulenburg, P., Laureys, S., Demertzi, A.* , & Wuyts, F. L.*. (13 January 2023). Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity. Communications Biology, 6, 46. doi:10.1038/s42003-022-04382-w
The prospect of continued manned space missions warrants an in-depth understanding of how prolong...
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Ippoliti, C., FADEUR, M., MALHERBE, C., DE FLINES, J., Verbrugge, A.-M., Gosseries, O., Ledoux, D., Misset, B., Laureys, S., Paquot, N., & Thibaut, A. (02 January 2023). What is the nutritional status of patients with prolonged disorders of consciousness? A retrospective cross-sectional study. Brain Injury, 37 (1), 54 - 62. doi:10.1080/02699052.2022.2145361
("[en] BACKGROUND: Nutritional status of patients with disorders of consciousness (DoC) is poorly...
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Fritz, P., Lejeune, N., CASSOL, H., Laureys, S., Gosseries, O., & Martial, C. (2023). Near-death experiences: what do we know? In C. Schnakers & S. Laureys, Coma and Disorders of Consciousness, 3rd edition (3rd). Springer; Softcover reprin. doi:10.1007/978-3-031-50563-8_13
Editorial reviewed
He, J., Zhang, H., Dang, Y., Zhuang, Y., Ge, Q., Yang, Y., Xu, L., Xia, X., Laureys, S., Yu, S., & Zhang, W. (2023). Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness. Brain Stimulation, 16 (5), 1522 - 1532. doi:10.1016/j.brs.2023.09.021
[en] BACKGROUND: Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) ...
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Laureys, S. (2023). Le sommeil c’est bon pour le cerveau. Paris, France: Éditions Odile Jacob.
Pourquoi le sommeil est-il si important ? Pourquoi avons-nous fréquemment des insomnies ? Le prof...
Laureys, S., Schiettecatte, E., & Neumann, O. (2023). Ethical dilemmas in disorders of consciousness: Good communication makes good medicine. Developmental Medicine and Child Neurology, 65 (12), 1656 - 1657. doi:10.1111/dmcn.15753
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Martial, C., CASSOL, H., Slater, M., Bourdin, P., Mensen, A., Ramon, O., Laureys, S.* , & Nunez Novo, P.*. (2023). EEG signature of out-of-body experiences induced by virtual reality: a novel methodological approach. Journal of Cognitive Neuroscience. doi:10.1162/jocn_a_02011
Out-of-body experiences (OBE) are subjective experiences of seeing one’s own body and the environ...
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Martial, C., Poirrier, A.-L., Pottier, L., CASSOL, H., Mortaheb, S., Panda, R., Lopez, M., Perrin, T., Boilevin, A., Gosseries, O., & Laureys, S. (2023). From nose to brain: the effect of lemon inhalation observed by whole brain voxel to voxel functional connectivity. Cortex: A Journal Devoted to the Study of the Nervous System and Behavior. doi:10.1016/j.cortex.2023.04.012
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Meys, M., Wang, Z., Abagnale, S., Kaan, B. O., Alnagger, N., Bardiau, M., Beaudart, C., Laureys, S., Gosseries, O., Thibaut, A., Sala, A., & Annen, J. (2023). Global Neurophysiological Measures in Disorders of Consciousness: a MetaAnalysis. European Journal of Neurology, Supplement 1, 120-87.
Editorial reviewed
Mikolić, A., Steyerberg, E. W., Polinder, S., Wilson, L., Zeldovich, M., von Steinbuechel, N., Newcombe, V. F. J., Menon, D. K., van der Naalt, J., Lingsma, H. F., Maas, A. I. R., van Klaveren, D., Ledoux, D., Ghuysen, A. (Other coll.), Laureys, S. (Other coll.), & Misset, B. (Other coll.). (2023). Prognostic Models for Global Functional Outcome and Post-Concussion Symptoms Following Mild Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study. Journal of Neurotrauma, 40 (15-16), 1651 - 1670. doi:10.1089/neu.2022.0320
After mild traumatic brain injury (mTBI), a substantial proportion of individuals do not fully re...
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Panda, R.* , Vanhaudenhuyse, A.* , Piarulli, A., Annen, J., Demertzi, A., Alnagger, N., Chennu, S., Laureys, S., Faymonville, M.-E.* , & Gosseries, O.*. (2023). Altered brain connectivity and network topological organization in a non-ordinary state of consciousness induced by hypnosis. Journal of Cognitive Neuroscience. doi:10.1162/jocn_a_02019
Hypnosis has been shown to be of clinical utility; however, its underlying neural mechanisms rema...
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Perl, Y. S., Pallavicini, C., Piccinini, J., Demertzi, A., Bonhomme, V., Martial, C., Panda, R., Alnagger, N., Annen, J., Gosseries, O., Ibañez, A., Laufs, H., Sitt, J. D., Jirsa, V. K., Kringelbach, M. L., Laureys, S., Deco, G., & Tagliazucchi, E. (2023). Low-dimensional organization of global brain states of reduced consciousness. Cell Reports, 42 (5), 112491. doi:10.1016/j.celrep.2023.112491
Brain states are frequently represented using a unidimensional scale measuring the richness of s...
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Radstake, W. E., Jillings, S., Laureys, S., Demertzi, A., Sunaert, S., Van Ombergen, A., & Wuyts, F. L. (2023). Neuroplasticity in F16 fighter jet pilots. Frontiers in Physiology, 14, 1082166. doi:10.3389/fphys.2023.1082166
Exposure to altered g-levels causes unusual sensorimotor demands that must be dealt with by the ...
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Rousseau, A.-F., DAMS, L., Massart, Q., CHOQUER, L., Cassol, H., Laureys, S., Misset, B., Dardenne, N., Gosseries, O., & Martial, C. (2023). Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study. Critical Care, 27, 76. doi:10.1186/s13054-023-04348-2
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Sala, A., Kaan, B., Alnagger, N., Abagnale, S., Meys, M., Wang, Z., Bardiau, M., Eickhoff, S., Tettamanti, M., Laureys, S., Gosseries, O., Thibaut, A., & Annen, J. (2023). Brain alterations in disorders of consciousness: a coordinate-based metaanalysis. European Journal of Neurology, 30 (Supplement 1), 120-187.
Introduction We aim to shed light on the localization of brain alterations in Disorders of Consc...
Editorial reviewed
Sanz, L., Laureys, S., & Gosseries, O. (2023). Towards modern post-coma care based on neuroscientific evidence. International Journal of Clinical and Health Psychology, 23 (3), 100370. doi:10.1016/j.ijchp.2023.100370
[en] BACKGROUND: Understanding the mechanisms underlying human consciousness is pivotal to improv...
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Shou, F., Wang, J., Laureys, S., Cheng, L., Huang, W., & Di, H. (2023). Study protocol: Developing telephone follow-up scale for patients with disorders of consciousness. Frontiers in Public Health, 11, 1071008. doi:10.3389/fpubh.2023.1071008
[en] BACKGROUND: The significant lack of rehabilitation prognostic data is the main reason that a...
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Van de Velde, J., Levecque, K., Weijters, B., & Laureys, S. (2023). Doing what matters in times of stress: No-nonsense meditation and occupational well-being in COVID-19. PLoS ONE, 18 (11), 0292406. doi:10.1371/journal.pone.0292406
While the COVID-19 pandemic challenged the general public's health and well-being, it exacerbated...
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Vitello, M., Rosenfelder, M. J., Cardone, P., Niimi, M., Willacker, L., Thibaut, A., Lejeune, N., Laureys, S., Bender, A., & Gosseries, O. (2023). A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness. Frontiers in Neurology, 14, 1216468. doi:10.3389/fneur.2023.1216468
[en] BACKGROUND: Improving the functional recovery of patients with DoC remains one of the greate...
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Wang, A.* , Sun, L.* , Cheng, L., Hu, N., Chen, Y., Sanz, L., Thibaut, A., Gosseries, O., Laureys, S., Martial, C.* , & Di, H.*. (2023). Validation of the simplified evaluation of consciousness disorders (SECONDs) scale in Mandarin. Annals of Physical and Rehabilitation Medicine. doi:10.1016/j.rehab.2023.101764
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Brunoni, A. R., Ekhtiari, H., Antal, A., Auvichayapat, P., Baeken, C., Benseñor, I. M., Bikson, M., Boggio, P., Borroni, B., Brighina, F., Brunelin, J., Carvalho, S., Caumo, W., Ciechanski, P., Charvet, L., Clark, V. P., Cohen Kadosh, R., Cotelli, M., Datta, A., ... Fregni, F. (November 2022). Digitalized transcranial electrical stimulation: A consensus statement. Clinical Neurophysiology, 143, 154-165. doi:10.1016/j.clinph.2022.08.018
OBJECTIVE: Although relatively costly and non-scalable, non-invasive neuromodulation interventio...
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Rousseaux, F.* , Panda, R.* , Toussaint, C., Bicego, A. Y., Niimi, M., Faymonville, M.-E., Nyssen, A.-S., Laureys, S., Gosseries, O.* , & Vanhaudenhuyse, A.*. (2022). Virtual Reality Hypnosis in the management of pain: self-reported and neurophysiological measures in healthy subjects. European Journal of Pain. doi:10.1002/ejp.2045
BACKGROUND: Virtual reality hypnosis (VRH) has emerged as a new and promising option for pain ma...
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Mainali, S., Aiyagari, V., Alexander, S., Bodien, Y., Boerwinkle, V., Boly, M., Brown, E., Brown, J., Claassen, J., Edlow, B. L., Fink, E. L., Fins, J. J., Foreman, B., Frontera, J., Geocadin, R. G., Giacino, J., Gilmore, E. J., Gosseries, O., Hammond, F., ... Curing Coma Campaign, C. (October 2022). Correction to: Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical Care, 37 (2), 608-609. doi:10.1007/s12028-022-01536-w
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Soler-Toscano, F., Galadí, J. A., Escrichs, A., Sanz Perl, Y., López-González, A., Sitt, J. D., Annen, J., Gosseries, O., Thibaut, A., Panda, R., Esteban, F. J., Laureys, S., Kringelbach, M. L., Langa, J. A., & Deco, G. (September 2022). What lies underneath: Precise classification of brain states using time-dependent topological structure of dynamics. PLoS Computational Biology, 18 (9), 1010412. doi:10.1371/journal.pcbi.1010412
The self-organising global dynamics underlying brain states emerge from complex recursive nonlin...
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Panda, R., Thibaut, A., Lopez-Gonzalez, A., Escrichs, A., Bahri, M. A., Hillebrand, A., Deco, G., Laureys, S., Gosseries, O., Annen, J.* , & Tewarie, P.*. (02 August 2022). Disruption in structural-functional network repertoire and time-resolved subcortical fronto-temporoparietal connectivity in disorders of consciousness. eLife, 11. doi:10.7554/eLife.77462
Understanding recovery of consciousness and elucidating its underlying mechanism is believed to ...
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Escrichs, A.* , Perl, Y. S.* , Uribe, C., Camara, E., Türker, B., Pyatigorskaya, N., López-González, A., Pallavicini, C., Panda, R., Annen, J., Gosseries, O., LAUREYS, S., Naccache, L., Sitt, J. D., Laufs, H., Tagliazucchi, E., Kringelbach, M. L.* , & Deco, G.*. (29 June 2022). Unifying turbulent dynamics framework distinguishes different brain states. Communications Biology, 5 (1), 638. doi:10.1038/s42003-022-03576-6
Significant advances have been made by identifying the levels of synchrony of the underlying dyna...
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Mat, B., Sanz, L., Arzi, A., Boly, M., LAUREYS, S., & Gosseries, O. (2022). New behavioral signs of consciousness in patients with severe brain injuries. Seminars in Neurology. doi:10.1055/a-1883-0861
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Mainali, S., Aiyagari, V., Alexander, S., Bodien, Y., Boerwinkle, V., Boly, M., Brown, E., Brown, J., Claassen, J., Edlow, B. L., Fink, E. L., Fins, J. J., Foreman, B., Frontera, J., Geocadin, R. G., Giacino, J., Gilmore, E. J., Gosseries, O., Hammond, F., ... Curing Coma Campaign collaborators. (2022). Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical Care, 1 - 25. doi:10.1007/s12028-022-01505-3
This proceedings article presents actionable research targets on the basis of the presentations a...
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Barra, A., Rosenfelder, M., Mortaheb, S., Carrière, M., Martens, G., Bodien, Y. G., Morales-Quezada, L., Bender, A., LAUREYS, S., Thibaut, A., & Fregni, F. (24 March 2022). Transcranial Pulsed-Current Stimulation versus Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Pilot, Sham-Controlled Cross-Over Double-Blind Study. Brain Sciences, 12 (4), 429. doi:10.3390/brainsci12040429
Transcranial direct-current stimulation (tDCS) over the prefrontal cortex can improve signs of co...
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Bonin, E., Delsemme, Z., Blandin, V., Alnagger, N., Thibaut, A., FAYMONVILLE, M.-E., LAUREYS, S., VANHAUDENHUYSE, A.* , & Gosseries, O.*. (21 March 2022). French Survey on Pain Perception and Management in Patients with Locked-In Syndrome. Diagnostics, 12 (3), 769. doi:10.3390/diagnostics12030769
Patients with locked-in syndrome (LIS) may suffer from pain, which can significantly affect their...
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Lee, M., Sanz, L., Barra, A., WOLFF, A., Nieminen, J. O., Boly, M., Rosanova, M., Casarotto, S., BODART, O., Annen, J., Thibaut, A., Panda, R., BONHOMME, V., Massimini, M., Tononi, G., LAUREYS, S., Gosseries, O.* , & Lee, S.-W.*. (25 February 2022). Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning. Nature Communications, 13 (1), 1064. doi:10.1038/s41467-022-28451-0
Consciousness can be defined by two components: arousal (wakefulness) and awareness (subjective e...
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Grégoire, C., Marie, N., Sombrun, C., FAYMONVILLE, M.-E., Kotsou, I., Van Nitsen, V., De Ribaucourt, S., JERUSALEM, G., LAUREYS, S., VANHAUDENHUYSE, A.* , & Gosseries, O.*. (2022). Hypnosis, meditation and self-induced cognitive trance to improve post-treatment oncological patients’ quality of life: study protocol. Frontiers in Psychology. doi:10.3389/fpsyg.2022.807741
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Vitello, M.* , Szymkowicz, E.* , Laureys, S., Alnagger, N., Gosseries, O.* , & Thibaut, A.*. (2022). Neuroimaging and neurophysiological diagnosis and prognosis in paediatric disorders of consciousness. Developmental Medicine and Child Neurology. doi:10.1111/dmcn.15150
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Aubinet, C., Chatelle, C., Gosseries, O., Carrière, M., Laureys, S., & Majerus, S. (2022). Residual implicit and explicit language abilities in patients with disorders of consciousness: A systematic review. Neuroscience and Biobehavioral Reviews, 132, 391-409. doi:10.1016/j.neubiorev.2021.12.001
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Barisano, G., Sepehrband, F., Collins, H. R., Jillings, S., Jeurissen, B., Taylor, J. A., Schoenmaekers, C., De Laet, C., Rukavishnikov, I., Nosikova, I., Litvinova, L., Rumshiskaya, A., Annen, J., Sijbers, J., Laureys, S., Van Ombergen, A., Petrovichev, V., Sinitsyn, V., Pechenkova, E., ... Wuyts, F. L. (2022). The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts. Proceedings of the National Academy of Sciences of the United States of America, 119 (17). doi:10.1073/pnas.2120439119
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and v...
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Bonin, E., Binda Fossati, M. L., Chatelle, C., Martens, G., Martial, C., Briand, M.-M., Bejor, M., Laureys, S., & Thibaut, A. (2022). Pain and spastic features in chronic DOC patient: A cross-sectional retrospective study. Annals of Physical and Rehabilitation Medicine. doi:10.1016/j.rehab.2021.101566
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Bonin, E., Binda Fossati, M. L., Filippini, M., Bornheim, S., Lejeune, N., O'Brien, A., Bodart, O., Laureys, S., Thibaut, A., & Chatelle, C. (2022). Evaluation of the effect of analgesic treatment on signs of nociception-related behaviors during physiotherapy in patients with disorders of consciousness: a pilot crossover randomized controlled trial. Pain. doi:10.1097/j.pain.0000000000002367
Neuro-orthopedic disorders are common in patients with disorders of consciousness (DOC) and can l...
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Ceyisakar, I. E., Huijben, J. A., Maas, A. I. R., Lingsma, H. F., van Leeuwen, N., CENTER-TBI participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), Barzó, P. (Other coll.), Beauvais, R. (Other coll.), Beer, R. (Other coll.), ... Zoerle, T. (Other coll.). (2022). Can We Cluster ICU Treatment Strategies for Traumatic Brain Injury by Hospital Treatment Preferences? Neurocritical Care. doi:10.1007/s12028-021-01386-y
BACKGROUND: In traumatic brain injury (TBI), large between-center differences in treatment and o...
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Doroshin, A., Jillings, S., Jeurissen, B., Tomilovskaya, E., Pechenkova, E., Nosikova, I., Rumshiskaya, A., Litvinova, L., Rukavishnikov, I., De Laet, C., Schoenmaekers, C., Sijbers, J., Laureys, S., Petrovichev, V., Van Ombergen, A., Annen, J., Sunaert, S., Parizel, P. M., Sinitsyn, V., ... Wuyts, F. L. (2022). Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight. Frontiers in Neural Circuits, 16, 815838. doi:10.3389/fncir.2022.815838
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, a...
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Gosseries, O., & Laureys, S. (2022). Severe Brain Damage: Coma and Related Disorders of Consciousness. In Neuroscience in the 21st Century (pp. 3757-3790). Springer International Publishing. doi:10.1007/978-3-030-88832-9_95
Progress in intensive care efforts has increased the number of patients who survive severe acute ...
Peer reviewed
Laureys, S. (2022). Cerveaugraphie : comprendre le cerveau. France: Hachette Pratique.
Mais qu'est-ce que j'ai dans la tête ? Comment faire pour être un génie, un grand Cerveau ? Est-c...
Laureys, S. (2022). Méditer avec Dr Steven Laureys – carnet d’exercices de méditation. Paris, France: Editions Odile Jacob.
Après le best-seller La méditation, c’est bon pour le cerveau, voici le carnet d’exercices de méd...
Sakai, H., Harada, T., Larroque, S., Demertzi, A., Sugawara, T., Ito, T., Wada, Y., Fukunaga, M., Sadato, N., & Laureys, S. (2022). Left parietal involvement in motion sickness susceptibility revealed by multimodal magnetic resonance imaging. Human Brain Mapping, 43 (3), 1103-1111. doi:10.1002/hbm.25710
Susceptibility to motion sickness varies greatly across individuals. However, the neural mechanis...
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Six, S., Poelaert, J., Laureys, S., Maîresse, O., Theuns, P., Bilsen, J., & Deschepper, R. (2022). A Response to: Letter to the Editor Regarding “Neurophysiological Assessments During Continuous Sedation Until Death Put Validity of Observational Assessments Into Question: A Prospective Observational Study”. Pain and Therapy, 11 (2), 743 - 746. doi:10.1007/s40122-022-00369-x
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Vitello, M., Briand, M.-M., Ledoux, D., Annen, J., El Tahry, R., Laureys, S., Martin, D., Gosseries, O., & Thibaut, A. (2022). Transcutaneous vagal nerve stimulation to treat disorders of consciousness: protocol for a double-blind randomized controlled trial. International Journal of Clinical and Health Psychology, 23 (2). doi:10.1016/j.ijchp.2022.100360
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Böhm, J. K., Schaeben, V., Schäfer, N., Güting, H., Lefering, R., Thorn, S., Schöchl, H., Zipperle, J., Grottke, O., Rossaint, R., Stanworth, S., Curry, N., Maegele, M., CENTER-TBI Participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), ... Zoerle, T. (Other coll.). (2021). Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis. Neurocritical Care. doi:10.1007/s12028-021-01400-3
BACKGROUND: Trauma-induced coagulopathy in traumatic brain injury (TBI) remains associated with ...
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Mikolic, A., Groeniger, J. O., Zeldovich, M., Wilson, L., van Lennep, J. R., van Klaveren, D., Polinder, S., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury, Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), Barzó, P. (Other coll.), Beauvais, R. (Other coll.), ... Zoerle, T. (Other coll.). (December 2021). Explaining Outcome Differences between Men and Women following Mild Traumatic Brain Injury. Journal of Neurotrauma, 38 (23), 3315-3331. doi:10.1089/neu.2021.0116
Men and women differ in outcomes following mild traumatic brain injury (TBI). In the Collaborati...
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Horton, L., Rhodes, J., Menon, D. K., Maas, A. I. R., Wilson, L., Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI), Gruen, R. L. (Other coll.), Cameron, P. (Other coll.), Donoghue, E. (Other coll.), Gantner, D. (Other coll.), Trapani, T. (Other coll.), Vallance, S. (Other coll.), Murray, L. (Other coll.), Brooker, J. (Other coll.), Bragge, P. (Other coll.), Rosenfeld, J. (Other coll.), Cooper, J. D. (Other coll.), Helbok, R. (Other coll.), Beer, R. (Other coll.), ... Vespa, P. M. (Other coll.). (01 November 2021). Questionnaires vs Interviews for the Assessment of Global Functional Outcomes After Traumatic Brain Injury. JAMA Network Open, 4 (11), 2134121. doi:10.1001/jamanetworkopen.2021.34121
IMPORTANCE: An interview is considered the gold standard method of assessing global functional o...
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van Veen, E., van der Jagt, M., Citerio, G., Stocchetti, N., Gommers, D., Burdorf, A., Menon, D. K., Maas, A. I. R., Kompanje, E. J. O., Lingsma, H. F., CENTER-TBI investigators and, P., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), ... Zoerle, T. (Other coll.). (October 2021). Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study. Intensive Care Medicine, 47 (10), 1115-1129. doi:10.1007/s00134-021-06484-1
BACKGROUND: In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) ...
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Huie, J. R., Mondello, S., Lindsell, C. J., Antiga, L., Yuh, E. L., Zanier, E. R., Masson, S., Rosario, B. L., Ferguson, A. R., Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI), Adeoye, O. (Other coll.), Badjatia, N. (Other coll.), Boase, K. (Other coll.), Bodien, Y. (Other coll.), Bullock, M. R. (Other coll.), Chesnut, R. (Other coll.), Corrigan, J. D. (Other coll.), Crawford, K. (Other coll.), Diaz-Arrastia, R. (Other coll.), ... Buki, A. (Other coll.). (15 September 2021). Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations. Journal of Neurotrauma, 38 (18), 2514-2529. doi:10.1089/neu.2019.6762
Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and...
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Aubinet, C.* , Cassol, H.* , BODART, O.* , Sanz, L., Wannez, S., Martial, C., THIBAUT, A., Martens, G., Carrière, M., Gosseries, O., LAUREYS, S.* , & Chatelle, C.*. (September 2021). Simplified Evaluation of CONsciousness Disorders (SECONDs) in individuals with severe brain injury: A validation study. Annals of Physical and Rehabilitation Medicine, 64 (5), 101432. doi:10.1016/j.rehab.2020.09.001
Background The Coma Recovery Scale-Revised (CRS-R) is the gold standard to assess severely brain-...
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Citerio, G., Robba, C., Rebora, P., Petrosino, M., Rossi, E., Malgeri, L., Stocchetti, N., Galimberti, S., Menon, D. K., Center-TBI participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), ... Kornaropoulos, E. (Other coll.). (September 2021). Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Medicine, 47 (9), 961-973. doi:10.1007/s00134-021-06470-7
PURPOSE: To describe the management of arterial partial pressure of carbon dioxide (PaCO(2)) in ...
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Del Pozo, S. M., Laufs, H., BONHOMME, V., LAUREYS, S., Balenzuela, P., & Tagliazucchi, E. (September 2021). Unconsciousness reconfigures modular brain network dynamics. Chaos, 31 (9), 093117. doi:10.1063/5.0046047
The dynamic core hypothesis posits that consciousness is correlated with simultaneously integrate...
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Mortaheb, S., Filippini, M. M., Kaux, J.-F., Annen, J., Lejeune, N., Martens, G., calderon, M. A. F., LAUREYS, S., & Thibaut, A. (September 2021). Neurophysiological Biomarkers of Persistent Post-Concussive Symptoms: A Scoping Reveiw. Frontiers in Neurology, 12, 687197. doi:10.3389/fneur.2021.687197
Background and Objectives: Persistent post-concussive symptoms (PCS) consist of neurologic and ps...
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Yuh, E. L., Jain, S., Sun, X., Pisica, D., Harris, M. H., Taylor, S. R., Markowitz, A. J., Mukherjee, P., Verheyden, J., Giacino, J. T., Levin, H. S., McCrea, M., Stein, M. B., Temkin, N. R., Diaz-Arrastia, R., Robertson, C. S., Lingsma, H. F., Okonkwo, D. O., Maas, A. I. R., ... Kondziella, D. (Other coll.). (01 September 2021). Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. JAMA Neurology, 78 (9), 1137-1148. doi:10.1001/jamaneurol.2021.2120
IMPORTANCE: A head computed tomography (CT) with positive results for acute intracranial hemorrh...
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Sewalt, C. A., Gravesteijn, B. Y., Menon, D., Lingsma, H. F., Maas, A. I. R., Stocchetti, N., Venema, E., Lecky, F. E., CENTER TBI Participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), ... Skandsen, T. (Other coll.). (04 August 2021). Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 29 (1), 113. doi:10.1186/s13049-021-00930-1
BACKGROUND: Prehospital care for patients with traumatic brain injury (TBI) varies with some eme...
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Böhm, J. K., Güting, H., Thorn, S., Schäfer, N., Rambach, V., Schöchl, H., Grottke, O., Rossaint, R., Stanworth, S., Curry, N., Lefering, R., Maegele, M., CENTER-TBI Participants and, I., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), ... Zoerle, T. (Other coll.). (August 2021). Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis. Neurocritical Care, 35 (1), 184-196. doi:10.1007/s12028-020-01151-7
BACKGROUND: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associa...
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Sanz, L., Thibaut, A., Edlow, B., Laureys, S., & Gosseries, O. (August 2021). Update on neuroimaging in disorders of consciousness. Current Opinion in Neurology, 34 (4), 488-496. doi:10.1097/WCO.0000000000000951
Purpose of review Neuroimaging has acquired a prominent place in the assessment of disorders of ...
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Wiegers, E. J. A., Lingsma, H. F., Huijben, J. A., Cooper, D. J., Citerio, G., Frisvold, S., Helbok, R., Maas, A. I. R., Menon, D. K., Moore, E. M., Stocchetti, N., Dippel, D. W., Steyerberg, E. W., van der Jagt, M., CENTER-TBI, OzENTER-TBI Collaboration, G., Brooker, J. (Other coll.), Bragge, P. (Other coll.), Rosenfeld, J. (Other coll.), ... Jordan, A. (Other coll.). (August 2021). Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study. The Lancet Neurology, 20 (8), 627-638. doi:10.1016/S1474-4422(21)00162-9
BACKGROUND: Fluid therapy-the administration of fluids to maintain adequate organ tissue perfusi...
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Perl, Y. S., Pallavicini, C., Ipiña, I. P., Demertzi, A., BONHOMME, V., Martial, C., Panda, R., Annen, J., Ibañez, A., Kringelbach, M., Deco, G., Laufs, H., Sitt, J., Laureys, S., & Tagliazucchi, E. (2021). Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness. PLoS Computational Biology. doi:10.1371/journal.pcbi.1009139
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometim...
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MELOTTE, E., MAUDOUX, A., DELHALLE, S., Lagier, A., Thibaut, A., Aubinet, C., KAUX, J.-F., VANHAUDENHUYSE, A., LEDOUX, D., Laureys, S., & Gosseries, O. (July 2021). Swallowing in individuals with disorders of consciousness: A cohort study. Annals of Physical and Rehabilitation Medicine, 64 (4), 101403. doi:10.1016/j.rehab.2020.04.008
Background. After a period of coma, a proportion of individuals with severe brain injury remain i...
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Sanz Perl, Y., Bocaccio, H., Pallavicini, C., Pérez-Ipiña, I., LAUREYS, S., Laufs, H., Kringelbach, M., Deco, G., & Tagliazucchi, E. (July 2021). Nonequilibrium brain dynamics as a signature of consciousness. Physical Review. E, 104 (1-1), 014411. doi:10.1103/PhysRevE.104.014411
The cognitive functions of human and nonhuman primates rely on the dynamic interplay of distribut...
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Gravesteijn, B. Y., Sewalt, C. A., Venema, E., Nieboer, D., Steyerberg, E. W., CENTER-TBI, C., Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), Barzó, P. (Other coll.), Beauvais, R. (Other coll.), Beer, R. (Other coll.), ... Zoerle, T. (Other coll.). (01 June 2021). Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study. Journal of Neurotrauma, 38 (13), 1842-1857. doi:10.1089/neu.2020.7218
In medical research, missing data is common. In acute diseases, such as traumatic brain injury (...
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Thibaut, A.* , Panda, R.* , Annen, J., Sanz, L., Naccache, L., Martial, C., Chatelle, C., Aubinet, C., Bonin, E., Briand, M.-M., Cecconi, B., Wannez, S., Stender, J., Laureys, S., & Gosseries, O. (03 May 2021). Preservation of brain activity in unresponsive patients identifies MCS star. Annals of Neurology, 90 (1), 89-100. doi:10.1002/ana.26095
Objectives: Brain-injured patients who are unresponsive at the bedside (i.e., vegetative state/un...
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MELOTTE, E., Belorgeot, M., Herr, R., Simon, J., KAUX, J.-F., LAUREYS, S., Sanz, L., Lagier, A., MORSOMME, D., Pellas, F., & Gosseries, O. (April 2021). The Development and Validation of the SWADOC: A Study Protocol for a Multicenter Prospective Cohort Study. Frontiers in Neurology, 12, 662634. doi:10.3389/fneur.2021.662634
Background: After a coma, patients with severe brain injury may present disorders of consciousnes...
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Riemann, L., Voormolen, D. C., Rauen, K., Zweckberger, K., Unterberg, A., Younsi, A., Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury, The Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain, Åkerlund, C. (Other coll.), Amrein, K. (Other coll.), Andelic, N. (Other coll.), Andreassen, L. (Other coll.), Anke, A. (Other coll.), Antoni, A. (Other coll.), Audibert, G. (Other coll.), Azouvi, P. (Other coll.), Azzolini, M. L. (Other coll.), Bartels, R. (Other coll.), Barzó, P. (Other coll.), ... Zoerle, T. (Other coll.). (26 February 2021). Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography. Journal of Neurosurgery: Pediatrics, 27 (5), 538-547. doi:10.3171/2020.9.PEDS20421
OBJECTIVE: The aim of this paper was to evaluate the prevalence of postconcussive symptoms and t...
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Sanz, L.* , Aubinet, C.* , Cassol, H., BODART, O., Wannez, S., Bonin, E., Barra, A., Lejeune, N., Martial, C., Chatelle, C., LEDOUX, D., Laureys, S., Thibaut, A., & Gosseries, O. (2021). SECONDs administration guidelines: A fast tool for assessing consciousness in brain-injured patients. Journal of Visualized Experiments, (168), 61968. doi:10.3791/61968
Establishing an accurate diagnosis is crucial for patients with disorders of consciousness (DoC) ...
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Annen, J.* , Panda, R.* , Martial, C., Piarulli, A., Nery, G., Sanz, L., Valdivia-Valdivia, J., LEDOUX, D., Gosseries, O.* , & Laureys, S.*. (2021). Mapping the functional brain state of a world champion freediver in static dry apnea. Brain Structure and Function, 226, 2675–2688. doi:10.1007/s00429-021-02361-1
Voluntary apnea showcases extreme human adaptability in trained individuals like professional fre...
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Aubinet, C., Chatelle, C., Gillet, S., Lejeune, N., Thunus, M., HENNEN, N., Cassol, H., LAUREYS, S., & Majerus, S. (2021). The Brief Evaluation of Receptive Aphasia test for the detection of language impairment in severely brain-injured patients. Brain Injury, 35 (705), 717. doi:10.1080/02699052.2021.1894482
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Candia-Rivera, D.* , Annen, J.* , Gosseries, O., Martial, C., THIBAUT, A., LAUREYS, S.* , & Tallon-Baudry, C.*. (2021). Neural responses to heartbeats detect residual signs of consciousness during resting state in post-comatose patients. Journal of Neuroscience. doi:10.1523/JNEUROSCI.1740-20.2021
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Hammond, F. M., Katta-Charles, S., Russell, M. B., Zafonte, R. D., Claassen, J., Wagner, A. K., Puybasset, L., Egawa, S., Laureys, S., Diringer, M., & Stevens, R. D. (2021). Research Needs for Prognostic Modeling and Trajectory Analysis in Patients with Disorders of Consciousness. Neurocritical Care, 35 (Suppl 1), 55-67. doi:10.1007/s12028-021-01289-y
BACKGROUND: The current state of the science regarding the care and prognosis of patients with di...
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Harada, T., Sugawara, T., Ito, T., Wada, Y., Fukunaga, M., Sadato, N., Larroque, S., Demertzi, A., Laureys, S., & Sakai, H. (2021). Vestibular Morphological Asymmetry Associated With Motion Sickness Susceptibility. Frontiers in Neuroscience, 15, 763040. doi:10.3389/fnins.2021.763040
Sensory conflicts leading to motion sickness can occur not only between but also within sensory m...
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Ihalainen, R., Gosseries, O., de Steen, F. V., Raimondo, F., Panda, R., Bonhomme, V., Marinazzo, D., Bowman, H., Laureys, S., & Chennu, S. (2021). How hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness: Computational modelling of anaesthetic-induced LOC. NeuroImage, 117841. doi:10.1016/j.neuroimage.2021.117841
In recent years, specific cortical networks have been proposed to be crucial for sustaining consc...
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Laureys, S. (2021). The No-Nonsense Meditation Book : A scientist's guide to the power of meditation. United Kingdom: Green Tree - Bloomsbury Publishing.
Dr Steven Laureys has conducted ground-breaking research into human consciousness for more than 2...
López-González, A.* , Panda, R.* , Ponce-Alvarez, A., Zamora-López, G., Escrichs, A., Martial, C., Thibaut, A., Kringelbach, M. L., Annen, J., Laureys, S., & Gustavo, D. (2021). Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics. Communications Biology. doi:10.1038/s42003-021-02537-9
Low level states of consciousness are characterized by disruptions of brain activity that sustain...
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Løvstad, M., Løke, D., Borgen, I. M., Voormolen, D. C., Howe, E. I., Forslund, M. V., Dahl, H. M., von Steinbuechel, N., CENTER-TBI participants, I., Andelic, N., Røe, C., Brunborg, C., Zeldovich, M., Beer, R. (Other coll.), Bellander, B.-M. (Other coll.), Belli, A. (Other coll.), Benali, H. (Other coll.), Berardino, M. (Other coll.), Beretta, L. (Other coll.), ... Lejeune, A. (Other coll.). (January 2021). Correction to: Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study. Journal of Neurology, 268 (1), 74-76. doi:10.1007/s00415-020-10174-1
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Martens, G., Ibáñez-Soria, D., Barra, A., Soria-Frisch, A., Piarulli, A., Gosseries, O., Salvador, R., Rojas, A., Nitsche, M. A., Kroupi, E., Laureys, S., Ruffini, G., & Thibaut, A. (2021). A novel closed-loop EEG-tDCS approach to promote responsiveness of patients in minimally conscious state: a study protocol. Behavioural Brain Research, 113311. doi:10.1016/j.bbr.2021.113311
Transcranial direct current stimulation (tDCS) applied over the prefrontal cortex has been shown ...
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Martial, C., Fontaine, G., Gosseries, O., Carhart-Harris, R., Timmermann, C., Laureys, S., & Cassol, H. (2021). Losing the Self in Near-Death Experiences: The Experience of Ego-Dissolution. Brain Sciences, 11 (7). doi:10.3390/brainsci11070929
Many people who have had a near-death experience (NDE) describe, as part of it, a disturbed sense...
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Martial, C., Greyson, B., Simon, J., Puttaert, N., Gosseries, O., CHARLAND-VERVILLE, V., LAUREYS, S., & Cassol, H. (2021). Response to “A new scale to assess near-death experiences” [Letter to the Editor]. Journal of Near-Death Studies.
Editorial reviewed
Peinkhofer, C.* , Martial, C.* , Cassol, H., Laureys, S., & Kondziella, D. (2021). The evolutionary origin of near-death experiences: a systematic investigation. Brain Communications, 3 (3), 132. doi:10.1093/braincomms/fcab132
Near-death experiences are known from all parts of the world, various times and numerous cultural...
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Piarulli, A., Annen, J., Kupers, R., Laureys, S., & Martial, C. (2021). High-Density EEG in a Charles Bonnet Syndrome Patient during and without Visual Hallucinations: A Case-Report Study. Cells. doi:10.3390/cells10081991
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Preiser, J.-C., Laureys, S., van Zanten, A. R. H., & Van Gossum, A. (2021). Computer-Assisted Prescription: The Future of Nutrition Care? JPEN Journal of Parenteral and Eternal Nutrition. doi:10.1002/jpen.2008
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Six, S., Laureys, S., Poelaert, J., Maîresse, O., Theuns, P., Bilsen, J., & Deschepper, R. (2021). Neurophysiological Assessments During Continuous Sedation Until Death Put Validity of Observational Assessments Into Question: A Prospective Observational Study. Pain and Therapy, 10 (1), 377-390. doi:10.6084/m9.figshare.13102412
INTRODUCTION: In case of untreatable suffering at the end of life, continuous sedation until deat...
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Staquet, C., Faymonville, M.-E., Gosseries, O., Demertzi, A., Laureys, S., & Vanhaudenhuyse, A. (2021). La neuro-imagerie – vers une nouvelle (re)connaissance de l’hypnose en facultés. In A.-S. Nyssen & M.-E. Faymonville, 150 ans d'hypnose à l'université de Liège (pp. 25-34). Liège, Unknown/unspecified: Presse universitaire de Liège.
Editorial reviewed
Thibaut, A., Di Perri, C., Heine, L., Moissenet, F., Chantraine, F., Schreiber, C., Filipetti, P., Martial, C., Annen, J., Laureys, S., & Gosseries, O. (2021). Neuroplastic changes mediate motor recovery with implanted peroneal nerve stimulator in individuals with chronic stroke: an open-label multimodal pilot study. Annals of Physical and Rehabilitation Medicine. doi:10.1016/j.rehab.2020.01.004
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Yang, H., Ye, C., Liu, X., Sun, L., Wang, A., Wang, J., Hu, N., Hu, X., Gosseries, O., Laureys, S., Di, H., & Fang, J. (2021). Corrigendum: Estimating the Minimal Number of Repeated Examinations for Random Responsiveness With the Coma Recovery Scale-Revised as an Example. Frontiers in Integrative Neuroscience, 15, 745196. doi:10.3389/fnint.2021.745196
This corrects the article DOI: 10.3389/fnint.2021.685627.
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Yang, H., Ye, C., Liu, X., Sun, L., Wang, A., Wang, J., Hu, N., Hu, X., Gosseries, O., Laureys, S., Di, H., & Fang, J. (2021). Estimating the Minimal Number of Repeated Examinations for Random Responsiveness With the Coma Recovery Scale-Revised as an Example. Frontiers in Integrative Neuroscience, 15, 685627. doi:10.3389/fnint.2021.685627
Objective: The aim of this study was to develop a general method to estimate the minimal number o...
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Martial, C., Simon, J., Puttaert, N., Gosseries, O., CHARLAND-VERVILLE, V., Nyssen, A.-S., Greyson, B., LAUREYS, S., & Cassol, H. (2020). The Near-Death Experience Content (NDE-C) scale: Development and psychometric validation. Consciousness and Cognition. doi:10.1016/j.concog.2020.103049
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Yan, Y., Demertzi, A., Xia, Y., Wang, J., Hu, N., Zhang, Z., Di, H., & Laureys, S. (2020). Ethics of life-sustaining treatment in locked-in syndrome: A Chinese survey. Annals of Physical and Rehabilitation Medicine. doi:10.1016/j.rehab.2019.09.011
BACKGROUND: Locked-in syndrome (LIS) characterizes individuals who have experienced pontine lesio...
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Mensen, A., BODART, O., Thibaut, A., Wannez, S., Annen, J., Laureys, S., & Gosseries, O. (25 September 2020). Decreased evoked slow-activity after tDCS in disorders of consciousness. Frontiers in Systems Neuroscience, 14 (62). doi:10.3389/fnsys.2020.00062
Due to life-saving medical advances, the diagnosis and treatment of disorders of consciousness (D...
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Blauwblomme, T.* , Demertzi, A.* , Tacchela, J. M., Fillon, L., Bourgeois, M., Losito, E., Eisermann, M., Marinazzo, D., Raimondo, F., Alcauter, S., Van De Steen, F., Colenbier, N., Laureys, S., Dangouloff-Ros, V., Naccache, L., Boddaert, N., & Nabbout, R. (2020). Complete hemispherotomy leads to lateralized functional organization and lower level of consciousness in the isolated hemisphere. Epilepsia Open. doi:10.1002/epi4.12433
Objective To quantify whole‐brain functional organization after complete hemispherotomy, characte...
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Carrière, M., Larroque, S. K., Martial, C., Bahri, M. A., Aubinet, C., Perrin, F., LAUREYS, S., & Heine, L. (2020). An Echo of Consciousness: Brain Function During Preferred Music. Brain Connectivity. doi:10.1089/brain.2020.0744
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Martial, C., Cassol, H., & LAUREYS, S. (2020). De NDE als opkomend wetenschappelijk onderzoeksgebied. In Pim van Lommel, Het geheim van Elysion: 45 jaar studie naar nabij-de-dood-ervaringen over bewustzijn in liefde zonder waarheen. Van Warven Produkties.
Editorial reviewed
Lejeune, N., van Erp, W., Rohaut, B., Sanz, L., Laureys, S., & Chatelle, C. (2020). États de conscience altérée: soins palliatifs et décisions de fin de vie. In R. Le Berre (Ed.), Manuel de soins palliatifs (5e édition, pp. 727-743). Paris, France: Dunod.
Editorial reviewed
Sanz Perl, Pallavicini, C., Pérez Ipiña, I., Demertzi, A., BONHOMME, V., Martial, C., Panda, R., Annen, J., Ibañez, A., Kringelbach, M., Deco, G., Laufs, H., Sitt, J., LAUREYS, S., & Tagliazucchi, E. (2020). Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness. PLoS Biology. doi:10.1101/2020.07.02.185157
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometim...
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Carrière, M., Mortaheb, S., Raimondo, F., Annen, J., Barra, A., Binda Fossati, M. L., Chatelle, C., Hermann, B., Martens, G., Di Perri, C., LAUREYS, S., & Thibaut, A. (2020). Neurophysiological Correlates of a Single Session of Prefrontal tDCS in Patients with Prolonged Disorders of Consciousness: A Pilot Double-Blind Randomized Controlled Study. Brain Sciences. doi:10.3390/brainsci10070469
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Cecconi, B., Laureys, S., & Annen, J. (2020). Islands of awareness or islands of cortical complexity? [letter to the editor]. Trends in Neurosciences.
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Arnts, H., van Erp, W., Sanz, L., Lavrijsen, J., Schuurman, R., Laureys, S., Vandertop, W. P., & van den Munckhof, P. (June 2020). The dilemma of hydrocephalus in prolonged disorders of consciousness. Journal of Neurotrauma, 37 (20), 2150-2156. doi:10.1089/neu.2020.7129
Prolonged disorders of consciousness (DOC) are considered to be amongst the most severe outcomes ...
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Cassol, H., Bonin, E., Bastin, C., Puttaert, N., Charland-Verville, V., Laureys, S., & Martial, C. (May 2020). Near-Death Experience Memories Include More Episodic Components Than Flashbulb Memories. Frontiers in Psychology, 11 (888). doi:10.3389/fpsyg.2020.00888
Memories of near-death experiences (NDEs) are recalled as “realer” than memories of other real or...
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Charland-Verville, V.* , Ribeiro de Paula, D.* , Martial, C., Cassol, H., Antonopoulos, G., Blaine, C., Soddu, A.* , & Laureys, S.*. (2020). Characterization of near-death experiences using text mining analyses: a preliminary study. PLoS ONE. doi:10.1371/journal.pone.0227402
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Gosseries, O.* , Fecchio, M.* , Wolff, A., Sanz, L., Sombrun, C., VANHAUDENHUYSE, A.* , & Laureys, S.*. (February 2020). Behavioural and brain responses in cognitive trance: A TMS-EEG case study. Clinical Neurophysiology, 131 (2), 586-588. doi:10.1016/j.clinph.2019.11.011
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Martial, C., Cassol, H., Laureys, S., & Gosseries, O. (2020). Near-death experience as a probe to explore (disconnected) consciousness. Trends in Cognitive Sciences. doi:10.1016/j.tics.2019.12.010
Forty-five years ago, the first evidence of near-death experience (NDE) during comatose state was...
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Andelic, N., Røe, C., Brunborg, C., Zeldovich, M., Løvstad, M., Løke, D., Borgen, I. M., Voormolen, D. C., Howe, E. I., Forslund, M. V., Dahl, H. M., von Steinbuechel, N., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., ... CENTER-TBI participants investigators. (2020). Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study. Journal of Neurology. doi:10.1007/s00415-020-10022-2
Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic ...
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Annen, J., Laureys, S., & Gosseries, O. (2020). Brain-computer interfaces for consciousness assessment and communication in severely brain-injured patients. In J. D. R. Millán & N. F. Ramsey (Ed.), Handbook of Clinical Neurology. Volume 168: Brain-Computer Interfaces (pp. 137-152). Elsevier B.V. doi:10.1016/B978-0-444-63934-9.00011-1
Patients with disorders of consciousness (DOC) suffer from awareness deficits. Comorbidities such...
Editorial reviewed
Annen, J., Laureys, S., & Gosseries, O. (2020). Consciousness and communication BCIs in severe brain-injured patients. In Handbook Brain-Computer Interfacing: Neural Devices for paralysis in neurological practise and beyond (pp. 137-152). Elsevier.
Peer reviewed
Annen, J., Mertel, I., Xu, R., Chatelle, C., Lesenfants, D., Ortner, R., Bonin, E., Guger, C., Laureys, S., & Muller, F. (2020). Auditory and somatosensory p3 are complementary for the assessment of patients with disorders of consciousness. Brain Sciences, 10 (10), 1-14. doi:10.3390/brainsci10100748
The evaluation of the level of consciousness in patients with disorders of consciousness (DOC) is...
Peer Reviewed verified by ORBi
Aubinet, C., Cassol, H., Gosseries, O., Bahri, M. A., Larroque, S. K., Majerus, S., Martial, C., Martens, G., Carrière, M., Chatelle, C., Laureys, S., & Thibaut, A. (2020). Brain Metabolism but Not Gray Matter Volume Underlies the Presence of Language Function in the Minimally Conscious State (MCS): MCS+ Versus MCS− Neuroimaging Differences. Neurorehabilitation and Neural Repair, 34 (2), 172-184. doi:10.1177/1545968319899914
Background. The minimally conscious state (MCS) is subcategorized into MCS− and MCS+, depending o...
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Barra, A., Carrière, M., LAUREYS, S., & Martial, C. (2020). From unconscious to conscious: a spectrum of states. In M. Overgaard, J. Mogensen, ... A. Kirkeby-Hinrup, Beyond the Neural Correlates of Consciousness. Taylor & Francis.
Peer reviewed
Bonin, E., Lejeune, N., Thibaut, A., Cassol, H., Antonopoulos, G., Wannez, S., Martial, C., Schnakers, C., LAUREYS, S., & Chatelle, C. (2020). Nociception Coma Scale Revised allows to identify patients with preserved neural basis for pain experience. Journal of Pain. doi:10.1016/j.jpain.2019.11.004
The Nociception Coma Scale-Revised (NCS-R) was developed to help assess pain in patients with dis...
Peer Reviewed verified by ORBi
Bonin, E., Martens, G., Cassol, H., Chatelle, C., Laureys, S., & Thibaut, A. (2020). PET Imaging in Altered States of Consciousness: Coma, Sleep, and Hypnosis. In A. van Waarde, A. Otte, E. F. J. de Vries, R. A. J. O. Dierckx, ... K. L. Leenders (Eds.), PET and SPECT in Neurology (2nd edition). Berlin, Germany: Springer Nature. doi:10.1007/978-3-030-53168-3_45
Positron emission tomography (PET) allows studies of cerebral metabolism and blood flow and has b...
Peer reviewed
Briand, M.-M., Gosseries, O., Staumont, B., Laureys, S., & Thibaut, A. (2020). Transcutaneous Auricular Vagal Nerve Stimulation and Disorders of Consciousness: A Hypothesis for Mechanisms of Action. Frontiers in Neurology, 11. doi:10.3389/fneur.2020.00933
Disorders of consciousness (DoC) are the hallmark of severe acquired brain injuries characterized...
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Carrière, M., Cassol, H., Aubinet, C., Panda, R., THIBAUT, A., Larroque, S., Simon, J., Martial, C., Bahri, M. A., Chatelle, C., Martens, G., Chennu, S., LAUREYS, S., & Gosseries, O. (2020). Auditory localisation should be considered as a sign of minimally conscious state based on multimodal findings. Brain Communications. doi:10.1093/braincomms/fcaa195
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Cavaliere, C., Aiello, M., Soddu, A., Laureys, S., Reislev, N. L., Ptito, M., & Kupers, R. (2020). Organization of the commissural fiber system in congenital and late-onset blindness. NeuroImage: Clinical, 25. doi:10.1016/j.nicl.2019.102133
We investigated the effects of blindness on the structural and functional integrity of the corpus...
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Cecconi, B., Annen, J., & LAUREYS, S. (2020). Can human neurological tests of consciousness be applied to octopus? Animal Sentience. doi:10.51291/2377-7478.1667
If the anatomy, physiology and behaviour of a species differ substantially from our own, can we i...
Cecconi, B., LAUREYS, S., & Annen, J. (2020). Islands of Awareness or Cortical Complexity? [letter to the editor]. Trends in Neurosciences. doi:10.1016/j.tins.2020.05.007
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Comanducci, A., Boly, M., Claassen, J., De Lucia, M., Gibson, R. M., Juan, E., Laureys, S., Naccache, L., Owen, A. M., Rosanova, M., Rossetti, A. O., Schnakers, C., Sitt, J. D., Schiff, N. D., & Massimini, M. (2020). Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group. Clinical Neurophysiology. doi:10.1016/j.clinph.2020.07.015
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the instrument...
Peer Reviewed verified by ORBi
Cortese, D., Riganello, F., Arcuri, F., Lucca, L. F., Tonin, P., Schnakers, C., & Laureys, S. (2020). The Trace Conditional Learning of the Noxious Stimulus in UWS Patients and Its Prognostic Value in a GSR and HRV Entropy Study. Frontiers in Human Neuroscience, 14. doi:10.3389/fnhum.2020.00097
The assessment of the consciousness level of Unresponsive Wakefulness Syndrome (UWS) patients oft...
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Gravesteijn, B. Y., Nieboer, D., Ercole, A., Lingsma, H. F., Nelson, D. W., van Calster, B., Steyerberg, E. W., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P., Beauvais, R., ... CENTER-TBI collaborators. (2020). Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury. Journal of Clinical Epidemiology, 122, 95-107. doi:10.1016/j.jclinepi.2020.03.005
Objective: We aimed to explore the added value of common machine learning (ML) algorithms for pre...
Peer Reviewed verified by ORBi
Gravesteijn, B. Y., Sewalt, C. A., Nieboer, D., Menon, D. K., Maas, A., Lecky, F., Klimek, M., Lingsma, H. F., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P., ... Zoerle, T. (2020). Tracheal intubation in traumatic brain injury: a multicentre prospective observational study. British Journal of Anaesthesia. doi:10.1016/j.bja.2020.05.067
Background: We aimed to study the associations between pre- and in-hospital tracheal intubation a...
Peer Reviewed verified by ORBi
Heilinger, A., Ortner, R., La Bella, V., Lugo, Z. R., Chatelle, C., Laureys, S., Spataro, R., & Guger, C. (2020). Corrigendum: Performance Differences Using a Vibro-Tactile P300 BCI in LIS-Patients Diagnosed With Stroke and ALS. Frontiers in Neuroscience, 14, 637905. doi:10.3389/fnins.2020.637905
[This corrects the article DOI: 10.3389/fnins.2018.00514.].
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Huijben, J. A., Wiegers, E. J. A., Ercole, A., De Keizer, N. F., Maas, A. I. R., Steyerberg, E. W., Citerio, G., Wilson, L., Polinder, S., Nieboer, D., Menon, D., Lingsma, H. F., Van Der Jagt, M., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Audibert, G., Azouvi, P., ... Clusmann, H. (2020). Quality indicators for patients with traumatic brain injury in European intensive care units: A CENTER-TBI study. Critical Care, 24 (1). doi:10.1186/s13054-020-2791-0
Background: The aim of this study is to validate a previously published consensus-based quality i...
Peer Reviewed verified by ORBi
Huijben, J. A., Wiegers, E. J. A., Lingsma, H. F., Citerio, G., Maas, A. I. R., Menon, D. K., Ercole, A., Nelson, D., van der Jagt, M., Steyerberg, E. W., Helbok, R., Lecky, F., Peul, W., Birg, T., Zoerle, T., Carbonara, M., Stocchetti, N., Åkerlund, C., Amrein, K., ... CENTER-TBI investigators and participants. (2020). Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe: a CENTER-TBI analysis. Intensive Care Medicine, 46 (5), 995-1004. doi:10.1007/s00134-020-05965-z
Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (I...
Peer Reviewed verified by ORBi
Javarone, M. A., Gosseries, O., Marinazzo, D., Noirhomme, Q., BONHOMME, V., LAUREYS, S., & Chennu, S. (2020). A mean field approach to model levels of consciousness from EEG recordings. Journal of Statistical Mechanics: Theory and Experiment, 8, 083405. doi:10.1088/1742-5468/ababfb
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Jillings, S., Van Ombergen, A., Tomilovskaya, E., Rumshiskaya, A., Litvinova, L., Nosikova, I., Pechenkova, E., Rukavishnikov, I., Kozlovskaya, I. B., Manko, O., Danilichev, S., Sunaert, S., Parizel, P. M., Sinitsyn, V., Petrovichev, V., Laureys, S., Eulenburg, P., Sijbers, J., Wuyts, F. L., & Jeurissen, B. (2020). Macro- And microstructural changes in cosmonauts' brains after long-duration spaceflight. Science Advances, 6 (36). doi:10.1126/sciadv.aaz9488
Long-duration spaceflight causes widespread physiological changes, although its effect on brain s...
Peer Reviewed verified by ORBi
Kondziella, D., Bender, A., Diserens, K., van Erp, W., Estraneo, A., Formisano, R., Laureys, S., Naccache, L., Ozturk, Ş., Rohaut, B., Sitt, J. D., Stender, J., Tiainen, M., Rossetti, A. O.* , Gosseries, O.* , & Chatelle, C.*. (2020). European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness. European Journal of Neurology, 27 (5), 741-756. doi:10.1111/ene.14151
Background and purpose: Patients with acquired brain injury and acute or prolonged disorders of c...
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Lejeune, N., Thibaut, A., Martens, G., Martial, C., Wannez, S., LAUREYS, S., & Chatelle, C. (2020). Can the Nociception Coma Scale-Revised be used in patients with a tracheostomy? Archives of Physical Medicine and Rehabilitation. doi:10.1016/j.apmr.2019.09.020
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Lugo, Z. R., Pokorny, C., Pellas, F., Noirhomme, Q., Laureys, S., Müller-Putz, G., & Kübler, A. (2020). Mental imagery for brain-computer interface control and communication in non-responsive individuals. Annals of Physical and Rehabilitation Medicine, 63 (1), 21-27. doi:10.1016/j.rehab.2019.02.005
Background: People who survive severe brain damage may eventually develop a prolonged consciousne...
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Martens, G., Kroupi, E., Bodien, Y., Frasso, G., Annen, J., Cassol, H., Barra, A., Martial, C., Gosseries, O., Lejeune, N., Soria-Frisch, A., Ruffini, G., Laureys, S., & Thibaut, A. (2020). Behavioral and electrophysiological effects of network-based frontoparietal tDCS in patients with severe brain injury: A randomized controlled trial. NeuroImage: Clinical. doi:10.1016/j.nicl.2020.102426
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Murovec, N., Heilinger, A., Xu, R., Ortner, R., Spataro, R., La Bella, V., Miao, Y., Jin, J., Chatelle, C., Laureys, S., Allison, B. Z., & Guger, C. (2020). Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness. Frontiers in Neuroscience, 14. doi:10.3389/fnins.2020.00294
Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive...
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Robba, C., Galimberti, S., Graziano, F., Wiegers, E. J. A., Lingsma, H. F., Iaquaniello, C., Stocchetti, N., Menon, D., Citerio, G., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Beer, R., ... The CENTER-TBI ICU Participants and Investigators. (2020). Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study. Intensive Care Medicine, 46. doi:10.1007/s00134-020-05935-5
Purpose: Indications and optimal timing for tracheostomy in traumatic brain-injured (TBI) patient...
Peer Reviewed verified by ORBi
Rousseaux, F., Bicego, A. Y., LEDOUX, D., MASSION, P., NYSSEN, A.-S., FAYMONVILLE, M.-E., LAUREYS, S., & VANHAUDENHUYSE, A. (2020). Hypnosis associated with 3D immersive virtual reality technology in the management of pain: A review of the literature. Journal of Pain Research. doi:10.2147/JPR.S231737
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Rudas, J., Martinez, D., Castellanos, G., Demertzi, A., Martial, C., Carrière, M., Aubinet, C., Soddu, A., Laureys, S., & Gomez, F. (2020). Time-Delay Latency of Resting-State Blood Oxygen Level-Dependent Signal Related to the Level of Consciousness in Patients with Severe Consciousness Impairment. Brain Connectivity, 10 (2), 83-94. doi:10.1089/brain.2019.0716
Recent evidence on resting-state functional magnetic resonance imaging (rs-fMRI) suggests that he...
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Sarasso, S., D'Ambrosio, S., Fecchio, M., Casarotto, S., Viganò, A., Landi, C., Mattavelli, G., Gosseries, O., Quarenghi, M., Laureys, S., Devalle, G., Rosanova, M., & Massimini, M. (2020). Local sleep-like cortical reactivity in the awake brain after focal injury. Brain: a Journal of Neurology, 143 (12), 3672-3684. doi:10.1093/brain/awaa338
The functional consequences of focal brain injury are thought to be contingent on neuronal altera...
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Six, S., Bilsen, J., Laureys, S., Poelaert, J., Theuns, P., & Deschepper, R. (2020). A Reflection on Using Observational Measures for the Assessment and/or Monitoring of Level of Consciousness in Palliatively Sedated Patients. Journal of Palliative Medicine. doi:10.1089/jpm.2019.0574
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Six, S., Van Overmeire, R., Bilsen, J., Laureys, S., Poelaert, J., Theuns, P., & Deschepper, R. (2020). Attitudes of professional caregivers and family members regarding the use of monitoring devices to improve assessments of pain and discomfort during continuous sedation until death. Journal of Pain and Symptom Management. doi:10.1016/j.jpainsymman.2020.02.015
Context Assessing consciousness and pain during continuous sedation until death (CSD) by behavior...
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Thibaut, A., Bodien, Y. G., Laureys, S., & Giacino, J. T. (2020). Correction to: Minimally conscious state “plus”: diagnostic criteria and relation to functional recovery (Journal of Neurology, (2020), 267, 5, (1245-1254), 10.1007/s00415-019-09628-y). Journal of Neurology, 267 (5), 1255-1259. doi:10.1007/s00415-020-09760-0
Following electronic publication of the above-referenced manuscript, we discovered that one of th...
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Thibaut, A., Bodien, Y. G., Laureys, S., & Giacino, J. T. (2020). Minimally conscious state “plus”: diagnostic criteria and relation to functional recovery. Journal of Neurology, 267 (5), 1245-1254. doi:10.1007/s00415-019-09628-y
Background: We investigated the relationship between three language-dependent behaviors (i.e., co...
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Timmers, M., Van Dijck, J. T. J. M., Van Wijk, R. P. J., Legrand, V., Van Veen, E., Maas, A. I. R., Menon, D. K., Citerio, G., Stocchetti, N., Kompanje, E. J. O., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., ... Zoerle, T. (2020). How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study. BMC Medical Ethics, 21 (1). doi:10.1186/s12910-020-00480-8
Background: The European Union (EU) aims to optimize patient protection and efficiency of health-...
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van Erp, W., Lavrijsen, J. C. M., Vos, P. E., Laureys, S., & Koopmans, R. T. C. M. (2020). Unresponsive wakefulness syndrome: Outcomes from a vicious circle. Annals of Neurology, 87 (1), 12-18. doi:10.1002/ana.25624
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van Wijk, R. P. J., van Dijck, J. T. J. M., Timmers, M., van Veen, E., Citerio, G., Lingsma, H. F., Maas, A. I. R., Menon, D. K., Peul, W. C., Stocchetti, N., Kompanje, E. J. O., Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., ... The CENTER-TBI investigators and participants. (2020). Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study. Journal of Critical Care, 59, 6-15. doi:10.1016/j.jcrc.2020.05.004
Purpose: Enrolling traumatic brain injury (TBI) patients with an inability to provide informed co...
Peer Reviewed verified by ORBi
Voormolen, D. C., Polinder, S., von Steinbuechel, N., Feng, Y., Wilson, L., Oppe, M., Haagsma, J. A., Åkerlund, C., Adams, H., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P., ... the CENTER-TBI participants and investigators. (2020). Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom. Quality of Life Research. doi:10.1007/s11136-020-02583-6
Purpose: The Quality of Life after Brain Injury overall scale (QOLIBRI-OS) measures health-relate...
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Wang, J., Di, H., Hua, W., Cheng, L., Xia, Z., Hu, Z., Huang, W., Chatelle, C., & Laureys, S. (2020). A study of the reliability and validity of the Chinese version of the Nociception Coma Scale–Revised. Clinical Rehabilitation, 34 (8), 1112-1121. doi:10.1177/0269215520927445
Objective: The aim of the study was to check on the reliability and validity of the translated ve...
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Wang, J., Hu, X., Hu, Z., Sun, Z., Laureys, S., & Di, H. (2020). The misdiagnosis of prolonged disorders of consciousness by a clinical consensus compared with repeated coma-recovery scale-revised assessment. BMC Neurology, 20 (1). doi:10.1186/s12883-020-01924-9
Background: Previous studies have shown that a single Coma-Recovery Scale-Revision (CRS-R) assess...
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Wang, J., Wang, W., Laureys, S., & Di, H. (2020). Burnout syndrome in healthcare professionals who care for patients with prolonged disorders of consciousness: a cross-sectional survey. BMC Health Services Research, 20 (1), 841. doi:10.1186/s12913-020-05694-5
BACKGROUND: Burnout is more common among healthcare professionals, that is an important problem o...
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Cassol, H., Martial, C., & Laureys, S. (2019). Les expériences de mort imminente. In A. Dechene & B. Dupont, Crises. Liège, Belgium: ULiège - Université de Liège.
Les expériences de mort imminente (EMI) désignent un ensemble d’événements mentaux émotionnelleme...
Peer reviewed
Martial, C., Mensen, A., CHARLAND-VERVILLE, V., VANHAUDENHUYSE, A., Rentmeister, D., Bahri, M. A., Cassol, H., Englebert, J., Gosseries, O., LAUREYS, S., & Faymonville, M.-E. (2019). Neurophenomenology of near-death experience memory in hypnotic recall: a within-subject EEG study. Scientific Reports. doi:10.1038/s41598-019-50601-6
The neurobiological basis of near-death experiences (NDEs) is unknown, but a few studies attempte...
Peer Reviewed verified by ORBi
Bonin, E., Wolff, A., Sanz, L., Laureys, S., & Chatelle, C. (September 2019). Évaluation clinique des états de conscience altérée: quelle échelle utiliser ? Lettre du Neurologue: le Courrier du Spécialiste, XXIII (7), 253-254.
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Martens, G., Fregni, F., Carrière, M., Barra, A., Laureys, S., & Thibaut, A. (2019). Single tDCS session of motor cortex in patients with disorders of consciousness: a pilot study. Brain Injury. doi:10.1080/02699052.2019.1667537
Primary Objective: Patients with disorders of consciousness (DOC) face a lack of treatments and r...
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BONHOMME, V., STAQUET, C., Montupil, J., DEFRESNE, A., KIRSCH, M., Martial, C., VANHAUDENHUYSE, A., Chatelle, C., Larroque, S. K., Raimondo, F., Demertzi, A., BODART, O., LAUREYS, S., & Gosseries, O. (2019). General Anesthesia: A Probe to Explore Consciousness. Frontiers in Systems Neuroscience. doi:10.3389/fnsys.2019.00036
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Annen, J., Filippini, M. M., Bonin, E., Cassol, H., Aubinet, C., Carrière, M., Gosseries, O., Thibaut, A., Barra, A., Wolff, A., Sanz, L., Martial, C., Laureys, S., & Chatelle, C. (18 July 2019). Diagnostic accuracy of the CRS-R index in patients with disorders of consciousness. Brain Injury, 33 (11), 1409-1412. doi:10.1080/02699052.2019.1644376
Objective: To obtain a CRS-R index suitable for diagnosis of patients with disorders of conscious...
Peer Reviewed verified by ORBi
Golkowski, D., Larroque, S. K., VANHAUDENHUYSE, A., Plenevaux, A., Boly, M., Di Perri, C., Ranft, A., Schneider, G., Laureys, S., Jordan, D., BONHOMME, V., & Ilg, R. (June 2019). Changes in Whole Brain Dynamics and Connectivity Patterns during Sevoflurane- and Propofol-induced Unconsciousness Identified by Functional Magnetic Resonance Imaging. Anesthesiology, 130 (6), 898-911. doi:10.1097/ALN.0000000000002704
Background: A key feature of the human brain is its capability to adapt flexibly to changing exte...
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Thibaut, A., Schiff, N., Giacino, J., LAUREYS, S., & Gosseries, O. (June 2019). Therapeutic interventions in patients with prolonged disorders of consciousness. The Lancet Neurology, 18 (6), 600-614. doi:10.1016/S1474-4422(19)30031-6
The management of patients with severe brain injuries and prolonged disorders of consciousness ra...
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Sanz, L., Lejeune, N., Blandiaux, S., Bonin, E., Thibaut, A., Stender, J., Farber, N., Zafonte, R., Schiff, N., Laureys, S., & Gosseries, O. (19 March 2019). Treating disorders of consciousness with apomorphine: protocol for a double-blind randomized controlled trial using multimodal assessments. Frontiers in Neurology, 10 (248). doi:10.3389/fneur.2019.00248
Background: There are few available therapeutic options to promote recovery among patients with c...
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Cassol, H., D'Argembeau, A., Charland-Verville, V., Laureys, S.* , & Martial, C.*. (01 March 2019). Memories of near-death experiences: are they self-defining? Neuroscience of Consciousness, 5 (1). doi:10.1093/nc/niz002
Some people report memories of near-death experiences (NDEs) after facing situations of impending...
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Martial, C.* , Cassol, H.* , Charland-Verville, V., Pallavicini, C., Sanz, C., Zamberlan, F., Martínez Vivot, R., Erowid, F., Erowid, E., LAUREYS, S., Greyson, B., & Tagliazucchi, E. (2019). Neurochemical models of near-death experiences: a large-scale study based on the semantic similarity of written reports. Consciousness and Cognition. doi:10.1016/j.concog.2019.01.011
The real or perceived proximity to death often results in a non-ordinary state of consciousness c...
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Six, S., Laureys, S., Poelaert, J., Bilsen, J., Theuns, P., Musch, L., & Deschepper, R. (March 2019). Should we include monitors to improve assessment of awareness and pain in unconscious palliatively sedated patients? A case report. Palliative Medicine, 33 (6), 712-716. doi:10.1177/0269216319835149
Background: Awareness and pain during palliative sedation is typically assessed by observational ...
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Demertzi, A.* , Tagliazucchi, E.* , Dehaene, S., Deco, G., Barttfeld, P., Raimondo, F., Martial, C., Fernandez-Espejo, D., Rohaut, B., Voss, H., Schiff, N., Owen, A., Laureys, S., Naccache, L., & Sitt, J. (February 2019). Human consciousness is supported by dynamic complex patterns of brain signal coordination. Science Advances, 5 (2), 7603. doi:10.1126/sciadv.aat7603
Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined w...
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Martens, G., Deltombe, T., Foidart-Dessalle, M., Laureys, S., & Thibaut, A. (February 2019). Clinical and electrophysiological investigation of spastic muscle overactivity in patients with disorders of consciousness following severe brain injury. Clinical Neurophysiology, 130 (2). doi:10.1016/j.clinph.2018.10.021
Objective The clinical and electrophysiological profile of spastic muscle overactivity (SMO) is ...
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Armstrong, M. J., Giacino, J. T., Katz, D. I., Schiff, N. D., Whyte, J., Ashman, E. J., Ashwal, S., Barbano, R., Hammond, F. M., Laureys, S., Ling, G. S. F., Nakase-Richardson, R., Seel, R. T., Yablon, S., Getchius, T. S. D., & Gronseth, G. S. (2019). Author response: Practice guideline update recommendations summary: Disorders of consciousness: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology; the American Congress of Rehabilitation Medicine; and the National Institute on Disability, Independent Living, and Rehabilitation Research. Neurology, 92 (24), 1164. doi:10.1212/WNL.0000000000007669
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Aubinet, C., Panda, R., Larroque, S. K., Cassol, H., Bahri, M. A., Carrière, M., Wannez, S., Majerus, S., Laureys, S., & Thibaut, A. (2019). Reappearance of Command-Following Is Associated With the Recovery of Language and Internal-Awareness Networks: A Longitudinal Multiple-Case Report. Frontiers in Systems Neuroscience, 13 (8), 10.3389/fnsys.2019.00008. doi:10.3389/fnsys.2019.00008
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Bogdanov, V. B., Bogdanov, O. V., Vigano, A., Noirhomme, Q., Laureys, S., Dallel, R., Phillips, C., & Schoenen, J. (2019). Increased cerebral responses to salient transitions between alternating stimuli in chronic migraine with medication overuse headache and during migraine attacks. Cephalalgia, 39 (8), 988-999. doi:10.1177/0333102418825359
Introduction In a previous study exploring central pain modulation with heterotopic stimuli in he...
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Cassol, H., Martial, C., Annen, J., Martens, G., Charland-Verville, V., Majerus, S., & Laureys, S. (2019). A systematic analysis of distressing near-death experience accounts. Memory, 27, 1122-1129. doi:10.1080/09658211.2019.1626438
Near-death experiences (NDEs) are usually associated with positive affect, however, a small propo...
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Colombo, M. A., Napolitani, M., Boly, M., Gosseries, O., Casarotto, S., Rosanova, M., Brichant, J.-F., Boveroux, P., Rex, S., Laureys, S., Massimini, M., Chieregato, A., & Sarasso, S. (2019). The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine. NeuroImage, 189, 631-644. doi:10.1016/j.neuroimage.2019.01.024
Despite the absence of responsiveness during anesthesia, conscious experience may persist. Howeve...
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Comolatti, R., Pigorini, A., Casarotto, S., Fecchio, M., Faria, G., Sarasso, S., Rosanova, M., Gosseries, O., Boly, M., BODART, O., LEDOUX, D., Brichant, J.-F., Nobili, L., Laureys, S., Tononi, G., Massimini, M., & Casali, A. G. (2019). A fast and general method to empirically estimate the complexity of brain responses to transcranial and intracranial stimulations. Brain Stimulation, 12 (5), 1280-1289. doi:10.1016/j.brs.2019.05.013
BACKGROUND: The Perturbational Complexity Index (PCI) was recently introduced to assess the capac...
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Gosseries, O., Schnakers, C., & Laureys, S. (2019). Editorial: Between Theory and Clinic: The Contribution of Neuroimaging in the Field of Consciousness Disorders. Frontiers in Neurology, 10, 165. doi:10.3389/fneur.2019.00165
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LAUREYS, S., & Ricard, M. (Other coll.). (2019). La méditation, c'est bon pour le cerveau. Paris, France: Odile Jacob.
Martial, C., Larroque, S. K., Cavaliere, C., Wannez, S., Annen, J., Kupers, R., LAUREYS, S., & Di Perri, C. (2019). Resting-state functional connectivity and cortical thickness characterization of a patient with Charles Bonnet syndrome. PLoS ONE. doi:10.1371/journal.pone.0219656
Charles Bonnet syndrome (CBS) is a rare condition characterized by visual impairment associated w...
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Martinez, D. E., Rudas, J., Demertzi, A., Charland-Verville, V., Soddu, A., Laureys, S., & Gomez, F. (2019). Reconfiguration of large-scale functional connectivity in patients with disorders of consciousness. Brain and Behavior, 1476. doi:10.1002/brb3.1476
INTRODUCTION: Functional connectivity alterations within individual resting state networks (RSNs)...
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Michel, M., Beck, D., Block, N., Blumenfeld, H., Brown, R., Carmel, D., Carrasco, M., Chirimuuta, M., Chun, M., Cleeremans, A., Dehaene, S., Fleming, S. M., Frith, C., Haggard, P., He, B. J., Heyes, C., Goodale, M. A., Irvine, L., Kawato, M., ... Yoshida, M. (2019). Opportunities and challenges for a maturing science of consciousness. Nature Human Behaviour. doi:10.1038/s41562-019-0531-8
Scientific research on consciousness is critical to multiple scientific, clinical, and ethical is...
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Pace-Schott, E. F., Amole, M. C., Aue, T., Balconi, M., Bylsma, L. M., Critchley, H., Demaree, H. A., Friedman, B. H., Gooding, A. E. K., Gosseries, O., Jovanovic, T., Kirby, L. A. J., Kozlowska, K., Laureys, S., Lowe, L., Magee, K., Marin, M.-F., Merner, A. R., Robinson, J. L., ... VanElzakker, M. B. (2019). Physiological feelings. Neuroscience and Biobehavioral Reviews, 103, 267-304. doi:10.1016/j.neubiorev.2019.05.002
The role of peripheral physiology in the experience of emotion has been debated since the 19th ce...
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Pechenkova, E. V., Nosikova, I. N., Rumshiskaya, A. D., Litvinova, L. D., Rukavishnikov, I. V., Mershina, E. A., Sinitsin, V. E., Van Ombergen, A., Jeurissen, B., Jillings, S., Laureys, S., Sijbers, J., Grishin, A., Chernikova, L. A., Naumov, I. A., Kornilova, L. N., Wuyts, F. L., Tomilovskaya, E. S., & Kozlovskaya, I. B. (2019). Alterations of functional brain connectivity after long-duration spaceflight as revealed by fMRI. Frontiers in Physiology, 10 (MAY), 23. doi:10.3389/fphys.2019.00761
The present study reports alterations of task-based functional brain connectivity in a group of 1...
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Riganello, F., Larroque, S. K., Di Perri, C., Prada, V., Sannita, G. W., & LAUREYS, S. (2019). Measures Of CNS-Autonomic Interaction And Responsiveness In Disorder Of Consciousness. Frontiers in Neuroscience. doi:10.3389/fnins.2019.00530
Neuroimaging studies have demonstrated functional interactions between autonomic (ANS) and brain ...
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Rizkallah, J., Annen, J., Modolo, J., Gosseries, O., Benquet, P., Mortaheb, S., Amoud, H., Cassol, H., Mheich, A., Thibaut, A., Chatelle, C., Hassan, M., Panda, R., Wendling, F., & Laureys, S. (2019). Decreased integration of EEG source-space networks in disorders of consciousness. NeuroImage: Clinical, 23, 1-9. doi:10.1016/j.nicl.2019.101841
Increasing evidence links disorders of consciousness (DOC) with disruptions in functional connect...
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Ruiz de Miras, J., Soler, F., Iglesias-Parro, S., Ibanez-Molina, A. J., Casali, A. G., Laureys, S., Massimini, M., Esteban, F. J., Navas, J., & Langa, J. A. (2019). Fractal dimension analysis of states of consciousness and unconsciousness using transcranial magnetic stimulation. Computer Methods and Programs in Biomedicine. doi:10.1016/j.cmpb.2019.04.017
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Thibaut, A., Piarulli, A., Martens, G., Chatelle, C., & Laureys, S. (2019). Effect of multichannel transcranial direct current stimulation to reduce hypertonia in individuals with prolonged disorders of consciousness: A randomized controlled pilot study. Annals of Physical and Rehabilitation Medicine. doi:10.1016/j.rehab.2019.05.009
BACKGROUND: Spasticity management in severely brain-injured patients with disorders of conscious...
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van Erp, W., Aben, A. M. L., Lavrijsen, J. C. M., Vos, P. E., Laureys, S., & Koopmans, R. T. C. M. (2019). Unexpected emergence from the vegetative state: delayed discovery rather than late recovery of consciousness. Journal of Neurology, 266 (12), 3144-3149. doi:10.1007/s00415-019-09542-3
Background: The vegetative state, also known as the unresponsive wakefulness syndrome, is one of ...
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Van Ombergen, A., Jillings, S., Jeurissen, B., Tomilovskaya, E., Rumshiskaya, A., Litvinova, L., Nosikova, I., Pechenkova, E., Rukavishnikov, I., Manko, O., Danylichev, S., Rühl, R. M., Kozlovskaya, I. B., Sunaert, S., Parizel, P. M., Sinitsyn, V., Laureys, S., Sijbers, P., Eulenburg, P. Z., & Wuyts, F. L. (2019). Brain ventricular volume changes induced by long-duration spaceflight. Proceedings of the National Academy of Sciences of the United States of America, 116 (21), 10531-10536. doi:10.1073/pnas.1820354116
Long-duration spaceflight induces detrimental changes in human physiology. Its residual effects a...
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VANHAUDENHUYSE, A., LEDOUX, D., Gosseries, O., Demertzi, A., LAUREYS, S., & FAYMONVILLE, M.-E. (2019). Can subjective ratings of absorption, dissociation, and time perception during “neutral hypnosis” predict hypnotizability?: An exploratory study. International Journal of Clinical and Experimental Hypnosis, 67 (1), 28-38. doi:10.1080/00207144.2019.1553765
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Wang, F., Hu, N., Hu, X., Jing, S., Heine, L., Thibaut, A., Huang, W., Yan, Y., Wang, J., Schnakers, C., Laureys, S., & Di, H. (2019). Detecting Brain Activity Following a Verbal Command in Patients With Disorders of Consciousness. Frontiers in Neuroscience. doi:10.3389/fnins.2019.00976
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Wang, J., Wang, J., Hu, X., Xu, L., Tian, J., Li, J., Fang, D., Huang, W., Sun, Y., He, M., Laureys, S., & Di, H. (2019). The Initiation of Swallowing Can Indicate the Prognosis of Disorders of Consciousness: A Self-Controlled Study. Frontiers in Neurology, 10, 1184. doi:10.3389/fneur.2019.01184
Objective: To detect the initiation of swallowing in patients with disorders of consciousness (DO...
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Wu, G.-R., Di Perri, C., CHARLAND-VERVILLE, V., Martial, C., Carrière, M., VANHAUDENHUYSE, A., LAUREYS, S., & Marinazzo, D. (2019). Modulation of the spontaneous hemodynamic response function across levels of consciousness. NeuroImage. doi:10.1016/j.neuroimage.2019.07.011
Functional imaging research has already contributed with several results to the study of neural c...
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Zhang, Y., Wang, Y., Schnakers, C., He, M., Luo, H., Cheng, L., Wang, F., Nie, Y., Huang, W., Hu, X., Laureys, S., & Di, H. (2019). Validation of the Chinese version of the Coma Recovery Scale-Revised (CRS-R). Brain Injury, 33 (4), 529-533. doi:10.1080/02699052.2019.1566832
Primary Objective: This study aims to validate the Chinese version of the Coma Recovery Scale-Rev...
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Sanz, L., Laureys, S., & Gosseries, O. (December 2018). Les états de conscience altérée : études comportementales et de neuro-imagerie. Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques, 10 (4), 313-321. doi:10.1684/nrp.2018.0481
Disorders of consciousness after a coma are both a clinical challenge for caregivers and a unique...
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Riganello, F.* , Larroque, S. K.* , Bahri, M. A., Heine, L., Martial, C., Carrière, M., CHARLAND-VERVILLE, V., Aubinet, C., VANHAUDENHUYSE, A., Chatelle, C., LAUREYS, S., & Di Perri, C. (12 September 2018). A Heartbeat Away From Consciousness: Heart Rate Variability Entropy Can Discriminate Disorders of Consciousness and Is Correlated With Resting-State fMRI Brain Connectivity of the Central Autonomic Network. Frontiers in Neurology, 9, 769. doi:10.3389/fneur.2018.00769
Background: Disorders of consciousness are challenging to diagnose, with inconsistent behavioral ...
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Aubinet, C., Murphy, L., Bahri, M. A., Larroque, S. K., Cassol, H., Annen, J., Carrière, M., Wannez, S., Thibaut, A., Laureys, S., & Gosseries, O. (14 August 2018). Brain, behavior, and cognitive interplay in disorders of consciousness: A multiple case study. Frontiers in Neurology, 9 (665), 1-10. doi:10.3389/fneur.2018.00665
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Timmermann, C., Roseman, L., Williams, L., Erritzoe, D., Martial, C., Cassol, H., LAUREYS, S., Nutt, D., & Carhart-Harris, R. (2018). DMT models the near-death experience. Frontiers in Psychology. doi:10.3389/fpsyg.2018.01424
Near-death experiences (NDEs) are complex subjective experiences, which have been previously asso...
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Martial, C., Cassol, H., Charland-Verville, V., Merckelbach, H., & LAUREYS, S. (2018). Fantasy proneness correlates with the intensity of near-death experience. Frontiers in Psychiatry. doi:10.3389/fpsyt.2018.00190
Little is known about the personality characteristics of those who have experienced a “Near-Death...
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Thibaut, A., Chatelle, C., VANHAUDENHUYSE, A., Martens, G., Cassol, H., Barra, A., Martial, C., Carrière, M., LAUREYS, S., & Gosseries, O. (June 2018). Transcranial direct current stimulation unveils covert consciousness. Brain Stimulation, 11 (3), 642-644. doi:10.1016/j.brs.2018.02.002
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Martens, G., Lejeune, N., O'Brien, A., Fregni, F., Martial, C., Wannez, S., Laureys, S., & Thibaut, A. (2018). Randomized controlled trial of home-based 4-week tDCS in chronic minimally conscious state. Brain Stimulation. doi:10.1016/j.brs.2018.04.021
Background Patients with chronic disorders of consciousness face a significant lack of treatment ...
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Wolff, A., Blandiaux, S., Cassol, H., Chatelle, C., Laureys, S., & Gosseries, O. (2018). Evaluations comportementales chez les patients en état de conscience altérée. In C. Jourdan, F. Pellas, J. Luauté, B. Chevalier, ... X. de Boissezon, Etats de conscience altérée - Actualités diagnostiques, pronostiques et thérapeutiques. Montpellier, France: SAURAMPS MÉDICAL.
A l’heure actuelle, l’évaluation de la conscience chez les patients sortant du coma reste un chal...
Peer reviewed
Annen, J., Frasso, G., Crone, J., Heine, L., Di Perri, C., Martial, C., Cassol, H., Demertzi, A., Naccache, L., & LAUREYS, S. (2018). Regional brain volumetry and brain function in severely brain-injured patients. Annals of Neurology. doi:10.1002/ana.25214
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MELOTTE, E.* , MAUDOUX, A.* , DELHALLE, S., Martial, C., Antonopoulos, G., Larroque, S., Wannez, S., FAYMONVILLE, M.-E., KAUX, J.-F., LAUREYS, S.* , Gosseries, O.* , & VANHAUDENHUYSE, A.*. (April 2018). Is oral feeding compatible with an unresponsive wakefulness syndrome? Journal of Neurology, 265 (4), 954-961. doi:10.1007/s00415-018-8794-y
The aim of the study is to explore the possibility of oral feeding in unresponsive wakefulness sy...
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Piarulli, A., Zaccaro, A., Laurino, M., Menicucci, D., De Vito, A., Bruschini, L., Berrettini, S., Bergamasco, M., Laureys, S., & Gemignani, A. (April 2018). Ultra-slow mechanical stimulation of olfactory epithelium modulates consciousness by slowing cerebral rhythms in humans. Scientific Reports, 8 (1). doi:10.1038/s41598-018-24924-9
The coupling between respiration and neural activity within olfactory areas and hippocampus has r...
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Velly, L., Perlbarg, V., Boulier, T., Adam, N., Delphine, S., Luyt, C. É., Battisti, V., Torkomian, G., Arbelot, C., Chabanne, R., Jean, B., Di Perri, C., Laureys, S., Citerio, G., Vargiolu, A., Rohaut, B., Bruder, N., Girard, N., Silva, S., ... MRI-COMA Investigators. (April 2018). Use of brain diffusion tensor imaging for the prediction of long-term neurological outcomes in patients after cardiac arrest: a multicentre, international, prospective, observational, cohort study. The Lancet Neurology, 17 (4), 317-326. doi:10.1016/S1474-4422(18)30027-9
Background: Prediction of neurological outcome after cardiac arrest is a major challenge. The aim...
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BODART, O., Amico, E., Gomez, F., Casali, A., Wannez, S., Heine, L., Thibaut, A., Annen, J., Boly, M., Casarotto, S., Rosanova, M., Massimini, M., Laureys, S.* , & Gosseries, O.*. (2018). Global structural integrity and effective connectivity in patients with disorders of consciousness. Brain Stimulation. doi:10.1016/j.brs.2017.11.006
Background Previous studies have separately reported impaired functional, structural, and effecti...
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Cassol, H.* , Pétré, B.* , Degrange, S., Martial, C., Charland-Verville, V., Lallier, F., Bragard, I., Guillaume, M., & Laureys, S. (2018). Qualitative thematic analysis of the phenomenology of near-death experiences. PLoS ONE. doi:10.1371/journal.pone.0193001
Near-death experiences (NDEs) refer to profound psychological events that can have an important i...
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Annen, J., Blandiaux, S., Lejeune, N., Bahri, M. A., Thibaut, A., Cho, W., Guger, C., Chatelle, C.* , & Laureys, S.*. (2018). BCI performance and brain metabolism profile in severely brain-injured patients without response to command at bedside. Frontiers in Neuroscience. doi:10.3389/fnins.2018.00370
Detection and interpretation of signs of "covert command following" in patients with disorders of...
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Aubinet, C., Larroque, S. K., Heine, L., Martial, C., Majerus, S., Laureys, S., & Di Perri, C. (2018). Clinical sub-categorization of minimally conscious state according to resting functional connectivity. Human Brain Mapping, 39, 4519-4532. doi:10.1002/hbm.24303
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BODART, O., Fecchio, M., Massimini, M., Wannez, S., Virgillito, A., Casarotto, S., Rosanova, M., Lutz, A., Ricard, M., Laureys, S., & Gosseries, O. (2018). Meditation-induced modulation of brain response to transcranial magnetic stimulation [letter to the editor]. Brain Stimulation, 11 (6), 1397-1400. doi:10.1016/j.brs.2018.08.018
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Boly, M., & Laureys, S. (2018). Functional 'unlocking': Bedside detection of covert awareness after severe brain damage. Brain: a Journal of Neurology, 141 (5), 1239-1241. doi:10.1093/brain/awy080
This scientific commentary refers to ‘Characterization of EEG signals revealing covert cognition ...
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Cassol, H., Aubinet, C., Thibaut, A., Wannez, S., Martial, C., Martens, G., & Laureys, S. (2018). Diagnostic, pronostic et traitements des troubles de la conscience. NPG : Neurologie, Psychiatrie, Gériatrie, 18. doi:10.1016/j.npg.2017.04.001
Les progrès de la médecine et des soins intensifs ont conduit à une augmentation du nombre de pat...
Peer reviewed
Cassol, H., Wolff, A., Chatelle, C., Gosseries, O., Laureys, S., & Thibaut, A. (2018). Conscience et états de conscience altérée. In Jourdan, C, Pellas, F, Luauté, J, Chevallier, J.-B, ... de Boissezon, X, Etats de conscience altérée (pp. 9-24). Montpellier, France: Sauramps MEDICAL.
Peer reviewed
Chatelle, C., Hauger, S. L., Martial, C., Becker, F., Eifert, B., Boering, D., Giacino, J., LAUREYS, S., Løvstad, M., & Maurer-Karattup, P. (2018). Assessment of nociception and pain in participants with unresponsive or minimally conscious state after acquired brain injury: the relationship between the Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised. Archives of Physical Medicine and Rehabilitation. doi:10.1016/j.apmr.2018.03.009
Objectives: To investigate the relation between consciousness and nociceptive responsiveness (ie,...
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Cruse, D., Thibaut, A., Demertzi, A., Nantes, J. C., Bruno, M.-A., Gosseries, O., VANHAUDENHUYSE, A., Bekinschtein, T. A., Owen, A., & Laureys, S. (2018). Correction: Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States [BMC Med. 11, (2013) (18)] DOI: 10.1186/1741-7015-11-18. BMC Medicine, 16 (1). doi:10.1186/s12916-018-1139-y
The original article [1] contains an error affecting the actigraphy time-stamps throughout the ar...
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Darracq, M., Funk, C. M., Polyakov, D., Riedner, B., Gosseries, O., Nieminen, J. O., BONHOMME, V., Brichant, J.-F., Boly, M., Laureys, S., Tononi, G., & Sanders, R. D. (2018). Evoked Alpha Power is Reduced in Disconnected Consciousness During Sleep and Anesthesia. Scientific Reports, 8 (1). doi:10.1038/s41598-018-34957-9
Sleep and anesthesia entail alterations in conscious experience. Conscious experience may be abse...
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Di Perri, C.* , Amico, E.* , Heine, L., Annen, J., Martial, C., Larroque, S. K., Soddu, A., Marinazzo, D., & LAUREYS, S. (2018). Multifaceted Brain Networks Reconfiguration in Disorders of Consciousness Uncovered by Co-Activation Patterns. Human Brain Mapping. doi:10.1002/hbm.23826
Introduction: Given that recent research has shown that functional connectivity is not a static p...
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Engemann, D. A.* , Raimondo, F.* , King, J.-R., Rohaut, B., Louppe, G., Faugeras, F., Annen, J., Cassol, H., Gosseries, O., Fernandez-Slezak, D., Laureys, S., Naccache, L., Dehaene, S., & Sitt, J. D. (2018). Robust EEG-based cross-site and cross-protocol classification of states of consciousness. Brain: a Journal of Neurology, 141 (11), 3179-3192. doi:10.1093/brain/awy251
Determining the state of consciousness in patients with disorders of consciousness is a challengi...
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Guger, C., Spataro, R., Pellas, F., Allison, B. Z., Heilinger, A., Ortner, R., Cho, W., Xu, R., La Bella, V., Edlinger, G., Annen, J., Mandala, G., Chatelle, C.* , & Laureys, S.*. (2018). Assessing Command-Following and Communication With Vibro-Tactile P300 Brain-Computer Interface Tools in Patients With Unresponsive Wakefulness Syndrome. Frontiers in Neuroscience, 12, 423. doi:10.3389/fnins.2018.00423
Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor disablities, ...
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Huijben, J. A., Volovici, V., Cnossen, M. C., Haitsma, I. K., Stocchetti, N., Maas, A. I. R., Menon, D. K., Ercole, A., Citerio, G., Nelson, D., Polinder, S., Steyerberg, E. W., Lingsma, H. F., van der Jagt, M., Adams, H., Alessandro, M., Allanson, J., Amrein, K., Andaluz, N., ... van der Naalt, J. (2018). Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Critical Care, 22 (1), 90. doi:10.1186/s13054-018-2000-6
BACKGROUND: General supportive and preventive measures in the intensive care management of trauma...
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Lesenfants, D., Habbal, D., Chatelle, C., Soddu, A., Laureys, S., & Noirhomme, Q. (2018). Toward an Attention-Based Diagnostic Tool for Patients With Locked-in Syndrome. Clinical EEG and Neuroscience, 49 (2), 122-135. doi:10.1177/1550059416674842
Electroencephalography (EEG) has been proposed as a supplemental tool for reducing clinical misdi...
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Martens, G., Blandiaux, S., Wolff, A., Gosseries, O., Laureys, S., & Chatelle, C. (2018). Evaluation de la douleur chez le patient cérébrolésé en état de conscience altérée. In Jourdan, C, Pellas, F, Luauté, J, Chevallier, J.-B, ... de Boissezon, X, Etats de conscience altérée. Sauramps MEDICA.
La douleur se définit comme une “expérience sensorielle et émotionnelle désagréable associée à un...
Peer reviewed
Moe, H. K., Moen, K. G., Skandsen, T., Kvistad, K. A., Laureys, S., Håberg, A., & Vik, A. (2018). The influence of traumatic axonal injury in thalamus and brainstem on level of consciousness at scene or admission: A clinical magnetic resonance imaging study. Journal of Neurotrauma, 35 (7), 975-984. doi:10.1089/neu.2017.5252
The aim of this study was to investigate how traumatic axonal injury (TAI) lesions in the thalamu...
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Mortensen, K. N., Gjedde, A., Thompson, G. J., Herman, P., Parent, M. J., Rothman, D. L., Kupers, R., Ptito, M., Stender, J., Laureys, S., Riedl, V., Alkire, V. T., & Hyder, F. (2018). Impact of global mean normalization on regional glucose metabolism in the human brain. Neural Plasticity, 2018. doi:10.1155/2018/6120925
Because the human brain consumes a disproportionate fraction of the resting body's energy, positr...
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Riganello, F.* , Chatelle, C.* , Schnakers, C., & LAUREYS, S. (2018). Heart Rate Variability as an indicator of nociceptive pain in disorders of consciousness? Journal of Pain and Symptom Management. doi:10.1016/j.jpainsymman.2018.09.016
CONTEXT: Heart rate variability (HRV) is thought to reflect the affective and physiological aspe...
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Rosanova, M.* , Fecchio, M.* , Casarotto, S., Sarasso, S., Casali, A. G., Pigorini, A., Comanducci, A., Seregni, F., Devalle, G., Citerio, G., BODART, O., Boly, M., Gosseries, O., Laureys, S., & Massimini, M. (2018). Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients. Nature Communications, 9 (1). doi:10.1038/s41467-018-06871-1
Unresponsive wakefulness syndrome (UWS) patients may retain intact portions of the thalamocortica...
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Sair, H. I., Hannawi, Y., Li, S., Kornbluth, J., Demertzi, A., Di Perri, C., Chabanne, R., Jean, B., Benali, H., Perlbarg, V., Pekar, J., Luyt, C.-É., Galanaud, D., Velly, L., Puybasset, L., Laureys, S., Caffo, B., & Stevens, R. D. (2018). Early functional connectome integrity and 1-year recovery in comatose survivors of cardiac arrest. Radiology, 287 (1), 247-255. doi:10.1148/radiol.2017162161
Purpose: To assess whether early brain functional connectivity is associated with functional reco...
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Sanders, R. D., Banks, M. I., Darracq, M., Moran, R., Sleigh, J., Gosseries, O., BONHOMME, V., Brichant, J.-F., Rosanova, M., Raz, A., Tononi, G., Massimini, M., Laureys, S., & Boly, M. (2018). Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy. British Journal of Anaesthesia, 121 (5), 1084-1096. doi:10.1016/j.bja.2018.07.006
Background: Impaired consciousness has been associated with impaired cortical signal propagation ...
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Sanz, L., Laureys, S., & Gosseries, O. (2018). Disorders of consciousness: behavioral and neuroimaging studies. In Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques. ADRSC.
Peer reviewed
Six, S., Laureys, S., Poelaert, J., Bilsen, J., Theuns, P., & Deschepper, R. (2018). Comfort in palliative sedation (Compas): A transdisciplinary mixed method study protocol for linking objective assessments to subjective experiences. BMC Palliative Care, 17 (1). doi:10.1186/s12904-018-0316-2
Background: In case of untreatable suffering at the end of life, palliative sedation may be chose...
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Sun, Y., Wang, J., Heine, L., Huang, W., Wang, J., Hu, N., Hu, X., Fang, X., Huang, S., Laureys, S., & Di, H. (2018). Personalized objects can optimize the diagnosis of EMCS in the assessment of functional object use in the CRS-R: A double blind, randomized clinical trial. BMC Neurology, 18 (1). doi:10.1186/s12883-018-1040-5
Background: Behavioral assessment has been acted as the gold standard for the diagnosis of disord...
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Thibaut, A., Chennu, S., Chatelle, C., Martens, G., Annen, J., Cassol, H., & Laureys, S. (2018). Theta network centrality correlates with tDCS response in disorders of consciousness. Brain Stimulation, 11 (6), 1407-1409. doi:10.1016/j.brs.2018.09.002
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Thibaut, A., Wannez, S., Deltombe, T., Martens, G., Laureys, S., & Chatelle, C. (2018). Physical therapy in patients with disorders of consciousness: Impact on spasticity and muscle contracture. NeuroRehabilitation, 42 (2), 199-205. doi:10.3233/NRE-172229
BACKGROUND: Spasticity is a frequent complication after severe brain injury, which may prevent th...
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Van Ombergen, A., Jillings, S., Jeurissen, B., Tomilovskaya, E., Rühl, R. M., Rumshiskaya, A., Nosikova, I., Litvinova, L., Annen, J., Pechenkova, E. V., Kozlovskaya, I. B., Sunaert, S., Parizel, P. M., Sinitsyn, V., Laureys, S., Sijbers, J., Zu Eulenburg, P., & Wuyts, F. L. (2018). Brain Tissue-Volume Changes in Cosmonauts [letter to the editor]. New England Journal of Medicine, 379 (17), 1678-1680. doi:10.1056/NEJMc1809011
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van Ommen, H. J., Thibaut, A., VANHAUDENHUYSE, A., Heine, L., Charland-Verville, V., Wannez, S., BODART, O., Laureys, S., & Gosseries, O. (2018). Resistance to eye opening in patients with disorders of consciousness. Journal of Neurology, 1-5. doi:10.1007/s00415-018-8849-0
Introduction: Resistance to eye opening (REO) is a commonly encountered phenomenon in clinical pr...
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VANHAUDENHUYSE, A., Charland-Verville, V., Thibaut, A., Chatelle, C., Tshibanda, J.-F. L., Maudoux, A., Faymonville, M.-E., Laureys, S., & Gosseries, O. (2018). Conscious while being considered in an unresponsive wakefulness syndrome for 20 years. Frontiers in Neurology, 9 (AUG). doi:10.3389/fneur.2018.00671
Despite recent advances in our understanding of consciousness disorders, accurate diagnosis of se...
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Walter, U., Fernández-Torre, J. L., Kirschstein, T., & Laureys, S. (2018). When is “brainstem death” brain death? The case for ancillary testing in primary infratentorial brain lesion. Clinical Neurophysiology, 129 (11), 2451-2465. doi:10.1016/j.clinph.2018.08.009
The widely accepted concept of brain death (BD) comprises the demonstration of irreversible coma ...
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Wannez, S., Gosseries, O., Azzolini, D., Martial, C., Cassol, H., Aubinet, C., Annen, J., Martens, G., Bodart, O., Heine, L., Charland-Verville, V., Thibaut, A., Chatelle, C., VANHAUDENHUYSE, A., Demertzi, A., Schnakers, C., Donneau, A.-F., & Laureys, S. (2018). Prevalence of coma-recovery scale-revised signs of consciousness in patients in minimally conscious state. Neuropsychological Rehabilitation, 28 (8), 1350-1359. doi:10.1080/09602011.2017.1310656
Different behavioural signs of consciousness can distinguish patients with an unresponsive wakefu...
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Wielek, T., Lechinger, J., Wislowska, M., Blume, C., Ott, P., Wegenkittl, S., Del Giudice, R., Heib, D. P. J., Mayer, H. A., Laureys, S., Pichler, G., & Schabus, M. (2018). Sleep in patients with disorders of consciousness characterized by means of machine learning. PLoS ONE, 13 (1), 0190458. doi:10.1371/journal.pone.0190458
Sleep has been proposed to indicate preserved residual brain functioning in patients suffering fr...
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Martens, G., LAUREYS, S., & Thibaut, A. (2017). Spasticity Management in Disorders of Consciousness. Brain Sciences. doi:10.3390/brainsci7120162
Background: Spasticity is a motor disorder frequently encountered after a lesion involving the ce...
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Stephan, J., Radiguer, F., Martial, C., Franconie, C., LAUREYS, S., & Wauquiez, G. (2017). États de conscience altérée: Quel rôle pour les neuropsychologues ? Neurologies.
Avec les progrès des techniques de soins intensifs et de réanimation, de nombreuses personnes sur...
Editorial reviewed
Martial, C., Cassol, H., Antonopoulos, G., Charlier, T., Héros, J., Donneau, A.-F., Charland-Verville, V., & LAUREYS, S. (2017). Corrigendum: Temporality of Features in Near-Death Experience Narratives. Frontiers in Human Neuroscience.
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Martial, C., Cassol, H., Antonopoulos, G., Charlier, T., Héros, J., Donneau, A.-F., Charland-Verville, V., & Laureys, S. (2017). Temporality of Features in Near-Death Experience Narratives. Frontiers in Human Neuroscience. doi:10.3389/fnhum.2017.00311
Background: After an occurrence of a Near-Death Experience (NDE), Near- Death Experiencers (NDErs...
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Heine, L., Tillmann, B., Hauet, M., Juliat, A., Dubois, A., Laureys, S., Kandel, M., Plailly, J., Luauté, J., & Perrin, F. (2017). Effects of preference and sensory modality on behavioral reaction in patients with disorders of consciousness. Brain Injury. doi:10.1080/02699052.2017.1306108
Background: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a ...
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Ribeiro de Paula, D., Ziegler, E., Abeyasinghe, P., Das, T., Cavaliere, C., Aiello, M., Heine, L., Di Perri, C., Demertzi, A., Noirhomme, Q., Charland-Verville, V., VANHAUDENHUYSE, A., Stender, J., Gomez, F., TSHIBANDA, L., LAUREYS, S., Owen, A., & Soddu, A. (16 February 2017). A method for independent component graph analysis of resting-state fMRI. Brain and Behavior, 7 (3). doi:10.1002/brb3.626
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Noirhomme, Q., Brecheisen, R., Lesenfants, D., Antonopoulos, G., & Laureys, S. (15 January 2017). "Look at my classifier's result": Disentangling unresponsive from (minimally) conscious patients. NeuroImage, 145, 288-303. doi:10.1016/j.neuroimage.2015.12.006
Given the fact that clinical bedside examinations can have a high rate of misdiagnosis, machine l...
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Amico, E., BODART, O., Rosanova, M., Gosseries, O., Heine, L., Van Mierlo, P., Martial, C., Massimini, M., Marinazzo, D.* , & Laureys, S.*. (2017). Tracking dynamic interactions between structural and functional connectivity: a TMS/EEG-dMRI study. Brain Connectivity. doi:10.1089/brain.2016.0462
Transcranial magnetic stimulation (TMS) in combination with neuroimaging techniques allows to mea...
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Amico, E., Marinazzo, D., Di Perri, C., Heine, L., Annen, J., Martial, C., Dzemidzic, M., KIRSCH, M., BONHOMME, V., Laureys, S., & Goni, J. (2017). Mapping the functional connectome traits of levels of consciousness. NeuroImage. doi:10.1016/j.neuroimage.2017.01.020
Examining task-free functional connectivity (FC) in the human brain offers insights on how sponta...
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Annen, J., Laureys, S., & Gosseries, O. (2017). People with disorders of consciousness. In International Handbook of Neuropsychological Rehabilitation (pp. 124-135). Taylor and Francis. doi:10.4324/9781315629537
Peer reviewed
BODART, O., Gosseries, O., Wannez, S., Thibaut, A., Annen, J., Boly, M., Rosanova, M., Casali, A., Casarotto, S., Tononi, G., Massimini, M., & LAUREYS, S. (2017). Measures of metabolism and complexity in the brain of patients with disorders of consciousness. NeuroImage: Clinical, 14, 354-362. doi:10.1016/j.nicl.2017.02.002
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Charland-Verville, V., Martial, C., Cassol, H., & Laureys, S. (2017). Near-death experiences: actual considerations. In C. Schnakers & S. Laureys, Coma and Disorders of Consciousness, Second Edition. Springer. doi:10.1007/978-3-319-55964-3_14
The notion that death represents a passing to an afterlife, where we are reunited with loved ones...
Peer reviewed
Chennu, S., Annen, J., Wannez, S., Thibaut, A., Chatelle, C., Cassol, H., Martens, G., Schnakers, C., Gosseries, O., Menon, D., & Laureys, S. (2017). Brain networks predict metabolism, diagnosis and prognosis at the bedside in disorders of consciousness. Brain: a Journal of Neurology, 140 (8), 2120-2132. doi:10.1093/brain/awx163
Recent advances in functional neuroimaging have demonstrated novel potential for informing diagno...
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Cnossen, M. C., Huijben, J., van der Jagt, M. F., Volovici, V., van Essen, T. A., Polinder, S., Nelson, D. W., Ercole, A., Stocchetti, N., Citerio, G., Peul, W. C., Francony, G., Frantzén, J., Freo, U., Frisvold, S., Furmanov, A., Gagliardo, P., Galanaud, D., Gao, G., ... Fossi, F. (2017). Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: A survey in 66 neurotrauma centers participating in the CENTER-TBI study. Critical Care, 21 (1). doi:10.1186/s13054-017-1816-9
Background: No definitive evidence exists on how intracranial hypertension should be treated in p...
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Crone, J. S., Lutkenhoff, E. S., Bio, B. J., Laureys, S., & Monti, M. M. (2017). Testing proposed neuronal models of effective connectivity within the cortico-basal gangliathalamo-cortical loop during loss of consciousness. Cerebral Cortex, 27 (4), 2727-2738. doi:10.1093/cercor/bhw112
In recent years, a number of brain regions and connectivity patterns have been proposed to be cru...
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Di, H., He, M., Zhang, Y., Cheng, L., Wang, F., Nie, Y., Huang, W., Laureys, S., & Schnakers, C. (2017). Chinese translation of the Coma Recovery Scale—Revised. Brain Injury, 31 (3), 363-365. doi:10.1080/02699052.2016.1255780
Background: Misdiagnosis rate is high in patients with disorders of consciousness, potentially le...
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Di Perri, C., Cavaliere, C., Bodart, O., Thibaut, A., Bahri, M. A., Soddu, A., & Laureys, S. (2017). Sleep, Coma, Vegetative and Minimally 4 Conscious States. In Sleep Disorders Medicine (pp. 1-13). Springer. doi:10.1007/978-1-4939-6578-6_43
Farisco, M., Laureys, S., & Evers, K. (2017). The intrinsic activity of the brain and its relation to levels and disorders of consciousness. Mind and Matter, 15 (2), 197-219.
Science and philosophy still lack an overarching theory of consciousness. We suggest that a furth...
Peer reviewed
Gosseries, O., Laureys, S., & Kotchoubey, B. (2017). Unresponsive Wakefulness Syndrome (Vegetative State) and Related States. In Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier.
Peer reviewed
Guger, C., Coyle, D., Mannia, D., De Lucia, M., Leigh, H., Edlow, B., Peters, B., Eddy, B., Nam, C., Noirhomme, Q., Allison, B., & Annen, J. (2017). Trends in BCI Research I: Brain-Computer Interfaces for Assessment of Patients with Locked-in Syndrome or Disorders of Consciousness. In Brain-Computer Interface Research. Springer.
Peer reviewed
Guldenmund, P.* , VANHAUDENHUYSE, A.* , Sanders, R. D., Sleigh, J., Bruno, M.-A., Demertzi, A., Bahri, M. A., JAQUET, O., Sanfilippo, J., Baquero Duarte, K. A., Boly, M., Brichant, J.-F., Laureys, S.* , & Bonhomme, V.*. (2017). Brain functional connectivity differentiates dexmedetomidine from propofol and natural sleep. British Journal of Anaesthesia, 119 (4), 674-684. doi:10.1093/bja/aex257
Background We used functional connectivity measures from brain resting state functional magnetic ...
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Huang, W., Wannez, S., Fregni, F., Hu, X., Jing, S., Martens, G., He, M., Di, H., Laureys, S., & Thibaut, A. (2017). Repeated stimulation of the posterior parietal cortex in patients in minimally conscious state: A sham-controlled randomized clinical trial. Brain Stimulation, 10 (3), 718-720. doi:10.1016/j.brs.2017.02.001
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KIRSCH, M., Guldenmund, P., Bahri, M. A., Demertzi, A., Baquero Duarte, K. A., Heine, L., Charland-Verville, V., VANHAUDENHUYSE, A., BRUNO, M.-A., Gosseries, O., Di Perri, C., Ziegler, E., BRICHANT, J.-F., Soddu, A., BONHOMME, V., & LAUREYS, S. (2017). Sedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity. Anesthesia and Analgesia, 124 (2). doi:10.1213/ANE.0000000000001721
Peer Reviewed verified by ORBi
Lugo, Z., Pellas, F., Blandin, V., Laureys, S., & Gosseries, O. (2017). Assessment of needs, psychological impact and quality of life in families of patients with locked-in syndrome. Brain Injury, 31 (12), 1590-1596. doi:10.1080/02699052.2017.1347277
OBJECTIVE: Family needs of patients with acquired brain injuries have been studied for about thre...
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Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., Citerio, G., Coburn, M., Cooper, D. J., Crowder, A. T., Czeiter, E., Czosnyka, M., Diaz-Arrastia, R., Dreier, J. P., Duhaime, A.-C., ... Zumbo, F. (2017). Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. The Lancet Neurology, 16 (12), 987-1048. doi:10.1016/S1474-4422(17)30371-X
A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is l...
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MAGIS, D., D'Ostilio, K., Thibaut, A., De Pasqua, V., GERARD, P., HUSTINX, R., LAUREYS, S., & SCHOENEN, J. (2017). Cerebral metabolism before and after external trigeminal nerve stimulation in episodic migraine. Cephalalgia. doi:10.1177/0333102416656118
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Martens, G., Foidart-Dessalle, M., Laureys, S., & Thibaut, A. (2017). How Does Spasticity Affect Patients with Disorders of Consciousness? In C. Schnakers & S. Laureys, Coma and Disorders of Consciousness. Springer International Publishing. doi:10.1007/978-3-319-55964-3_7
Editorial reviewed
Martial, C., Charland-Verville, V., Cassol, H., Didone, V., Van der Linden, M., & Laureys, S. (2017). Intensity and memory characteristics of near-death experiences. Consciousness and Cognition. doi:10.1016/j.concog.2017.06.018
Memories of Near-Death Experiences (NDEs) seem to be very detailed and stable over time. At prese...
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Martial, C., Charland-Verville, V., Dehon, H., & Laureys, S. (2017). False memory susceptibility in coma survivors with and without a near-death experience. Psychological Research. doi:10.1007/s00426-017-0855-9
It has been postulated that memories of neardeath experiences (NDEs) could be (at least in part) ...
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Schnakers, C., & Laureys, S. (2017). Coma and disorders of consciousness. (Second edition). Springer International Publishing. doi:10.1007/978-3-319-55964-3
This revised and expanded second edition discusses the assessment and treatment of patients recov...
Silva, S., Peran, P., Kerhuel, L., Malagurski, B., Chauveau, N., Bataille, B., Lotterie, J. A., Celsis, P., Aubry, F., Citerio, G., Jean, B., Chabanne, R., Perlbarg, V., Velly, L., Galanaud, D., VANHAUDENHUYSE, A., Fourcade, O., Laureys, S., & Puybasset, L. (2017). Brain gray matter MRI morphometry for neuroprognostication after cardiac arrest. Critical Care Medicine, 45 (8), 763-e771. doi:10.1097/CCM.0000000000002379
Objectives: We hypothesize that the combined use of MRI cortical thickness measurement and subcor...
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Stender, J., Laureys, S., & Gosseries, O. (2017). Global disorders of consciousness. In M. Velmans & S. Schneider, The Blackwell Companion to Consciousness. Wiley-Blackwell.
Peer reviewed
Stramaglia, S., Pellicoro, M. F., Angelini, L., Amico, E., Aerts, H., Cortés, J. M., Laureys, S., & Marinazzo, D. (2017). Ising model with conserved magnetization on the human connectome: Implications on the relation structure-function in wakefulness and anesthesia. Chaos, 27 (4). doi:10.1063/1.4978999
Dynamical models implemented on the large scale architecture of the human brain may shed light on...
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Thibaut, A., Moissenet, F., Di Perri, C., Schreiber, C., Remacle, A., Kolanowski, E., CHANTRAINE, F., BERNARD, C., HUSTINX, R., Tshibanda, J.-F., Filipetti, P., Laureys, S., & Gosseries, O. (2017). Brain plasticity after implanted peroneal nerve electrical stimulation to improve gait in chronic stroke patients: Two case reports. NeuroRehabilitation, 40 (2), 251-258. doi:10.3233/NRE-161410
BACKGROUND: Recent studies have shown that stimulation of the peroneal nerve using an implantable...
Peer Reviewed verified by ORBi
Thibaut, A., Wannez, S., Donneau, A.-F., Chatelle, C., Gosseries, O., Bruno, M.-A., & Laureys, S. (2017). Controlled clinical trial of repeated prefrontal tDCS in patients with chronic minimally conscious state. Brain Injury, 31 (4), 466-474. doi:10.1080/02699052.2016.1274776
OBJECTIVES: To assess the effects of repeated transcranial direct current stimulation (tDCS) sess...
Peer Reviewed verified by ORBi
Van Ombergen, A., Demertzi, A., Tomilovskaya, Jeurissen, B., Sijbers, J., Kozlovskaya, I. B., Parizel, P. M., Van de Heyning, P. H., Sunaert, S., Laureys, S., & Wuyts, F. L. (2017). The effect of spaceflight and microgravity on the human brain. Journal of Neurology, 264 (1), 18–22. doi:10.1007/s00415-017-8427-x
Microgravity, confinement, isolation, and immobilization are just some of the features astronauts...
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Van Ombergen, A., Heine, L., Jillings, S., Roberts, E. R., Jeurissen, B., Van Rompaey, V., Mucci, V., Vanhecke, S., Sijbers, J., Vanhevel, F., Sunaert, S., Bahri, M. A., Van de Heyning, P. H., Laureys, S., & Wuyts, F. L. (2017). Altered functional brain connectivity in patients with visually induced dizziness. NeuroImage, 14, 538-545. doi:10.1016/j.nicl.2017.02.020
Background: Vestibular patients occasionally report aggravation or triggering of their symptoms b...
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Van Ombergen, A., Laureys, S., Sunaert, S., Tomilovskaya, E., Parizel, P., & Wuyts, F. (2017). Spaceflight-induced neuroplasticity in humans as measured by MRI: What do we know so far? NPJ Microgravity, 3 (1). doi:10.1038/s41526-016-0010-8
Space travel poses an enormous challenge on the human body; microgravity, ionizing radiation, abs...
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Van Ombergen, A., Wuyts, F. L., Jeurissen, B., Sijbers, J., Vanhevel, F., Jillings, S., Parizel, P. M., Sunaert, S., Van De Heyning, P. H., Dousset, V., Laureys, S., & Demertzi, A. (2017). Intrinsic functional connectivity reduces after first-time exposure to short-term gravitational alterations induced by parabolic flight. Scientific Reports, 7 (1). doi:10.1038/s41598-017-03170-5
Spaceflight severely impacts the human body. However, little is known about how gravity and gravi...
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Wang, F., He, Y., Qu, J., Xie, Q., Lin, Q., Ni, X., Chen, Y., Pan, J., Laureys, S., Yu, R., & Li, Y. (2017). Enhancing clinical communication assessments using an audiovisual BCI for patients with disorders of consciousness. Journal of Neural Engineering, 14 (4). doi:10.1088/1741-2552/aa6c31
Objective. The JFK coma recovery scale-revised (JFK CRS-R), a behavioral observation scale, is wi...
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Wannez, S., Heine, L., Thonnard, M., BODART, O., Annen, J., Charland-Verville, V., Martens, G., Aubinet, C., Martial, C., VANHAUDENHUYSE, A., Chatelle, C., Thibaut, A., Schnakers, C., Demertzi, A., Gosseries, O.* , & LAUREYS, S.*. (2017). The repetition of behavioral assessments in diagnosis of disorders of consciousness. Annals of Neurology, 81 (6), 883-889. doi:10.1002/ana.24962
OBJECTIVE: To determine whether repeated examinations using the Coma Recovery Scale-Revised (CRS-...
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Wannez, S.* , Hoyoux, T.* , Langohr, T., Bodart, O., Martial, C., Wertz, J., Chatelle, C., Verly, J., & Laureys, S. (2017). Objective assessment of visual pursuit in patients with disorders of consciousness: an exploratory study. Journal of Neurology. doi:10.1007/s00415-017-8469-0
Peer Reviewed verified by ORBi
Wannez, S., VANHAUDENHUYSE, A., Laureys, S., & Brédart, S. (2017). Mirror efficiency in the assessment of visual pursuit in patients in minimally conscious state. Brain Injury, 1429-1435. doi:10.1080/02699052.2017.1376755
OBJECTIVE: Visual pursuit should be tested with a mirror in patients with disorders of consciousn...
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BONHOMME, V., VANHAUDENHUYSE, A., Demertzi, A., Bruno, M.-A., JAQUET, O., Bahri, M. A., Plenevaux, A., Boly, M., BOVEROUX, P., Soddu, A., BRICHANT, J.-F., MAQUET, P., & LAUREYS, S. (November 2016). Resting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers. Anesthesiology, 125 (5), 873-878. doi:10.1097/ALN.0000000000001275
Background: Consciousness-altering anesthetic agents disturb connectivity between brain regions c...
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Cavaliere, C., Aiello, M., Di Perri, C., Amico, E., Martial, C., Thibaut, A., Laureys, S., & Soddu, A. (2016). Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients. Frontiers in Cellular Neuroscience. doi:10.3389/fncel.2016.00257
Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in d...
Peer Reviewed verified by ORBi
Annen, J.* , Heine, L.* , Ziegler, E., Frasso, G., Bahri, M. A., Di Perri, C., Stender, J., Martial, C., Wannez, S., D'Ostilio, K., Amico, E., Antonopoulos, G., BERNARD, C., TSHIBANDA, L., HUSTINX, R., & Laureys, S. (06 June 2016). Function–structure connectivity in patients with severe brain injury as measured by MRI-DWI and FDG-PET. Human Brain Mapping, 37 (11), 3707-3720. doi:10.1002/hbm.23269
Peer Reviewed verified by ORBi
Bodart, O., Thibaut, A., Laureys, S., & Gosseries, O. (2016). Disorders of Consciousness. In G. Citerio, M. Smith, ... A. Kofke (Eds.), Oxford Textbook of neurocritical care. London, United Kingdom: Oxford University Press.
Peer reviewed
Antoine, N., Genon, S., Bastin, C., Bahri, M. A., Aussems, C., JEDIDI, H., Laureys, S., Collette, F., & Salmon, E. (2016). Self in Dementia. In Mishara, P. Corlett, P. Fletcher, ... M. Schwartz, Phenomenological Neuropsychiatry, How Patient Experience Bridges Clinic with Clinical Neuroscience. New York, United States - New York: Springer.
Peer reviewed
Arbour, C., Baril, A.-A., Westwick, H. J., Potvin, M.-J., Gilbert, D., Giguère, J.-F., Lavigne, G. J., Desautels, A., Bernard, F., Laureys, S., & Gosselin, N. (2016). Visual Fixation in the ICU: A Strong Predictor of Long-Term Recovery after Moderate-to-Severe Traumatic Brain Injury∗. Critical Care Medicine, 44 (12), 1186-e1193. doi:10.1097/CCM.0000000000001960
Objective: Posttraumatic amnesia is superior to the initial Glasgow Coma Scale score for predicti...
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Bodart, O., & Laureys, S. (2016). Imaging the Central Nervous System. In A. Webb, D. Angus, S. Finfer, L. Gattinoni, ... M. Singer (Eds.), Oxford Textbook of Critical Care, Second Edition. London, United Kingdom: Oxford University Press.
Peer reviewed
Casarotto, S., Commanducci, A., Rosanova, M., Sarasso, S., Fecchio, M., Napolitani, M., Pigorini, A., Adenauer, C., Trimarchi, P., Boly, M., Gosseries, O., BODART, O., Curto, F., Landi, C., Mariotti, M., Devalle, G., LAUREYS, S., Tononi, G., & Massimini, M. (2016). Stratification of unresponsive patients by an independently validated index of brain complexity. Annals of Neurology, 80 (5). doi:10.1002/ana.24779
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Chatelle, C., Bodien, Y. G., Carlowicz, C., Wannez, S., Charland-Verville, V., Gosseries, O., Laureys, S., Seel, R. T., & Giacino, J. T. (2016). Detection and Interpretation of Impossible and Improbable Coma Recovery Scale-Revised Scores. Archives of Physical Medicine and Rehabilitation, 97 (8), 1295-1300.e4. doi:10.1016/j.apmr.2016.02.009
Objective To determine the frequency with which specific Coma Recovery Scale-Revised (CRS-R) subs...
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Chatelle, C., De Val, M. D., Catano, A., Chaskis, C., Seeldrayers, P., Laureys, S., Biston, P., & Schnakers, C. (2016). Is the Nociception Coma Scale-Revised a Useful Clinical Tool for Managing Pain in Patients with Disorders of Consciousness? Clinical Journal of Pain. doi:10.1097/AJP.0000000000000259
OBJECTIVES: Our objective was to assess the clinical interest of the Nociception Coma Scale Revis...
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Chatelle, C., LAUREYS, S., & Demertzi, A. (2016). Pain and Nociception in Disorders of Consciousness. In F. Luis Garcia-Larrea & P. L. Jackson (Eds.), Pain and the Conscious Brain (pp. 139-154). IASP Wolters Kluwers.
Peer reviewed
Cnossen, M. C., Polinder, S., Lingsma, H. F., Maas, A. I. R., Menon, D., Steyerberg, E. W., Adams, H., Alessandro, M., Allanson, J., Amrein, K., Andaluz, N., Andelic, N., Andrea, N., Andreassen, L., Anke, A., Antoni, A., Ardon, H., Audibert, G., Auslands, K., ... Van Der Naalt, J. (2016). Variation in structure and process of care in traumatic brain injury: Provider profiles of European Neurotrauma Centers participating in the CENTER-TBI study. PLoS ONE, 11 (8). doi:10.1371/journal.pone.0161367
Introduction: The strength of evidence underpinning care and treatment recommendations in traumat...
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Demertzi, A., Van Ombergen, A., Tomilovskaya, E., Jeurissen, B., Pechenkova, E., Di Perri, C., Litvinova, L., Amico, E., Rumshiskaya, A., Rukavishnikov, I., Sijbers, J., Sinitsyn, V., Kozlovskaya, I. B., Sunaert, S., Parizel, P. M., Van de Heyning, P. H., Laureys, S., & Wuyts, F. L. (2016). Erratum to: Cortical reorganization in an astronaut’s brain after long-duration spaceflight (Brain Struct Funct, DOI 10.1007/s00429-015-1054-3). Brain Structure and Function, 221 (5), 2877. doi:10.1007/s00429-016-1209-x
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Demertzi, A.* , Van Ombergen, A.* , Tomilovskaya, E., Jeurissen, B., Pechenkova, E., Di Perri, C., Litvinova, L., Amico, E., Rumshuskaya, A., Rukavishnikow, I., Sijbers, J., Sinitsyn, V., Kozlovskaya, I. B., Sunaert, S., Parizel, P. M., Van De Heyning, P. H., Laureys, S., & Wuyts, F. L. (2016). Cortical reorganization in an astronaut's brain after long-duration spaceflight. Brain Structure and Function, 221 (5), 2873-2876. doi:10.1007/s00429-015-1054-3
To date, hampered physiological function after exposure to microgravity has been primarily attrib...
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Di Perri, C., Annen, J., Antonopoulos, G., Amico, E., Cavaliere, C., & Laureys, S. (2016). Measuring consciousness through imaging. In Brain Function and Responsiveness in Disorders of Consciousness (pp. 51-65). Springer International Publishing. doi:10.1007/978-3-319-21425-2_5
At present, the global hallmark of impaired consciousness appears to be a reduced metabolism in a...
Peer reviewed
Di Perri, C., Bahri, M. A., Amico, E., Thibaut, A., Heine, L., Antonopoulos, G., Charland-Verville, V., Wannez, S., Gomez, F., HUSTINX, R., TSHIBANDA, L., Demertzi, A.* , Soddu, A.* , & Laureys, S.*. (2016). Neural correlates of consciousness in patients who have emerged from a minimally conscious state: A cross-sectional multimodal imaging study. The Lancet Neurology, 15, 830-842. doi:10.1016/S1474-4422(16)00111-3
Background Between pathologically impaired consciousness and normal consciousness exists a scarce...
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Di Perri, C., Thibaut, A., Heine, L., Annen, J., & Laureys, S. (2016). Towards new methods of diagnosis in disorders of consciousness – Authors' reply [letter to the editor]. The Lancet Neurology, 15 (11), 1115-1116. doi:10.1016/S1474-4422(16)30205-8
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Fischer, D., Boes, A. D., Demertzi, A., Evrard, H. C., Laureys, S., Edlow, B. L., Liu, H., Saper, C., Pascual-Leone, A., Fox, M. D., & Geerling, J. C. (2016). A human brain network derived from coma-causing brainstem lesions. Neurology, 87 (23), 2427-2434. doi:10.1212/WNL.0000000000003404
OBJECTIVE To characterize a brainstem location specific to coma-causing lesions, and its function...
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Gosseries, O., Pistoia, F., Charland-Verville, V., Carolei, A., Sacco, S., & Laureys, S. (2016). The Role of Neuroimaging Techniques in Establishing Diagnosis, Prognosis and Therapy in Disorders of Consciousness. Open Neuroimaging Journal, 10, 52-68. doi:10.2174/1874440001610010052
Non-communicative brain damaged patients raise important clinical and scientific issues. Here, we...
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Gudenmund, P., Gantner, I., Baquero Duarte, K. A., Das, T., Demertzi, A., BOVEROUX, P., BONHOMME, V., VANHAUDENHUYSE, A., Bruno, M.-A., Gosseries, O., Noirhomme, Q., KIRSCH, M., Boly, M., Owen, A., LAUREYS, S., Gomez Fernandez Blanco, C., & Soddu, A. (2016). Propofol-induced Frontal Cortex Disconnection: a Study of Resting State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies. Brain Connectivity, 3 (3), 225-237. doi:10.1089/brain.2015.0369
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Guldenmund, P., Soddu, A., Baquero Duarte, K. A., VANHAUDENHUYSE, A., Bruno, M.-A., Gosseries, O., LAUREYS, S., & Gomez, F. (2016). Structural brain injury in patients with disorders of consciousness: a voxel-based morphometry study. Brain Injury. doi:10.3109/02699052.2015.1118765
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Heine, L., Laureys, S., & Schnakers, C. (2016). Behavioral responsiveness in patients with disorders of consciousness. In M. M. Monti & W. G. Sannita (Eds.), Brain Function and Responsiveness in Disorders of Consciousness (pp. 25-36). Springer International Publishing. doi:10.1007/978-3-319-21425-2_3
Until now, the main way to assess whether a patient is conscious or not is to observe what he can...
KIRSCH, M., Wannez, S., Thibaut, A., LAUREYS, S., BRICHANT, J.-F., & BONHOMME, V. (2016). Positron Emission Tomography: Basic Principles, New Applications, and Studies Under Anesthesia. International Anesthesiology Clinics. doi:10.1097/AIA.0000000000000090
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Laureys, S. (2016). Traumatic brain damage: Severe brain damage: Coma and disorders of consciousness. In Neuroscience in the 21st Century: From Basic to Clinical, Second Edition, 2016-01-01 (pp. 3341-3368). Springer New York. doi:10.1007/978-1-4939-3474-4_95
Progress in intensive care efforts has increased the number of patients who survive severe acute ...
Lesenfants, D.* , Habbal, D.* , Chatelle, C., Schnakers, C., Laureys, S., & Noirhomme, Q. (2016). Electromyographic decoding of response to command in disorders of consciousness. Neurology, 87 (20), 2099-2107. doi:10.1212/WNL.0000000000003333
Objective: To propose a new methodology based on single-trial analysis for detecting residual res...
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Lugo, Z. R., Quitadamo, L. R., Bianchi, L., Pellas, F., Veser, S., Lesenfants, D., Real, R. G. L., Herbert, C., Guger, C., Kotchoubey, B., Mattia, D., Kübler, A., Laureys, S., & Noirhomme, Q. (2016). Cognitive processing in non-communicative patients: What can event-related potentials tell us? Frontiers in Human Neuroscience, 10 (NOV2016). doi:10.3389/fnhum.2016.00569
Event-related potentials (ERP) have been proposed to improve the differential diagnosis of non-re...
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Owen, A. M., Schiff, N. D., & Laureys, S. (2016). The Assessment of Conscious Awareness in the Vegetative State. In S. LAUREYS, O. Gosseries, ... G. Tononi (Eds.), The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology (2nd edition, pp. 155-166). Elsevier Inc. doi:10.1016/B978-0-12-800948-2.00010-8
The assessment of patients in the vegetative state is extremely complex and depends frequently on...
Piarulli, A., Bergamasco, M., Thibaut, A., Cologan, V., Gosseries, O.* , & Laureys, S.*. (2016). EEG ultradian rhythmicity differences in disorders of consciousness during wakefulness. Journal of Neurology, 263 (9), 1746-1760. doi:10.1007/s00415-016-8196-y
Temporal fluctuations of cognitively-mediated behaviors in minimally conscious state (MCS) have b...
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Pignat, J.-M., Mauron, E., Jöhr, J., Gilart de Keranflec'h, C., Van De Ville, D., Preti, M. G., Meskaldji, D. E., Hömberg, V., Laureys, S., Draganski, B., Frackowiak, R., & Diserens, K. (2016). Outcome prediction of consciousness disorders in the acute stage based on a complementary motor behavioural tool. PLoS ONE, 11 (6). doi:10.1371/journal.pone.0156882
Introduction Attaining an accurate diagnosis in the acute phase for severely brain-damaged patien...
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Soddu, A.* , Gomez, F.* , Heine, L., Di Perri, C., Bahri, M. A., Voss, H. U., Bruno, M.-A., VANHAUDENHUYSE, A., Phillips, C., Demertzi, A., Chatelle, C., Schrouff, J., Thibaut, A., Charland-Verville, V., Noirhomme, Q., Salmon, E., TSHIBANDA, L., Schiff, N. D., & LAUREYS, S. (2016). Correlation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousness. Brain and Behavior, 6 (1), 1-15. doi:10.1002/brb3.424
Introduction: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is...
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Stender, J., Mortensen, K. N., Thibaut, A., Darkner, S., Laureys, S., Gjedde, A., & Kupers, R. (2016). The Minimal Energetic Requirement of Sustained Awareness after Brain Injury. Current Biology, 26 (11), 1494-1499. doi:10.1016/j.cub.2016.04.024
Differentiation of the minimally conscious state (MCS) and the unresponsive wakefulness syndrome ...
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Tagliazucchi, E., Chialvo, D. R., Siniatchkin, M., Amico, E., Brichant, J.-F., BONHOMME, V., Noirhomme, Q., Laufs, H., & Laureys, S. (2016). Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics. Journal of the Royal Society, Interface, 13 (114). doi:10.1098/rsif.2015.1027
Loss of cortical integration and changes in the dynamics of electrophysiological brain signals ch...
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Chatelle, C., & LAUREYS, S. (Eds.). (2015). Assessing Pain and Communication in Disorders of Consciousness. New York, United States: Psychology Press. doi:10.4324/9781315747200
Heine, L., Castro, M., Martial, C., Tillmann, B., Laureys, S., & Perrin, F. (2015). Exploration of functional connectivity during preferred music stimulation in patients with disorders of consciousness. Frontiers in Psychology. doi:10.3389/fpsyg.2015.01704
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Thibaut, A., & Laureys, S. (October 2015). Brain stimulation in patients with disorders of consciousness. Principles and Practice of Clinical Research, 1 (3).
Background and Aim: There is a long history of brain stimulation in medical science, and it was t...
Peer reviewed
Kudenchuk, P., Sandroni, C., Drinhaus, H., Böttiger, B., Cariou, A., Sunde, K., Dworschak, M., Taccone, F., Deye, N., Friberg, H., Laureys, S., LEDOUX, D., Oddo, M., Legriel, S., Hantson, P., Diehl, J., & Laterre, P. (2015). Breakthrough in cardiac arrest: reports from the 4th Paris International Conference. Annals of Intensive Care. doi:10.1186/s13613-015-0064-x
Jean-Luc Diehl The French Intensive Care Society organized on 5th and 6th June 2014 its 4th Paris...
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Heine, L., Bahri, M. A., Cavaliere, C., Andrea, S., Reislev, N., Laureys, S., Ptito, M., & Kupers, R. (01 July 2015). Prevalence of increases in functional connectivity in visual, somatosensory and language areas in congenital blindness. Frontiers in Neuroanatomy, 3 (295). doi:10.3389/fnana.2015.00086
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Liegeois, R., Ziegler, E., Bahri, M. A., Phillips, C., Geurts, P., Gomez, F., Yeo, T., VANHAUDENHUYSE, A., Soddu, A., LAUREYS, S., & Sepulchre, R. (2015). Cerebral functional connectivity periodically (de)synchronizes with anatomical constraints. Brain Structure and Function. doi:10.1007/s00429-015-1083-y
This paper studies the link between resting-state functional connectivity (FC), measured by the c...
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Piarulli, A., Charland-Verville, V., & Laureys, S. (May 2015). Cognitive auditory evoked potentials in coma: can you hear me? Brain: a Journal of Neurology, 138 (Pt5), 1129-1137. doi:10.1093/brain/awv069
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Lutkenhoff, E., Chiang, J., TSHIBANDA, L., Kamau, E., KIRSCH, M., Pickard, J., Laureys, S., Owen, A., & Monti, M. (2015). Thalamic and extrathalamic mechanisms of consciousness after severe brain injury. Annals of Neurology. doi:10.1002/ana.24423
Abstract OBJECTIVE: What mechanisms underlie the loss and recovery of consciousness after severe ...
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Schnakers, C., Bessou, H., Rubi-Fessen, I., Hartmann, A., Fink, G. R., Meister, I. G., Giacino, J. T., Laureys, S., & Majerus, S. (16 April 2015). Impact of Aphasia on Consciousness Assessment: A Cross-Sectional Study. Neurorehabilitation and Neural Repair, 29, 41-47. doi:10.1177/1545968314528067
BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-inj...
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Charland-Verville, V., Lugo, Z., Jourdan, J.-P., Donneau, A.-F., & Laureys, S. (30 March 2015). Near-Death Experiences in patients with locked-in syndrome: Not always a blissful journey. Consciousness and Cognition, 34, 28-32. doi:10.1016/j.concog.2015.03.011
Memories of Near-Death Experiences (NDEs) most often are recounted as emotionally positive events...
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Bogdanov, V., Vigano, A., Noirhomme, Q., Bogdanova, O., Guy, N., LAUREYS, S., Renshaw, P., Dallel, R.* , Phillips, C.* , & Schoenen, J.*. (2015). Cerebral responses and role of the prefrontal cortex in conditioned pain modulation: an fMRI study in healthy subjects. Behavioural Brain Research. doi:10.1016/j.bbr.2014.11.028
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Bruno, M.-A., Nizzi, M.-C., Laureys, S., & Gosseries, O. (2015). Consciousness in the Locked-In Syndrome. In S. Laureys, O. Gosseries, ... G. Tononi, The Neurology of Consciousness (pp. 187-202). Elsevier Inc. doi:10.1016/B978-0-12-800948-2.00012-1
Patients in a locked-in syndrome (LIS) are selectively de-efferented (i.e., they have no means of...
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Charland-Verville, V., Laureys, S., Gosseries, O., Thibaut, A., & Bruno, M.-A. (2015). The chronic clinical setting. In Clinical Neurophysiology in Disorders of Consciousness: Brain Function Monitoring in the ICU and beyond (pp. 95-106). Springer-Verlag Vienna. doi:10.1007/978-3-7091-1634-0_8
The past 15 years have provided an unprecedented collection of discoveries that have increased ou...
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Charland-Verville, V., VANHAUDENHUYSE, A., Laureys, S., & Gosseries, O. (2015). The scientific study of coma and related states. In The Constitution of Phenomenal Consciousness. Towards a science and theory. John Benjamins Publishing Company.
Peer reviewed
Chatelle, C., Lesenfants, D., Bodien, Y. G., LAUREYS, S., & Noirhomme, Q. (2015). Brain computer interface for assessing consciousness in severely brain-injured patients. In A. Rosetti & S. LAUREYS (Eds.), Clinical Neurophysiology in Disorders of Consciousness. Wien, Austria: Springer. doi:10.1007/978-3-7091-1634-0_11
Demertzi, A.* , Antonopoulos, G.* , Heine, L., Voss, H. U., Crone, J. S., de Los Angeles, C., Bahri, M. A., Di Perri, C., VANHAUDENHUYSE, A., Charland-Verville, V., Kronbichler, M., Trinka, E., Phillips, C., Gomez, F., TSHIBANDA, L., Soddu, A., Schiff, N. D., Whitfield-Gabrieli, S.* , & Laureys, S.*. (2015). Intrinsic functional connectivity differentiates minimally conscious from unresponsive patients. Brain: a Journal of Neurology, 138, 2619-2631. doi:10.1093/brain/awv169
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Demertzi, A., & Laureys, S. (2015). Detecting Levels of Consciousness. In N. Levy & J. Clausen (Eds.), Handbook of Neuroethics (pp. 665-667). Dordrecht, Netherlands: Springer. doi:10.1007/978-94-007-4707-4_39
Patients with disordered consciousness due to brain injury pose medical and ethical challenges. R...
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Demertzi, A., & Laureys, S. (2015). Thinking on patients’ behalf: attitudes of healthcare providers towards medico-ethical issues in non-communicating patients. In D. Sturma, L. Honnefelder, ... M. Fuchs (Eds.), Yearbook for Science and Ethics (pp. 147–162). Berlin, Germany: De Gruyter GmbH. doi:10.1515/jwiet-2015-0111
Peer reviewed
Demertzi, A., VANHAUDENHUYSE, A., Noirhomme, Q., FAYMONVILLE, M.-E., & LAUREYS, S. (2015). Hypnosis modulates behavioural measures and subjective ratings about external and internal awareness. Journal of Physiology - Paris, 109 (4), 173-179. doi:10.1016/j.jphysparis.2015.11.002
In altered subjective states, the behavioural quantification of external and internal awareness r...
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Farisco, M., Laureys, S., & Evers, K. (2015). Externalization of consciousness. Scientific possibilities and clinical implications. Current Topics in Behavioral Neurosciences, 19, 205-222. doi:10.1007/7854_2014_338
The paper starts by analyzing recent advancements in neurotechnological assessment of residual co...
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Gosseries, O., Sarasso, S., Casarotto, S., Boly, M., Schnakers, C., Napolitani, M., Bruno, M.-A., LEDOUX, D., Tshibanda, J. F. L., Massimini, M., Laureys, S., & Rosanova, M. (2015). On the cerebral origin of EEG responses to TMS: Insights from severe cortical lesions. Brain Stimulation, 8 (1), 142-149. doi:10.1016/j.brs.2014.10.008
Background Transcranial magnetic stimulation combined with electroencephalography (TMS/EEG) repre...
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Heine, L., Demertzi, A., Laureys, S., & Gosseries, O. (2015). Consciousness: And Disorders of Consciousness. In A. W. Toga (Ed.), Brain mapping : an encyclopedic reference (pp. 1067-1073). Elsevier. doi:10.1016/B978-0-12-397025-1.00133-0
Peer reviewed
Heine, L., Di Perri, C., Soddu, A., Gomez, F., Laureys, S., & Demertzi, A. (2015). Imaging correlation in non-communicating patients. In A. O. Rossetti & S. Laureys (Eds.), Clinical Neurophysiology in Disorders of Consciousness-Brain Function Monitoring in the ICU and beyond (pp. 149-157). Vienna, Austria: Springer-Verlag. doi:10.1007/978-3-7091-1634-0_12
The diagnosis and medical management of patients with acute or chronic disorders of consciousness...
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Laureys, S., Gosseries, O., & Tononi, G. (2015). Preface. In S. Laureys, O. Gosseries, ... G. Tononi, The Neurology of Consciousness. Elsevier Inc. doi:10.1016/B978-0-12-800948-2.00029-7
LAUREYS, S., Gosseries, O., & Tononi, G. (Eds.). (2015). The Neurology of Consciousness: : Cognitive Neuroscience and Neuropathology. (2nd ed). Elsevier. doi:10.1016/C2013-0-18738-7
Lesenfants, D., Chatelle, C., Laureys, S., & Noirhomme, Q. (2015). Interfaces cerveau-ordinateur, locked-in syndrome et troubles de la conscience. MS. Medecine Sciences, 31 (10), 904-11. doi:10.1051/medsci/20153110017
Detecting signs of consciousness in patients with severe brain injury constitutes a real challeng...
Li, Y., Pan, J., He, Y., Wang, F., Laureys, S., Xie, Q., & Yu, R. (2015). Detecting number processing and mental calculation in patients with disorders of consciousness using a hybrid brain-computer interface system. BMC Neurology, 15 (1), 259. doi:10.1186/s12883-015-0521-z
Background: For patients with disorders of consciousness such as coma, a vegetative state or a mi...
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Lugo, Z. R., Bruno, M.-A., Gosseries, O., Demertzi, A., Heine, L., Thonnard, M., Blandin, V., Pellas, F., & Laureys, S. (2015). Beyond the gaze: Communicating in chronic locked-in syndrome. Brain Injury, 29, 1056-1061. doi:10.3109/02699052.2015.1004750
OBJECTIVE Locked-in syndrome (LIS) usually follows a brainstem stroke and is characterized by par...
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Sarasso, S.* , Boly, M.* , Napolitani, M., Gosseries, O., Charland-Verville, V., Casarotto, S., Rosanova, M., Casali, A. G., Brichant, J.-F., BOVEROUX, P., Rex, S., Tononi, G., Laureys, S., & Massimini, M. (2015). Consciousness and complexity during unresponsiveness induced by propofol, xenon, and ketamine. Current Biology, 25 (23), 3099-3105. doi:10.1016/j.cub.2015.10.014
A common endpoint of general anesthetics is behavioral unresponsiveness [1], which is commonly as...
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Schartner, M., Seth, A., Noirhomme, Q., Boly, M., Bruno, M.-A., Laureys, S., & Barrett, A. (2015). Complexity of multi-dimensional spontaneous EEG decreases during propofol induced general anaesthesia. PLoS ONE, 10 (8). doi:10.1371/journal.pone.0133532
Emerging neural theories of consciousness suggest a correlation between a specific type of neural...
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Schnakers, C., Giacino, J. T., Løvstad, M., Habbal, D., Boly, M., Di, H., Majerus, S., & Laureys, S. (2015). Preserved Covert Cognition in Noncommunicative Patients With Severe Brain Injury? Neurorehabilitation and Neural Repair. doi:10.1177/1545968314547767
Background. Despite recent evidence suggesting that some severely brain-injured patients retain s...
Stender, J., Kupers, R., Rodell, A., Thibaut, A., Chatelle, C., Bruno, M.-A., Gejl, M., Bernard, C., HUSTINX, R., Laureys, S., & Gjedde, A. (2015). Quantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients. Journal of Cerebral Blood Flow and Metabolism, 35 (1), 58-65. doi:10.1038/jcbfm.2014.169
The differentiation of the vegetative or unresponsive wakefulness syndrome (VS/UWS) from the mini...
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Thibaut, A., BODART, O., Laureys, S., & Canavero, S. (2015). Chronic disorders of consciousness. In S. Canavero (Ed.), Surgical Principles of Therapeutic Cortical Stimulation. De Gruyter.
Thibaut, A., Deltombe, T., Wannez, S., Gosseries, O., Ziegler, E., Dieni, C., Deroy, M., & Laureys, S. (2015). Impact of soft splints on upper limb spasticity in chronic patients with disorders of consciousness: A randomized, single-blind, controlled trial. Brain Injury, 29 (7-8). doi:10.3109/02699052.2015.1005132
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Thibaut, A., Di Perri, C., Bodart, O., & Laureys, S. (2015). Behavioural Diagnosis of Disorders of Consciousness. In A. Rossetti & S. Laureys (Eds.), Clinical Neurophysiology in Disorders of Consciousness. Paris, France: Springer-Verlag.
Peer reviewed
Thibaut, A., Di Perri, C., Chatelle, C., Bruno, M.-A., Bahri, M. A., Wannez, S., Piarulli, A., BERNARD, C., Martial, C., Heine, L., HUSTINX, R., & Laureys, S. (2015). Clinical Response to tDCS Depends on Residual Brain Metabolism and Grey Matter Integrity in Patients With Minimally Conscious State. Brain Stimulation, 8 (6), 1116-23. doi:10.1016/j.brs.2015.07.024
BACKGROUND: Transcranial direct current stimulation (tDCS) was recently shown to promote recovery...
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Tononi, G., Boly, M., Gosseries, O., & Laureys, S. (2015). The Neurology of Consciousness: An Overview. In O. Gosseries, G. Tononi, ... S. Laureys (Ed.), The Neurology of Consciousness (pp. 407-461). Elsevier Inc. doi:10.1016/B978-0-12-800948-2.00025-X
This final chapter provides the reader with an overview of the neurological and neurobiological l...
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van Erp, W., Lavrijsen, J. C. M., Vos, P. E., Bor, H., Laureys, S., & Koopmans, R. T. (2015). The vegetative state: Prevalence, misdiagnosis, and treatment limitations. Journal of the American Medical Directors Association, 16 (1), 85.e9-85.e14. doi:10.1016/j.jamda.2014.10.014
Introduction: Patients in a vegetative state/unresponsive wakefulness syndrome (VS/UWS) open thei...
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VANHAUDENHUYSE, A., Laureys, S., & FAYMONVILLE, M.-E. (2015). The use of hypnosis in severe brain injury rehabilitation: a case report. Acta Neurologica Belgica. doi:10.1007/s13760-015-0459-3
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Wang, F., Di, H., Hu, X., Jing, S., Thibaut, A., Di Perri, C., Huang, W., Nie, Y., Schnakers, C., & Laureys, S. (2015). Cerebral response to subject's own name showed high prognostic value in traumatic vegetative state. BMC Medicine, 13 (1). doi:10.1186/s12916-015-0330-7
Background: Previous studies have shown the prognostic value of stimulation elicited blood-oxygen...
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Charland-Verville, V., Lesenfants, D., Sela, L., Noirhomme, Q., Ziegler, E., Chatelle, C., Plotkin, A., Sobel, N., & Laureys, S. (23 December 2014). Detection of response to command using voluntary control of breathing in disorders of consciousness. Frontiers in Human Neuroscience, 8 (1020). doi:10.3389/fnhum.2014.01020
BACKGROUND: Detecting signs of consciousness in patients in a vegetative state/unresponsive wakef...
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Bicego, A. Y., Lejoly, K., Maudoux, A., Lefèbvre, P., Laureys, S., SchweizerSchweizer, V., Diserens, K., FAYMONVILLE, M.-E., & VANHAUDENHUYSE, A. (October 2014). Swallowing in disorders of consciousness. Revue Neurologique, 170 (10). doi:10.1016/j.neurol.2014.04.004
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VANHAUDENHUYSE, A., Laureys, S., & Faymonville, M.-E. (October 2014). Neurophysiology of hypnosis. Clinical Neurophysiology, 44, 343-353. doi:10.1016/j.neucli.2013.09.006
We here review behavioral, neuroimaging and electrophysiological studies of hypnosis as a state, ...
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Napolitani, M.* , Bodart, O.* , Canali, P., Seregni, F., Rosanova, M., Laureys, S., Massimini, M., & Gosseries, O. (September 2014). Transcranial magnetic stimulation combined with high density EEG in altered states of consciousness. Brain Injury, 28 (9), 1180-1189. doi:10.3109/02699052.2014.920524
Background: This review discusses the advantages of transcranial magnetic stimulation combined wi...
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Charland-Verville, V., & Laureys, S. (2014). How Does Your Formulation of Lesion-Induced States of Diminished Consciousness Fit with AIM? Do You Suppose That Brain Stem Damage Affects Activation (A) and Modulation (M)? In N. T. J. Allan Hobson (Ed.), Dream Consciousness: A New Approach to the Brain and Its Mind (pp. 101-109). Zug, Switzerland: Springer.
Allan Hobson’s AIM model (Hobson, 1998) is build according to three main dimensions. The first co...
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Laureys, S., Bodart, O., & Gosseries, O. (August 2014). The Glasgow Coma Scale: time for critical reappraisal? The Lancet Neurology, Vol 13, 755-757. doi:10.1016/S1474-4422(14)70152-8
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Pan, J., Xie, Q., He, Y., Wang, F., Di, H., Laureys, S., Yu, R., & Li, Y. (2014). Detecting awareness in patients with disorders of consciousness using a hybrid brain–computer interface. Journal of Neural Engineering. doi:10.1088/1741-2560/11/5/056007
Objective. The bedside detection of potential awareness in patients with disorders of consciousne...
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van Erp, W., Lavrijsen, J. C. M., Van De Laar, F. A., Vos, P. E., Laureys, S., & Koopmans, R. T. (2014). The vegetative state/unresponsive wakefulness syndrome: a systematic review of prevalence studies. European Journal of Neurology. doi:10.1111/ene.12483
One of the worst outcomes of acquired brain injury is the vegetative state, recently renamed ‘unr...
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Amico, E., Gomez, F., Di Perri, C., VANHAUDENHUYSE, A., Lesenfants, D., BOVEROUX, P., BONHOMME, V., BRICHANT, J.-F., Marinazzo, D., & LAUREYS, S. (June 2014). Posterior Cingulate Cortex-Related Co-Activation Patterns: A Resting State fMRI Study in Propofol-Induced Loss of Consciousness. PLoS ONE, 9. doi:10.1371/journal.pone.0100012
Background: Recent studies have been shown that functional connectivity of cerebral areas is not ...
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Habbal, D.* , Gosseries, O.* , Noirhomme, Q., Renaux, J., Lesenfants, D., Bekinschtein, T., Majerus, S., Laureys, S., & Schnakers, C. (2014). Volitional electromyographic responses in disorders of consciousness. Brain Injury. doi:10.3109/02699052.2014.920519
The aim of the study was to validate the use of electromyography (EMG) for detecting responses to...
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Charland-Verville, V., Jourdan, J.-P., Thonnard, M., LEDOUX, D., Donneau, A.-F., Quertemont, E., & Laureys, S. (27 May 2014). Near-death experiences in non-life-threatening events and coma of different etiologies. Frontiers in Human Neuroscience, 8 (203). doi:10.3389/fnhum.2014.00203
BACKGROUND: Near death experiences (NDEs) are increasingly being reported as a clearly identifiab...
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Lesenfants, D., Habbal, D., Lugo, Lebeau, M., Horki, P., Amico, E., Pokorny, C., Gomez, F., Soddu, A., Muller-Putz, G., Laureys, S., & Noirhomme, Q. (2014). An independent SSVEP-based brain-computer interface in locked-in-syndrome. Journal of Neural Engineering. doi:10.1088/1741-2560/11/3/035002
OBJECTIVE: Steady-state visually evoked potential (SSVEP)-based brain-computer interfaces (BCIs...
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Fridman, E. A., Beattie, B. J., Broft, A., Laureys, S., & Schiff, N. D. (2014). Regional cerebral metabolic patterns demonstrate the role of anterior forebrain mesocircuit dysfunction in the severely injured brain. In Proceedings of the National Academy of Sciences of the United States of America. St-Louis, United States: Marcus E. Raichle. doi:10.1073/pnas.1320969111
Although disorders of consciousness (DOCs) demonstrate widely varying clinical presentations and ...
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Noirhomme, Q., Lesenfants, D., Gomez, F., Soddu, A., Schrouff, J., Garraux, G., Luxen, A., Phillips, C.* , & Laureys, S.*. (April 2014). Biased binomial assessment of cross-validated estimation of classification accuracies illustrated in diagnosis predictions. NeuroImage: Clinical, 4, 687-694. doi:10.1016/j.nicl.2014.04.004
Multivariate classification is used in neuroimaging studies to infer brain activation or in medic...
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Charland-Verville, V., Thonnard, M., Dehon, H., Laureys, S., & VANHAUDENHUYSE, A. (30 March 2014). Can the phenomenology of near death experiences memories be compared to memories of real and imagined events? MS. Medecine Sciences, 30 (3), 246-248. doi:10.1051/medsci/20143003009
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Van Der Eerden, A., Khalilzadeh, O., Perlbarg, V., Dinkel, J., Sanchez, P., Vos, P., Luyt, C.-E., Stevens, R., Menjot de Champfleur, N., Delmaire, C., Tollard, E., Gupta, R., Dormont, D., Laureys, S., Benali, H., VANHAUDENHUYSE, A., Galanaud, D., & Puybasset, L. (February 2014). White Matter Changes in Comatose Survivors of Anoxic Ischemic Encephalopathy and Traumatic Brain Injury: Comparative Diffusion-Tensor Imaging Study. Radiology, 270. doi:10.1148/radiol.13122720
Purpose:To analyze white matter pathologic abnormalities by using diffusion-tensor (DT) imaging i...
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Bodart, O., Charland-Verville, V., Laureys, S., & Gosseries, O. (2014). Neuroimaging in Disorders of Consciousness. In M. Filippi (Ed.), Oxford Textbook of Clinical Neurology. London, United Kingdom: Oxford University Press.
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BODART, O., & LAUREYS, S. (2014). Predicting outcome from subacute unresponsive wakefulness syndrome or vegetative state. Critical Care, 18 (2), 132. doi:10.1186/cc13831
Predicting recovery of consciousness in patients who survive their coma but evolve to a vegetativ...
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Chatelle, C., LAUREYS, S., & Noirhomme, Q. (2014). Brain Computer Interfaces and diagnosis. In G. Grübler & E. Hildt (Eds.), Brain-Computer-Interfaces in their ethical, social and cultural contexts. Dordrecht, Netherlands: Springer.
Chatelle, C., Thibaut, A., Bruno, M.-A., Boly, M., Bernard, C., Hustinx, R., Schnakers, C., & Laureys, S. (2014). Nociception coma scale-revised scores correlate with metabolism in the anterior cingulate cortex. Neurorehabilitation and Neural Repair, 28 (2), 149-52. doi:10.1177/1545968313503220
BACKGROUND: . The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possibl...
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Chatelle, C.* , Thibaut, A.* , Gosseries, O., Bruno, M.-A., Demertzi, A., BERNARD, C., HUSTINX, R., TSHIBANDA, L., Bahri, M. A., & Laureys, S. (2014). Changes in cerebral metabolism in patients with a minimally conscious state responding to zolpidem. Frontiers in Neuroscience, 8, 917. doi:10.3389/fnhum.2014.00917
BACKGROUND: Zolpidem, a short-acting non-benzodiazepine GABA agonist hypnotic, has been shown to ...
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Chatelle, C., Thibaut, A., Wythe, J., De Val, M. D., Laureys, S., & Schnakers, C. (2014). Pain issues in disorders of consciousness. Brain Injury, 28 (9), 1202-1208. doi:10.3109/02699052.2014.920518
Background: The assessment of pain and nociception in non-communicative patients with disorders o...
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Crone, J. S., Soddu, A., Höller, Y., Vanhaudenhuyse, A., Schurz, M., Bergmann, J., Schmid, E., Trinka, E., Laureys, S., & Kronbichler, M. (2014). Altered network properties of the fronto-parietal network and the thalamus in impaired consciousness. NeuroImage: Clinical, 240-248. doi:10.1016/j.nicl.2013.12.005
Recovery of consciousness has been associated with connectivity in the frontal cortex and parieta...
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Demertzi, A.* , Gomez, F.* , Crone, J.-S., Vanhaudenhuyse, A., TSHIBANDA, L., Noirhomme, Q., Thonnard, M., Charland-Verville, V., KIRSCH, M., LAUREYS, S.* , & Soddu, A.*. (2014). Multiple fMRI system-level baseline connectivity is disrupted in patients with consciousness alterations. Cortex: A Journal Devoted to the Study of the Nervous System and Behavior, 52, 35-46. doi:10.1016/j.cortex.2013.11.005
Introduction: In healthy conditions, group-level fMRI resting state analyses identify ten resting...
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Demertzi, A., Jox, R. J., Racine, E., & Laureys, S. (2014). A European survey on attitudes towards pain and end-of-life issues in locked-in syndrome. Brain Injury, 28 (9), 1209–1215. doi:10.3109/02699052.2014.920526
Objectives: Patients with locked-in syndrome often self-report a higher quality of life than gene...
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Demertzi, A., & Laureys, S. (2014). Consciousness alterations after severe brain injury. In G. R. Mangun & M. S. Gazzaniga (Eds.), The Cognitive Neurosciences (5th, pp. 811-819). Cambridge, United States: The MIT Press.
The past fifteen years have provided an unprecedented collection of discoveries that bear upon ou...
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Deschepper, R., Bilsen, J., & Laureys, S. (2014). Assessment of Patient Comfort During Palliative Sedation: Is it always Reliable? In Annual Update in Intensive Care and Emergency Medicine (pp. 663-675). J-L Vicent.
"When death knocks at the door of our ward, we do not easily open the door”, an intensivist once ...
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Di, H., Nie, Y., Hu, X., Tong, Y., Heine, L., Wannez, S., Huang, W., Yu, D., He, M., Thibaut, A., Schnakers, C., & Laureys, S. (2014). Assessment of visual fixatio in vegetative and minimally conscious states. BMC Neurology, 14 (147). doi:10.1186/1471-2377-14-147
Background: Visual fixation plays a key role in the differentiation between vegetative state/unre...
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Di Perri, C., Heine, L., Amico, E., Soddu, A., Laureys, S., & Demertzi, A. (2014). Technology-based assessment in patients with disorders of consciousness. Annali dell'Istituto Superiore di Sanita, 50 (3), 209-220. doi:10.4415/ann_14_03_03
INTRODUCTION A number of studies highlight the difficulty in forming a diagnosis for patients wit...
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Di Perri, C., Stender, J., Laureys, S., & Gosseries, O. (2014). Corrigendum to "Functional neuroanatomy of disorders of consciousness" [Epilepsy Behav 30 (2014) 28-32]. Epilepsy and Behavior, 36, 153. doi:10.1016/j.yebeh.2014.04.004
Di Perri, C., Stender, J., Laureys, S., & Gosseries, O. (2014). Functional neuroanatomy of disorders of consciousness. Epilepsy and Behavior. doi:10.1016/j.yebeh.2013.09.014
Our understanding of the mechanisms of loss and recovery of consciousness, following severe brain...
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Di Perri, C., Thibaut, A., Soddu, A., Demertzi, A., & Laureys, S. (2014). Measuring consciousness in coma and related states. World Journal of Radiology, 6 (8), 589-597.
Consciousness is a prismatic and ambiguous concept that still eludes any universal definition. Se...
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Giacino, J. T., Fins, J. J., Laureys, S., & Schiff, N. D. (2014). Disorders of consciousness after acquired brain injury: the state of the science. Nature Reviews. Neurology. doi:10.1038/nrneurol.2013.279
The concept of consciousness continues to defy definition and elude the grasp of philosophical an...
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Gosseries, O.* , Charland-Verville, V.* , Thonnard, M., Bodart, O., Laureys, S., & Demertzi, A. (2014). Amantadine, Apomorphine and Zolpidem in the Treatment of Disorders of Consciousness. Current Pharmaceutical Design, 20.
Survivors of severe brain injuries may end up in a state of 'wakeful unresponsiveness' or in a mi...
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Gosseries, O., Di, H., Laureys, S., & Boly, M. (2014). Measuring consciousness in severely damaged brains. Annual Review of Neuroscience, 37, 457-78. doi:10.1146/annurev-neuro-062012-170339
Significant advances have been made in the behavioral assessment and clinical management of disor...
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Gosseries, O., & Laureys, S. (2014). Current knowledge on severe acquired brain injury with disorders of consciousness. Brain Injury, 28 (9), 1139-40. doi:10.3109/02699052.2014.932554
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Gosseries, O., Thibaut, A., Boly, M., Rosanova, M., Massimini, M., & Laureys, S. (2014). Assessing consciousness in coma and related states using transcranial magnetic stimulation combined with electroencephalography. Annales Françaises d'Anesthésie et de Réanimation. doi:10.1016/j.annfar.2013.11.002
Thanks to advances in medical care, an increased number of patients recover from coma. However, s...
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Gosseries, O., Zasler, N. D., & Laureys, S. (2014). Recent advances in disorders of consciousness: focus on the diagnosis. Brain Injury, 28 (9), 1141-50. doi:10.3109/02699052.2014.920522
BACKGROUND: Over the last two decades, there has been a considerable increase in knowledge of bra...
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Lugo, Z., Rodriguez, J., Lechner, A., Ortner, R., Gantner, I., Laureys, S., Noirhomme, Q., & Guger, C. (2014). A vibrotactile P300-based BCI for consciousness detection and communication. Clinical EEG and Neuroscience. doi:10.1177/1550059413505533
Brain–computer interface (BCI) has been used for many years for communication in severely disable...
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Marchant, N., Sanders, R., Sleigh, J., Vanhaudenhuyse, A., Bruno, M.-A., Brichant, J.-F., Laureys, S., & Bonhomme, V. (2014). How electroencephalography serves the anesthesiologist. Clinical EEG and Neuroscience, 45 (1), 22-32. doi:10.1177/1550059413509801
Major clinical endpoints of general anesthesia, such as the alteration of consciousness, are achi...
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Marinazzo, D., Gosseries, O., Boly, M., LEDOUX, D., Rosanova, M., Massimini, M., Noirhomme, Q., & Laureys, S. (2014). DIRECTED INFORMATION TRANSFER IN SCALP ELECTROENCEPHALOGRAPHIC RECORDINGS: INSIGHTS ON DISORDERS OF CONSCIOUSNESS. Clinical EEG and Neuroscience. doi:10.1177/1550059413510703
Introduction: The neural mechanisms underlying electrophysiological changes observed in patients ...
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Noirhomme, Q., & Laureys, S. (January 2014). Consciousness and Unconsciousness: An EEG Perspective. Clinical EEG and Neuroscience, 45, 4-5. doi:10.1177/1550059413519518
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Noirhomme, Q., Lehembre, R., Lugo, Z., Lesenfants, D., Luxen, A., Laureys, S., Oddo, M., & Rossetti, A. (2014). Automated analysis of background EEG and reactivity during therapeutic hypothermia in comatose patients after cardiac arrest. Clinical EEG and Neuroscience. doi:10.1177/1550059413509616
Visual analysis of electroencephalography (EEG) background and reactivity during therapeutic hypo...
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Sarasso, S., Rosanova, M., Casali, A. G., Casarotto, S., Fecchio, M., Boly, M., Gosseries, O., Tononi, G., Laureys, S., & Massimini, M. (2014). Quantifying cortical EEG responses to TMS in (un)consciousness. Clinical EEG and Neuroscience. doi:10.1177/1550059413513723
We normally assess another individual's level of consciousness based on her or his ability to int...
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Stender, J.* , Gosseries, O.* , Bruno, M.-A., Charland-Verville, V., VANHAUDENHUYSE, A., Demertzi, A., Chatelle, C., Thonnard, M., Thibaut, A., Heine, L., Soddu, A., Boly, M., Schnakers, C., Gjedde, A., & Laureys, S. (2014). Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study. The Lancet Neurology, 384 (9942), 514-522. doi:10.1016/S0140-6736(14)60042-8
Background: Bedside clinical examinations can have high rates of misdiagnosis of unresponsive wak...
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Thibaut, A., Bruno, M.-A., LEDOUX, D., Demertzi, A., & Laureys, S. (2014). tDCS in patients with disorders of consciousness: sham-controlled randomised double blind study. Neurology, 82 (13), 1112-1118. doi:10.1212/WNL.0000000000000260
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Thibaut, A., Chatelle, C., Stender, J., Demertzi, A., BERNARD, C., HUSTINX, R., LAUREYS, S., & Bruno, M.-A. (2014). Positron emission tomography imaging in altered states of consciousness: Coma, sleep and hypnosis. In R. Dierckx, A. Otte, E. Vries, A. Waarde, ... K. Leenders (Eds.), PET and SPECT in Neurology (pp. 965-986). Paris, France: Springer.
Positron emission tomography (PET) allows studies of cerebral metabolism and blood flow and has b...
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Thonnard, M.* , Gosseries, O.* , Demertzi, A., Lugo, Z., Vanhaudenhuyse, A., Bruno, M.-A., Chatelle, C., Thibaut, A., Charland-Verville, V., Habbal, D., Schnakers, C., & Laureys, S. (January 2014). Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study. Functional Neurology, 28 (4), 259-64.
Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousnes...
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Thonnard, M.* , Wannez, S.* , Keen, S., Brédart, S., Bruno, M.-A., Gosseries, O., Demertzi, A., Thibaut, A., Chatelle, C., Charland-Verville, V., Heine, L., Habbal, D., Laureys, S., & VANHAUDENHUYSE, A. (2014). Detection of visual pursuit in patients in minimally conscious state: a matter of stimuli and visual plane? Brain Injury, 28 (9), 1164-70. doi:10.3109/02699052.2014.920521
OBJECTIVES: The aim of this study was to determine whether the assessment of pursuit eye movement...
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VANHAUDENHUYSE, A., Demertzi, A., Brédart, S., & LAUREYS, S. (2014). Self in the vegetative state. In A. Mishara, P. Corlett, P. Fletcher, ... M. Schwartz, Phenomenological Neuropsychiatry: Bridging the Clinic with Clinical Neuroscience. New York, United States - New York: Springer.
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Lee, G., Fattinger, S., Mouthon, A.-L., Noirhomme, Q., & Huber, R. (05 December 2013). Electroencephalogram approximate entropy influenced by both age and sleep. Frontiers in Neuroanatomy, 7 (33). doi:10.3389/fninf.2013.00033
The use of information-based measures to assess changes in conscious state is an increasingly pop...
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Williams, S., Conte, M., Goldfine, A., Noirhomme, Q., Gosseries, O., Thonnard, M., Beattie, B., Hersh, J., Katz, D., Victor, J., Laureys, S., & Schiff, N. (2013). Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury. eLife. doi:10.7554/eLife.01157
Zolpidem produces paradoxical recovery of speech, cognitive and motor functions in select subject...
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Di Perri, C., Bastianello, S., Bartsch, A. J., Pistarini, C., Maggioni, G., Magrassi, L., Imberti, R., Pichiecchio, A., Vitali, P., Laureys, S., & Di Salle, F. (October 2013). Limbic hyperconnectivity in the vegetative state. Neurology, Vol 81, 1417-1424. doi:10.1212/WNL.0b013e3182a43b78
Objective: To investigate functional connectivity between the default mode network (DMN) and othe...
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Malinowska, U., Chatelle, C., Bruno, M.-A., Noirhomme, Q., Laureys, S., & Durka, P. (October 2013). Electroencephalographic profiles for differentiation of disorders of consciousness. BioMedical Engineering OnLine, 12. doi:10.1186/1475-925X-12-109
BACKGROUND: Electroencephalography (EEG) is best suited for long-term monitoring of brain functi...
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Monti, M., Lutkenoff, E., Rubinov, M., BOVEROUX, P., Vanhaudenhuyse, A., Gosseries, O., Bruno, M.-A., Noirhomme, Q., Boly, M., & Laureys, S. (October 2013). Dynamic change of global and local information processing in Propofol-induced loss and recovery of consciousness. PLoS Computational Biology, 9, 10. doi:10.1371/journal.pcbi.1003271
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Pokorny, C., Klobassa, D., Pichler, G., Erlbeck, H., Real, R., Kübler, A., Lesenfants, D., Habbal, D., Noirhomme, Q., Risetti, M., Mattia, D., & Müller-Putz, G. (October 2013). The auditory P300-based single-switch brain–computer interface:Paradigm transition from healthy subjects to minimally consciouspatients. Artificial Intelligence in Medicine, 59 (2), 81-90. doi:10.1016/j.artmed.2013.07.003
Objective: Within this work an auditory P300 brain–computer interface based on tone stream segreg...
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Combaz, A.* , Chatelle, C.* , Robben, A., Vanhoof, G., Goeleven, A., Thijs, V., Van Hulle, M., & Laureys, S. (25 September 2013). A Comparison of Two Spelling Brain-Computer Interfaces Based on Visual P3 and SSVEP in Locked-In Syndrome. PLoS ONE, 8 (9), 73691. doi:10.1371/journal.pone.0073691
Objectives: We study the applicability of a visual P3-based and a Steady State Visually Evoked Po...
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Deschepper, R., Laureys, S., Hachimi-Idrissi, S., Poelaert, J., & Bilsen, J. (September 2013). Palliative sedation: Why we should be more concerned about the risks that patients experience an uncomfortable death. Pain, Vol 154, 1505-1508. doi:10.1016/j.pain.2013.04.038
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Gomez Jaramillo, F. A.* , Phillips, C.* , Soddu, A., Boly, M., BOVEROUX, P., Vanhaudenhuyse, A., Bruno, M.-A., Gosseries, O., BONHOMME, V., Laureys, S., & Noirhomme, Q. (19 August 2013). Changes in Effective Connectivity by Propofol Sedation. PLoS ONE, 8 (8), 71370. doi:10.1371/journal.pone.0071370
Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studie...
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Casali, A.* , Gosseries, O.* , Rosanova, M., Boly, M., Sarasso, S., Casali, K., Casarotto, S., Bruno, M.-A., Laureys, S., Tononi, G., & Massimini, M. (14 August 2013). A theoretically based index of consciousness independent of sensory processing and behavior. Science Translational Medicine, 5. doi:10.1126/scitranslmed.3006294
One challenging aspect of the clinical assessment of brain-injured, unresponsive patients is the ...
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Boly, M., Sanders, R., Mashour, G., & Laureys, S. (August 2013). Consciousness and responsiveness: Lessons from anaesthesia and the vegetative state. Current Opinion in Anaesthesiology, Vol 26, 444-449. doi:10.1097/ACO.0b013e3283628b5d
PURPOSE OF REVIEW: The aim of this article is to review recent behavioural and neuroimaging studi...
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Lapitskaya, N.* , Gosseries, O.* , DE PASQUA, V., Pedersen, A., Nielsen, MAERTENS DE NOORDHOUT, A., & LAUREYS, S. (July 2013). Abnormal corticospinal excitability in patients with disorders of consciousness. Brain Stimulation, Volume 6, 590-597. doi:10.1016/j.brs.2013.01.002
Background: Transcranial magnetic stimulation (TMS) has been frequently used to explore changes i...
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Charland-Verville, V., Bruno, M.-A., Bahri, M. A., Demertzi, A., Desseilles, M., Chatelle, C., Vanhaudenhuyse, A., HUSTINX, R., BERNARD, C., TSHIBANDA, L., Laureys, S., & Zeman, A. (12 April 2013). Brain dead yet mind alive: A positron emission tomography case study of brain metabolism in Cotard’s syndrome. Cortex: A Journal Devoted to the Study of the Nervous System and Behavior, 49 (7), 1997-1999. doi:10.1016/j.cortex.2013.03.003
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Thonnard, M.* , Charland-Verville, V.* , Brédart, S., Dehon, H., LEDOUX, D., Laureys, S., & Vanhaudenhuyse, A. (27 March 2013). Characteristics of Near-Death Experiences Memories as Compared to Real and Imagined Events Memories. PLoS ONE, 8 (3). doi:10.1371/journal.pone.0057620
Since the dawn of time, Near-Death Experiences (NDEs) have intrigued and, nowadays, are still not...
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Cheng, L.* , Gosseries, O.* , Ying, L., Yu, X., Gao, H., He, M., Schnakers, C., LAUREYS, S., & Di, H. (18 March 2013). Assessment of localisation to auditory stimulation in post-comatose states: Use the patient's own name. BMC Neurology, Vol 13. doi:10.1186/1471-2377-13-27
Background: At present, there is no consensus on how to clinically assess localisation to sound i...
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Cologan, V., Drouot, X., Parapatics, S., Delorme, A., Gruber, G., MOONEN, G., & Laureys, S. (March 2013). Sleep in the unresponsive wakefulness syndrome and minimally conscious state. Journal of Neurotrauma, 30 (5), 339-346. doi:10.1089/neu.2012.2654
The goal of our study was to investigate different aspects of sleep, namely the sleep-wake cycle ...
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Jox, R., Bernat, J., Laureys, S., & Racine, E. (February 2013). Disorders of consciousness: Are we ready for a paradigm shift? - Authors' reply. The Lancet, Vol 12, 132. doi:10.1016/S1474-4422(12)70286-7
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Goldfine, A., Bardin, J., Noirhomme, Q., Fins, J., Schiff, N., & Victor, J. (26 January 2013). Reanalysis of “Bedside detection of awareness in the vegetative state: a cohort study”. The Lancet, 381, 289-291. doi:10.1016/S0140-6736(13)60125-7
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Cruse, D., Thibaut, A., Demertzi, A., Nantes, J., Bruno, M.-A., Gosseries, O., Vanhaudenhuyse, A., Bekinschtein, T., Owen, A., & Laureys, S. (24 January 2013). Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States. BMC Neuroscience, 11 (18). doi:10.1186/1741-7015-11-18
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Bodart, O., Laureys, S., & Gosseries, O. (2013). Coma and disorders of consciousness: scientific advances and practical considerations for clinicians. Seminars in Neurology, 33, 83-90. doi:10.1055/s-0033-1348965
Recently, neuroscientists and clinicians have seen the rapid evolution of diagnoses in disorders ...
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Bruno, M.-A., Laureys, S., & Demertzi, A. (2013). Coma and disorders of consciousness. In Handbook of Clinical Neurology. Ethical and Legal Issues in Neurology (pp. 205-213). Elsevier. doi:10.1016/B978-0-444-53501-6.00017-2
Patients in coma, vegetative state/unresponsive wakefulness syndrome, and in minimally conscious ...
Peer reviewed
Cruse, D., Chennu, S., Chatelle, C., Bekinschtein, T. A., Fernandez-Espejo, D., Pickard, J. D., Laureys, S., & Owen, A. M. (2013). Reanalysis of "Bedside detection of awareness in the vegetative state: a cohort study" - Authors' reply. The Lancet, 381 (9863), 291-2. doi:10.1016/S0140-6736(13)60126-9
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Demertzi, A., Gosseries, O., LEDOUX, D., Laureys, S., & Bruno, M.-A. (2013). Quality of life and end-of-life decisions after brain injury. In N. Warren & L. Manderson (Eds.), Reframing disability and quality of life: a global perspective (pp. 95-110). Dordrecht, Netherlands: Springer.
Peer reviewed
Demertzi, A., Racine, E., Bruno, M.-A., LEDOUX, D., Gosseries, O., Vanhaudenhuyse, A., Thonnard, M., Soddu, A., MOONEN, G., & Laureys, S. (2013). Pain perception in disorders of consciousness: Neuroscience, clinical care, and ethics in dialogue. Neuroethics, 6 (1), 37-50. doi:10.1007/s12152-011-9149-x
Pain, suffering and positive emotions in patients in vegetative state/unresponsive wakefulness sy...
Peer reviewed
Demertzi, A., Soddu, A., & Laureys, S. (January 2013). Consciousness supporting networks. Current Opinion in Neurobiology, 23 (2), 239–244. doi:10.1016/j.conb.2012.12.003
Functional neuroimaging shows that patients with disorders of consciousness exhibit disrupted sys...
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Demertzi, A., Vanhaudenhuyse, A., Brédart, S., Heine, L., Di Perri, C., & Laureys, S. (2013). Looking for the self in pathological unconsciousness. Frontiers in Human Neuroscience, 7, 1-6. doi:10.3389/fnhum.2013.00538
There is an intimate relationship between consciousness and the notion of self. By studying patie...
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Gantner, S., BODART, O., Laureys, S., & Demertzi, A. (2013). Our rapidly changing understanding of acute and chronic disorders of consciousness: challenges for neurologists. Future Neurology, 8 (1), 43-54. doi:10.2217/fnl.12.77
A number of recent studies suggest that some ‘vegetative state’ patients have been misdiagnosed, ...
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Gosseries, O., Boly, M., & Laureys, S. (2013). Transcranial magnetic stimulation coupled to EEG: a new tool to assess brain function in coma. In Annual Update in Intensive Care and Emergency Medicine. Springer-Verlag.
Peer reviewed
Gosseries, O., & LAUREYS, S. (2013). WFN Launches Coma and Disorders of Consciousness Research Group. World Neurology, 28 (1).
Peer reviewed
Guldenmund, J. P., Demertzi, A., BOVEROUX, P., Boly, M., Vanhaudenhuyse, A., Bruno, M.-A., Gosseries, O., Noirhomme, Q., Brichant, J.-F., BONHOMME, V., Laureys, S., & Soddu, A. (2013). Thalamus, Brainstem and Salience Network Connectivity Changes During Propofol-Induced Sedation and Unconsciousness. Brain Connectivity, 3. doi:10.1089/brain.2012.0117
In this functional magnetic resonance imaging study, we examined the effect of mild propofol seda...
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Lule, D.* , Noirhomme, Q.* , Kleih, S. C., Chatelle, C., Halder, S., Demertzi, A., Bruno, M.-A., Gosseries, O., Vanhaudenhuyse, A., Schnakers, C., Thonnard, M., Soddu, A., Kubler, A., & Laureys, S. (2013). Probing command following in patients with disorders of consciousness using a brain-computer interface. Clinical Neurophysiology, 124 (1), 101-6. doi:10.1016/j.clinph.2012.04.030
OBJECTIVE: To determine if brain-computer interfaces (BCIs) could serve as supportive tools for d...
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Stoll, J.* , Chatelle, C.* , Carter, O., Koch, C.* , Laureys, S.* , & Einhauser, W. (2013). Pupil responses allow communication in locked-in syndrome patients. Current Biology, 23 (15), 647-8. doi:10.1016/j.cub.2013.06.011
For patients with severe motor disabilities, a robust means of communication is a crucial factor ...
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Thibaut, A., Chatelle, C., Gosseries, O., Laureys, S., & Bruno, M.-A. (2013). La stimulation transcranienne a courant continu : un nouvel outil de neurostimulation. Revue Neurologique, 169. doi:10.1016/j.neurol.2012.05.008
Transcranial direct current stimulation (tDCS) is a safe method to modulate cortical excitability...
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Thibaut, A., Chatelle, C., Ziegler, E., Bruno, M.-A., Laureys, S., & Gosseries, O. (2013). Spasticity after stroke: Physiology, assessment and treatment. Brain Injury, 27 (10), 1093-1105. doi:10.3109/02699052.2013.804202
Spasticity following a stroke occurs in about 30% of patients. The mechanisms underlying this dis...
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Guldenmund, J. P., Stender, J., Heine, L., & Laureys, S. (2012). Mindsight: Diagnostics in Disorders of Consciousness. Critical Care Research and Practice. doi:10.1155/2012/624724
Diagnosis of patients with disorders of consciousness (comprising coma, vegetative state/unrespon...
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MAUDOUX, A., LEFEBVRE, P., CABAY, J.-E., Vanhaudenhuyse, A., Demertzi, A., Laureys, S., & Soddu, A. (2012). Auditory Resting-State Network Connectivity in Tinnitus: a Functionnal MRI Study. PLoS ONE.
The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have fo...
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Barrett, A. B., Murphy, M., Bruno, M.-A., Noirhomme, Q., Boly, M., Laureys, S., & Seth, A. K. (2012). Granger causality analysis of steady-state electroencephalographic signals during propofol-induced anaesthesia. PLoS ONE, 7 (1), 29072. doi:10.1371/journal.pone.0029072
Changes in conscious level have been associated with changes in dynamical integration and segrega...
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Boly, M., Massimini, M., Garrido, M. I., Gosseries, O., Noirhomme, Q., Laureys, S., & Soddu, A. (2012). Brain connectivity in disorders of consciousness. Brain Connectivity, 2 (1), 1-10. doi:10.1089/brain.2011.0049
The last 10 years witnessed a considerable increase in our knowledge of brain function in survivo...
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Boly, M., Moran, R., Murphy, M., BOVEROUX, P., Bruno, M.-A., Noirhomme, Q., LEDOUX, D., BONHOMME, V., BRICHANT, J.-F., Tononi, G., Laureys, S., & Friston, K. (2012). Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness. Journal of Neuroscience, 32 (20), 7082-90. doi:10.1523/JNEUROSCI.3769-11.2012
The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of debate. Rec...
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Boly, M., Perlbarg, V., Marrelec, G., Schabus, M., Laureys, S., Doyon, J., Pelegrini-Issac, M., Maquet, P., & Benali, H. (2012). Hierarchical clustering of brain activity during human nonrapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1111133109
Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain functi...
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BONHOMME, V., BOVEROUX, P., Brichant, J.-F., Laureys, S., & Boly, M. (2012). Neural correlates of consciousness during general anesthesia using functional magnetic resonance imaging (fMRI). Archives Italiennes de Biologie, 150 (2-3), 155-63.
This paper reviews the current knowledge about the mechanisms of anesthesia-induced alteration of...
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Bruno, M.-A., LEDOUX, D., Vanhaudenhuyse, A., Gosseries, O., Thibaut, A., & Laureys, S. (2012). Prognosis of patients with altered states of consciousness. In C. Schnakers & S. Laureys (Eds.), Coma and disorders of consciousness. London, United Kingdom: Springer/Verlag. doi:10.1007/978-1-4471-2440-5_2
Peer reviewed
Bruno, M.-A., Majerus, S., Boly, M., Vanhaudenhuyse, A., Schnakers, C., Gosseries, O., Boveroux, P., KIRSCH, M., Demertzi, A., Bernard, C., Hustinx, R., Moonen, G., & Laureys, S. (2012). Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients. Journal of Neurology, 259 (6), 1087-98. doi:10.1007/s00415-011-6303-7
Patients in a minimally conscious state (MCS) show restricted signs of awareness but are unable t...
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Charland-Verville, V., Habbal, D., Laureys, S., & Gosseries, O. (2012). Coma and related disorders. Schweizer Archiv für Neurologie und Psychiatrie, 163 (8), 265-272. doi:10.4414/sanp.2012.00131
Disorders of consciousness represent a major challenge in clinical practice. The last decade of ...
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Chatelle, C., Chennu, S., Noirhomme, Q., Cruse, D., Owen, A. M., & Laureys, S. (2012). Brain-computer interfacing in disorders of consciousness. Brain Injury, 26 (12), 1510-22. doi:10.3109/02699052.2012.698362
Background: Recent neuroimaging research has strikingly demonstrated the existence of covert awar...
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Chatelle, C., Lugo, Z., Noirhomme, Q., Sorger, B., & Lulé, D. (2012). Brain-Computer Interface: A Communication Aid? In C. Schnakers & S. Laureys (Eds.), Coma and Disorders of Consciousness (pp. 67-78). London, United Kingdom: Springer. doi:10.1007/978-1-4471-2440-5_7
Chatelle, C., Majerus, S., Whyte, J., Laureys, S., & Schnakers, C. (2012). A sensitive scale to assess nociceptive pain in patients with disorders of consciousness. Journal of Neurology, Neurosurgery and Psychiatry, 83 (12), 1233-7. doi:10.1136/jnnp-2012-302987
OBJECTIVE: To determine the sensitivity of the Nociception Coma Scale (NCS), the first scale deve...
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Cruse, D., Chennu, S., Chatelle, C., Fernandez-Espejo, D., Bekinschtein, T. A., Pickard, J. D., Laureys, S., & Owen, A. M. (2012). Relationship between etiology and covert cognition in the minimally conscious state. Neurology, 78 (11), 816-22. doi:10.1212/WNL.0b013e318249f6f0
OBJECTIVES: Functional neuroimaging has shown that the absence of externally observable signs of ...
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Demertzi, A., Gosseries, O., Bruno, M.-A., Schnakers, C., Vanhaudenhuyse, A., Chatelle, C., Charland-Verville, V., Thibaut, A., Thonnard, M., & Laureys, S. (2012). The ethics of managing disorders of consciousness. In C. Schnakers & S. Laureys (Eds.), Coma and disorders of consciousness (pp. 25-34). London, United Kingdom: Springer/Verlag. doi:10.1007/978-1-4471-2440-5_14
Peer reviewed
Demertzi, A., & Laureys, S. (2012). Where in the brain is pain? Evaluating painful experiences in non-communicative patients. In S. Richmond, G. Rees, ... S. Edwards (Eds.), I know what you are thinking: brain imaging and mental privacy (pp. 89-98). Oxford University Press.
Peer reviewed
Fernandez-Espejo, D., Soddu, A., Cruse, D., Palacios, E. M., Junque, C., Vanhaudenhuyse, A., Rivas, E., Newcombe, V., Menon, D. K., Pickard, J. D., Laureys, S., & Owen, A. M. (2012). A role for the default mode network in the bases of disorders of consciousness. Annals of Neurology, 72 (3), 335-43. doi:10.1002/ana.23635
OBJECTIVE: Functional connectivity in the default mode network (DMN) is known to be reduced in pa...
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Galanaud, D., Perlbarg, V., Gupta, R., Stevens, R. D., Sanchez, P., Tollard, E., de Champfleur, N. M., Dinkel, J., Faivre, S., Soto-Ares, G., Veber, B., Cottenceau, V., Masson, F., Tourdias, T., Andre, E., Audibert, G., Schmitt, E., Ibarrola, D., Dailler, F., ... Puybasset, L. (2012). Assessment of White Matter Injury and Outcome in Severe Brain Trauma: A Prospective Multicenter Cohort. Anesthesiology, 117 (6), 1300-1310. doi:10.1097/ALN.0b013e3182755558
BACKGROUND:: Existing methods to predict recovery after severe traumatic brain injury lack accura...
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Gomez, F., Soddu, A., Noirhomme, Q., VANHAUDENHUYSE, A., TSHIBANDA, L., Leporé, N., & LAUREYS, S. (2012). DTI based structural damage characterization for Disorders of Consciousness. Proceedings. International Conference on Image Processing. doi:10.1109/ICIP.2012.6467095
Peer reviewed
Gosseries, O., Demertzi, A., LEDOUX, D., Bruno, M.-A., Vanhaudenhuyse, A., Thibaut, A., Laureys, S., & Schnakers, C. (2012). Burnout in healthcare workers managing chronic patients with disorders of consciousness. Brain Injury, 26, 1493-1499. doi:10.3109/02699052.2012.695426
Objectives: The aim of this study was to assess the presence of burnout among professional caregi...
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Gosseries, O., Thonnard, M., & Laureys, S. (2012). Pharmacological treatments. In Coma et états de conscience altérée (pp. 121-138). Springer-Verlag London Ltd. doi:10.1007/978-1-4471-2440-5_12
We review the current state of knowledge for potentially useful drugs acting on the recovery of c...
Peer reviewed
Guldenmund, J. P., Vanhaudenhuyse, A., Boly, M., Laureys, S., & Soddu, A. (2012). A default mode of brain function in altered states of consciousness. Archives Italiennes de Biologie, 150 (2-3), 107-21.
Using modern brain imaging techniques, new discoveries are being made concerning the spontaneous ...
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Heine, L., Soddu, A., Gomez, F., Vanhaudenhuyse, A., TSHIBANDA, L., Thonnard, M., Charland-Verville, V., KIRSCH, M., Laureys, S., & Demertzi, A. (2012). Resting state networks and consciousness Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states. Frontiers in Psychology, 3, 295. doi:10.3389/fpsyg.2012.00295
In order to better understand the functional contribution of resting state activity to conscious ...
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Laureys, S., & Schiff, N. (2012). Coma and consciousness: Paradigms (re)framed by neuroimaging. NeuroImage. doi:10.1016/j.neuroimage.2011.12.041
The past 15years has provided an unprecedented collection of discoveries that bear upon our scien...
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Lehembre, R., Bruno, M.-A., Vanhaudenhuyse, A., Chatelle, C., Cologan, V., Leclercq, Y., Soddu, A., Macq, B., Laureys, S., & Noirhomme, Q. (2012). Resting-state EEG study of comatose patients: a connectivity and frequency analysis to find differences between vegetative and minimally conscious states. Functional Neurology, 27 (1), 41-47.
The aim of this study was to look for differences in the power spectra and in EEG connectivity me...
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Lehembre, R.* , Gosseries, O.* , Lugo, Z., JEDIDI, Z., Chatelle, C., Sadzot, B., Laureys, S., & Noirhomme, Q. (2012). Electrophysiological investigations of brain function in coma, vegetative and minimally conscious patients. Archives Italiennes de Biologie, 150 (2-3), 122-39.
Electroencephalographic activity in the context of disorders of consciousness is a swiss knife li...
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Luyt, C.-E., Galanaud, D., Perlbarg, V., Vanhaudenhuyse, A., Stevens, R. D., Gupta, R., Besancenot, H., Krainik, A., Audibert, G., Combes, A., Chastre, J., Benali, H., Laureys, S., & Puybasset, L. (2012). Diffusion Tensor Imaging to Predict Long-term Outcome after Cardiac Arrest: A Bicentric Pilot Study. Anesthesiology, 117 (6), 1311-1321. doi:10.1097/ALN.0b013e318275148c
BACKGROUND: Prognostication in comatose survivors of cardiac arrest is a major clinical challenge...
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MAUDOUX, A., Lefèbvre, P., CABAY, J.-E., Demertzi, A., Vanhaudenhuyse, A., Laureys, S., & Soddu, A. (2012). Auditory resting-state network connectivity in tinnitus: a functional MRI study. PLoS ONE, 7 (5), 36222. doi:10.1371/journal.pone.0036222
The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have fo...
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MAUDOUX, A., Lefèbvre, P., Cabay, J.-E., Demertzi, A., Vanhaudenhuyse, A., Laureys, S., & Soddu, A. (2012). Connectivity graph analysis of the auditory resting state network in tinnitus. Brain Research, 1485, 10-21. doi:10.1016/j.brainres.2012.05.006
Thirteen chronic tinnitus patients and fifteen age-matched healthy controls were studied on a 3T ...
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Nizzi, M. C., Demertzi, A., Gosseries, O., Bruno, M.-A., Jouen, F., & Laureys, S. (2012). From armchair to wheelchair: How patients with a locked-in syndrome integrate bodily changes in experienced identity. Consciousness and Cognition, 21, 431-437. doi:10.1016/j.concog.2011.10.010
Different sort of people are interested in personal identity. Philosophers frequently ask what it...
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Noirhomme, Q., & Lehembre, R. (2012). Electrophysiology and disorders of consciousness. In C. Schnakers & S. Laureys (Eds.), Coma and disorders of consciousness. Springer. doi:10.1007/978-1-4471-2440-5_6
Ovadia-Caro, S., Nir, Y., Soddu, A., Ramot, M., Hesselmann, G., Vanhaudenhuyse, A., Dinstein, I., Tshibanda, J.-F. L., Boly, M., Harel, M., Laureys, S., & Malach, R. (2012). Reduction in inter-hemispheric connectivity in disorders of consciousness. PLoS ONE, 7 (5), 37238. doi:10.1371/journal.pone.0037238
Clinical diagnosis of disorders of consciousness (DOC) caused by brain injury poses great challen...
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Rosanova, M.* , Gosseries, O.* , Casarotto, S., Boly, M., Casali, A. G., Bruno, M.-A., Mariotti, M., BOVEROUX, P., Tononi, G., Laureys, S., & Massimini, M. (2012). Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients. Brain: a Journal of Neurology, 135 (Pt 4), 1308-20. doi:10.1093/brain/awr340
Patients surviving severe brain injury may regain consciousness without recovering their ability ...
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Schnakers, C., Chatelle, C., Demertzi, A., Majerus, S., & LAUREYS, S. (2012). What about pain in disorders of consciousness? AAPS Journal, 14, 437-444. doi:10.1208/s12248-012-9346-5
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Soddu, A., Vanhaudenhuyse, A., Bahri, M. A., Bruno, M.-A., Boly, M., Demertzi, A., Tshibanda, J. F., Phillips, C., Stanziano, M., Ovadia-Caro, S., Nir, Y., Maquet, P., Papa, M., Malach, R., Laureys, S., & Noirhomme, Q. (2012). Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness. Human Brain Mapping, 36, 37-43. doi:10.1002/hbm.21249
Objectives:Recent fMRI studies have shown that it is possible to reliably identify the default-mo...
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Thibaut, A., Bruno, M.-A., Chatelle, C., Gosseries, O., Vanhaudenhuyse, A., Demertzi, A., Schnakers, C., Thonnard, M., CHARLAND-VERVILLE, V., BERNARD, C., Bahri, M. A., Phillips, C., Boly, M., Hustinx, R., & Laureys, S. (2012). Metabolic activity in external and internal awareness networks in severely brain-damaged patients. Journal of Rehabilitation Medicine, 44 (6), 487-94. doi:10.2340/16501977-0940
OBJECTIVE: An extrinsic cerebral network (encompassing lateral frontoparietal cortices) related t...
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Vanhaudenhuyse, A., Boly, M., Bruno, M.-A., Gosseries, O., Demertzi, A., KIRSCH, M., TSHIBANDA, L., Thonnard, M., Charland-Verville, V., Chatelle, C., Thibaut, A., Laureys, S., & Soddu, A. (2012). Functional imaging and impaired consciousness. In C. Schnakers & S. Laureys (Eds.), Coma and disorders of consciousness (pp. 25-34). London, United Kingdom: Springer/Verlag. doi:10.1007/978-1-4471-2440-5_3
Peer reviewed
VANHAUDENHUYSE, A., Demertzi, A., Brédart, S., & LAUREYS, S. (2012). Évaluation de la conscience de soi chez les patients non communicants. In S. Brédart & M. Van der Linden (Eds.), Identité et cognition (pp. 251-268). Bruxelles, Belgium: De Boek.
Peer reviewed
Demertzi, A., Schabus, M., Weilhart, K., Roehm, D., Bruno, M.-A., & LAUREYS, S. (2011). Wachkoma: medizinische Grundlagen und neurowissenschaftliche Revolution. In R. Jox, G. D. Borasio, ... K. Kühlmeyer (Eds.), Leben im Koma Interdisziplinäre Perspektiven auf das Problem des Wachkomas (pp. 21-32). Stuttgart, Germany: W. Kohlhammer GmbH.
Demertzi, A., Gosseries, O., Bruno, M.-A., Schnakers, C., Vanhaudenhuyse, A., Chatelle, C., Charland-Verville, V., THIBAUT, A., Thonnard, M., & LAUREYS, S. (2011). Désordres de la conscience : aspects éthiques. In C. Schnakers & S. LAUREYS (Eds.), Comas et états de conscience altérée (pp. 157-164). Paris, France: Springer-Verlag.
L’apparition de la ventilation mécanique dans les années cinquante et le développement des soins ...
Peer reviewed
Demertzi, A., Soddu, A., FAYMONVILLE, M.-E., Bahri, M. A., Gosseries, O., Vanhaudenhuyse, A., Phillips, C., Maquet, P., Luxen, A., & Laureys, S. (23 August 2011). Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity. Progress in Brain Research, 193, 309-322. doi:10.1016/B978-0-444-53839-0.00020-X
Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-...
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Demertzi, A., LAUREYS, S., & Bruno, M.-A. (2011). The ethics in disorders of consciousness. In J. L. Vincent (Ed.), Annual Update in Intensive Care and Emergency Medicine (1st, pp. 675-682). Heidelberg, Germany: Springer. doi:10.1007/978-3-642-18081-1
The introduction of the mechanical ventilator in the 1950s and the development of intensive care ...
MAGIS, D., Bruno, M.-A., FUMAL, A., Gerardy, P.-Y., HUSTINX, R., LAUREYS, S., & Schoenen, J. (24 February 2011). Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study. BMC Neurology, 11, 25. doi:10.1186/1471-2377-11-25
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Bruno, M.-A., Bernheim, J., LEDOUX, D., Pellas, F., Demertzi, A., & Laureys, S. (23 February 2011). A survey on self-assessed well-being in a cohort of chronic locked-in syndrome patients: happy majority, miserable minority. BMJ Open, 1. doi:10.1136/bmjopen-2010-000039
Objectives Locked-in syndrome (LIS) consists of anarthria and quadriplegia while consciousness is...
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Demertzi, A., Schnakers, C., Soddu, A., Bruno, M.-A., Gosseries, O., Vanhaudenhuyse, A., & Laureys, S. (February 2011). Neural plasticity lessons from disorders of consciousness. Frontiers in Psychology, 1, 1-7. doi:10.3389/fpsyg.2010.00245
Communication and intentional behavior are supported by the brain?s integrity at a structural and...
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Boly, M., Garrido, M. I., Gosseries, O., Bruno, M.-A., BOVEROUX, P., Schnakers, C., Massimini, M., Litvak, V., Laureys, S., & Friston, K. (2011). Preserved feedforward but impaired top-down processes in the vegetative state. Science, 332 (6031), 858-62. doi:10.1126/science.1202043
Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontopariet...
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Boly, M., Garrido, M. I., Gosseries, O., Bruno, M.-A., BOVEROUX, P., Schnakers, C., Massimini, M., Litvak, V., Laureys, S., & Friston, K. (2011). Response to comment on "preserved feedforward but impaired top-down processes in the vegetative state". Science, 334 (6060), 1203. doi:10.1126/science.1210240
King et al. raise some technical issues about our recent study showing impaired top-down processe...
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BONHOMME, V., BOVEROUX, P., HANS, P., Brichant, J.-F., Vanhaudenhuyse, A., Boly, M., & Laureys, S. (2011). Influence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity. Current Opinion in Anaesthesiology, 24 (5), 474-9. doi:10.1097/ACO.0b013e32834a12a1
PURPOSE OF REVIEW: To describe recent studies exploring brain function under the influence of hyp...
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BONHOMME, V., BOVEROUX, P., Vanhaudenhuyse, A., HANS, P., Brichant, J.-F., Jaquet, O., Boly, M., & LAUREYS, S. (2011). Linking sleep and general anesthesia mechanisms: this is no walkover. Acta Anaesthesiologica Belgica, 62 (3), 161-171.
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Bruno, M.-A., Fernandez-Espejo, D., Lehembre, R., TSHIBANDA, L., Vanhaudenhuyse, A., Gosseries, O., LOMMERS, E., Napolitani, M., Noirhomme, Q., Boly, M., Papa, M., Owen, A., Maquet, P., Laureys, S., & Soddu, A. (2011). Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy". Progress in Brain Research, 193, 323-33. doi:10.1016/B978-0-444-53839-0.00021-1
Beside behavioral assessment of patients with disorders of consciousness, neuroimaging modalities...
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Bruno, M.-A.* , Gosseries, O.* , Ledoux, D., Hustinx, R., & Laureys, S. (2011). Assessment of consciousness with electrophysiological and neurological imaging techniques. Current Opinion in Critical Care. doi:10.1097/MCC.0b013e328343476d
PURPOSE OF REVIEW: Brain MRI (diffusion tensor imaging and spectroscopy) and functional neuroimag...
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Bruno, M.-A., LEDOUX, D., LAMBERMONT, B., DAMAS, F., Schnakers, C., Vanhaudenhuyse, A., Gosseries, O., & Laureys, S. (2011). Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an Intensive Care Unit Population. Neurocritical Care, 15 (3), 447-53. doi:10.1007/s12028-011-9547-2
BACKGROUND: The Full Outline of UnResponsiveness (FOUR) has been proposed as an alternative for t...
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Bruno, M.-A., LEDOUX, D., Vanhaudenhuyse, A., Gosseries, O., Thibaut, A., & Laureys, S. (2011). Pronostic des patients récupérant du coma. In C. Schnakers & S. Laureys (Eds.), Coma et états de conscience altérée. France: Springer/Verlag.
Peer reviewed
Bruno, M.-A., Vanhaudenhuyse, A., Thibaut, A., Moonen, G., & Laureys, S. (2011). From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness. Journal of Neurology, 258 (7), 1373-84. doi:10.1007/s00415-011-6114-x
Functional neuroimaging and electrophysiology studies are changing our understanding of patients ...
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Chatelle, C., & LAUREYS, S. (2011). Understanding disorders of consciousness. In J. Illes & B. Sahakian (Eds.), The Oxford Handbook of Neuroethics. New York, United States - New York: Oxford University Press.
Chatelle, C., Laureys, S., & Schnakers, C. (2011). Disorders of consciousness: what do we know? In S. Dehaene & Y. Christen (Eds.), Characterizing Consciousness: From Cognition to the Clinic? (pp. 85-98). Berlin, Germany: Springer.
Chatelle, C., Lugo, Z., Noirhomme, Q., Sorger, B., & Dorothée, L. (2011). Interface cerveau-ordinateur : une aide à la communication ? In C. Schnakers & S. Laureys (Eds.), Coma et états de conscience altérée (pp. 73-84). France: Springer.
Cruse, D., Chennu, S., Chatelle, C., Bekinschtein, T. A., Fernandez-Espejo, D., Pickard, J. D., Laureys, S., & Owen, A. M. (2011). Bedside detection of awareness in the vegetative state: a cohort study. The Lancet, 378 (9809), 2088-94. doi:10.1016/S0140-6736(11)61224-5
BACKGROUND: Patients diagnosed as vegetative have periods of wakefulness, but seem to be unaware ...
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Demertzi, A., LEDOUX, D., Bruno, M.-A., Vanhaudenhuyse, A., Gosseries, O., Soddu, A., Schnakers, C., MOONEN, G., & Laureys, S. (2011). Attitudes towards end-of-life issues in disorders of consciousness : a European survey. Journal of Neurology, 258, 1058-1065. doi:10.1007/s00415-010-5882-z
Previous European surveys showed the support of healthcare professionals for treatment withdrawal...
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Gosseries, O.* , Bruno, M.-A.* , Chatelle, C., Vanhaudenhuyse, A., Schnakers, C., Soddu, A., & LAUREYS, S. (2011). Disorders of consciousness: What's in a name? NeuroRehabilitation, 28, 3-14. doi:10.3233/NRE-2011-0625
Following a coma, some patients may “awaken” without voluntary interaction or communication with ...
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Gosseries, O., Laureys, S., & Vanhaudenhuyse, A. (2011). Comment évaluer la conscience chez des patients sévèrement cérébro-lésés ? In I. Lutte (Ed.), L’évaluation du traumatisme crânien (pp. 13-51). Limal, Belgium: Anthemis.
Gosseries, O., Schnakers, C., LEDOUX, D., Vanhaudenhuyse, A., Bruno, M.-A., Demertzi, A., Noirhomme, Q., Lehembre, R., Damas, P., Goldman, S., Peeters, E., Moonen, G., & Laureys, S. (2011). Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state. Functional Neurology, 36, 25-30.
Monitoring the level of consciousness in brain injured patients with disorders of consciousness i...
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Gosseries, O., Thonnard, M., & Laureys, S. (2011). Les traitements pharmacologiques chez les patients récupérant du coma. In C Schnakers & S Laureys (Ed.), Comas et états de conscience altérée (pp. 127-146). Paris, France: Springer-Verlag.
Gosseries, O., Vanhaudenhuyse, A., Bruno, M.-A., Demertzi, A., Schnakers, C., Boly, M., MAUDOUX, A., MOONEN, G., & Laureys, S. (2011). Disorders of consciousness: coma, vegetative and minimally conscious states. In D. Cvetkovic & I. Cosic (Ed.), States of Consciousness: Experimental Insights into Meditation, Waking, Sleep and Dreams (pp. 29-55). Berlin, Germany: Springer-Verlag.
Landsness, E.* , Bruno, M.-A.* , Noirhomme, Q., Riedner, B., Gosseries, O., Schnakers, C., Massimini, M., Laureys, S., Tononi, G., & Boly, M. (2011). Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious state. Brain: a Journal of Neurology, 134 (Pt 8), 2222-32. doi:10.1093/brain/awr152
The existence of normal sleep in patients in a vegetative state is still a matter of debate. Prev...
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Leclercq, Y., Schrouff, J., Noirhomme, Q., Maquet, P., & Phillips, C. (2011). fMRI Artefact Rejection and Sleep Scoring Toolbox. Computational Intelligence and Neuroscience. doi:10.1155/2011/598206
This paper proposes a toolbox for handling large EEG/ MEG data sets, rejecting the artefact linke...
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Murphy, M., Bruno, M.-A., Riedner, B. A., BOVEROUX, P., Noirhomme, Q., Landsness, E. C., BRICHANT, J.-F., Phillips, C., Massimini, M., Laureys, S., Tononi, G., & Boly, M. (2011). Propofol anesthesia and sleep: a high-density EEG study. Sleep, 34 (3), 283-91. doi:10.1093/sleep/34.3.283
STUDY OBJECTIVES: The electrophysiological correlates of anesthetic sedation remain poorly unders...
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Noirhomme, Q., & Laureys, S. (2011). Altering consciousness and neuropathology. In E. Cardeña & M. Winkelman (Eds.), Altering ocnsciousness: Multidisciplinary perspectives. Volume 2: Biological and Psychological Perspectives (pp. 263-278). Santa Barbara, United States - California: Praeger.
Noirhomme, Q., & Lehembre, R. (2011). Electrophysiologie des états de conscience altérée. In C. Schnakers & S. Laureys (Eds.), Coma et états de conscience altérée (pp. 61-72). Paris, France: Springer-Verlag.
Phillips, C., Bruno, M.-A., Maquet, P., Boly, M., Noirhomme, Q., Schnakers, C., Vanhaudenhuyse, A., Bonjean, M., Hustinx, R., Moonen, G., Luxen, A., & Laureys, S. (2011). "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients. NeuroImage, 56 (2), 797–808. doi:10.1016/j.neuroimage.2010.05.083
The vegetative state is a devastating condition where patients awaken from their coma (i.e., open...
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Schrouff, J., Perlbarg, V., Boly, M., Marrelec, G., BOVEROUX, P., Vanhaudenhuyse, A., Bruno, M.-A., Laureys, S., Phillips, C., Pélégrini-Issac, M., Maquet, P., & Benali, H. (2011). Brain functional integration decreases during propofol-induced loss of consciousness. NeuroImage, 57 (1), 198-205. doi:10.1016/j.neuroimage.2011.04.020
Consciousness has been related to the amount of integrated information that the brain is able to ...
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Soddu, A., Vanhaudenhuyse, A., Demertzi, A., Bruno, M.-A., TSHIBANDA, L., Di, H., Melanie, B., Papa, M., Laureys, S., & Noirhomme, Q. (2011). Resting state activity in patients with disorders of consciousness. Functional Neurology, 26 (1), 37-43.
Recent advances in the study of spontaneous brain activity have demonstrated activity patterns th...
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Thonnard, M., Boly, M., Bruno, M.-A., Chatelle, C., Gosseries, O., Laureys, S., & Vanhaudenhuyse, A. (2011). La neuro-imagerie: un outil diagnostique des etats de conscience alteree. MS. Medecine Sciences, 27 (1), 77-81. doi:10.1051/medsci/201127177
Vegetative and minimally conscious states diagnosis remained a major clinical challenge. New para...
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Vanhaudenhuyse, A., Boly, M., Bruno, M.-A., Gosseries, O., Demertzi, A., Laureys, S., & Soddu, A. (2011). Imagerie fonctionnelle et états de conscience altérée. In C. Schnakers & S. LAUREYS (Eds.), Coma et états de conscience altérée. France: Springer/Verlag.
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Vanhaudenhuyse, A.* , Demertzi, A.* , Schabus, M., Noirhomme, Q., Brédart, S., Boly, M., Phillips, C., Soddu, A., Luxen, A., MOONEN, G., & Laureys, S. (2011). Two distinct neuronal networks mediate the awareness of environment and of self. Journal of Cognitive Neuroscience, 23 (3), 570-578. doi:10.1162/jocn.2010.21488
Evidence from functional neuroimaging studies on resting state suggests that there are two distin...
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Noirhomme, Q., Soddu, A., Lehembre, R., Vanhaudenhuyse, A., Boveroux, P., Boly, M., & Laureys, S. (20 December 2010). Brain connectivity in pathological and pharmacological coma. Frontiers in Systems Neuroscience, 4, 6. doi:10.3389/fnsys.2010.00160
Recent studies in patients with disorders of consciousness (DOC) tend to support the view that aw...
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Laureys, S., Celesia, G. G., Cohadon, F., Lavrijsen, J., Leon-Carrion, J., Sannita, W. G., Sazbon, L., Schmutzhard, E., von Wild, K. R., Zeman, A., & Dolce, G. (November 2010). Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Medicine, 8, 68. doi:10.1186/1741-7015-8-68
BACKGROUND: Some patients awaken from coma (that is, open the eyes) but remain unresponsive (that...
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Vanhaudenhuyse, A., Monti, M., Coleman, M., Boly, M., Pickard, J., TSHIBANDA, L., Owen, A., & Laureys, S. (2010). Willful Modulation of Brain Activity in Disorders of Consciousness. New England Journal of Medicine. doi:10.1056/NEJMoa0905370
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Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., Brichant, J.-F., Bonhomme, V., Maquet, P., Greicius, M. D., Laureys, S., & Boly, M. (2010). Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness. Anesthesiology, 113 (5), 1038-53. doi:10.1097/ALN.0b013e3181f697f5
BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Rest...
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Bruno, M.-A., Gosseries, O., Vanhaudenhuyse, A., Chatelle, C., & Laureys, S. (2010). État végétatif et état de conscience minimale : un devenir pire que la mort ? In Enjeux éthiques en réanimation. Paris, France: Springer-Verlag.
Bruno, M.-A.* , Soddu, A.* , Demertzi, A., Laureys, S., Gosseries, O., Schnakers, C., Boly, M., Noirhomme, Q., Thonnard, M., Chatelle, C., & Vanhaudenhuyse, A. (2010). Disorders of consciousness: Moving from passive to resting state and active paradigms. Cognitive Neuroscience, 1 (1), 193–203. doi:10.1080/17588928.2010.485677
Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vege...
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Bruno, M.-A., Vanhaudenhuyse, A., Schnakers, C., Boly, M., Gosseries, O., Demertzi, A., Majerus, S., Moonen, G., Hustinx, R., & Laureys, S. (2010). Visual fixation in the vegetative state: an observational case series PET study. BMC Neurology, 10, 35. doi:10.1186/1471-2377-10-35
BACKGROUND: Assessment of visual fixation is commonly used in the clinical examination of patient...
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Chatelle, C., Laureys, S., Majerus, S., & Schnakers, C. (2010). Eye gaze and conscious processing in severely brain-injured patients. Behavioral and Brain Sciences, 33 (6), 442-443. doi:10.1017/s0140525x10001494
Niedenthal et al. discuss the importance of eye gaze in embodied simulation and, more globally, i...
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Chatelle, C., Schnakers, C., Bruno, M.-A., Gosseries, O., Laureys, S., & Vanhaudenhuyse, A. (2010). La Sensory Modality Assessment and Rehabilitation Technique (SMART) : une echelle comportementale d'evaluation et de revalidation pour des etats alteres de conscience. Revue Neurologique, 166 (8-9), 675-82. doi:10.1016/j.neurol.2010.01.011
INTRODUCTION: Difficulties in detecting bedside signs of consciousness in non-communicative patie...
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Cologan, V., Schabus, M., LEDOUX, D., MOONEN, G., Maquet, P., & Laureys, S. (2010). Sleep in disorders of consciousness. Sleep Medicine Reviews, 14 (2), 97-105. doi:10.1016/j.smrv.2009.04.003
From a behavioral as well as neurobiological point of view, sleep and consciousness are intimatel...
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Laureys, S., & Demertzi, A. (2010). Is there anybody in there? In T. Fuchs, H. Sattel, ... P. Henningsen (Eds.), The embodied self. Dimensions, Coherence and Disorders (pp. 95-110). Schattauer.
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Monti, M. M., Laureys, S., & Owen, A. M. (2010). The vegetative state. BMJ: British Medical Journal, 341, 3765. doi:10.1136/bmj.c3765
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Noirhomme, Q., Soddu, A., Vanhaudenhuyse, A., Lehembre, R., Bruno, M.-A., Gosseries, O., Demertzi, A., Maudoux, A., Schnakers, C., Boveroux, P., Boly, M., & Laureys, S. (2010). Functional Neuroimaging Approaches to the Changing Borders of Consciousness. Journal of Psychophysiology, 24 (2), 68-75. doi:10.1027/0269-8803/a000015
The bedside diagnosis of vegetative and minimally conscious patients is extremely challenging, an...
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Qin, P., Di, H., Liu, Y., Yu, S., Gong, Q., Duncan, N., Weng, X., Laureys, S., & Northoff, G. (2010). Anterior cingulate activity and the self in disorders of consciousness. Human Brain Mapping, 31 (12), 1993-2002. doi:10.1002/hbm.20989
OBJECTIVES: The aim of this study was to investigate the relationship between medial cortical act...
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Schnakers, C., Chatelle, C., Majerus, S., Gosseries, O., De Val, M., & Laureys, S. (2010). Assessment and detection of pain in noncommunicative severely brain-injured patients. Expert Review of Neurotherapeutics, 10 (11), 1725-31. doi:10.1586/ern.10.148
Detecting pain in severely brain-injured patients recovering from coma represents a real challeng...
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Schnakers, C., Chatelle, C., Vanhaudenhuyse, A., Majerus, S., Ledoux, D., Boly, M., Bruno, M.-A., Boveroux, P., Demertzi, A., Moonen, G., & Laureys, S. (2010). The nociception coma scale: A new tool to assess nociception in disorders of consciousness. Pain, 148, 215-219. doi:10.1016/j.pain.2009.09.028
Assessing behavioral responses to nociception is difficult in severely brain-injured patients rec...
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Schnakers, C., Gosseries, O., LEDOUX, D., & Laureys, S. (2010). Impact psychologique de la prise en charge des patients récupérant du coma sur les familles et l’équipe soignante. In Enjeux éthiques en réanimation. Springer-Verlag.
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Thonnard, M., Chatelle, C., Gosseries, O., Vanhaudenhuyse, A., Laureys, S., & Bruno, M.-A. (2010). Quelles attitudes médicales et éthiques adopter envers le patient en locked-in syndrome? In L. Puybasset (Ed.), Enjeux éthiques en réanimation (pp. 111-118). Paris, France: Springer-Verlag.
Tshibanda, L., Vanhaudenhuyse, A., Boly, M., Soddu, A., Bruno, M.-A., Moonen, G., Laureys, S., & Noirhomme, Q. (2010). Neuroimaging after coma. Neuroradiology, 52 (1), 15-24. doi:10.1007/s00234-009-0614-8
Following coma, some patients will recover wakefulness without signs of consciousness (only showi...
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Vanhaudenhuyse, A.* , Noirhomme, Q.* , Tshibanda, L., Bruno, M.-A., Boveroux, P., Schnakers, C., Soddu, A., Perlbarg, V., Ledoux, D., Brichant, J.-F., Moonen, G., Maquet, P., Greicius, M. D., Laureys, S., & Boly, M. (2010). Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain: a Journal of Neurology, 133 (Pt 1), 161-71. doi:10.1093/brain/awp313
The 'default network' is defined as a set of areas, encompassing posterior-cingulate/precuneus, a...
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Noirhomme, Q., Laureys, S., & Boly, M. (December 2009). Sleep vs Coma. Frontiers in Neuroscience, 3 (3), 406-407.
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Lule, D., Zickler, K., Hacker, S., Bruno, M.-A., Demertzi, A., Pellas, F., Laureys, S., & Kubler, A. (13 October 2009). Life can be worth living in locked-in syndrome. Progress in Brain Research, 177, 339-351. doi:10.1016/S0079-6123(09)17723-3
The locked-in syndrome (LIS) describes patients who are awake and conscious but severely deeffere...
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Stanziano, M., Soddu, A., Papa, M., Laureys, S., & Noirhomme, Q. (October 2009). I disturbi dello stato di coscienza come modello di studio dei suoi correlati neurali. Paradoxa, 3 (4), 106-118.
Ysebaert, D., Van Beeumen, G., De Greef, K., Squifflet, J.-P., Detry, O., De Roover, A., Delbouille, M.-H., Van Donink, W., Roeyen, G., Chapelle, T., Bosmans, J. L., Van Raemdonck, D., Faymonville, M., Laureys, S., Lamy, M., & Cras, P. (March 2009). Organ Procurement After Euthanasia: Belgian Experience. Transplantation Proceedings, 41, 585-586. doi:10.1016/j.transproceed.2008.12.025
Euthanasia was legalized in Belgium in 2002 for adults under strict conditions. The patient must ...
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Boly, M., Tshibanda, L., Vanhaudenhuyse, A., Noirhomme, Q., Schnakers, C., Ledoux, D., Boveroux, P., Garweg, C., Lambermont, B., Phillips, C., Luxen, A., Moonen, G., Bassetti, C., Maquet, P., & Laureys, S. (2009). Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Human Brain Mapping, 30 (8), 2393-400. doi:10.1002/hbm.20672
Recent studies on spontaneous fluctuations in the functional MRI blood oxygen level-dependent (BO...
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Boveroux, P., Bonhomme, V., Kirsch, M., Noirhomme, Q., Ledoux, D., Hans, G., Laureys, S., Luxen, A., & Brichant, J.-F. (2009). Mécanismes de l'anesthésie générale: apport de l'imagerie fonctionnelle. Revue Médicale de Liège, 64 (Synthèse 2009), 36-41.
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Bruno, M.-A., Schnakers, C., Damas, F., Pellas, F., Lutte, I., Bernheim, J., Majerus, S., Moonen, G., Goldman, S., & Laureys, S. (2009). Locked-in syndrome in children: report of five cases and review of the literature. Pediatric Neurology, 41, 237-246. doi:10.1016/j.pediatrneurol.2009.05.001
The locked-in syndrome is a rare neurologic disorder defined by (1) the presence of sustained eye...
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Dang Vu, T. T., Desseilles, M., Peigneux, P., Laureys, S., & Maquet, P. (2009). PET activation patterns. In R. Stickgold & M. Walker (Eds.), The Neuroscience of Sleep (pp. 30-36). London, United Kingdom: Academic Press.
Dang Vu, T. T., Desseilles, M., Peigneux, P., Laureys, S., & Maquet, P. (2009). Sleep and Sleep States: PET activation patterns. In L. Squire (Ed.), Encyclopedia of Neuroscience (volume 8, pp. 955-61). Oxford, United Kingdom: Academic Press. doi:10.1016/B978-008045046-9.00056-5
Demertzi, A., Laureys, S., & Boly, M. (2009). Coma, persistent vegetative states, and diminished consciousness. In W. P. Banks (Ed.), Encyclopedia of Consciousness (1, pp. 147-156). Oxford, United Kingdom: Elsevier. doi:10.1016/B978-012373873-8.00017-7
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Demertzi, A., Liew, C., Ledoux, D., Bruno, M.-A., Sharpe, M., Laureys, S., & Zeman, A. (2009). Dualism persists in the science of mind. Annals of the New York Academy of Sciences, 1157, 1-9. doi:10.1111/j.1749-6632.2008.04117.x
The relationship between mind and brain has philosophical, scientific, and practical implications...
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Demertzi, A., Schnakers, C., Ledoux, D., Chatelle, C., Bruno, M.-A., Vanhaudenhuyse, A., Boly, M., Moonen, G., & Laureys, S. (2009). Different beliefs about pain perception in the vegetative and minimally conscious states: a European survey of medical and paramedical professionals. Progress in Brain Research, 177, 329-38. doi:10.1016/S0079-6123(09)17722-1
Pain management in severely brain-damaged patients constitutes a clinical and ethical stake. At t...
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FAYMONVILLE, M.-E., Vogt, B., Maquet, P., & Laureys, S. (2009). Hypnosis and cingulate-mediated mechanisms of analgesia. In B. Vogt (Ed.), Cingulate Neurobiology and Disease (pp. 381-400). United Kingdom: Oxford University Press.
Fontaine, R., Vanhaudenhuyse, A., Demertzi, A., Laureys, S., & Faymonville, M.-E. (2009). Apport de la neuro-imagerie fonctionnelle à l'étude de la douleur. Revue du Rhumatisme, 76, 593-598. doi:10.1016/j.rhum.2009.04.001
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Gosseries, O., Bruno, M.-A., Vanhaudenhuyse, A., Schnakers, C., & Laureys, S. (2009). Consciousness in the Locked-in Syndrome. In S. Laureys & G. Tononi (Ed.), The Neurology of Consciousness (pp. 191-203). Oxford, United Kingdom: Elsevier. doi:10.1016/B978-0-12-374168-4.00015-0
Majerus, S., Bruno, M.-A., Schnakers, C., Giacino, J., & Laureys, S. (2009). The problem of aphasia in the assessment of consciousness in brain damaged patients. Progress in Brain Research, 177, 49-61. doi:10.1016/S0079-6123(09)17705-1
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Noirhomme, Q., Boly, M., Bonhomme, V., Boveroux, P., Phillips, C., Peigneux, P., Soddu, A., Luxen, A., Moonen, G., Maquet, P., & Laureys, S. (2009). Bispectral index correlates with regional cerebral blood flow during sleep in distinct cortical and subcortical structures in humans. Archives Italiennes de Biologie, 147 (1-2), 51-7.
The relationship between the Bispectral Index (BIS), an EEG-based monitor of anesthesia, and brai...
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Noirhomme-Renard, F., & Noirhomme, Q. (2009). Les facteurs associés à un allaitement maternel prolongé au-delà de trois mois : une revue de la littérature. Journal de Pédiatrie et de Puériculture. doi:10.1016/j.jpp.2009.03.006
L’Organisation mondiale de la santé (OMS) recommande un allaitement maternel exclusif jusqu’à six...
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Owen, A. M., Schiff, N. D., & Laureys, S. (2009). A new era of coma and consciousness science. Progress in Brain Research, 177, 399-411. doi:10.1016/S0079-6123(09)17728-2
In the past ten years, rapid technological developments in the field of neuroimaging have produce...
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Peters, F., Majerus, S., Collette, F., Degueldre, C., Del Fiore, G., Laureys, S., Moonen, G., & Salmon, E. (2009). Neural substrates of phonological and lexicosemantic representations in Alzheimer's disease. Human Brain Mapping, 30 (1), 185-99. doi:10.1002/hbm.20493
The language profile of patients suffering from Alzheimer's disease (AD) is characterized not onl...
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Schiff, N., & Laureys, S. (Eds.). (2009). Disorders of consciousness, volume 1157. New-York, United States: Wiley-Blackwell.
Advances in neuroimaging and neuroscience hold significant promise for improving understanding of...
Schnakers, C., Faymonville, M., & Laureys, S. (2009). Ethical implications : pain, coma and related disorders. In W. P. Banks (Ed.), Encyclopedia of Consciousness (pp. 243-250). London, United Kingdom: Elsevier. doi:10.1016/B978-012373873-8.00027-X
Schnakers, C., Perrin, F., Schabus, M., Hustinx, R., Majerus, S., Moonen, G., Boly, M., Vanhaudenhuyse, A., Bruno, M.-A., & Laureys, S. (2009). Detecting consciousness in a total Locked-in syndrome: an active event related paradigm. Neurocase: Case Studies in Neuropsychology, Neuropsychiatry and Behavioural Neurology, 25, 1-7. doi:10.1080/13554790902724904
Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility...
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Schnakers, C., Vanhaudenhuyse, A., Giacino, J., Ventura, M., Boly, M., Majerus, S., Moonen, G., & Laureys, S. (2009). Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurology, 9, 35. doi:10.1186/1471-2377-9-35
BACKGROUND: Previously published studies have reported that up to 43% of patients with disorders ...
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Soddu, A., Boly, M., Nir, Y., Noirhomme, Q., Vanhaudenhuyse, A., Demertzi, A., Arzi, A., Ovadia, S., Stanziano, M., Papa, M., Laureys, S., & Malach, R. (2009). Reaching across the abyss: recent advances in functional magnetic resonance imaging and their potential relevance to disorders of consciousness. Progress in Brain Research, 177, 261-274. doi:10.1016/S0079-6123(09)17718-X
Disorders of consciousness (DOC) raise profound scientific, clinical, ethical, and philosophical ...
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Sorger, B., Dahmen, B., Reithler, J., Gosseries, O., Maudoux, A., Laureys, S., & Goebel, R. (2009). Another kind of 'BOLD Response': answering multiple-choice questions via online decoded single-trial brain signals. Progress in Brain Research, 177, 275-92. doi:10.1016/S0079-6123(09)17719-1
The term 'locked-in'syndrome (LIS) describes a medical condition in which persons concerned are s...
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TSHIBANDA, L., Vanhaudenhuyse, A., Bruno, M.-A., Boly, M., Soddu, A., Laureys, S., & Moonen, G. (2009). MRI in coma survivors. Revue Médicale de Liège, 64, 42-8.
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TSHIBANDA, L., Vanhaudenhuyse, A., Galanaud, D., Boly, M., Laureys, S., & Puybasset, L. (2009). Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls. Progress in Brain Research, 177, 215-29. doi:10.1016/S0079-6123(09)17715-4
The status of comatose patient is currently established on the basis of the patient-exhibited beh...
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Vanhaudenhuyse, A., Boly, M., Balteau, E., Schnakers, C., Moonen, G., Luxen, A., Lamy, M., Degueldre, C., Brichant, J.-F., Maquet, P., Laureys, S., & Faymonville, M. (2009). Pain and non-pain processing during hypnosis: a thulium-YAG event-related fMRI study. NeuroImage, 47 (3), 1047-54. doi:10.1016/j.neuroimage.2009.05.031
The neural mechanisms underlying the antinociceptive effects of hypnosis still remain unclear. Us...
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Vanhaudenhuyse, A., Boly, M., Laureys, S., & FAYMONVILLE, M.-E. (2009). Neurophysiological correlates of hypnotic analgesia. Contemporary Hypnosis, 26 (1), 15-23. doi:10.1002/ch.373
This short review describes recent advances in understanding hypnotic modulation of pain. Our cur...
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Vanhaudenhuyse, A., Thonnard, M., & Laureys, S. (2009). Towards a neuro-scientific explanation of near-death experiences? In J.-L. Vincent (Ed.), Yearbook of intensive care and emergency medecine (pp. 961-968). Berlin, Germany: Springer-Verlag.
Laureys, S., & Boly, M. (October 2008). The changing spectrum of coma. Nature Clinical Practice Neurology, 4 (10), 544-546. doi:10.1038/ncpneuro0887
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Detry, O., Laureys, S., Faymonville, M., Deroover, A., Squifflet, J.-P., Lamy, M., & Meurisse, M. (September 2008). Organ donation after physician-assisted death. Transplant International, 21 (9), 915. doi:10.1111/j.1432-2277.2008.00701.x
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Laureys, S., Boly, M., & Moonen, G. (June 2008). The boundaries of consciousness: lessons from coma and related states. Advances in Clinical Neuroscience and Rehabilitation, 8 (2).
Peer reviewed
Bonhomme, V., Maquet, P., Phillips, C., Plenevaux, A., Hans, P., Luxen, A., Lamy, M., & Laureys, S. (March 2008). The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volunteers. Anesthesia and Analgesia, 106 (3), 899-909. doi:10.1213/ane.0b013e3181619685
BACKGROUND: Through their action on the locus coeruleus, alpha2-adrenoceptor agonists induce rapi...
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Vanhaudenhuyse, A., Schnakers, C., Brédart, S., & Laureys, S. (February 2008). Assessment of visual pursuit in post-comatose states: use a mirror. Journal of Neurology, Neurosurgery and Psychiatry, 79 (2). doi:10.1136/jnnp.2007.121624
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Boly, M., Faymonville, M.-E., Schnakers, C., Peigneux, P., Lambermont, B., Phillips, C., Lancellotti, P., Luxen, A., Lamy, M., Moonen, G., Maquet, P., & Laureys, S. (2008). Perception of pain in the minimally conscious state with PET activation: an observational study. The Lancet Neurology, 7 (11), 1013-20. doi:10.1016/S1474-4422(08)70219-9
BACKGROUND: Patients in a minimally conscious state (MCS) show restricted self or environment awa...
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Boly, M., Phillips, C., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Peigneux, P., Faymonville, M., Maquet, P., & Laureys, S. (2008). Consciousness and cerebral baseline activity fluctuations. Human Brain Mapping, 29, 868-874. doi:10.1002/hbm.20602
The origin of within-subject variability in perceptual experiments is poorly understood. We here...
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Boly, M., Phillips, C., Tshibanda, L., Vanhaudenhuyse, A., Schabus, M., Dang Vu, T. T., Moonen, G., Hustinx, R., Maquet, P., & Laureys, S. (2008). Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function? Annals of the New York Academy of Sciences, 1129, 119-29. doi:10.1196/annals.1417.015
Spontaneous brain activity has recently received increasing interest in the neuroimaging communit...
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BOVEROUX, P., BONHOMME, V., KIRSCH, M., Noirhomme, Q., LEDOUX, D., HANS, G., Laureys, S., Luxen, A., & Brichant, J.-F. (2008). Mécanismes de l'anesthésie générale: apport de l'imagerie fonctionnelle. Revue Médicale de Liège, 64, 36-41.
Peer reviewed
Boveroux, P., Bonhomme, V., Vanhaudenhuyse, A., Maquet, P., & Laureys, S. (2008). Brain function in physiologically, pharmacologically, and pathologically altered states of consciousness. International Anesthesiology Clinics, 46 (3), 131-146. doi:10.1097/AIA.0b013e318181a8b3
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Boveroux, P., Kirsch, M., Boly, M., Massion, P., Sadzot, B., Lambermont, B., Lancellotti, P., Piret, S., Damas, P., Damas, F., Moonen, G., Laureys, S., & Ledoux, D. (2008). Evaluation du pronostic neurologique dans les encéphalopathies postanoxiques. Réanimation, 17, 613-17. doi:10.1016/j.reaurg.2008.07.012
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Bruno, M.-A., Bernheim, J. L., Schnakers, C., & Laureys, S. (2008). Locked-in: don't judge a book by its cover. Journal of Neurology, Neurosurgery and Psychiatry, 79 (1), 2. doi:10.1136/jnnp.2007.125294
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Bruno, M.-A., Pellas, F., Bernheim, J. L., Ledoux, D., Goldman, S., Demertzi, A., Majerus, S., Vanhaudenhuyse, A., Blandin, V., Boly, M., Boveroux, P., Moonen, G., Laureys, S., & Schnakers, C. (2008). Quelle vie apres le Locked-In syndrome? Revue Médicale de Liège, 63 (5-6), 445-51.
The Locked-In Syndrome (LIS) is classically caused by an anterior pontine vascular lesion and cha...
Peer reviewed
Bruno, M.-A., Pellas, F., Schnakers, C., Van Eeckhout, P., Bernheim, J., Pantke, K. H., Damas, F., Faymonville, M., Moonen, G., Goldman, S., & Laureys, S. (2008). Le Locked-In Syndrome : la conscience emmurée. Revue Neurologique, 164, 322-335. doi:10.1016/j.neurol.2007.12.010
The Locked-In syndrome(LIS) is defined by: (i) the presence of sustained eye opening (bilateral p...
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Chatelle, C., Vanhaudenhuyse, A., Mergam, A.-N., De Val, M., Majerus, S., Boly, M., Bruno, M.-A., Boveroux, P., Demertzi, A., Gosseries, O., Ledoux, D., Peigneux, P., Salmon, E., Moonen, G., Faymonville, M.-E., Laureys, S., & Schnakers, C. (2008). Mesurer la douleur chez le patient non communicant. Revue Médicale de Liège, 63 (5-6), 429-37.
Pain is a subjective experience. Its assessment is based on the subject's direct verbal report. T...
Peer reviewed
Demertzi, A., Vanhaudenhuyse, A., Bruno, M.-A., Schnakers, C., Boly, M., BOVEROUX, P., Maquet, P., Moonen, G., & Laureys, S. (2008). Is there anybody in there? Detecting awareness in disorders of consciousness. Expert Review of Neurotherapeutics, 8 (11), 1719-30. doi:10.1586/14737175.8.11.1719
The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain i...
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Gosseries, O., Demertzi, A., Noirhomme, Q., Tshibanda, J., Boly, M., de Beeck, M. O., Hustinx, R., Maquet, P., Salmon, E., Moonen, G., Luxen, A., Laureys, S., & De Tiege, X. (2008). Que mesure la neuro-imagerie fonctionnelle: IRMf, TEP & MEG? Revue Médicale de Liège, 63 (5-6), 231-7.
Functional cerebral imaging techniques allow the in vivo study of human cognitive and sensorimoto...
Peer reviewed
Kirsch, M., Boveroux, P., Massion, P., Sadzot, B., Boly, M., Lambermont, B., Lamy, M., Damas, P., Moonen, G., Laureys, S., & Ledoux, D. (2008). Comment prédire l'évolution du coma post-anoxique? Revue Médicale de Liège, 63 (5-6), 263-268.
Peer reviewed
Laureys, S., Boly, M., Schnakers, C., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Ledoux, D., Faymonville, M.-E., Lamy, M., Franck, G., Luxen, A., Maquet, P., & Moonen, G. (2008). Revelations from the unconscious: studying residual brain function in coma and related states. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 163 (7-9), 381-8; discussion 388-90.
The purpose of our research is to contribute to a better understanding of the residual brain func...
Laureys, S., FAYMONVILLE, M.-E., BOLY, M., Schnakers, C., Vanhaudenhuyse, A., Bruno, M.-A., BOVEROUX, P., Gosseries, O., & Majerus, S. (2008). Bewusstseinsstörungen - Diagnose und Prognose. In T. Junginger (Ed.), Grenzsituationen der Intensivmedizin-Entscheidungsgrundlagen (pp. 3-16). Berlin, Germany: Springer Verlag.
Laureys, S., & Fins, J. J. (2008). Are we equal in death? Neurology, 70, 15 e15. doi:10.1212/01.wnl.0000303264.66049.c1
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Ledoux, D., Piret, S., Boveroux, P., Bruno, M.-A., Vanhaudenhuyse, A., Damas, P., Moonen, G., & Laureys, S. (2008). Les échelles d’évaluation des états de conscience altérée. Réanimation, 17, 695-701. doi:10.1016/j.reaurg.2008.07.004
L’évaluation de l’état de conscience revêt une importance clinique considé- rable. En effet, déte...
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Noirhomme, Q., Kitney, R. I., & Macq, B. (2008). Single-trial EEG source reconstruction for brain-computer interface. IEEE Transactions on Biomedical Engineering, 55 (5), 1592-601. doi:10.1109/TBME.2007.913986
A new way to improve the classification rate of an EEG-based brain-computer interface (BCI) could...
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Noirhomme, Q., Schnakers, C., & Laureys, S. (2008). A twitch of consciousness: defining the boundaries of vegetative and minimally conscious states. Journal of Neurology, Neurosurgery and Psychiatry, 79 (7), 741-2. doi:10.1136/jnnp.2007.142216
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Salmon, E., D'Argembeau, A., Bastin, C., Feyers, D., Phillips, C., Laureys, S., Maquet, P., & Collette, F. (2008). Imagerie cérébrale de la réflexion sur soi. Revue Médicale de Liège, 63, 458-460.
Precise brain regions are activated when a subject gives a judgment on himself. Those are the med...
Peer reviewed
Schnakers, C., Hustinx, R., Vandewalle, G., Majerus, S., Moonen, G., Boly, M., Vanhaudenhuyse, A., & Laureys, S. (2008). Measuring the effect of amantadine in chronic anoxic minimally conscious state. Journal of Neurology, Neurosurgery and Psychiatry, 79 (2), 225-7. doi:10.1136/jnnp.2007.124099
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Schnakers, C., Ledoux, D., Majerus, S., Damas, P., Damas, F., Lambermont, B., Lamy, M., Vanhaudenhuyse, A., Moonen, G., & Laureys, S. (2008). Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders. Brain Injury, 22 (12), 926-931. doi:10.1080/02699050802530565
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Schnakers, C., Majerus, S., Giacino, J., Vanhaudenhuyse, A., Bruno, M.-A., Boly, M., Moonen, G., Damas, P., Ventura, M., Laureys, S., Lambermont, B., Lamy, M., & Damas, F. (2008). A french validation study of the Coma Recovery Scaled-Revised (CRS-R). Brain Injury, 22 (10), 786-792. doi:10.1080/02699050802403557
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Schnakers, C., Majerus, S., Goldman, S., Boly, M., Van Eeckhout, S., Moonen, G., VANHAUDENHUYSE, A., & LAUREYS, S. (2008). Cognitive function in locked-in syndrome. Journal of Neurology, 255, 323-330. doi:10.1007/s00415-008-0544-0
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Schnakers, C., Perrin, F., Schabus, M., Majerus, S., Ledoux, D., Damas, P., Boly, M., Vanhaudenhuyse, A., Bruno, M.-A., Moonen, G., & Laureys, S. (2008). Voluntary brain processing in disorders of consciousness. Neurology, 71 (20), 1614-1620. doi:10.1212/01.wnl.0000334754.15330.69
Background: Disentangling the vegetative state from the minimally conscious state is often diffic...
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Thonnard, M., Schnakers, C., Boly, M., Bruno, M.-A., BOVEROUX, P., Laureys, S., & Vanhaudenhuyse, A. (2008). Experiences de mort imminente: phenomenes paranormaux ou neurologiques? Revue Médicale de Liège, 63 (5-6), 438-44.
Seeing a bright light at the end of a tunnel or having a sense of being out of the physical body ...
Peer reviewed
Vanhaudenhuyse, A., Boveroux, P., Boly, M., Schnakers, C., Bruno, M.-A., Kirsch, M., Demertzi, A., Lamy, M., Maquet, P., Laureys, S., & Faymonville, M.-E. (2008). Hypnose et perception de la douleur. Revue Médicale de Liège, 63 (5-6), 424-8.
Improvement in functional neuroimaging allows researchers to disentangle the brain mechanisms inv...
Peer reviewed
Vanhaudenhuyse, A., Giacino, J., Schnakers, C., Kalmar, K., Smart, C., Bruno, M.-A., Gosseries, O., Moonen, G., & Laureys, S. (2008). Blink to visual threat does not herald consciousness in the vegetative state. Neurology, 71 (17), 1374-5. doi:10.1212/01.wnl.0000320110.70134.60
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Vanhaudenhuyse, A., Laureys, S., & Perrin, F. (2008). Cognitive Event-Related Potentials in Comatose and Post-Comatose States. Neurocritical Care, 8 (2), 262-70. doi:10.1007/s12028-007-9016-0
We review the interest of cognitive event-related potentials (ERPs) in comatose, vegetative, or m...
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Laureys, S., & Boly, M. (December 2007). What is it like to be vegetative or minimally conscious? Current Opinion in Neurology, 20 (6), 609-613. doi:10.1097/WCO.0b013e3282f1d6dd
Purpose of review Patients in a vegetative or minimally conscious state continue to pose problems...
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Laureys, S., Perrin, F., & Brédart, S. (September 2007). Self-consciousness in non-communicative patients. Consciousness and Cognition, 16 (3), 722-741, discussion 742-5. doi:10.1016/j.concog.2007.04.004
The clinical and para-clinical examination of residual self-consciousness in non-communicative se...
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Owen, A. M., Coleman, M. R., Boly, M., Davis, M. H., Laureys, S., & Pickard, J. D. (August 2007). Using functional magnetic resonance imaging to detect covert awareness in the vegetative state. Archives of Neurology, 64 (8), 1098-1102. doi:10.1001/archneur.64.8.1098
The assessment of patients with disorders of consciousness, including the vegetative state, is di...
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Boly, M., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Phillips, C., Peigneux, P., Maquet, P., & Laureys, S. (17 July 2007). Baseline brain activity fluctuations predict somatosensory perception in humans. Proceedings of the National Academy of Sciences of the United States of America, 104 (29), 12187-12192. doi:10.1073/pnas.0611404104
In perceptual experiments, within-individual fluctuations in perception are observed across multi...
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Boly, M., Coleman, M. R., Davis, M. H., Hampshire, A., Bor, D., Moonen, G., Maquet, P., Pickard, J. D., Laureys, S., & Owen, A. M. (01 July 2007). When thoughts become action: An fMRI paradigm to study volitional brain activity in non-communicative brain injured patients. NeuroImage, 36 (3), 979-992. doi:10.1016/j.neuroimage.2007.02.047
The assessment of voluntary behavior in non-communicative brain injured patients is often challen...
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Laureys, S. (May 2007). Eyes open, brain shut. Scientific American, 296 (5), 84-89. doi:10.1038/scientificamerican0507-84
Recent progress in medical care has greatly increased the number of people who survive acute brai...
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Di, H. B., Yu, S. M., Weng, X. C., Laureys, S., Yu, D., Li, J. Q., Qin, P. M., Zhu, Y. H., Zhang, S. Z., & Chen, Y. Z. (20 March 2007). Cerebral response to patient's own name in the vegetative and minimally conscious states. Neurology, 68 (12), 895-899. doi:10.1212/01.wnl.0000258544.79024.d0
Background: A challenge in the management of severely brain- damaged patients with altered states...
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Owen, A. M., Coleman, M. R., Boly, M., Davis, M. H., Laureys, S., Jolles, D., & Pickard, J. D. (02 March 2007). Response to comments on "Detecting awareness in the vegetative state". Science, 315 (5816). doi:10.1126/science.1135583
Additional data, supported by relevant functional neuroimaging literature, confirm that the “norm...
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Bruno, M.-A., Pellas, F., Bernheim, J., Schnakers, C., Vanhaudenhuyse, A., & LAUREYS, S. (2007). Qualité de vie et locked-in syndrome. In F. Pellas, C. Kiefer, J. Weiss, ... J. Pelisier (Eds.), Entretiens de Médecine Physique et de Réadaptation. Elsevier Masson.
Peer reviewed
Collette, F., Van der Linden, M., Laureys, S., Arigoni, F., Del Fiore, G., Degueldre, C., Luxen, A., & Salmon, E. (January 2007). Mapping the updating process: common and specific brain activations across different versions of the running span task. Cortex: A Journal Devoted to the Study of the Nervous System and Behavior, 43 (1), 146-158. doi:10.1016/S0010-9452(08)70452-0
Neuroimaging studies exploring the neural substrates of executive functioning have only rarely in...
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Grave de Peralta Menendez, R., Noirhomme, Q., Cincotti, F., Mattia, D., Aloise, F., & Gonzalez Andino, S. (2007). Modern electrophysiological methods for brain-computer interfaces. Computational Intelligence and Neuroscience, 56986. doi:10.1155/2007/56986
Modern electrophysiological studies in animals show that the spectrum of neural oscillations enco...
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Kupers, R., Maeyaert, J., Boly, M., Faymonville, M.-E., & Laureys, S. (2007). Naloxone-insensitive epidural placebo analgesia in a chronic pain patient. Anesthesiology, 106 (6), 1239-42. doi:10.1097/01.anes.0000265418.68005.8a
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Schnakers, C., Vanhaudenhuyse, A., Bruno, M.-A., & Laureys, S. (2007). Evaluation cognitive chez le patient en locked-in syndrome. In F. Pellas, C. Kiefer, J. Weiss, ... J. Pelisier (Eds.), Entretiens de Médecine Physique et de Réadaptation. Elsevier Masson.
Peer reviewed
Vanhaudenhuyse, A., Bruno, M.-A., Brédart, S., Plenevaux, A., & Laureys, S. (2007). The challenge of disentangling reportability and phenomenal consciousness in post-comatose states. Behavioral and Brain Sciences, 30 (5-6), 529-530. doi:10.1017/S0140525X0700310X
Determining whether or not noncommunicative patients are phenomenally conscious is a major clinic...
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Vanhaudenhuyse, A., Bruno, M.-A., Schnakers, C., Boly, M., BOVEROUX, P., Moonen, G., Perrin, F., Pantke, K.-H., & Laureys, S. (2007). Locked-in syndrome et états de conscience altérée: comment détecter la conscience? In F. Pellas, C. Kiefer, J. Weiss, ... J. Pélissier (Eds.), Eveil de coma et états limites. Elsevier Masson.
Peer reviewed
Vanhaudenhuyse, A., Schnakers, C., Boly, M., Bruno, M.-A., Gosseries, O., Cologan, V., Boveroux, P., Ledoux, D., Piret, S., Phillips, C., Moonen, G., Luxen, A., Maquet, P., Brédart, S., & Laureys, S. (2007). Evaluation comportementale et par neuroimagerie fonctionnelle des patients en état végétatif. Revue Médicale de Liège, 62 Spec No, 15-20.
Currently, there remains a high rate of misdiagnosis of the vegetative state. This should incite ...
Peer reviewed
Vanhaudenhuyse, A., Schnakers, C., Boly, M., Perrin, F., Brédart, S., & Laureys, S. (2007). Detecting consciousness in minimally conscious patients. Réanimation, 16, 527-532. doi:10.1016/j.reaurg.2007.09.010
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Giacino, J. T., Hirsch, J., Schiff, N. D., & Laureys, S. (December 2006). Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness [letter to the editor]. Archives of Physical Medicine and Rehabilitation, 87 (12, Suppl. 2), 67-S76. doi:10.1016/j.apmr.2006.07.272
Objective: To describe the theoretic framework, design, and potential clinical applications of fu...
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Laureys, S., Giacino, J. T., Schiff, N. D., Schabus, M., & Owen, A. M. (December 2006). How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs? Current Opinion in Neurology, 19 (6), 520-527. doi:10.1097/WCO.0b013e3280106ba9
Purpose of review We discuss the problems of evidence-based neurorehabilitation in disorders of c...
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Schnakers, C., Giacino, J., Kalmar, K., Piret, S., Lopez, E., Boly, M., Malone, R., & Laureys, S. (December 2006). Does the FOUR score correctly diagnose the vegetative and minimally conscious states? Annals of Neurology, 60 (6), 744-745. doi:10.1002/ana.20919
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Owen, A., Coleman, M., Boly, M., Davis, M., Laureys, S., & Picard, J. (2006). Detecting Awareness in the Vegetative State. Science. doi:10.1126/science.1130197
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Laureys, S., Boly, M., & Maquet, P. (July 2006). Tracking the recovery of consciousness from coma. Journal of Clinical Investigation, 116 (7), 1823-1825. doi:10.1172/JCI29172
Predicting the chances of recovery of consciousness and communication in patients who survive the...
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Peigneux, P., Orban, P., Balteau, E., Degueldre, C., Luxen, A., Laureys, S., & Maquet, P. (April 2006). Offline persistence of memory-related cerebral activity during active wakefulness. PLoS Biology, 4 (4), 100. doi:10.1371/journal.pbio.0040100
Much remains to be discovered about the fate of recent memories in the human brain. Several studi...
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Fumal, A., Laureys, S., Di Clemente, L., Boly, M., Bohotin, V., Vandenheede, M., Coppola, G., Salmon, E., Kupers, R., & Schoenen, J. (February 2006). Orbitofrontal cortex involvement in chronic analgesic-overuse headache evolving from episodic migraine. Brain: a Journal of Neurology, 129 (Pt 2), 543-550. doi:10.1093/brain/awh691
The way in which medication overuse transforms episodic migraine into chronic daily headache is u...
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Vogt, B. A., Vogt, L., & Laureys, S. (15 January 2006). Cytology and functionally correlated circuits of human posterior cingulate areas. NeuroImage, 29 (2), 452-466. doi:10.1016/j.neuroimage.2005.07.048
Human posterior cingulate cortex (PCC) and retrosplenial cortex (RSC) form the posterior cingulat...
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Brédart, S., Delchambre, M., & Laureys, S. (January 2006). One's Own Face Is Hard to Ignore. Quarterly Journal of Experimental Psychology, 59 (1), 46-52. doi:10.1080/17470210500343678
One's own face possesses two properties that make it prone to grab attention: It is a face, and, ...
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Desseilles, M., Dang Vu, T. T., Laureys, S., Peigneux, P., Degueldre, C., Phillips, C., & Maquet, P. (2006). A prominent role for amygdaloid complexes in the Variability in Heart Rate (VHR) during Rapid Eye Movement (REM) sleep relative to wakefulness. NeuroImage, 32 (3), 1008-1015. doi:10.1016/j.neuroimage.2006.06.008
Rapid eye movement sleep (REMS) is associated with intense neuronal activity, rapid eye movements...
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Faymonville, M.-E., Boly, M., & Laureys, S. (2006). Functional neuroanatomy of the hypnotic state. Journal of Physiology - Paris, 99 (4-6), 463-9. doi:10.1016/j.jphysparis.2006.03.018
The neural mechanisms underlying hypnosis and especially the modulation of pain perception by hyp...
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Noirhomme, Q. (2006). Localisation of brain functions: stimuling brain activity and source reconstruction for classification [Doctoral thesis]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/108683
Perrin, F., Schnakers, C., Schabus, M., Degueldre, C., Goldman, S., Brédart, S., Faymonville, M., Lamy, M., Moonen, G., Luxen, A., Maquet, P., & Laureys, S. (2006). Brain response to one's own name in vegetative state, minimally conscious state and locked-in syndrome. Archives of Neurology, 63, 562-569. doi:10.1001/archneur.63.4.562
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Laureys, S. (December 2005). The neural correlate of (un)awareness: lessons from the vegetative state [letter to the editor]. Trends in Cognitive Sciences, 9 (12), 556-559. doi:10.1016/j.tics.2005.10.010
Consciousness has two main components: wakefulness and awareness. The vegetative state is charact...
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Laureys, S., Perrin, F., Schnakers, C., Boly, M., & Majerus, S. (December 2005). Residual cognitive function in comatose, vegetative and minimally conscious states. Current Opinion in Neurology, 18 (6), 726-733. doi:10.1097/01.wco.0000189874.92362.12
Purpose of review The clinical evaluation of cognition in non-communicative severely brain-damage...
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Laureys, S., Piret, S., & Ledoux, D. (December 2005). Quantifying consciousness. The Lancet Neurology, 4 (12), 789-790. doi:10.1016/S1474-4422(05)70230-1
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Laureys, S. (November 2005). Science and Society: Death, Unconsciousness and the Brain. Nature Reviews. Neuroscience, 6 (11), 899-909. doi:10.1038/nrn1789
The concept of death has evolved as technology has progressed. This has forced medicine and socie...
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Dumarey, N. E., Massager, N., Laureys, S., & Goldman, S. (September 2005). Voxel-based assessment of spinal tap test-induced regional cerebral blood flow changes in normal pressure hydrocephalus. Nuclear Medicine Communications, 26 (9), 757-763. doi:10.1097/01.mnm.0000170937.90958.22
Objective Normal pressure hydrocephalus (NPH) is a cause of dementia that may be amended by medic...
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Collette, F., Van der Linden, M., Laureys, S., Delfiore, G., Degueldre, C., Luxen, A., & Salmon, E. (August 2005). Exploring the unity and diversity of the neural substrates of executive functioning. Human Brain Mapping, 25 (4), 409-423. doi:10.1002/hbm.20118
Previous studies exploring the neural substrates of executive functioning used task-specific anal...
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Collette, F., Olivier, L., Van der Linden, M., Laureys, S., Delfiore, G., Luxen, A., & Salmon, E. (July 2005). Involvement of both prefrontal and inferior parietal cortex in dual-task performance. Cognitive Brain Research, 24 (2), 237-251. doi:10.1016/j.cogbrainres.2005.01.023
This PET study explored the neural substrate of both dual-task management and integration task us...
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Baars, B. J., & Laureys, S. (June 2005). One, not two, neural correlates of consciousness. Trends in Cognitive Sciences, 9 (6), 269-269. doi:10.1016/j.tics.2005.04.008
Although we admire Ned Block's effort to include cognitive neuroscience in his philosophical work...
D'Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., Luxen, A., & Salmon, E. (01 April 2005). Self-referential reflective activity and its relationship with rest : a PET study. NeuroImage, 25 (2), 616-624. doi:10.1016/j.neuroimage.2004.11.048
This study used positron emission tomography (PET) to identify the brain substrate of self-refere...
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Majerus, S., Van der Linden, M., Collette, F., Laureys, S., Poncelet, M., Degueldre, C., Delfiore, G., Luxen, A., & Salmon, E. (March 2005). Modulation of brain activity during phonological familiarization. Brain and Language, 92 (3), 320-331. doi:10.1016/j.bandl.2004.07.003
We measured brain activity in 12 adults for the repetition of auditorily presented words and nonw...
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Boly, M., Faymonville, M.-E., Peigneux, P., Lambermont, B., Damas, F., Luxen, A., Lamy, M., Moonen, G., Maquet, P., & Laureys, S. (2005). Cerebral processing of auditory and noxious stimuli in severely brain injured patients: Differences between VS and MCS. Neuropsychological Rehabilitation, 15 (3-4, Jul-Sep), 283-289. doi:10.1080/09602010443000371
We review cerebral processing of auditory and noxious stimuli in minimally conscious state (MCS) ...
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Dang Vu, T. T., Desseilles, M., Laureys, S., Degueldre, C., Perrin, F., Phillips, C., Maquet, P., & Peigneux, P. (2005). Cerebral correlates of delta waves during non-REM sleep revisited. NeuroImage, 28 (1), 14-21. doi:10.1016/j.neuroimage.2005.05.028
We aimed at characterizing the neural correlates of delta activity during Non Rapid Eye Movement ...
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Destrebecqz, A., Peigneux, P., Laureys, S., Degueldre, C., Del Fiore, G., Aerts, J., Luxen, A., Van der Linden, M., Cleeremans, A., & Maquet, P. (2005). The neural correlates of implicit and explicit sequence learning : Interacting networks revealed by the process dissociation procedure. Learning and Memory, 12 (5), 480-490. doi:10.1101/lm.95605
In two (H15O)-O-2 PET scan experiments, we investigated the cerebral correlates of explicit and i...
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Kupers, R., Faymonville, M.-E., & Laureys, S. (2005). The cognitive modulation of pain: hypnosis- and placebo-induced analgesia. Progress in Brain Research, 150, 251-69. doi:10.1016/S0079-6123(05)50019-0
Nowadays, there is compelling evidence that there is a poor relationship between the incoming sen...
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Laureys, S., Pellas, F., Van Eeckhout, P., Ghorbel, S., Schnakers, C., Perrin, F., Berre, J., Faymonville, M.-E., Pantke, K.-H., Damas, F., Lamy, M., Moonen, G., & Goldman, S. (2005). The locked-in syndrome : what is it like to be conscious but paralyzed and voiceless? [letter to the editor]. Progress in Brain Research, 150 (Boundaries of Consciousness: Neurobiology and Neuropathology), 495-511. doi:10.1016/S0079-6123(05)50034-7
The locked-in syndrome (pseudocoma) describes patients who are awake and conscious but selectivel...
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Majerus, S., Gill-Thwaites, H., Andrews, K., & Laureys, S. (2005). Behavioral Evaluation of Consciousness in Severe Brain Damage. Progress in Brain Research, 150 (Boundaries of Consciousness: Neurobiology and Neuropathology), 397-413. doi:10.1016/S0079-6123(05)50028-1
This paper reviews the current state of bedside behavioral assessment in brain-damaged patients w...
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Maquet, P., Ruby, P., Maudoux, A., Albouy, G., Sterpenich, V., Dang Vu, T. T., Desseilles, M., Boly, M., Perrin, F., Peigneux, P., & Laureys, S. (2005). Human cognition during REM sleep and the activity profile within frontal and parietal cortices: a reappraisal of functional neuroimaging data. Progress in Brain Research, 150 (Boundaries of Consciousness: Neurobiology and Neuropathology), 219-227. doi:10.1016/S0079-6123(05)50016-5
In this chapter, we aimed at further characterizing the functional neuroanatomy of the human rapi...
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Maquet, P., Sterpenich, V., Albouy, G., Dang Vu, T. T., Desseilles, M., Boly, M., Ruby, P., Laureys, S., & Peigneux, P. (2005). Brain imaging on passing to sleep. In P. L. Parmeggiani & R. Velluti (Eds.), The physiologic nature of sleep (pp. 123-137). London, United Kingdom: Imperial College Press.
Perrin, F., Maquet, P., Peigneux, P., Ruby, P., Degueldre, C., Balteau, E., Del Fiore, G., Moonen, G., Luxen, A., & Laureys, S. (2005). Neural mechanisms involved in the detection of our first name : A combined ERPs and PET study. Neuropsychologia, 43 (1), 12-19. doi:10.1016/j.neuropsychologia.2004.07.002
In everyday social interactions, hearing our own first name captures our attention and gives rise...
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Salmon, E., Ruby, P., Perani, D., Kalbe, E., Laureys, S., Adam, S., & Collette, F. (2005). Two Aspects of Impaired Consciousness in Alzheimer's Disease. Progress in Brain Research, 150 (Boundaries of Consciousness: Neurobiology and Neuropathology), 287-98. doi:10.1016/S0079-6123(05)50021-9
Alzheimer's disease (AD) is a degenerative dementia characterized by different aspects of impaire...
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Schnakers, C., Majerus, S., & Laureys, S. (2005). Bispectral analysis of electroencephalogram signals during recovery from coma : preliminary findings. Neuropsychological Rehabilitation, 15 (3-4), 381-388. doi:10.1080/09602010443000524
The aim of this study was to investigate the accuracy of bispectral index (BIS), spectral edge fr...
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Vogt, B. A., & Laureys, S. (2005). Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Progress in Brain Research, 150 (Boundaries of Consciousness: Neurobiology and Neuropathology), 205-217. doi:10.1016/S0079-6123(05)50015-3
Neuronal aggregates involved in conscious awareness are not evenly distributed throughout the CNS...
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Faymonville, M.-E., Pantke, K.-H., Berré, J., Sadzot, B., Ferring, M., De Tiège, X., Mavroudakis, N., van Bogaert, P., Lambermont, B., Damas, P., Franck, G., Lamy, M., Luxen, A., Moonen, G., Goldman, S., Maquet, P., & Laureys, S. (December 2004). Zerebrale Funktionen bei hirngeschädigten Patienten. Was bedeuten Koma, "vegetative state“, "minimally conscious state“, "Locked-in-Syndrom“ und Hirntod? Anaesthesist, 53 (12), 1195-1202. doi:10.1007/s00101-004-0747-4
Comatose, vegetative, minimally conscious or locked-in patients represent a problem in terms of d...
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Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., Luxen, A., & Maquet, P. (28 October 2004). Are spatial memories strengthened in the human hippocampus during slow wave sleep? Neuron, 44 (3), 535-545. doi:10.1016/j.neuron.2004.10.007
In rats, the firing sequences observed in hippocampal ensembles during spatial learning are repla...
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De Tiège, X., Goldman, S., Laureys, S., Verheulpen, D., Chiron, C., Wetzburger, C., Paquier, P., Chaigne, D., Poznanski, N., Jambaque, I., Hirsch, É., Dulac, O., & van Bogaert, P. (14 September 2004). Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep. Neurology, 63 (5), 853-857. doi:10.1212/01.wnl.0000137015.04054.2c
Background: Epileptic syndromes with continuous spikes and waves during sleep (CSWS) represent a ...
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Laureys, S., Perrin, F., Faymonville, M., Schnakers, C., Boly, M., Bartsch, V., Majerus, S., Moonen, G., & Maquet, P. (14 September 2004). Cerebral processing in the minimally conscious state. Neurology, 63 (5), 916-918. doi:10.1212/01.WNL.0000137421.30792.9B
We studied a patient in a minimally conscious state using PET and cognitive evoked potentials. Ce...
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Laureys, S., Owen, A. M., & Schiff, N. D. (September 2004). Brain function in coma, vegetative state, and related disorders. The Lancet Neurology, 3 (9), 537-546. doi:10.1016/S1474-4422(04)00852-X
We review the nosological criteria and functional neuroanatomical basis for brain death, coma, ve...
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Laureys, S., & Goldman, S. (August 2004). Imagine imaging neural activity in crying infants and in their caring parents. Behavioral and Brain Sciences, 27 (4), 465. doi:10.1017/s0140525x04290100
Soltis' paper contains little data on the underlying neural substrate of the discussed signal fun...
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Maquet, P., Ruby, P., Schwartz, S., Laureys, S., Albouy, G., Dang Vu, T. T., Desseilles, M., Boly, M., Melchior, G., & Peigneux, P. (July 2004). Regional organisation of brain activity during paradoxical sleep (PS). Archives Italiennes de Biologie, 142 (4), 413-419.
Human brain function is regionally organised during paradoxical sleep (PS) in a very different wa...
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Peigneux, P., Van der Linden, M., Garraux, G., Laureys, S., Degueldre, C., Aerts, J., Del Fiore, G., Moonen, G., Luxen, A., & Salmon, E. (March 2004). Imaging a cognitive model of apraxia: The neural substrate of gesture-specific cognitive processes. Human Brain Mapping, 21 (3), 119-142. doi:10.1002/hbm.10161
The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychologic...
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Fontaine, R., Fuchs, S., Hardy, R., Lacroix, J., Laureys, S., Lecart, M. P., Libbrecht, D., Malaise, N., Martin, D., Salamun, I., Tomasella, M., & Faymonville, M.-E. (February 2004). Prise en charge de la douleur chronique en équipe pluridisciplinaire. Revue Médicale de Liège, 59 (2), 81-88.
Assessment of chronic pain is one of medicine's most difficult challenges. A structured and flexi...
Boly, M., FAYMONVILLE, M.-E., Peigneux, P., LAMBERMONT, B., Damas, P., Del Fiore, G., Degueldre, C., Franck, G., Luxen, A., Lamy, M., Moonen, G., Maquet, P., & Laureys, S. (2004). Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state. Archives of Neurology, 61 (2), 233-8. doi:10.1001/archneur.61.2.233
BACKGROUND: The minimally conscious state (MCS) is a recently defined clinical condition; it diff...
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Laureys, S. (2004). Functional neuroimaging in the vegetative state. NeuroRehabilitation, 19 (4), 335-341. doi:10.3233/nre-2004-19410
The interest of functional imaging in patients in a vegetative state is twofold. First, the veget...
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Laureys, S., Faymonville, M.-E., De Tiège, X., Peigneux, P., Berré, J., Moonen, G., Goldman, S., & Maquet, P. (2004). Brain function in the vegetative state. In Brain Death and Disorders of Consciousness (pp. 229-238). New York, United States - New York: Kluwer Academic/Plenum Publ.
Maquet, P., Perrin, F., Laureys, S., Dang Vu, T. T., Desseilles, M., Boly, M., & Peigneux, P. (2004). Cerebral functional segregation and integration during human sleep. In P.-H. Luppi (Ed.), Sleep: Circuits and Functions (pp. 225- 238). Boca Raton, United States - Florida: CRC Press.
Noirhomme, Q., Ferrant, M., Vandermeeren, Y., Olivier, E., Macq, B., & Cuisenaire, O. (2004). Registration and real-time visualization of transcranial magnetic stimulation with 3-D MR images. IEEE Transactions on Biomedical Engineering, 51 (11), 1994-2005. doi:10.1109/TBME.2004.834266
This paper describes a method for registering and visualizing in real-time the results of transcr...
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Peigneux, P., Melchior, G., Schmidt, C., Dang Vu, T. T., Boly, M., Laureys, S., & Maquet, P. (2004). Memory processing during sleep: mechanisms and evidence from neuroimaging studies. Psychologica Belgica, 44 (1-2), 121-142.
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Perrin, F., Peigneux, P., Fuchs, S., Verhaeghe, S., Laureys, S., Middleton, B., Degueldre, C., Del Fiore, G., Vandewalle, G., Balteau, E., Poirrier, R., Moreau, V., Luxen, A., Maquet, P., & Dijk, D. J. (2004). Nonvisual responses to light exposure in the human brain during the circadian night. Current Biology, 14 (20), 1842-6. doi:10.1016/j.cub.2004.09.082
The brain processes light information to visually represent the environment but also to detect ch...
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Schnakers, C., Majerus, S., & Laureys, S. (2004). Diagnostic et évaluation des états de conscience altérée. Réanimation, 13 (5), 368-375. doi:10.1016/j.reaurg.2004.03.019
Ces dernières années, le nombre de patients en état de conscience altérée a fortement augmenté. E...
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Baars, B. J., Ramsoy, T. Z., & Laureys, S. (December 2003). Brain, conscious experience and the observing self. Trends in Neurosciences, 26 (12), 671-675. doi:10.1016/j.tins.2003.09.015
Conscious perception, like the sight of a coffee cup, seems to involve the brain identifying a st...
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Peigneux, P., Laureys, S., Fuchs, S., Destrebecqz, A., Collette, F., Delbeuck, X., Phillips, C., Aerts, J., Del Fiore, G., Degueldre, C., Luxen, A., Cleeremans, A., & Maquet, P. (September 2003). Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep. NeuroImage, 20 (1), 125-134. doi:10.1016/S1053-8119(03)00278-7
We have previously shown that several brain areas are activated both during sequence learning at ...
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Robe, P., Dubuisson, A., Bartsch, S., Damas, P., & Laureys, S. (August 2003). Favourable outcome of a brain trauma patient despite bilateral loss of cortical somatosensory evoked potential during thiopental sedation [letter to the editor]. Journal of Neurology, Neurosurgery and Psychiatry, 74 (8), 1157-1158. doi:10.1136/jnnp.74.8.1157
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Faymonville, M.-E., Roediger, L., Del Fiore, G., Delgueldre, C., Phillips, C., Lamy, M., Luxen, A., Maquet, P., & Laureys, S. (July 2003). Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Cognitive Brain Research, 17 (2), 255-262. doi:10.1016/S0926-6410(03)00113-7
The neural mechanisms underlying the antinociceptive effects of hypnosis are not well understood....
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Majerus, S., Laureys, S., Collette, F., Del Fiore, G., Degueldre, C., Luxen, A., Van der Linden, M., Maquet, P., & Metz-Lutz, M.-N. (July 2003). Phonological short-term memory networks following recovery from Landau and Kleffner syndrome. Human Brain Mapping, 19 (3), 133-144. doi:10.1002/hbm.10113
Landau-Kleffner syndrome (LKS) is a rare acquired aphasia occurring in otherwise healthy children...
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Schaefer, A., Collette, F., Philippot, P., Van der Linden, M., Laureys, S., Delfiore, G., Degueldre, C., Maquet, P., Luxen, A., & Salmon, E. (April 2003). Neural correlates of "hot" and "cold" emotional processing : a multilevel approach to the functional anatomy of emotion. NeuroImage, 18 (4), 938-949. doi:10.1016/S1053-8119(03)00009-0
The neural correlates of two hypothesized emotional processing modes, i.e., schematic and proposi...
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De Tiége, X., Laureys, S., Goldman, S., Massat, I., Lotstra, F., Mendlewicz, J., Bier, J.-C., & Berré, J. (2003). Regional cerebral glucose metabolism in akinetic catatonia and after remission. Journal of Neurology, Neurosurgery and Psychiatry, 74 (7), 1003-1004. doi:10.1136/jnnp.74.7.1003
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Destrebecqz, A., Peigneux, P., Laureys, S., Degueldre, C., Del Fiore, G., Aerts, J., Luxen, A., Van Der Linden, M., Cleeremans, A., & Maquet, P. (2003). Cerebral correlates of explicit sequence learning. Cognitive Brain Research, 16 (3), 391-398. doi:10.1016/S0926-6410(03)00053-3
Using positron emission tomography (PET) and regional cerebral blood flow (rCBF) measurements, we...
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Faymonville, M.-E., Laureys, S., Joris, J., Lamy, M., & Maquet, P. (2003). Partie VI: Techniques et monitoring particuliers, chapitre 5: Hypnose et anesthésie: aspects neurophysiologiques et implications pratiques. Arnette.
Laureys, S., Salmon, E., Goldman, S., & Majerus, S. (2003). Functional neuroimaging of auditory processing. Acta Oto-Rhino-Laryngologica Belgica, 57 (4), 267-273.
There is a complex functional organization of the central auditory system from the brainstem to p...
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Maquet, P., Laureys, S., Perrin, F., Ruby, P., Melchior, G., Boly, M., Dang Vu, T. T., Desseilles, M., & Peigneux, P. (2003). Festina lente: evidences for fast and slow learning processes and a role for sleep in human motor skill learning. Learning and Memory, 10 (4), 237-9. doi:10.1101/lm.64303
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Maquet, P., Peigneux, P., Laureys, S., Desseilles, M., Boly, M., & Dang Vu, T. T. (2003). Off-line processing of memory traces during human sleep: Contribution of functional neuroimaging. Sleep and Biological Rhythms, 1, 75-83. doi:10.1046/j.1446-9235.2003.00009.x
Sleep is thought to participate in the consolidation of recent memory traces. We tested this hypo...
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Laureys, S., Antoine, S., Boly, M., Elincx, S., Faymonville, M.-E., Berré, J., Sadzot, B., Ferring, M., De Tiège, X., van Bogaert, P., Hansen, I., Damas, P., Mavroudakis, N., Lambermont, B., Del Fiore, G., Aerts, J., Degueldre, C., Phillips, C., Franck, G., ... Maquet, P. (December 2002). Brain function in the vegetative state. Acta Neurologica Belgica, 102 (4), 177-185.
Positron emission tomography (PET) techniques represent a useful tool to better understand the re...
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Laureys, S., Faymonville, M.-E., Peigneux, P., Damas, P., Lambermont, B., Del Fiore, G., Degueldre, C., Aerts, J., Luxen, A., Franck, G., Lamy, M., Moonen, G., & Maquet, P. (October 2002). Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. NeuroImage, 17 (2), 732-741. doi:10.1016/S1053-8119(02)91236-X
The persistent vegetative state (PVS) is a devastating medical condition characterized by preserv...
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Laureys, S., Peigneux, P., Perrin, F., & Maquet, P. (03 July 2002). Sleep and motor skill learning. Neuron, 35 (1), 5-7. doi:10.1016/S0896-6273(02)00766-3
The improvement of a perceptual or motor skill continues after training has ended. The central qu...
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Maquet, P., Peigneux, P., Laureys, S., & Smith, C. (July 2002). Be caught napping : you're doing more than resting your eyes. Nature Neuroscience, 5 (7), 618-619. doi:10.1038/nn0702-618
Sleep is suggested to repair fatigue or to enhance memory consolidation. A new paper shows that t...
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Majerus, S., Collette, F., Van der Linden, M., Peigneux, P., Laureys, S., Delfiore, G., Degueldre, C., Luxen, A., & Salmon, E. (June 2002). A PET investigation of lexicality and phonotactic frequency in oral language processing. Cognitive Neuropsychology, 19 (4), 343-360. doi:10.1080/02643290143000213
Lexicality and phonotactic frequency effects are observed in many cognitive studies on language p...
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Laureys, S., Majerus, S., & Moonen, G. (2002). Neurological and behavioural assessment tools for coma and vegetative state. In J.-L. Vincent, Yearbook of intensive care and emergency medicine (pp. 715-726). New York, United States - New York: Springer.
Peigneux, P., Laureys, S., Delbeuck, X., & Maquet, P. (21 December 2001). Sleeping brain, learning brain : The role of sleep for memory systems. Neuroreport, 12 (18), 111-A124. doi:10.1097/00001756-200112210-00001
The hypothesis that sleep participates in the consolidation of recent memory traces has been inve...
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Peigneux, P., Salmon, E., Garraux, G., Laureys, S., Willems, S., Dujardin, K., Degueldre, C., Lemaire, C., Luxen, A., Moonen, G., Franck, G., Destee, A., & Van der Linden, M. (09 October 2001). Neural and cognitive bases of upper limb apraxia in corticobasal degeneration. Neurology, 57 (7), 1259-1268. doi:10.1212/WNL.57.7.1259
OBJECTIVE: To investigate the neural and cognitive bases of upper limb apraxia in corticobasal de...
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Peigneux, P., Laureys, S., Fuchs, S., Delbeuck, X., Degueldre, C., Aerts, J., Delfiore, G., Luxen, A., & Maquet, P. (September 2001). Generation of rapid eye movements during paradoxical sleep in humans. NeuroImage, 14 (3), 701-708. doi:10.1006/nimg.2001.0874
Although rapid eye movements (REMs) are a prominent feature of paradoxical sleep (PS), their orig...
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Laureys, S., Faymonville, M.-E., Berre, J., Antoine, S., Damas, P., Van Bogaert, P., Lambermont, B., Damas, F., Janssens, N., Degueldre, C., Lemaire, C., Del Fiore, G., Aerts, J., Ebinger, G., Luxen, A., Moonen, G., Lamy, M., Goldrnan, S., & Maquet, P. (2001). Etudes par tomographie à émission de positons chez des patients en coma, en état végétatif ou de conscience minimale, en «locked-in syndrome» et en mort cérébrale. In L'évaluation neurophysiologique des comas, de la mort encéphalique et des états végétatifs (pp. 367-376).
Laureys, S., Peigneux, P., Phillips, C., Fuchs, S., Degueldre, C., Aerts, J., Del Fiore, G., Petiau, C., Luxen, A., Van der Linden, M., Cleeremans, A., Smith, C., & Maquet, P. (2001). Experience-dependent changes in cerebral functional connectivity during human rapid eye movement sleep. Neuroscience, 105 (3), 521-525. doi:10.1016/S0306-4522(01)00269-X
One function of sleep is hypothesized to be the reprocessing and consolidation of memory traces (...
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Maquet, P., Laureys, S., Peigneux, P., Fuchs, S., Petiau, C., Phillips, C., Aerts, J., Del Fiore, G., Degueldre, C., Meulemans, T., Luxen, A., Franck, G., Van der Linden, M., Smith, C., & Cleeremans, A. (August 2000). Experience-dependent changes in cerebral activation during human REM sleep. Nature Neuroscience, 3 (8), 831-836. doi:10.1038/77744
The function of rapid-eye-movement (REM) sleep is stiil unknown. One prevailing hypothesis sugges...
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Peigneux, P., Maquet, P., Meulemans, T., Destrebecqz, A., Laureys, S., Degueldre, C., Delfiore, G., Aerts, J., Luxen, A., Franck, G., Van der Linden, M., & Cleeremans, A. (August 2000). Striatum forever, despite sequence learning variability : A random effect analysis of PET data. Human Brain Mapping, 10 (4), 179-194. doi:10.1002/1097-0193(200008)10:4<179::AID-HBM30>3.0.CO;2-H
This PET study is concerned with the what, where, and how of implicit sequence learning. In contr...
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Plenevaux, A., Lemaire, C., Aerts, J., Lacan, G., Rubins, D., Melega, W. P., Brihaye, C., Degueldre, C., Fuchs, S., Salmon, E., Maquet, P., Laureys, S., Damhaut, P., Weissmann, D., Le Bars, D., Pujol, J.-F., & Luxen, A. (July 2000). [(18)F]p-MPPF: A radiolabeled antagonist for the study of 5-HT(1A) receptors with PET. Nuclear Medicine and Biology, 27 (5), 467-71. doi:10.1016/S0969-8051(00)00113-X
This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphe...
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Faymonville, M., Laureys, S., Degueldre, C., DelFiore, G., Luxen, A., Franck, G., Lamy, M., & Maquet, P. (2000). Neural mechanisms of antinociceptive effects of hypnosis. Anesthesiology, 92 (5), 1257-67. doi:10.1097/00000542-200005000-00013
BACKGROUND: The neural mechanisms underlying the modulation of pain perception by hypnosis remain...
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LAUREYS, S., Degueldre, C., FAYMONVILLE, M.-E., DEL FIORE, G., DAMAS, P., LAMBERMONT, B., Luxen, A., Franck, G., LAMY, M., Moonen, G., & MAQUET, P. (2000). Altered thalamo-cortical drive in vegetative state. NeuroImage, 11(5):S773. doi:10.1016/s1053-8119(00)91702-6
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LAUREYS, S., FAYMONVILLE, M.-E., DAMAS, P., DEL FIORE, G., LAMBERMONT, B., Degueldre, C., Aerts, J., Franck, G., Luxen, A., LAMY, M., Moonen, G., & MAQUET, P. (2000). Cerebral processing in vegetatieve state II: Auditory stimulation. NeuroImage, 11(5):S772.
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Laureys, S., Faymonville, M., Degueldre, C., Del Fiore, G., Damas, P., Lambermont, B., Janssens, N., Aerts, J., Franck, G., Luxen, A., Moonen, G., Lamy, M., & Maquet, P. (2000). Auditory processing in the vegetative state. Brain: a Journal of Neurology, 123 ( Pt 8), 1589-601. doi:10.1093/brain/123.8.1589
H(2)(15)O-PET was used to investigate changes in regional cerebral blood flow in response to audi...
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Laureys, S., Faymonville, M., Del Fiore, G., Janssens, N., Degueldre, C., Aerts, J., Lamy, M., Luxen, A., Moonen, G., & Maquet, P. (2000). Brain activation during somatosensory and auditory stimulation in acute vegetative state of anoxic origin. In Physiological imaging of the brain with PET (pp. 319-327 (Chapter 47).
Laureys, S., Faymonville, M., Goldman, S., Degueldre, C., Phillips, C., Lambermont, B., Aerts, J., Lamy, M., Luxen, A., Franck, G., & Maquet, P. (2000). Impaired cerebral connectivity in vegetative state. In Physiological imaging of the brain with PET (pp. 329-334 (Chapter 48).
LAUREYS, S., FAYMONVILLE, M.-E., JANSSENS, N., DAMAS, P., DEL FIORE, G., LAMBERMONT, B., Degueldre, C., Aerts, J., Franck, G., Luxen, A., Moonen, G., LAMY, M., & MAQUET, P. (2000). Cerebral processing in vegetative state I: Somatosensory stimulation. NeuroImage, 11(5):S698. doi:10.1016/s1053-8119(00)91628-8
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LAUREYS, S., FAYMONVILLE, M.-E., JANSSENS, N., Degueldre, C., Peigneux, P., DEL FIORE, G., DAMAS, P., LAMBERMONT, B., Luxen, A., LAMY, M., Moonen, G., & MAQUET, P. (2000). Brain function during vegetative state and after recovery: A lesional approach to the study of human consciousness. Consciousness and Cognition, 9)2:S60.
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Laureys, S., Faymonville, M.-E., Luxen, A., Lamy, M., Franck, G., & Maquet, P. (2000). Restoration of thalamocortical connectivity after recovery from persistent vegetative state. The Lancet, 355 (9217), 1790-1791. doi:10.1016/S0140-6736(00)02271-6
Moreover, the performance on these factors is correlated to different anterior and posterior
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Laureys, S., Faymonville, M., Moonen, G., Luxen, A., & Maquet, P. (2000). PET scanning and neuronal loss in acute vegetative state. The Lancet, 355 (9217), 1825-1826. doi:10.1016/S0140-6736(05)73084-1
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Garraux, G., Salmon, E., Degueldre, C., Lemaire, C., Laureys, S., & Franck, G. (August 1999). Comparison of impaired subcortico-frontal metabolic networks in normal aging, subcortico-frontal dementia, and cortical frontal demential. NeuroImage, 10 (2), 149-162. doi:10.1006/nimg.1999.0463
Normal aging, progressive supranuclear palsy (PSP), and frontotemporal dementia (FTD) are charact...
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Laureys, S., Goldman, S., Phillips, C., van Bogaert, P., Aerts, J., Luxen, A., Franck, G., & Maquet, P. (April 1999). Impaired effective cortical connectivity in vegetative state : Preliminary investigation using PET. NeuroImage, 9 (4), 377-382. doi:10.1006/nimg.1998.0414
Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awarenes...
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Laureys, S., Lemaire, C., Maquet, P., Phillips, C., & Franck, G. (1999). Cerebral metabolism during vegetative state and after recovery to consciousness. Journal of Neurology, Neurosurgery and Psychiatry, 67 (1), 121-122. doi:10.1136/jnnp.67.1.121
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Laureys, S., Salmon, E., Garraux, G., Peigneux, P., Lemaire, C., Degueldre, C., & Franck, G. (1999). Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration. Journal of Neurology, 246 (12), 1151-8. doi:10.1007/s004150050534
Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages...
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Maquet, P., Petiau, C., Phillips, C., Laureys, S., Smith, C., Cleeremans, A., Luxen, A., Franck, G., & Van der Linden, M. (1999). Reactivation during REM sleep of cerebral areas involved in an serial reaction time task. NeuroImage, 9 (6 PART II).
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