[en] A number of recent studies suggest that some ‘vegetative state’ patients have
been misdiagnosed, judging by their ability to follow commands and in some
cases even communicate through brain activity. Such studies highlight the
difficulty in forming a diagnosis based only on behavioral assessments. We think
that neuroimaging and electrophysiology methods will be used more frequently
in clinical settings, integrated with existing behavioral assessments. Such efforts
are expected to lead to a more accurate understanding of individual patients’
cognitive abilities or even provide prognostic indicators. In terms of treatment
planning (i.e., pain management and end-of-life decision-making), patients with
disorders of consciousness are now offered the possibility of expressing their
preferences by means of brain–computer interfaces. What remains to be clarified
is the degree to which such indirect responses can be considered reliable and
of legal representation.
Disciplines :
Neurology
Author, co-author :
Gantner, Sylvia ; Université de Liège - ULiège > Centre de recherches du cyclotron
BODART, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Demertzi, Athina ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Our rapidly changing understanding of acute and chronic disorders of consciousness: challenges for neurologists
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Wijdicks EF. The diagnosis of brain death. N. Engl. J. Med. 344(16), 1215-1221 (2001).
Plum F, Posner JB. The Diagnosis of Stupor and Coma. FA Davis Co., PA, USA (1966).
Monti MM, Laureys S, Owen AM. The vegetative state. BMJ 341, c3765 (2010).
Laureys S, Celesia GG, Cohadon F, et al. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 8, 68 (2010).
Giacino JT, Ashwal S, Childs N, et al. The minimally conscious state. Neurology 58(3), 349-353 (2002).
Bruno MA, Vanhaudenhuyse A, Thibaut A, Moonen G, Laureys S. From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness. J. Neurol. 258(7), 1373-1384 (2011).
Bruno MA, Majerus S, Boly M, et al. Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients. J. Neurol. 259(6), 1087-1098 (2012).
Recommendations for use of uniform nomenclature pertinent to patients with severe alterations in consciousness. American Congress of Rehabilitation Medicine. Arch. Phys. Med. Rehabil. 76(2), 205-209 (1995).
Laureys S, Pellas F, Van Eeckhout P, et al. The locked-in syndrome: what is it like to be conscious but paralyzed and voiceless? Prog. Brain Res. 150, 495-511 (2005).
Posner JB, Saper CB, Schiff ND, Plum F. Plum and Posner's Diagnosis of Stupor and Coma. Oxford University Press, Oxford, UK (2007).
Vanhaudenhuyse A, Demertzi A, Schabus M, et al. Two distinct neuronal networks mediate the awareness of environment and of self. J. Cogn. Neurosci. 23(3), 570-578 (2011).
Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet 2(7872), 81-84 (1974).
Schnakers C, Giacino J, Kalmar K, et al. Does the FOUR score correctly diagnose the vegetative and minimally conscious states? Ann. Neurol. 60(6), 744-745 (2006).
Giacino JT, Kalmar K, Whyte J. The JFK coma recovery scale-revised: measurement characteristics and diagnostic utility. Arch. Phys. Med. Rehabil. 85(12), 2020-2029 (2004).
Seel RT, Sherer M, Whyte J, et al. Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research. Arch. Phys. Med. Rehabil. 91(12), 1795-1813 (2010).
Schnakers C, Vanhaudenhuyse A, Giacino J, et al. Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurol. 9, 35 (2009).
Laureys S, Owen AM, Schiff ND. Brain function in coma, vegetative state, and related disorders. Lancet Neurol. 3(9), 537-546 (2004).
Laureys S, Goldman S, Phillips C, et al. Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. NeuroImage 9(4), 377-382 (1999).
Laureys S, Faymonville ME, Luxen A, Lamy M, Franck G, Maquet P. Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 355(9217), 1790-1791 (2000).
Thibaut A, Bruno MA, Chatelle C, et al. Metabolic activity in external and internal awareness networks in severely brain-damaged patients. J. Rehabil. Med. 44(6), 487-494 (2012).
Boly M, Tshibanda L, Vanhaudenhuyse A, et al. Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum. Brain Mapp. 30(8), 2393-2400 (2009).
Soddu A, Vanhaudenhuyse A, Demertzi A, et al. Resting state activity in patients with disorders of consciousness. Funct. Neurol. 26(1), 37-43 (2011).
Vanhaudenhuyse A, Noirhomme Q, Tshibanda LJ, et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 133(Pt 1), 161-171 (2010).
Norton L, Hutchison RM, Young GB, Lee DH, Sharpe MD, Mirsattari SM. Disruptions of functional connectivity in the default mode network of comatose patients. Neurology 78(3), 175-181 (2012).
Lehembre R, Marie-Aurelie B, Vanhaudenhuyse A, et al. Resting-state EEG study of comatose patients: a connectivity and frequency analysis to find differences between vegetative and minimally conscious states. Funct. Neurol. 27(1), 41-47 (2012).
Schnakers C, Ledoux D, Majerus S, et al. Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders. Brain Inj. 22(12), 926-931 (2008).
Gosseries O, Schnakers C, Ledoux D, et al. Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state. Funct. Neurol. 26(1), 25-30 (2011).
Boly M, Garrido MI, Gosseries O, et al. Preserved feedforward but impaired top-down processes in the vegetative state. Science 332(6031), 858-862 (2011).
Rosanova M, Gosseries O, Casarotto S, et al. Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients. Brain 135(Pt 4), 1308-1320 (2012).
Babiloni C, Sara M, Vecchio F, et al. Cortical sources of resting-state a rhythms are abnormal in persistent vegetative state patients. Clin. Neurophysiol. 120(4), 719-729 (2009).
Boly M, Faymonville ME, Schnakers C, et al. Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol. 7(11), 1013-1020 (2008).
Laureys S, Perrin F, Faymonville ME, et al. Cerebral processing in the minimally conscious state. Neurology 63(5), 916-918 (2004).
Qin P, Di H, Yan X, et al. Mismatch negativity to the patient's own name in chronic disorders of consciousness. Neurosci. Lett. 448(1), 24-28 (2008).
Vanhaudenhuyse A, Laureys S, Perrin F. Cognitive event-related potentials in comatose and post-comatose states. Neurocrit. Care 8(2), 262-270 (2008).
Perrin F, Schnakers C, Schabus M, et al. Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome. Arch. Neurol. 63(4), 562-569 (2006).
Kotchoubey B, Kaiser J, Bostanov V, Lutzenberger W, Birbaumer N. Recognition of affective prosody in brain-damaged patients and healthy controls: a neurophysiological study using EEG and whole-head MEG. Cogn. Affect. Behav. Neurosci. 9(2), 153-167 (2009).
Owen AM, Coleman MR, Boly M, Davis MH, Laureys S, Pickard JD. Detecting awareness in the vegetative state. Science 313(5792), 1402 (2006).
Boly M, Coleman MR, Davis MH, et al. When thoughts become action: an fMRI paradigm to study volitional brain activity in non-communicative brain injured patients. NeuroImage 36(3), 979-992 (2007).
Rodriguez Moreno D, Schiff ND, Giacino J, Kalmar K, Hirsch J. A network approach to assessing cognition in disorders of consciousness. Neurology 75(21), 1871-1878 (2010).
Bekinschtein TA, Manes FF, Villarreal M, Owen AM, Della-Maggiore V. Functional imaging reveals movement preparatory activity in the vegetative state. Front. Hum. Neurosci. 5, 5 (2011).
Bardin JC, Fins JJ, Katz DI, et al. Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 134(Pt 3), 769-782 (2011).
Monti MM, Pickard JD, Owen AM. Visual cognition in disorders of consciousness: from V1 to top-down attention. Hum. Brain Mapp. doi:10.1002/hbm.21507 (2012) (Epub ahead of print).
Bauer G, Gerstenbrand F, Rumpl E. Varieties of the locked-in syndrome. J. Neurol. 221(2), 77-91 (1979).
Schnakers C, Perrin F, Schabus M, et al. Voluntary brain processing in disorders of consciousness. Neurology 71(20), 1614-1620 (2008).
Bekinschtein TA, Dehaene S, Rohaut B, Tadel F, Cohen L, Naccache L. Neural signature of the conscious processing of auditory regularities. Proc. Natl Acad. Sci. USA 106(5), 1672-1677 (2009).
Cruse D, Owen AM. Consciousness revealed: new insights into the vegetative and minimally conscious states. Curr. Opin. Neurol. 23(6), 656-660 (2010).
Cruse D, Chennu S, Chatelle C, et al. Bedside detection of awareness in the vegetative state: a cohort study. Lancet 378(9809), 2088-2094 (2011).
Goldfine AM, Victor JD, Conte MM, Bardin JC, Schiff ND. Determination of awareness in patients with severe brain injury using EEG power spectral analysis. Clin. Neurophysiol. 122(11), 2157-2168 (2011).
Monti MM, Vanhaudenhuyse A, Coleman MR, et al. Willful modulation of brain activity in disorders of consciousness. N. Engl. J. Med. 362(7), 579-589 (2010).
Birbaumer N, Murguialday AR, Cohen L. Brain-computer interface in paralysis. Curr. Opin. Neurol. 21(6), 634-638 (2008).
Kotchoubey B, Lang S, Winter S, Birbaumer N. Cognitive processing in completely paralyzed patients with amyotrophic lateral sclerosis. Eur. J. Neurol. 10(5), 551-558 (2003).
Lule D, Noirhomme Q, Kleih SC, et al. Probing command following in patients with disorders of consciousness using a brain-computer interface. Clin. Neurophysiol. doi:10.1016/j.clinph.2012.04.030 (2012) (Epub ahead of print).
Chatelle C, Chennu S, Noirhomme Q, Cruse D, Owen AM, Laureys S. Brain-computer interfacing in disorders of consciousness. Brain Inj. 26(12), 1510-1522 (2012).
Soddu A, Vanhaudenhuyse A, Bahri MA, et al. Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness. Hum. Brain Mapp. 33(4), 778-796 (2012).
Greenwald AG, Draine SC, Abrams RL. Three cognitive markers of unconscious semantic activation. Science 273(5282), 1699-1702 (1996).
Naccache L. Psychology. Is she conscious? Science 313(5792), 1395-1396 (2006).
Fox MD, Greicius M. Clinical applications of resting state functional connectivity. Front. Syst. Neurosci. 4, 19 (2010).
Bruno MA, Vanhaudenhuyse A, Schnakers C, et al. Visual fixation in the vegetative state: an observational case series PET study. BMC Neurol. 10, 35 (2010).
Giacino JT, Schnakers C, Rodriguez-Moreno D, Kalmar K, Schiff N, Hirsch J. Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold? Prog. Brain Res. 177, 33-48 (2009).
Andrews K, Murphy L, Munday R, Littlewood C. Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit. BMJ 313(7048), 13-16 (1996).
Childs NL, Mercer WN, Childs HW. Accuracy of diagnosis of persistent vegetative state. Neurology 43(8), 1465-1467 (1993).
Medical aspects of the persistent vegetative state (2). The Multi-Society Task Force on PVS. N. Engl. J. Med. 330(22), 1572-1579 (1994).
Giacino J, Kalmar K. The vegetative and minimally conscious states: a comparison of clinical features and functional outcome. J. Head Traum. Rehabil. 12(4), 36-51 (1997).
Whyte J, Gosseries O, Chervoneva I, et al. Predictors of short-term outcome in brain-injured patients with disorders of consciousness. Prog. Brain Res. 177, 63-72 (2009).
Estraneo A, Moretta P, Loreto V, Lanzillo B, Santoro L, Trojano L. Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. Neurology 75(3), 239-245 (2010).
Voss HU, Uluc AM, Dyke JP, et al. Possible axonal regrowth in late recovery from the minimally conscious state. J. Clin. Invest. 116(7), 2005-2011 (2006).
Luaute J, Maucort-Boulch D, Tell L, et al. Long-term outcomes of chronic minimally conscious and vegetative states. Neurology 75(3), 246-252 (2010).
Daltrozzo J, Wioland N, Mutschler V, Kotchoubey B. Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-Analysis. Clin. Neurophysiol. 118(3), 606-614 (2007).
Luaute J, Fischer C, Adeleine P, Morlet D, Tell L, Boisson D. Late auditory and event-related potentials can be useful to predict good functional outcome after coma. Arch. Phys. Med. Rehabil. 86(5), 917-923 (2005).
Fischer C, Luaute J, Nemoz C, Morlet D, Kirkorian G, Mauguiere F. Improved prediction of awakening or nonawakening from severe anoxic coma using tree-based classification analysis. Crit. Care Med. 34(5), 1520-1524 (2006).
Di HB, Yu SM, Weng XC, et al. Cerebral response to patient's own name in the vegetative and minimally conscious states. Neurology 68(12), 895-899 (2007).
Di H, Boly M, Weng X, Ledoux D, Laureys S. Neuroimaging activation studies in the vegetative state: predictors of recovery? Clin. Med. 8(5), 502-507 (2008).
Sara M, Pistoia F. Bedside detection of awareness in the vegetative state. Lancet 379(9827), 1702-1703 (2012).
Demertzi A, Schnakers C, Ledoux D, et al. Different beliefs about pain perception in the vegetative and minimally conscious states: a European survey of medical and paramedical professionals. Prog. Brain Res. 177, 329-338 (2009).
Demertzi A, Ledoux D, Bruno MA, et al. Attitudes towards end-of-life issues in disorders of consciousness: a European survey. J. Neurol. 258(6), 1058-1065 (2011).
Cabana MD, Rand CS, Powe NR, et al. Why don't physicians follow clinical practice guidelines? A framework for improvement. JAMA 282(15), 1458-1465 (1999).
Demertzi A, Racine E, Bruno M, et al. Pain perception in disorders of consciousness: neuroscience, clinical care, and ethics in dialogue. Neuroethics doi:0.1007/s12152-011-9149-x (2012) (Epub ahead of print).
Whyte J, Myers R. Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. Am. J. Phys. Med. Rehabil. 88(5), 410-418 (2009).
Clauss RP, Guldenpfennig WM, Nel HW, Sathekge MM, Venkannagari RR. Extraordinary arousal from semi-comatose state on zolpidem. A case report. S. Afr. Med. J. 90(1), 68-72 (2000).
Brefel-Courbon C, Payoux P, Ory F, et al. Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Ann. Neurol. 62(1), 102-105 (2007).
Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. N. Engl. J. Med. 363(27), 2638-2650 (2010).
Giacino JT, Whyte J, Bagiella E, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N. Engl. J. Med. 366(9), 819-826 (2012).
Schnakers C, Chatelle C, Vanhaudenhuyse A, et al. The nociception coma scale: a new tool to assess nociception in disorders of consciousness. Pain 148(2), 215-219 (2010).
Chatelle C, Majerus S, Whyte J, Laureys S, Schnakers C. A sensitive scale to assess nociceptive pain in patients with disorders of consciousness. J. Neurol. Neurosurg. Psychiatry 83(12), 1233-1237 (2012).
Laureys S, Faymonville ME, Peigneux P, et al. Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. NeuroImage 17(2), 732-741 (2002).
Schnakers C, Chatelle C, Demertzi A, Majerus S, Laureys S. What about pain in disorders of consciousness? AAPS J. 14(3), 437-444 (2012).
Schiff ND, Giacino JT, Kalmar K, et al. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448(7153), 600-603 (2007).
Lombardi F, Taricco M, De Tanti A, Telaro E, Liberati A. Sensory stimulation for brain injured individuals in coma or vegetative state. Cochrane Database Syst. Rev. (2), CD001427 (2002).
Phillips CL, Bruno MA, Maquet P, et al. 'Relevance vector machine' consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients. Neuroimage 56(2), 797-808 (2011).
Larriviere D, Bonnie RJ. Terminating artificial nutrition and hydration in persistent vegetative state patients: current and proposed state laws. Neurology 66(11), 1624-1628 (2006).
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.