Reference : Evoked Alpha Power is Reduced in Disconnected Consciousness During Sleep and Anesthesia
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/243510
Evoked Alpha Power is Reduced in Disconnected Consciousness During Sleep and Anesthesia
English
Darracq, M. [Department of Anesthesiology, University of Wisconsin, Madison, 53792, United States]
Funk, C. M. [Department of Psychiatry, University of Wisconsin, Madison, 53719, United States]
Polyakov, D. [Department of Anesthesiology, University of Wisconsin, Madison, 53792, United States]
Riedner, B. [Department of Psychiatry, University of Wisconsin, Madison, 53719, United States]
Gosseries, Olivia mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Nieminen, Jaakko O. [Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland]
BONHOMME, Vincent [Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation >]
Brichant, Jean-François [Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation >]
Boly, Mélanie [Department of Psychiatry, University of Wisconsin, Madison, 53719, United States, Department of Neurology, University of Wisconsin, Madison, 53792, United States]
Laureys, Steven [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Tononi, Giulio [Department of Psychiatry, University of Wisconsin, Madison, 53719, United States]
Sanders, R. D. [Department of Anesthesiology, University of Wisconsin, Madison, 53792, United States]
2018
Scientific Reports
Nature Publishing Group
8
1
Yes (verified by ORBi)
20452322
[en] Alpha Rhythm ; Anesthesia ; Cerebral Cortex ; Consciousness ; Evoked Potentials, Motor ; Humans ; Sleep ; Transcranial Magnetic Stimulation ; Unconsciousness ; Wakefulness
[en] Sleep and anesthesia entail alterations in conscious experience. Conscious experience may be absent (unconsciousness) or take the form of dreaming, a state in which sensory stimuli are not incorporated into conscious experience (disconnected consciousness). Recent work has identified features of cortical activity that distinguish conscious from unconscious states; however, less is known about how cortical activity differs between disconnected states and normal wakefulness. We employed transcranial magnetic stimulation–electroencephalography (TMS–EEG) over parietal regions across states of anesthesia and sleep to assess whether evoked oscillatory activity differed in disconnected states. We hypothesized that alpha activity, which may regulate perception of sensory stimuli, is altered in the disconnected states of rapid eye movement (REM) sleep and ketamine anesthesia. Compared to wakefulness, evoked alpha power (8–12 Hz) was decreased during disconnected consciousness. In contrast, in unconscious states of propofol anesthesia and non-REM (NREM) sleep, evoked low-gamma power (30–40 Hz) was decreased compared to wakefulness or states of disconnected consciousness. These findings were confirmed in subjects in which dream reports were obtained following serial awakenings from NREM sleep. By examining signatures of evoked cortical activity across conscious states, we identified novel evidence that suppression of evoked alpha activity may represent a promising marker of sensory disconnection. © 2018, The Author(s).
European Commission5P20MH077967Research Down Syndrome: K23 AG055700, R03NS096379Academy of Finland: 294625, 265680ARC-06/11-340Mind Science FoundationJames S. McDonnell FoundationP01AT004952EU-H2020-FETOPEN-GA686764, EU-H2020-FETFLAGSHIP-HBP-SGA1-GA720270, FNRSMedtronicPhilips Oral Healthcare
http://hdl.handle.net/2268/243510
10.1038/s41598-018-34957-9

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