[en] BACKGROUND: Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). We aimed to identify predictors and develop models for the prediction of depression and PTSD symptoms at 6 months post-TBI. METHODS: We analysed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury study. We used linear regression to model the relationship between predictors and depression (Patient Health Questionnaire-9) and PTSD symptoms (PTSD Checklist for Diagnostic and Statistical Manual for Mental Health Disorders Fifth Edition). Predictors were selected based on Akaike's Information Criterion. Additionally, we fitted logistic models for the endpoints 'probable MDD' and 'probable PTSD'. We also examined the incremental prognostic value of 2-3 weeks of symptoms. RESULTS: We included 2163 adults (76% Glasgow Coma Scale=13-15). Depending on the scoring criteria, 7-18% screened positive for probable MDD and about 10% for probable PTSD. For both outcomes, the selected models included psychiatric history, employment status, sex, injury cause, alcohol intoxication and total injury severity; and for depression symptoms also preinjury health and education. The performance of the models was modest (proportion of explained variance=R(2) 8% and 7% for depression and PTSD, respectively). Symptoms assessed at 2-3 weeks had a large incremental prognostic value (delta R(2)=0.25, 95% CI 0.24 to 0.26 for depression symptoms; delta R(2)=0.30, 95% CI 0.29 to 0.31 for PTSD). CONCLUSION: Preinjury characteristics, such as psychiatric history and unemployment, and injury characteristics, such as violent injury cause, can increase the risk of mental health problems after TBI. The identification of patients at risk should be guided by early screening of mental health.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Mikolić, Ana ; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands a.mikolic@erasmusmc.nl. ; Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
van Klaveren, David; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
Jost, Mathilde; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
Maas, Andrew Ir ; Department of Neurosurgery, University Hospital Antwerp, Edegem, Belgium. ; Department of Translational Neuroscience, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Shi, Shuyuan ; Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
Silverberg, Noah D ; Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada. ; Rehabilitation Research Program, Centre for Aging SMART, Vancouver Coastal Health, Vancouver, British Columbia, Canada.
Wilson, Lindsay ; Department of Psychology, University of Stirling, Stirling, UK.
Lingsma, Hester F; Department of Public Health, Erasmus MC, Rotterdam, The Netherlands.
Steyerberg, Ewout W; Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
CENTER-TBI Participants and, Investigators
Other collaborator :
Åkerlund, Cecilia
Amrein, Krisztina
Andelic, Nada
Andreassen, Lasse
Anke, Audny
Antoni, Anna
Audibert, Gérard
Azouvi, Philippe
Luisa Azzolini, Maria
Bartels, Ronald
Barzó, Pál
Beauvais, Romuald
Beer, Ronny
Bellander, Bo-Michael
Belli, Antonio
Benali, Habib
Berardino, Maurizio
Beretta, Luigi
Blaabjerg, Morten
Bragge, Peter
Brazinova, Alexandra
Brinck, Vibeke
Brooker, Joanne
Brorsson, Camilla
Buki, Andras
Bullinger, Monika
Cabeleira, Manuel
Caccioppola, Alessio
Calappi, Emiliana
Rosa Calvi, Maria
Cameron, Peter
Lozano, Guillermo Carbayo
Carbonara, Marco
Cavallo, Simona
Chevallard, Giorgio
Chieregato, Arturo
Citerio, Giuseppe
Clusmann, Hans
Coburn, Mark
Coles, Jonathan
D Cooper, Jamie
Correia, Marta
Čović, Amra
Curry, Nicola
Czeiter, Endre
Czosnyka, Marek
Dahyot Fizelier, Claire
Dark, Paul
Dawes, Helen
Keyser, Véronique De
Degos, Vincent
Della Corte, Francesco
Boogert, Hugo den
Depreitere, Bart
Đilvesi, Đula
Dixit, Abhishek
Donoghue, Emma
Dreier, Jens
Dulière, Guy Loup
Ercole, Ari
Esser, Patrick
Ezer, Erzsébet
Fabricius, Martin
L Feigin, Valery
Foks, Kelly
Frisvold, Shirin
Furmanov, Alex
Gagliardo, Pablo
Galanaud, Damien
Gantner, Dashiell
Gao, Guoyi
George, Pradeep
Ghuysen, Alexandre ; Université de Liège - ULiège > Département des sciences de la santé publique > Simulation médicale en situation critique
Giga, Lelde
Ben Glocker, Jagoš Golubovic
A Gomez, Pedro
Gratz, Johannes
Gravesteijn, Benjamin
Grossi, Francesca
L Gruen, Russell
Gupta, Deepak
A Haagsma, Juanita
Haitsma, Iain
Helbok, Raimund
Helseth, Eirik
Horton, Lindsay
Huijben, Jilske
J Hutchinson, Peter
Jacobs, Bram
Jankowski, Stefan
Jarrett, Mike
Yao Jiang, Ji
Johnson, Faye
Jones, Kelly
Karan, Mladen
G Kolias, Angelos
Kompanje, Erwin
Kondziella, Daniel
Kornaropoulos, Evgenios ; Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore)
Owe Koskinen, Lars
Kovács, Noémi
Kowark, Ana
Lagares, Alfonso
Lanyon, Linda
Laureys, Steven ; Université de Liège - ULiège > Département des sciences cliniques
Lecky, Fiona
Ledoux, Didier ; Université de Liège - ULiège > Département des sciences cliniques > Soins intensifs
Lefering, Rolf
Legrand, Valerie
Lejeune, Aurelie
Levi, Leon
Lightfoot, Roger
Lingsma, Hester
I Z Maas, Andrew
M Castaño León, Ana
Maegele, Marc
Majdan, Marek
Manara, Alex
Manley, Geoffrey
Martino, Costanza
Maréchal, Hugues
Mattern, Julia
McMahon, Catherine
Melegh, Béla
Menon, David
Menovsky, Tomas
Mikolic, Ana
Misset, Benoît ; Université de Liège - ULiège > Département des sciences cliniques
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