Article (Scientific journals)
Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations.
Huie, J Russell; Mondello, Stefania; Lindsell, Christopher J et al.
2021In Journal of Neurotrauma, 38 (18), p. 2514-2529
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Keywords :
Biomarkers; Brain Injuries, Traumatic/diagnosis; Common Data Elements; Data Interpretation, Statistical; Humans; Information Dissemination; Reference Standards; biomarkers; data sharing; traumatic brain injury
Abstract :
[en] Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence synthesis of these data are not trivial tasks. In this review, we discuss data management concepts and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps-discovery, evaluation, and evidence synthesis. First, complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Last, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on four major clinical projects (Transforming Research and Clinical Knowledge in TBI, Collaborative European NeuroTrauma Effectiveness Research in TBI, Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe, and Approaches and Decisions in Acute Pediatric TBI Trial), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities, and challenges, as well as examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Huie, J Russell;  Brain and Spinal Injury Center, Department of Neurological Surgery, University of
Mondello, Stefania;  Department of Biomedical and Dental Sciences and Morphofunctional Imaging,
Lindsell, Christopher J;  Department of Biostatistics, Vanderbilt University Medical Center, Nashville,
Antiga, Luca;  Orobix Srl, Bergamo, Italy.
Yuh, Esther L;  Brain and Spinal Injury Center, Department of Neurological Surgery, University of
Zanier, Elisa R;  Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Masson, Serge;  Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Rosario, Bedda L;  Department of Epidemiology, University of Pittsburgh Graduate School of Public
Ferguson, Adam R;  Brain and Spinal Injury Center, Department of Neurological Surgery, University of  ; San Francisco Veterans Affairs Medical Center (SFVAMC), San Francisco, California,
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI)
Other collaborator :
Adeoye, Opeolu
Badjatia, Neeraj
Boase, Kim
Bodien, Yelena
Bullock, M Ross
Chesnut, Randall
Corrigan, John D
Crawford, Karen
Diaz-Arrastia, Ramon
Dikmen, Sureyya
Duhaime, Ann-Christine
Bullinger, Monika
Cabeleira, Manuel
Calappi, Emiliana
Calvi, Maria Rosa
Cameron, Peter
Carbayo, Lozano Guillermo
Carbonara, Marco
Carise, Elsa
Carpenter, K
Castaño León, Ana M
Ellenbogen, Richard
Causin, Francesco
Chevallard, Giorgio
Chieregato, Arturo
Citerio, Giuseppe
Cnossen, Maryse
Coburn, Mark
Coles, Jonathan
Coles-Kemp, Lizzie
Collett, Johnny
Cooper, Jamie D
Feeser, V Ramana
Correia, Marta
Covic, Amra
Curry, Nicola
Czeiter, Endre
Czosnyka, Marek
Fizelier, Claire Dahyot
DAMAS, François ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie
Damas, Pierre
Dawes, Helen
De Keyser, Véronique ;  Université de Liège - ULiège > Département de Psychologie
Foreman, Brandon
Corte, Francesco Della
Depreitere, Bart
de Ruiter, Godard C W
Dilvesi, Dula
Ding, Shenghao
Dippel, Diederik
Dixit, Abhishek
Donoghue, Emma
Dreier, Jens
Dulière, Guy Loup
Gardner, Raquel
Engemann, Heiko
Ercole, Ari
Esser, Patrick
Ezer, Erzsébet
Fabricius, Martin
Feigin, Valery L
Feng, Junfeng
Foks, Kelly
Fossi, Francesca
Francony, Gilles
Gaudette, Etienne
Freo, Ulderico
Frisvold, Shirin
Furmanov, Alex
Gagliardo, Pablo
Galanaud, Damien
Gantner, Dashiell
Gao, Guoyi
Geleijns, Karin
George, Pradeep
GHUYSEN, Alexandre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des urgences
Giacino, Joseph
Giga, Lelde
Giraud, Benoit
Glocker, Ben
Golubovic, Jagos
Gomez, Pedro A
Gravesteijn, Benjamin
Grossi, Francesca
Gruen, Russell L
Gupta, Deepak
Haagsma, Juanita A
Goldman, Dana
Håberg, Asta Kristine
Jacobs, Bram
Haitsma, Iain
Hartings, Jed A
Helbok, Raimund
Helseth, Eirik
Hertle, Daniel
Hoedemaekers, Astrid
Hoefer, Stefan
Horton, Lindsay
Gonzalez, Luis
Huijben, Jilske
Hutchinson, Peter J
Jankowski, Stefan
Jarrett, Mike
Jelaca, Bojan
Jiang, Ji Yao
Jones, Kelly
Kamnitsas, Konstantinos
Karan, Mladen
Katila, Ari
Gopinath, Shankar
Kaukonen, Maija
Kerforne, Thomas
Kivisaari, Riku
Kolias, Angelos G
Kolumbán, Bálint
Kompanje, Erwin
Kolundzija, Ksenija
Kondziella, Daniel
Koskinen, Lars Owe
Kovács, Noémi
Gullapalli, Rao
Lagares, Alfonso
Lanyon, Linda
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau²
Lecky, Fiona
Ledig, Christian
Lefering, Rolf
Legrand, Valerie
Lei, Jin
Levi, Leon
Lightfoot, Roger
Hemphill, J Claude
Lingsma, Hester
Loeckx, Dirk
Lozano, Angels
Maas, Andrew I R
MacDonald, Stephen
Maegele, Marc
Marek, Majdan
Major, Sebastian
Manara, Alex
Manley, Geoffrey
Hotz, Gillian
MARTIN, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de neurochirurgie
Martin, Leon Francisco
Martino, Costanza
Maréchal, Hugues
Maruenda, Armando
Masala, Alessandro
Mattern, Julia
McFadyen, Charles
McMahon, Catherine
Melegh, Béla
Jain, Sonia
Menon, David
Menovsky, Tomas
Kossmann, Cristina Morganti
Mulazzi, Davide
Mühlan, Holger
Muraleedharan, Visakh
Murray, Lynnette
Nair, Nandesh
Negru, Ancuta
Nelson, David
Korley, Frederick
Newcombe, Virginia
Nieboer, Daan
Noirhomme, Quentin ;  Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging
Nyirádi, József
Oddo, Mauro
Oldenbeuving, Annemarie
Oresic, Matej
Ortolano, Fabrizio
Palotie, Aarno
Parizel, Paul M
Kramer, Joel
Patruno, Adriana
Payen, Jean François
Perera, Natascha
Perlbarg, Vincent
Persona, Paolo
Peul, Wilco
Piippo-Karjalainen, Anna
Pili, Floury Sébastien
Pirinen, Matti
Ples, Horia
Kreitzer, Natalie
Poca, Maria Antonia
Polinder, Suzanne
Pomposo, Inigo
Posti, Jussi
Puybasset, Louis
Radoi, Andreea
Ragauskas, Arminas
Raj, Rahul
Rambadagalla, Malinka
Real, Ruben
Levin, Harvey
Rehorčíková, Veronika
Rhodes, Jonathan
Ripatti, Samuli
Rocka, Saulius
Roe, Cecilie
Roise, Olav
Roks, Gerwin
Rosand, Jonathan
Rosenfeld, Jeffrey
Rosenlund, Christina
Machamer, Joan
Rosenthal, Guy
Rossaint, Rolf
Rossi, Sandra
Rueckert, Daniel
Rusnák, Martin
Sacchi, Marco
Sahakian, Barbara
Sahuquillo, Juan
Sakowitz, Oliver
Sala, Francesca
Madden, Christopher
Porras, Renan Sanchez
Sandor, Janos
Santos, Edgar
Sasu, Luminita
Savo, Davide
Schäffer, Nadine
Schipper, Inger
Schlößer, Barbara
Schmidt, Silke
Schoechl, Herbert
Manley, Geoffrey T
Schoonman, Guus
Schou, Rico Frederik
Schwendenwein, Elisabeth
Schöll, Michael
Sewalt, Charlie
Sir, Özcan
Skandsen, Toril
Smakman, Lidwien
Smeets, Dirk
Smielewski, Peter
Martin, Alastair
Sorinola, Abayomi
Stamatakis, Emmanuel
Stanworth, Simon
Steinbüchel, Nicole
Stevanovic, Ana
Stevens, Robert
Stewart, William
Steyerberg, Ewout W
Stocchetti, Nino
Sundström, Nina
McAllister, Thomas
Synnot, Anneliese
Taccone, Fabio Silvio
Takala, Riikka
Tamás, Viktória
Tanskanen, Päivi
Taylor, Mark Steven
Te Ao, Braden
Tenovuo, Olli
Telgmann, Ralph
Teodorani, Guido
McCrea, Michael
Theadom, Alice
Thomas, Matt
Tibboel, Dick
Tolias, Christos
Tshibanda, Jean Flory Luaba
Trapani, Tony
Tudora, Cristina Maria
Vajkoczy, Peter
Vallance, Shirley
Valeinis, Egils
Merchant, Randall
der Steen, Gregory Van
der Jagt, Mathieu van
de Naalt, J V
van Dijck, Jeroen T J M
van Essen, Thomas A
Hecke, Wim Van
Heugten, Caroline van
Praag, Dominique Van
Vyvere, Thijs Vande
Waesberghe, Julia Van
Mukherjee, Pratik
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Département des sciences cliniques
Vargiolu, Alessia
Vega, Emmanuel
Velt, Kimberley
Verheyden, Jan
Vespa, Paul M
Vik, Anne
Vilcinis, Rimantas
Vizzino, Giacinta
Lankamp, Carmen Vleggeert
Nelson, Lindsay
Volovici, Victor
Voormolen, Daphne
Vulekovic, Peter
Vámos, Zoltán
Wade, Derick
Wang, Kevin K W
Wang, Lei
Wessels, Lars
Wiegers, Eveline
Wildschut, Eno
Ngwenya, Laura B
Williams, Guy
Wilson, Lindsay
Winkler, Maren K L
Wolf, Stefan
Ylén, Peter
Younsi, Alexander
Zaaroor, Menashe
Zeiler, Frederik
Zhihui, Yang
Ziverte, Agate
Noel, Florence
Zumbo, Fabrizio
Okonkwo, David
Perl, Daniel
Puccio, Ava
Rabinowitz, Miri
Robertson, Claudia
Rosand, Jonathan
Sander, Angelle
Schnyer, David
Seabury, Seth
Stein, Murray
Taylor, Sabrina
Temkin, Nancy
Toga, Arthur
Valadka, Alex
Vassar, Mary
Vespa, Paul
Wang, Kevin
Yue, John K
Zafonte, Ross
Ackerlund, Cecilia
Adams, Hadie
Agnoletti, Vanni
Allanson, Judith
Amrein, Krisztina
Andaluz, Norberto
Andelic, Nada
Andreassen, Lasse
Anke, Audny
Antun, Azasevac
Antoni, Anna
Ardon, Hilko
Auslands, Kaspars
Azouvi, Philippe
Luisa Azzolini, Maria
Baciu, Camelia
Badenes, Rafael
Bartels, Ronald
Barzó, Pál
Bauerfeind, Ursula
Beauvais, Romuald
Beer, Ronny
Belda, Francisco Javier
Bellander, Bo Michael
Belli, Antonio
Bellier, Rémy
Benali, Habib
Benard, Thierry
Berardino, Maurizio
Beretta, Luigi
Beynon, Christopher
Bilotta, Federico
Binder, Harald
Biqiri, Erta
Blaabjerg, Morten
Boogert, Hugo den
Bragge, Peter
Brazinova, Alexandra
Brinck, Vibeke
Brooker, Joanne
Brorsson, Camilla
Buki, Andras
More authors (371 more) Less
Language :
English
Title :
Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations.
Publication date :
15 September 2021
Journal title :
Journal of Neurotrauma
ISSN :
0897-7151
eISSN :
1557-9042
Publisher :
Mary Ann Liebert, Us ny
Volume :
38
Issue :
18
Pages :
2514-2529
Peer reviewed :
Peer Reviewed verified by ORBi
Funding number :
UG3 NS106899/NS/NINDS NIH HHS/United States; I01 RX002787/RX/RRD VA/United States; R01 NS088475/NS/NINDS NIH HHS/United States; UH3 NS106899/NS/NINDS NIH HHS/United States; I01 RX002245/RX/RRD VA/United States
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