Resting state networks and consciousness Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states
[en] In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in fMRI functional connectivity under physiological (sleep), pharmacological (anesthesia) and pathological altered states of consciousness, such as brain death, coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. The reviewed RSNs were the DMN, left and right executive control, salience, sensorimotor, auditory and visual networks. We highlight some methodological issues concerning resting state analyses in severely injured brains mainly in terms of hypothesis-driven seed-based correlation analysis and data-driven independent components analysis approaches. Finally, we attempt to contextualize our discussion within theoretical frameworks of conscious processes. We think that this “lesion” approach allows us to better determine the necessary conditions under which normal conscious cognition takes place. At the clinical level, we acknowledge the technical merits of the resting state paradigm. Indeed, fast and easy acquisitions are preferable to activation paradigms in clinical populations. Finally, we emphasize the need to validate the diagnostic and prognostic value of fMRI resting state measurements in non-communicating brain damaged patients.
Disciplines :
Neurosciences & behavior Neurology
Author, co-author :
Heine, Lizette ; Université de Liège - ULiège > Centre de recherches du cyclotron
Soddu, Andrea ; Université de Liège - ULiège > Centre de recherches du cyclotron
KIRSCH, Murielle ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Demertzi, Athina ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Resting state networks and consciousness Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states
Publication date :
2012
Journal title :
Frontiers in Psychology
eISSN :
1664-1078
Publisher :
Switzerland Frontiers Research Foundation, Pully, Switzerland
Allen, E. A., Erhardt, E. B., Damaraju, E., Gruner, W., Segall, J. M., Silva, R. F., Havlicek, M., Rachakonda, S., Fries, J., Kalyanam, R., Michael, A. M., Caprihan, A., Turner, J. A., Eichele, T., Adelsheim, S., Bryan, A. D., Bustillo, J., Clark, V. P., Feldstein Ewing, S. W., Filbey, F., Ford, C. C., Hutchison, K., Jung, R. E., Kiehl, K. A., Kodituwakku, P., Komesu, Y. M., Mayer, A. R., Pearlson, G. D., Phillips, J. P., Sadek, J. R., Stevens, M., Teuscher, U., Thoma, R. J., and Calhoun, V. D. (2011). A baseline for the multivariate comparison of resting-state networks. Front. Syst. Neurosci. 5:2. doi:10.3389/fnsys.2011.00002
American Society of Anesthesiologists Task Force on Intraoperative Awareness. (2006). Practice advisory for intraoperative awareness and brain function monitoring a report by the American society of anesthesiologists task force on intraoperative awareness. Anesthesiology 104, 847-864.
Anderson, J. S., Druzgal, T. J., Lopez-Larson, M., Jeong, E. K., Desai, K., and Yurgelun-Todd, D. (2010). Network anticorrelations, global regression, and phase-shifted soft tissue correction. Hum. Brain Mapp. 32, 919-934.
Bardin, J. C., Fins, J. J., Katz, D. I., Hersh, J., Heier, L. A., Tabelow, K., Dyke, J. P., Ballon, D. J., Schiff, N. D., andVoss, H. U. (2011). Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 134, 769-782.
Beckmann, C. F., Deluca, M., Devlin, J. T., and Smith, S. M. (2005). Investigations into resting-state connectivity using independent component analysis. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360, 1001-1013.
Beckmann, C. F., and Smith, S. M. (2004). Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Trans. Med. Imaging 23, 137-152.
Beckmann, C. F., and Smith, S. M. (2004). Probabilistic independent component analysis for functional magnetic resonance imaging. IEEE Trans. Med. Imaging 23, 137-152.
Biswal, B., Yetkin, F. Z., Haughton, V. M., and Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echoplanar MRI. Magn. Reson. Med. 34, 537-541.
Boly, M., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Phillips, C., Peigneux, P., Maquet, P., and Laureys, S. (2007). Baseline brain activity fluctuations predict somatosensory perception in humans. Proc. Natl. Acad. Sci. U.S.A. 104, 12187-12192.
Boly, M., Perlbarg, V., Marrelec, G., Schabus, M., Laureys, S., Doyon, J., Pelegrini-Issac, M., Maquet, P., and Benali, H. (2012). Hierarchical clustering of brain activity during human nonrapid eye movement sleep. Proc. Natl. Acad. Sci. U.S.A. 109, 5856-5861.
Boly, M., Tshibanda, L., Vanhaudenhuyse, A., Noirhomme, Q., Schnakers, C., Ledoux, D., Boveroux, P., Garweg, C., Lambermont, B., Phillips, C., Luxen, A., Moonen, G., Bassetti, C., Maquet, P., and Laureys, S. (2009). Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum. Brain Mapp. 30, 2393-2400.
Boveroux, P., Vanhaudenhuyse, A., Bruno, M. A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., Brichant, J. F., Bonhomme, V., Maquet, P., Greicius, M. D., Laureys, S., and Boly, M. (2010). Breakdown of withinand between-network resting state functional magnetic resonance imaging connectivity during propofolinduced loss of consciousness. Anes-thesiology 113, 1038-1053.
Brewer, J. A., Worhunsky, P. D., Gray, J. R., Tang, Y. Y., Weber, J., and Kober, H. (2011). Meditation experience is associated with differences in default mode network activity and connectivity. Proc. Natl. Acad. Sci. U.S.A. 108, 20254-20259.
Brunetti, M., Della Penna, S., Ferretti, A., Del Gratta, C., Cianflone, F., Belardinelli, P., Caulo, M., Pizzella, V., Olivetti Belardinelli, M., and Romani, G. L. (2008). A frontoparietal network for spatial attention reorienting in the auditory domain: a human fMRI/MEG study of functional and temporal dynamics. Cereb. Cortex 18, 1139-1147.
Bruno, M.-A., Vanhaudenhuyse, A., Thibaut, A., Moonen, G., and Laureys, S. (2011). From unresponsive wakefulness to minimally conscious PLUS and functional lockedin syndromes: recent advances in our understanding of disorders of consciousness. J. Neurol. 258, 1373-1384.
Buckner, R. L., Andrews-Hanna, J. R., and Schacter, D. L. (2008). The brain's default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 1124, 1-38.
Bullmore, E., and Sporns, O. (2009). Complex brain networks: graph theoretical analysis of structural and functional systems. Nat. Rev. Neu-rosci. 10, 186-198.
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., Hobden, P., Evans, J., Feilding, A., Wise, R. G., and Nutt, D. J. (2012). Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc. Natl. Acad. Sci. U.S.A. 109, 2138-2143.
Chai, X. J., Castanon, A. N., Ongur, D., andWhitfield-Gabrieli, S. (2012). Anticorrelations in resting state networks without global signal regression. Neuroimage 59, 1420-1428.
Churchland, P. S. (2007). The necessaryand-sufficient boondoggle. Am. J. Bioeth. 7, 54-55; discussion W51-W54.
Cole, D. M., Smith, S. M., and Beckmann, C. F. (2010). Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Front. Syst. Neurosci. 4:8. doi:10.3389/fnsys.2010.00008
Cole, M. W., and Schneider, W. (2007). The cognitive control network: integrated cortical regions with dissociable functions. Neuroimage 37, 343-360.
Cordes, D., Haughton, V. M., Arfanakis, K., Carew, J. D., Turski, P. A., Moritz, C. H., Quigley, M. A., and Meyerand, M. E. (2001). Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data. AJNR Am. J. Neuroradiol. 22, 1326-1333.
Crone, J. S., Ladurner, G., Höller, Y., Golaszewski, S., Trinka, E., and Kronbichler, M. (2011). Deactivation of the default mode network as a marker of impaired consciousness: an fMRI study. PLoS ONE 6, e26373. doi:10.1371/journal.pone.0026373
Damoiseaux, J. S., Rombouts, S. A., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., and Beckmann, C. F. (2006). Consistent resting-state networks across healthy subjects. Proc. Natl. Acad. Sci. U.S.A. 103, 13848-13853.
De Luca, M., Beckmann, C. F., De Stefano, N., Matthews, P. M., and Smith, S. M. (2006). fMRI resting state networks define distinct modes of longdistance interactions in the human brain. Neuroimage 29, 1359-1367.
De Martino, F., Gentile, F., Esposito, F., Balsi, M., Di Salle, F., Goebel, R., and Formisano, E. (2007). Classification of fMRI independent components using IC-fingerprints and support vector machine classifiers. Neuroimage 34, 177-194.
Dehaene, S., and Changeux, J. P. (2005). Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness. PLoS Biol. 3, e141. doi:10.1371/journal.pbio.0030141
Dehaene, S., and Changeux, J. P. (2011). Experimental and theoretical approaches to conscious processing. Neuron 70, 200-227.
Dehaene, S., Sergent, C., and Changeux, J. P. (2003). A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proc. Natl. Acad. Sci. U.S.A. 100, 8520-8525.
Demertzi, A., Ledoux, D., Bruno, M.-A., Vanhaudenhuyse, A., Gosseries, O., Soddu, A., Schnakers, C., Moonen, G., and Laureys, S. (2011a). Attitudes towards end-of-life issues in disorders of consciousness: a European survey. J. Neurol. 258, 1058-1065.
Demertzi, A., Soddu, A., Faymonville, M. E., Bahri, M. A., Gosseries, O., Vanhaudenhuyse, A., Phillips, C., Maquet, P., Noirhomme, Q., Luxen, A., and Laureys, S. (2011b). Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity. Prog. Brain Res. 193, 309-322.
Demertzi, A., Racine, E., Bruno, M. A., Ledoux, D., Gosseries, O., Vanhaudenhuyse, A., Thonnard, M., Soddu, A., Moonen, G., and Laureys, S. (2012). Pain perception in disorders of consciousness: neuroscience, clinical care, and ethics in dialogue. Neu-roethics 1-14. doi:10.1007/s12152-011-9149-x
Demertzi, A., Schnakers, C., Ledoux, D., Chatelle, C., Bruno, M.-A., Vanhaudenhuyse, A., Boly, M., Moonen, G., and Laureys, S. (2009). Different beliefs about pain perception in the vegetative and minimally conscious states: a European survey of medical and paramedical professionals. Prog. Brain Res. 177, 329-338.
Derbyshire, S. W., Whalley, M. G., Stenger, V. A., and Oakley, D. A. (2004). Cerebral activation during hypnotically induced and imagined pain. Neuroimage 23, 392-401.
Esposito, F., Pignataro, G., Di Renzo, G., Spinali, A., Paccone, A., Tedeschi, G., and Annunziato, L. (2010). Alcohol increases spontaneous BOLD signal fluctuations in the visual network. Neuroimage 53, 534-543.
Fox, M. D., and Greicius, M. (2010). Clinical applications of resting state functional connectivity. Front. Syst. Neurosci. 4:19. doi:10.3389/fnsys.2010.00019
Fox, M. D., and Raichle, M. E. (2007). Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat. Rev. Neurosci. 8, 700-711.
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., and Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. U.S.A. 102, 9673.
Fox, M. D., Snyder, A. Z., Vincent, J. L., and Raichle, M. E. (2007). Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior. Neuron 56, 171-184.
Fox, M. D., Zhang, D., Snyder, A. Z., and Raichle, M. E. (2009). The global signal and observed anticorrelated resting state brain networks. J. Neu-rophysiol. 101, 3270-3283.
Fransson, P. (2005). Spontaneous lowfrequency BOLD signal fluctuations: an fMRI investigation of the restingstate default mode of brain function hypothesis. Hum. Brain Mapp. 26, 15-29.
Fukunaga, M., Horovitz, S. G., van Gelderen, P., de Zwart, J. A., Jansma, J. M., Ikonomidou, V. N., Chu, R., Deckers, R. H., Leopold, D. A., and Duyn, J. H(2006). Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages. Magn. Reson. Imaging 24, 979-992.
Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., Kelly, J. P., Rosenberg, J. H., Whyte, J., Zafonte, R. D., and Zasler, N. D. (2002). The minimally conscious state: definition and diagnostic criteria. Neurology 58, 349-353.
Goldberg, I. I., Harel, M., and Malach, R. (2006). When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 50, 329-339.
Golland, Y., Bentin, S., Gelbard, H., Benjamini, Y., Heller, R., Nir, Y., Hasson, U., and Malach, R. (2007). Extrinsic and intrinsic systems in the posterior cortex of the human brain revealed during natural sensory stimulation. Cereb. Cortex 17, 766-777
Greicius, M. D., Kiviniemi, V., Tervonen, O., Vainionpää, V., Alahuhta, S., Reiss, A. L., and Menon, V. (2008). Persistent default-mode network connectivity during light sedation. Hum. Brain Mapp. 29, 839-847.
Greicius, M. D., Krasnow, B., Reiss, A. L., and Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc. Natl. Acad. Sci. U.S.A. 100, 253.
Hobson, J. A., and Pace-Schott, E. F. (2002). The cognitive neuroscience of sleep: neuronal systems, consciousness, and learning. Nat. Rev. Neurosci. 3, 679-693.
Honey, C. J., Sporns, O., Cammoun, L., Gigandet, X., Thiran, J. P., Meuli, R., and Hagmann, P. (2009). Predicting human resting-state functional connectivity from structural connectivity. Proc. Natl. Acad. Sci. U.S.A. 106, 2035-2040.
Horovitz, S. G., Braun, A. R., Carr, W. S., Picchioni, D., Balkin, T. J., Fukunaga, M., and Duyn, J. H. (2009). Decoupling of the brain's default mode network during deep sleep. Proc. Natl. Acad. Sci. U.S.A. 106, 11376-11381.
Horovitz, S.G., Fukunaga, M., DeZwart, J. A., Van Gelderen, P., Fulton, S. C., Balkin, T. J., and Duyn, J. H. (2008). Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEGfMRI study. Hum. Brain Mapp. 29, 671-682.
Josipovic, Z., Dinstein, I., Weber, J., and Heeger, D. J. (2012). Influence of meditation on anticorrelated networks in the brain. Front. Hum. Neurosci. 5:183. doi:10.3389/fnhum.2011.00183
Kiviniemi, V. J., Haanpää, H., Kantola, J.-H., Jauhiainen, J., Vainionpää, V., Alahuhta, S., and Tervonen, O. (2005). Midazolam sedation increases fluctuation and synchrony of the resting brain BOLD signal. Magn. Reson. Imaging 23, 531-537.
Laird, A. R., Fox, P. M., Eickhoff, S. B., Turner, J. A., Ray, K. L., Mckay, D. R., Glahn, D. C., Beckmann, C. F., Smith, S. M., and Fox, P. T. (2011). Behavioral interpretations of intrinsic connectivity networks. J. Cogn. Neurosci. 23, 4022-4037.
Larson-Prior, L. J., Zempel, J. M., Nolan, T. S., Prior, F. W., Snyder, A. Z., and Raichle, M. E. (2009). Cortical network functional connectivity in the descent to sleep. Proc. Natl. Acad. Sci. U.S.A. 106, 4489-4494.
Laureys, S., Celesia, G. G., Cohadon, F., Lavrijsen, J., Leon-Carrrion, J., Sannita, W. G., Sazbon, L., Schmutzhard, E., VonWild, K. R., Zeman, A., Dolce, G., and Disorders of Consciousness, T. E. (2010). Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 8, 68. doi:10.1186/1741-7015-8-68
Laureys, S., Pellas, F., Van Eeckhout, P., Ghorbel, S., Schnakers, C., Perrin, F., Berre, J., Faymonville, M.-E., Pantke, K.-H., Damas, F., Lamy, M., Moonen, G., and Goldman, S. (2005). The locked-in syndrome: what is it like to be conscious but paralyzed and voiceless? Prog. Brain Res. 150, 495-511.
Lehembre, R., Bruno, M., Vanhaudenhuyse, A., Chatelle, C., Cologan, V., Leclercq, Y., Soddu, A., Macq, B., Laureys, S., and Noirhomme, Q. (2012). Resting state EEG study of comatose patients: a connectivity and frequency analysis to find differences between vegetative and minimally conscious states. Funct. Neurol. 27, 41-47.
Lou, H. C., Luber, B., Crupain, M., Keenan, J. P., Nowak, M., Kjaer, T. W., Sackeim, H. A., and Lisanby, S. H. (2004). Parietal cortex and representation of the mental self. Proc. Natl. Acad. Sci. U.S.A. 101, 6827-6832.
Majerus, S., Bruno, M. A., Schnakers, C., Giacino, J. T., and Laureys, S. (2009). The problem of aphasia in the assessment of consciousness in brain-damaged patients. Prog. Brain Res. 177, 49-61.
Martuzzi, R., Ramani, R., Qiu, M., Rajeevan, N., and Constable, R. T. (2010). Functional connectivity and alterations in baseline brain state in humans. Neuroimage 49, 823-834.
Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D., Grafton, S. T., and Macrae, C. N. (2007). Wandering minds: the default network and stimulus-independent thought. Science 315, 393-395.
Mazoyer, B., Zago, L., Mellet, E., Bricogne, S., Etard, O., Houde, O., Crivello, F., Joliot, M., Petit, L., and Tzourio-Mazoyer, N. (2001). Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res. Bull. 54, 287-298.
McGeown, W. J., Mazzoni, G., Venneri, A., and Kirsch, I. (2009). Hypnotic induction decreases anterior default mode activity. Conscious. Cogn. 18, 848-855.
McKiernan, K. A., D'angelo, B. R., Kaufman, J. N., and Binder, J. R. (2006).
Interrupting the "stream of consciousness": an fMRI investigation. Neuroimage 29, 1185-1191.
Menon, V., and Uddin, L. Q. (2010). Saliency, switching, attention and control: a network model of insula function. Brain Struct. Funct. 214, 655-667.
Monti, M. M., Pickard, J. D., and Owen, A. M. (2012). Visual cognition in disorders of consciousness: from V1 to top-down attention. Hum. Brain Mapp. doi: 10.1002/hbm.21507. [Epub ahead of print].
Monti, M. M., Vanhaudenhuyse, A., Coleman, M. R., Boly, M., Pickard, J. D., Tshibanda, L., Owen, A. M., and Laureys, S. (2010). Willful modulation of brain activity in disorders of consciousness. N. Engl. J. Med. 362, 579-589.
Murphy, K., Birn, R. M., Handwerker, D. A., Jones, T. B., and Bandettini, P. A. (2009). The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44, 893-905.
Norton, L., Hutchison, R. M., Young, G. B., Lee, D. H., Sharpe, M. D., and Mirsattari, S. M. (2012). Disruptions of functional connectivity in the default mode network of comatose patients. Neurology 78, 175-181
Ploner, M., Lee, M. C., Wiech, K., Bingel, U., and Tracey, I. (2010). Prestimulus functional connectivity determines pain perception in humans. Proc. Natl. Acad. Sci. U.S.A. 107, 355-360.
Posner, J., Saper, C., Schiff, N. D., and Plum, F. (eds). (2007). Plum and Pos-ner's Diagnosis of Stupor and Coma. New York: Oxford University Press. Raichle, M. E., Macleod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., and Shulman, G. L. (2001). A default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98, 676-682.
Raichle, M. E., and Snyder, A. Z. (2007). A default mode of brain function: a brief history of an evolving idea. Neuroimage 37, 1083-1090; discussion 1097-1089.
Roberts, G. M., and Garavan, H. (2010). Evidence of increased activation underlying cognitive control in ecstasy and cannabis users. Neu-roimage 52, 429-435.
Roberts, K. L., and Hall, D. A. (2008). Examining a supramodal network for conflict processing: a systematic review and novel functional magnetic resonance imaging data for related visual and auditory stroop tasks. J. Cogn. Neurosci. 20, 1063-1078.
Sämann, P. G., Wehrle, R., Hoehn, D., Spoormaker, V. I., Peters, H., Tully, C., Holsboer, F., and Czisch, M. (2011). Development of the brain's defaultmode networkfrom wakefulness to slow wave sleep. Cereb. Cortex 21, 2082-2093.
Sapir, A., D'Avossa, G., Mcavoy, M., Shulman, G. L., and Corbetta, M. (2005). Brain signals for spatial attention predict performance in a motion discrimination task. Proc. Natl. Acad. Sci. U.S.A. 102, 17810-17815.
Schiff, N. D., Rodriguez-Moreno, D., Kamal, A., Kim, K. H., Giacino, J. T., Plum, F., and Hirsch, J. (2005). fMRI reveals large-scale network activation in minimally conscious patients. Neurology 64, 514-523.
Schilbach, L., Eickhoff, S. B., Rotarska-Jagiela, A., Fink, G. R., and Vogeley, K. (2008). Minds at rest? Social cognition as the default mode of cognizing and its putative relationship to the "default system" of the brain. Conscious. Cogn. 17, 457-467.
Schrouff, J., Perlbarg, V., Boly, M., Marrelec, G., Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Laureys, S., Phillips, C., Pélégrini-Issac, M., Maquet, P., and Benali, H. (2011). Brain functional integration decreases during propofol-induced loss of consciousness. Neuroimage 57, 198-205.
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., and Greicius, M. D. (2007). Dissociable intrinsic connectivity networks for salience processing and executive control. J. Neu-rosci. 27, 2349-2356.
Seghier, M. L., Zeidman, P., Neufeld, N. H., Leff, A. P., and Price, C. J. (2010). Identifying abnormal connectivity in patients using dynamic causal modeling of FMRI responses. Front. Syst. Neurosci. 4:142. doi:10.3389/fnsys.2010.00142
Shen, S., Szameitat, A. J., and Sterr, A. (2007). VBM lesion detection depends on the normalization template: a study using simulated atrophy. Magn. Reson. Imaging 25, 1385-1396.
Shulman, G. L., Fiez, J. A., Corbetta, M., Buckner, R. L., Miezin, F. M., Raichle, M. E., and Petersen, S. E. (1997). Common blood flow changes across visual tasks: II. Decreases in cerebral cortex. J. Cogn. Neurosci. 9, 648-663.
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, M. P., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., and Beckmann, C. F. (2009). Correspondence of the brain's functional architecture during activation and rest. Proc. Natl. Acad. Sci. U.S.A. 106, 13040-13045.
Soddu, A., Vanhaudenhuyse, A., Bahri, M. A., Bruno, M. A., Boly, M., Demertzi, A., Tshibanda, J. F., Phillips, C., Stanziano, M., Ovadia-Caro, S., Nir, Y., Maquet, P., Papa, M., Malach, R., Laureys, S., and Noirhomme, Q. (2012). Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness. Hum. Brain Mapp. 33, 778-796.
Soddu, A., Vanhaudenhuyse, A., Demertzi, A., Marie-Aurelie, B., Tshibanda, L., Di, H., Melanie, B., Papa, M., Laureys, S., and Noirhomme, Q. (2011). Resting state activity in patients with disorders of consciousness. Funct. Neurol. 26, 37-43.
Stamatakis, E. A., Adapa, R. M., Absalom, A. R., and Menon, D. K. (2010). Changes in resting neural connectivity during propofol sedation. PLoS ONE 5, e14224. doi:10.1371/journal.pone.0014224
The Executive Committee of the American Psychological Association -Division of Psychological Hypnosis. (1994). Definition and description of hypnosis. Contemp. Hypn. 11, 142-162.
Tian, L., Jiang, T., Liu, Y., Yu, C., Wang, K., Zhou, Y., Song, M., and Li, K. (2007). The relationship within and between the extrinsic and intrinsic systems indicated by resting state correlational patterns of sensory cortices. Neuroimage 36, 684-690.
Tohka, J., Foerde, K., Aron, A., Tom, S., and Toga, A. (2008). Automatic independentcomponentlabelingfor artifact removal in fMRI. Neuroim-age 39, 1227-1245.
Tracey, I., and Mantyh, P.W. (2007). The cerebral signature for pain perception and its modulation. Neuron 55, 377-391.
van den Heuvel, M. P., and Hulshoff Pol, H. E. (2010). Exploring the brain network: a review on restingstate fMRI functional connectivity. Eur. Neuropsychopharmacol. 20, 519-534.
Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., Phillips, C., Soddu, A., Luxen, A., Moonen, G., and Laureys, S. (2011). Two distinct neuronal networks mediate the awareness of environment and of self. J. Cogn. Neurosci. 23, 570-578.
Vanhaudenhuyse, A., Noirhomme, Q., Tshibanda, L. J., Bruno, M.A., Boveroux, P., Schnakers, C., Soddu, A., Perlbarg, V., Ledoux, D., Brichant, J. F., Moonen, G., Maquet, P., Greicius, M. D., Laureys, S., and Boly, M. (2010). Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 133, 161-171.
Weissman, D. H., Roberts, K., Visscher, K., and Woldorff, M. G. (2006). The neural bases of momentary lapses in attention. Nat. Neurosci. 9, 971-978.
Whitfield-Gabrieli, S., Moran, J. M., Nieto-Castanon, A., Triantafyllou, C., Saxe, R., and Gabrieli, J. D. (2011). Associations and dissociations between default and selfreference networks in the human brain. Neuroimage 55, 225-232.
Wiech, K., Lin, C. S., Brodersen, K. H., Bingel, U., Ploner, M., and Tracey, I. (2010). Anterior insula integrates information about salience into perceptual decisions about pain. J. Neu-rosci. 30, 16324-16331.
Zalesky, A., Fornito, A., and Bullmore, E. (2012). On the use of correlation as a measure of network connectivity. Neuroimage 60, 2096-2106.
Zang, Y. F., He, Y., Zhu, C. Z., Cao, Q. J., Sui, M. Q., Liang, M., Tian, L. X., Jiang, T. Z., and Wang, Y. F. (2007). Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev. 29, 83-91.
Zeman, A. (2001). Consciousness. Brain 124, 1263-1289.
Zuo, X. N., Di Martino, A., Kelly, C., Shehzad, Z. E., Gee, D. G., Klein, D. F., Castellanos, F. X., Biswal, B.B., and Milham, M. P. (2010). The oscillating brain: complex and reliable. Neuroimage 49, 1432-1445.
