Article (Scientific journals)
Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
Thonnard, Marie; Gosseries, Olivia; Demertzi, Athina et al.
2014In Functional Neurology, 28 (4), p. 259-64
Peer Reviewed verified by ORBi
 

Files


Full Text
thonnard_gosseries_zolpidem_FNeurology2014.pdf
Publisher postprint (540.42 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Adult; Chronic Disease; Consciousness Disorders/drug therapy; Female; Humans; Male; Prospective Studies; Pyridines/therapeutic use
Abstract :
[en] Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic etiology) with a diagnosis of vegetative state/unresponsive wakefulness syndrome (n=28) or minimally conscious state (n=32) were behaviorally assessed using the Coma Recovery Scale-Revised (CRS-R) before and one hour after administration of 10 mg of zolpidem. At the group level, the diagnosis did not change after intake of zolpidem (p=0.10) and CRS-R total scores decreased (p=0.01). Twelve patients (20%) showed improved behaviors and/or CRS-R total scores after zolpidem administration but in only one patient was the diagnosis after zolpidem intake found to show a significant improvement (functional object use), which suggested a change of diagnosis. However, in this patient, a double-blind placebo-controlled trial was performed in order to better specify the effects of zolpidem, but the patient, on this trial, failed to show any clinical improvements. The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Pharmacy, pharmacology & toxicology
Author, co-author :
Thonnard, Marie  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Gosseries, Olivia   ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Lugo, Z
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bruno, Marie-Aurélie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Chatelle, Camille ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Thibaut, Aurore ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Charland-Verville, Vanessa ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Habbal, D
Schnakers, Caroline ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
 These authors have contributed equally to this work.
Language :
English
Title :
Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
Publication date :
January 2014
Journal title :
Functional Neurology
ISSN :
0393-5264
eISSN :
1971-3274
Publisher :
CIC Edizioni Internationali, Roma, Italy
Volume :
28
Issue :
4
Pages :
259-64
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 March 2014

Statistics


Number of views
140 (14 by ULiège)
Number of downloads
72 (6 by ULiège)

Scopus citations®
 
55
Scopus citations®
without self-citations
41

Bibliography


Similar publications



Contact ORBi