Vegetative state; Unresponsive wakefulness syndrome; Minimally conscious state; Brain injury; Transcranial magnetic stimulation; Motor evoked potentials; Somatosensory evoked potentials; Short latency afferent inhibition
Abstract :
[en] Background: Transcranial magnetic stimulation (TMS) has been frequently used to explore changes in the human motor cortex in different conditions, while the extent of motor cortex reorganization in patients in vegetative state (VS) (now known as unresponsive wakefulness syndrome, UWS) and minimally conscious (MCS) states due to severe brain damage remains largely unknown. Objective/hypothesis: It was hypothesized that cortical motor excitability would be decreased and would correlate to the level of consciousness in patients with disorders of consciousness. Methods: Corticospinal excitability was assessed in 47 patients (24 VS/UWS and 23 MCS) and 14 healthy controls. The test parameters included maximal peak-to-peak M-wave (Mmax), F-wave persistence, peripheral and central motor conduction times, sensory (SEP) and motor evoked (MEP) potential latencies and amplitudes, resting motor threshold (RMT), stimulus/response curves, and short latency afferent inhibition (SAI). TMS measurements were correlated to the level of consciousness (assessed using the Coma Recovery Scale-Revised). Results: On average, the patient group had lower Mmax, lower MEP and SEP amplitudes, higher RMTs, narrower stimulus/response curves, and reduced SAI compared to the healthy controls (P < 0.05). The SAI alterations were correlated to the level of consciousness (P < 0.05). Conclusions: The findings demonstrated the impairment of the cortical inhibitory circuits in patients with disorders of consciousness. Moreover, the significant relationship was found between cortical inhibition and clinical consciousness dysfunction.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Lapitskaya, Natallia ✱
Gosseries, Olivia ✱; Université de Liège - ULiège > Centre de recherches du cyclotron
DE PASQUA, Victor ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
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Bibliography
S. Laureys, G.G. Celesia, F. Cohadon, J. Lavrijsen, J. Leon-Carrion, and W.G. Sannita Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome BMC Medicine 8 2010 68
J.T. Giacino The vegetative and minimally conscious states: consensus-based criteria for establishing diagnosis and prognosis NeuroRehabilitation 19 4 2004 293 298
S. Laureys, M.E. Faymonville, A. Luxen, M. Lamy, G. Franck, and P. Maquet Restoration of thalamocortical connectivity after recovery from persistent vegetative state Lancet 355 9217 2000 1790 1791
R. Chen, D. Cros, A. Curra, V. Di Lazzaro, J.P. Lefaucheur, and M.R. Magistris The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee Clinical Neurophysiology 119 3 2008 504 532
K. Schiene, C. Bruehl, K. Zilles, M.S. Qu, G. Hagemann, and M. Kraemer Neuronal hyperexcitability and reduction of GABA(A)-receptor expression in the surround of cerebral photothrombosis Journal of Cerebral Blood Flow and Metabolism 16 5 1996 906 914
R. Domann, G. Hagemann, M. Kraemer, H.J. Freund, and O.W. Witte Electrophysiological changes in the surrounding brain tissue of photochemically induced cortical infarcts in the rat Neuroscience Letters 155 1 1993 69 72
T. Neumann-Haefelin, and O.W. Witte Periinfarct and remote excitability changes after transient middle cerebral artery occlusion Journal of Cerebral Blood Flow and Metabolism 20 1 2000 45 52
T. Mittmann, H.J. Luhmann, R. Schmidtkastner, U.T. Eysel, H. Weigel, and U. Heinemann Lseion-induced transient suppression of inhibitory function in rat neocortex in vitro Neuroscience 60 4 1994 891 906
P. Talelli, R.J. Greenwood, and J.C. Rothwell Arm function after stroke: neurophysiological correlates and recovery mechanisms assessed by transcranial magnetic stimulation Clinical Neurophysiology 117 8 2006 1641 1659
M. Fujiki, T. Hikawa, T. Abe, K. Ishii, and H. Kobayashi Reduced short latency afferent inhibition in diffuse axonal injury patients with memory impairment Neuroscience Letters 405 3 2006 226 230
A.V. Chistyakov, J.F. Soustiel, H. Hafner, M. Trubnik, G. Levy, and M. Feinsod Excitatory and inhibitory corticospinal responses to transcranial magnetic stimulation in patients with minor to moderate head injury Journal of Neurology, Neurosurgery and Psychiatry 70 5 2001 580 587
A.V. Chistyakov, H. Hafner, J.F. Soustiel, M. Trubnik, G. Levy, and M. Feinsod Dissociation of somatosensory and motor evoked potentials in non-comatose patients after head injury Clinical Neurophysiology 110 6 1999 1080 1089
N. Takeuchi, K. Ikoma, T. Chuma, and Y. Matsuo Measurement of transcallosal inhibition in traumatic brain injury by transcranial magnetic stimulation Brain Injury 20 9 2006 991 996
M. Bernabeu, A. Demirtas-Tatlidede, E. Opisso, R. Lopez, J.M. Tormos, and A. Pascual-Leone Abnormal corticospinal excitability in traumatic diffuse axonal brain injury Journal of Neurotrauma 26 12 2009 2185 2193
A.V. Chistyakov, J.F. Soustiel, H. Hafner, M. Elron, and M. Feinsod Altered excitability of the motor cortex after minor head injury revealed by transcranial magnetic stimulation Acta Neurochirurgica 140 5 1998 467 472
V. Di Lazzaro, A. Oliviero, F. Pilato, E. Saturno, M. Dileone, and P. Mazzone The physiological basis of transcranial motor cortex stimulation in conscious humans Clinical Neurophysiology 115 2 2004 255 266
H. Tokimura, V. Di Lazzaro, Y. Tokimura, A. Oliviero, P. Profice, and A. Insola Short latency inhibition of human hand motor cortex by somatosensory input from the hand The Journal of Physiology (London) 523 Pt 2 2000 503 513
R. Nardone, S. Golaszewski, G. Ladurner, F. Tezzon, and E. Trinka A review of transcranial magnetic stimulation in the in vivo functional evaluation of central cholinergic circuits in dementia Dementia and Geriatric Cognitive Disorders 32 1 2011 18 25
F. Manganelli, M. Ragno, G. Cacchio, V. Iodice, L. Trojano, and F. Silvaggio Motor cortex cholinergic dysfunction in CADASIL: a transcranial magnetic demonstration Clinical Neurophysiology 119 2 2008 351 355
N. Lapitskaya, M.R. Coleman, J.F. Nielsen, O. Gosseries, and A.M. de Noordhout Disorders of consciousness: further pathophysiological insights using motor cortex transcranial magnetic stimulation Progress in Brain Research 177 2009 191 200
S.H. Moosavi, P.H. Ellaway, M. Catley, M.J. Stokes, and N. Haque Corticospinal function in severe brain injury assessed using magnetic stimulation of the motor cortex in man Journal of Neurological Sciences 164 2 1999 179 186
J.T. Giacino, S. Ashwal, N. Childs, R. Cranford, B. Jennett, and D.I. Katz The minimally conscious state: definition and diagnostic criteria Neurology 58 3 2002 349 353
Royal College of Physicians The vegetative state: guidance on diagnosis and management Clinical Medicine 3 3 2003 249 254
S. Rossi, M. Hallett, P.M. Rossini, and A. Pascual-Leone Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research Clinical Neurophysiology 120 12 2009 2008 2039
J.T. Giacino, K. Kalmar, and J. Whyte The JFK coma recovery scale-revised: measurement characteristics and diagnostic utility Archives of Physical Medicine and Rehabilitation 85 12 2004 2020 2029
L. Puksa, E. Stalberg, and B. Falck Reference values of F wave parameters in healthy subjects Clinical Neurophysiology 114 6 2003 1079 1090
A. Samii, C.A. Luciano, J.M. Dambrosia, and M. Hallett Central motor conduction time: reproducibility and discomfort of different methods Muscle and Nerve 21 11 1998 1445 1450
P.M. Rossini, A. Berardelli, G. Deuschl, M. Hallett, A.M. Maertens de Noordhout, and W. Paulus Applications of magnetic cortical stimulation. The International Federation of Clinical Neurophysiology Electroencephalography and Clinical Neurophysiology Supplement 52 1999 171 185
G. Abbruzzese, and C. Trompetto Clinical and research methods for evaluating cortical excitability Journal of Clinical Neurophysiology 19 4 2002 307 321
V. Delvaux, G. Alagona, P. Gerard, V. De Pasqua, G. Pennisi, and A.M. de Noordhout Post-stroke reorganization of hand motor area: a 1-year prospective follow-up with focal transcranial magnetic stimulation Clinical Neurophysiology 114 7 2003 1217 1225
G. Pennisi, G. Rapisarda, R. Bella, V. Calabrese, A.M. de Noordhout, and P.J. Delwaide Absence of response to early transcranial magnetic stimulation in ischemic stroke patients - prognostic value for hand motor recovery Stroke 30 12 1999 2666 2670
V. Homberg, K.M. Stephan, and J. Netz Transcranial stimulation of motor cortex in upper motor neuron syndrome: its relation to the motor deficit Electroencephalography and Clinical Neurophysiology 81 5 1991 377 388
V. Di Lazzaro, A. Oliviero, P. Profice, L. Ferrara, E. Saturno, and F. Pilato The diagnostic value of motor evoked potentials Clinical Neurophysiology 110 7 1999 1297 1307
B. De Jonghe, T. Sharshar, J.P. Lefaucheur, F.J. Authier, I. Durand-Zaleski, and M. Boussarsar Paresis acquired in the intensive care unit - a prospective multicenter study JAMA 288 22 2002 2859 2867
S. Bagnato, C. Boccagni, A.S. Angelo, C. Prestandrea, M.C. Ronnano, and G. Galardi Neuromuscular involvement in vegetative and minimally conscious states following acute brain injury Journal of the Peripheral Nervous System 16 4 2011 315 321
M.R. Magistris, K.M. Rosler, A. Truffert, T. Landis, and C.W. Hess A clinical study of motor evoked potentials using a triple stimulation technique Brain 122 1999 265 279
V. Di Lazzaro, A. Oliviero, F. Pilato, P. Mazzone, A. Insola, and F. Ranieri Corticospinal volleys evoked by transcranial stimulation of the brain in conscious humans Neurological Research 25 2 2003 143 150
S. Kloppel, T. Baumer, J. Kroeger, M.A. Koch, C. Buchel, and A. Munchau The cortical motor threshold reflects microstructural properties of cerebral white matter NeuroImage 40 4 2008 1782 1791
H.R. Siebner, and J. Rothwell Transcranial magnetic stimulation: new insights into representational cortical plasticity Experimental Brain Research 148 1 2003 1 16
J. Vallssole, A. Pascualleone, J.P. Brasilneto, A. Cammarota, L. McShane, and M. Hallett Abnormal facilitation of the response to transcranial magnetic stimulation in patients with Parkinsons disease Neurology 44 4 1994 735 741
V. Di Lazzaro, P. Profice, F. Pilato, F. Capone, F. Ranieri, and L. Florio The level of cortical afferent inhibition in acute stroke correlates with long-term functional recovery in humans Stroke 43 1 2012 250 U493
V. Di Lazzaro, A. Oliviero, P.A. Tonali, C. Marra, A. Daniele, and P. Profice Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation Neurology 59 3 2002 392 397
V. Di Lazzaro, F. Pilato, M. Dileone, E. Saturno, A. Oliviero, and C. Marra In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias Neurology 66 7 2006 1111 1113
A. Oliviero, A.M. Leon, I. Holler, J.F. Vila, H.R. Siebner, and G. Della Marca Reduced sensorimotor inhibition in the ipsilesional motor cortex in a patient with chronic stroke of the paramedian thalamus Clinical Neurophysiology 116 11 2005 2592 2598
N.R. Selden, D.R. Gitelman, N. Salamon-Murayama, T.B. Parrish, and M.M. Mesulam Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain Brain 121 1998 2249 2257
N. Lapitskaya, S.K. Moerk, O. Gosseries, J.F. Nielsen, and A.M. de Noordhout Corticospinal excitability in patients with anoxic, traumatic, and non-traumatic diffuse brain injury Brain Stimul 6 2 2013 130 137
S. Bagnatoa, C. Boccagnia, A. Sant'Angeloa, C. Prestandreaa, S. Rizzob, and G. Galardi Patients in a vegetative state following traumatic brain injury display a reduced intracortical modulation Clinical Neurophysiology 123 10 2012 1937 1941 http://dx.doi.org/10.1016/j.clinph.2012.03.014
V. Di Lazzaro, F. Pilato, M. Dileone, P. Pfofice, C. Marra, and F. Ranieri In vivo functional evaluation of central cholinergic circuits in vascular dementia Clinical Neurophysiology 119 11 2008 2494 2500
R. Nardone, J. Bergmann, F. Tezzon, G. Ladurner, and S. Golaszewski Cholinergic dysfunction in subcortical ischaemic vascular dementia: a transcranial magnetic stimulation study Journal of Neural Transmission 115 5 2008 737 743
R. Nardone, P. De Blasi, M. Seidl, Y. Holler, F. Caleri, and F. Tezzon Cognitive function and cholinergic transmission in patients with subcortical vascular dementia and microbleeds: a TMS study Journal of Neural Transmission 118 9 2011 1349 1358
C.A. Masanic, M.T. Bayley, R. vanReekum, and M. Simard Open-label study of donepezil in traumatic brain injury Archives of Physical Medicine and Rehabilitation 82 7 2001 896 901
J.P. Taverni, G. Seliger, and S.W. Lichtman Donepezil mediated memory improvement in traumatic brain injury during post acute rehabilitation Brain Injury 12 1 1998 77 80
V. Di Lazzaro, A. Oliviero, E. Saturno, M. Dileone, F. Pilato, and R. Nardone Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans Journal of Physiology (London) 564 2 2005 661 668
W. Paulus, J. Classen, L.G. Cohen, C.H. Large, V. Di Lazzaro, and M. Nitsche State of the art: pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation Brain Stimul 1 3 2008 151 163
C. Babiloni, M. Pievani, F. Vecchio, C. Geroldi, F. Eusebi, and C. Fracassi White-matter lesions along the cholinergic tracts are related to cortical sources of EEG rhythms in amnesic mild cognitive impairment Human Brain Mapping 30 5 2009 1431 1443
D. Fernandez-Espejo, T. Bekinschtein, M.M. Monti, J.D. Pickard, C. Junque, and M.R. Coleman Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious state NeuroImage 54 1 2011 103 112
S. Laureys, S. Goldman, C. Phillips, P. Van Bogaert, J. Aerts, and A. Luxen Impaired effective cortical connectivity in vegetative state NeuroImage 9 4 1999 377 382
S. Laureys The neural correlate of (un)awareness: lessons from the vegetative state Trends in Cognitive Sciences 9 12 2005 556 559
M. Boly, M.I. Garrido, O. Gosseries, M.A. Bruno, P. Boveroux, and C. Schnakers Preserved feedforward but impaired top-down processes in the vegetative state Science 332 6031 2011 858 862
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