Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration.

Aged; Basal Ganglia/metabolism/radionuclide imaging; Brain Diseases/metabolism/radionuclide imaging; Corticobasal degeneration; Dopaminergic pathway; Glucose metabolism; Cerebral Cortex/metabolism/radionuclide imaging; Positron emission tomography; Dihydroxyphenylalanine/analogs & derivatives/pharmacokinetics; Parkinson's disease; Female; Fluorodeoxyglucose F18/pharmacokinetics; Glucose/metabolism; Humans; Male; Middle Aged; Nerve Degeneration/metabolism/radionuclide imaging; Parkinson Disease/metabolism/radionuclide imaging; Radiopharmaceuticals/pharmacokinetics; Reference Values; Tissue Distribution; Tomography, Emission-Computed

Abstract :

[en] Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages of corticobasal degeneration (CBD) and compared to Parkinson's disease (PD) patients with a similar degree of bradykinesia and rigidity and to healthy controls. Statistical parametric mapping analysis comparing CBD to controls showed metabolic decrease in premotor, primary motor, supplementary motor, primary sensory, prefrontal, and parietal associative cortices, and in caudate and thalamus contralateral to the side of clinical signs. Except for the prefrontal regions a similar metabolic pattern was observed when CBD was compared to PD. Putamen FDOPA uptake was decreased in both CBD and PD. Caudate FDOPA uptake in CBD patients was decreased contralateral to clinical signs when compared to controls, but was higher than in PD. In early stages of CBD, FDOPA and FDG PET patterns differed from those observed in PD. In CBD the asymmetry in FDOPA uptake was less pronounced than that of clinical signs or metabolic impairment.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurosciences & behavior
Neurology
Radiology, nuclear medicine & imaging

Author, co-author :

Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron - Département des sciences cliniques > Neurologie

Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie

Garraux, Gaëtan ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie

Peigneux, Philippe ; Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives

Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Franck, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Language :

English

Title :

Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration.

Publication date :

1999

Journal title :

Journal of Neurology

ISSN :

0340-5354

eISSN :

1432-1459

Publisher :

Springer Science & Business Media B.V., Darmstadt, Germany

Volume :

246

Issue :

Pages :

1151-8

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.springerlink.com/content/dnbx5t1wpe6mjtbd/

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 16 April 2009

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