Reference : A theoretically based index of consciousness independent of sensory processing and be...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/171542
A theoretically based index of consciousness independent of sensory processing and behavior
English
Casali, AG [> >]
Gosseries, Olivia mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Rosanova, M [> >]
Boly, M [> >]
Sarasso, S [> >]
Casali, KR [> >]
Casarotto, S [> >]
Bruno, Marie-Aurélie mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Laureys, Steven mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Tononi, G [> >]
Massimini, M [> >]
14-Aug-2013
Science Translational Medicine
5
Yes (verified by ORBi)
International
1946-6234
1946-6242
[en] adult ; anesthesia ; brain cortex ; brain function ; brain injury ; Anesthetics ; consciousness ; coma
[en] One challenging aspect of the clinical assessment of brain-injured, unresponsive patients is the lack of an objective measure of consciousness that is independent of the subject's ability to interact with the external environment. Theoretical considerations suggest that consciousness depends on the brain's ability to support complex activity patterns that are, at once, distributed among interacting cortical areas (integrated) and differentiated in space and time (information-rich). We introduce and test a theory-driven index of the level of consciousness called the perturbational complexity index (PCI). PCI is calculated by (i) perturbing the cortex with transcranial magnetic stimulation (TMS) to engage distributed interactions in the brain (integration) and (ii) compressing the spatiotemporal pattern of these electrocortical responses to measure their algorithmic complexity (information). We test PCI on a large data set of TMS-evoked potentials recorded in healthy subjects during wakefulness, dreaming, nonrapid eye movement sleep, and different levels of sedation induced by anesthetic agents (midazolam, xenon, and propofol), as well as in patients who had emerged from coma (vegetative state, minimally conscious state, and locked-in syndrome). PCI reliably discriminated the level of consciousness in single individuals during wakefulness, sleep, and anesthesia, as well as in patients who had emerged from coma and recovered a minimal level of consciousness. PCI can potentially be used for objective determination of the level of consciousness at the bedside
Centre de Recherches du Cyclotron - CRC
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/171542
10.1126/scitranslmed.3006294
http://www.scopus.com/record/display.url?eid=2-s2.0-84883894654&origin=inward&txGid=EAC9A70E1005EEF9B191D83D8500A8DF.iqs8TDG0Wy6BURhzD3nFA%3a1

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