Reference : Brain metabolism but not grey matter volume underlies the presence of language functi...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/242793
Brain metabolism but not grey matter volume underlies the presence of language function in the minimally conscious state
English
Aubinet, Charlène mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Cassol, Helena mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Gosseries, Olivia mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Bahri, Mohamed Ali mailto [Université de Liège - ULiège > > CRC In vivo Imaging-Aging & Memory >]
Larroque, Stephen Karl mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Majerus, Steve mailto [Université de Liège - ULiège > Département de Psychologie > Département de Psychologie >]
Martial, Charlotte mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Martens, Géraldine mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Carrière, Manon mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Chatelle, Camille mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
LAUREYS, Steven mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre intégré pluridisc. étude cerveau-cognition-conscience >]
Thibaut, Aurore mailto [Université de Liège - ULiège > > Consciousness-Coma Science Group >]
Jan-2020
Neurorehabilitation and Neural Repair
SAGE Science Press
34
2
172-184
Yes (verified by ORBi)
International
1545-9683
1552-6844
CA
[en] Background. The minimally conscious state (MCS) is subcategorized into MCS- and MCS+, depending on the absence or presence of high-level behavioral responses such as command following. Objective. We aim to investigate the functional and structural neuroanatomy underlying the presence of these responses in MCS- and MCS+ patients. Methods. In this cross-sectional retrospective study, chronic MCS patients were diagnosed using repeated Coma Recovery Scale-Revised assessments. Fluorodeoxyglucose-positron emission tomography data were acquired on 57 patients (16 MCS-; 41 MCS+) and magnetic resonance imaging with voxel-based morphometry analysis was performed on 66 patients (17 MCS-; 49 MCS+). Brain glucose metabolism and grey matter integrity were compared between patient groups and control groups. A metabolic functional connectivity analysis testing the hypothesis of preserved language network in MCS+ compared to MCS- was also done. Results. Patients in MCS+ presented higher metabolism mainly in the left middle temporal cortex, known to be important for semantic processing, compared to the MCS- group. The left angular gyrus was also functionally disconnected from the left prefrontal cortex in MCS- compared to MCS+. No significant differences were found in grey matter volume between patient groups. Conclusions. The clinical sub-categorization of MCS is supported by differences in brain metabolism but not in grey matter structure, suggesting that brain function in the language network is the main support for recovery of command-following, intelligible verbalization and/or intentional communication in the MCS. Better characterizing the neural correlates of residual cognitive abilities of MCS patients contributes to reduce their misdiagnosis and to adapt therapeutic approaches.
http://hdl.handle.net/2268/242793

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