Article (Scientific journals)
Nonequilibrium brain dynamics as a signature of consciousness.
Sanz Perl, Yonatan; Bocaccio, Hernán; Pallavicini, Carla et al.
2021In Physical Review. E, 104 (1-1), p. 014411
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Keywords :
Propofol; Animals; Brain; Unconsciousness; Wakefulness; Consciousness; Brain dynamics; Cognitive functions; Electrocorticography; Entropy production; Functional magnetic resonance imaging; Non equilibrium; Non-human primate; Probability flux; Statistical and Nonlinear Physics; Statistics and Probability; Condensed Matter Physics; Quantitative Biology - Neurons and Cognition
Abstract :
[en] The cognitive functions of human and nonhuman primates rely on the dynamic interplay of distributed neural assemblies. As such, it seems unlikely that cognition can be supported by macroscopic brain dynamics at the proximity of equilibrium. We confirmed this hypothesis by investigating electrocorticography data from nonhuman primates undergoing different states of unconsciousness (sleep, and anesthesia with propofol, ketamine, and ketamine plus medetomidine), and functional magnetic resonance imaging data from humans, both during deep sleep and under propofol anesthesia. Systematically, all states of reduced consciousness unfolded at higher proximity to equilibrium compared to conscious wakefulness, as demonstrated by the computation of entropy production and the curl of probability flux in phase space. Our results establish nonequilibrium macroscopic brain dynamics as a robust signature of consciousness, opening the way for the characterization of cognition and awareness using tools from statistical mechanics.
Disciplines :
Neurology
Author, co-author :
Sanz Perl, Yonatan ;  Universidad de San Andrés, Buenos Aires, B1644BID, Argentina ; Physics Department, University of Buenos Aires, and Buenos Aires Physics Institute, Buenos Aires 1428, Argentina ; Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona 08002, Spain
Bocaccio, Hernán ;  Physics Department, University of Buenos Aires, and Buenos Aires Physics Institute, Buenos Aires 1428, Argentina
Pallavicini, Carla;  Physics Department, University of Buenos Aires, and Buenos Aires Physics Institute, Buenos Aires 1428, Argentina
Pérez-Ipiña, Ignacio;  Physics Department, University of Buenos Aires, and Buenos Aires Physics Institute, Buenos Aires 1428, Argentina
LAUREYS, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau²
Laufs, Helmut ;  Department of Neurology, Christian Albrechts University Kiel, 24118 Kiel, Germany
Kringelbach, Morten ;  Department of Psychiatry, University of Oxford, Oxford OX12JD, United Kingdom
Deco, Gustavo;  Center for Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona 08002, Spain
Tagliazucchi, Enzo;  Physics Department, University of Buenos Aires, and Buenos Aires Physics Institute, Buenos Aires 1428, Argentina ; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago 7910000, Chile
Language :
English
Title :
Nonequilibrium brain dynamics as a signature of consciousness.
Publication date :
July 2021
Journal title :
Physical Review. E
ISSN :
2470-0045
eISSN :
2470-0053
Publisher :
American Physical Society, United States
Volume :
104
Issue :
1-1
Pages :
014411
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ANPCyT - Agencia Nacional de Promoción Científica y Tecnológica [AR]
Funding text :
The authors acknowledge funding from Agencia Nacional De Promoción Científica Y Tecnológica (Argentina), Grant No. PICT-2018-03103.
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since 07 November 2022

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