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Brain alterations in disorders of consciousness: a coordinate-based metaanalysis
Sala, Arianna; Kaan, Baris; Alnagger, Naji et al.
2023In European Journal of Neurology, 30 (Supplement 1), p. 120-187
Editorial reviewed
 

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Abstract :
[en] Introduction We aim to shed light on the localization of brain alterations in Disorders of Consciousness (DoC), by quantitatively synthesizing existing structural, functional and molecular evidence in patients with unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Methods In January 2022, we used MEDLINE, Scopus and Embase to search for resting-state MRI and PET studies, involving adults with prolonged DoC, diagnosed based on a validated behavioural scale. Two referees independently screened studies and extracted coordinates of whole-brain, voxel-based comparisons between groups of patients and controls or patients subgroups. Coordinate-based meta-analysis was performed via activation likelihood estimation. The full protocol is available on PROSPERO (CRD42022327151). Results As of January 2023, of the resulting 2045 MRI and 753 PET studies, 15 MRI and 18 PET studies met criteria for inclusion, for a total of 454 UWS and 572 MCS patients and 277 controls (Fig. 1). The primary analysis, including studies comparing DoC patients vs. controls, revealed brain alterations in cortical regions, medially (precuneus, posterior/middle cingulate gyrus) and laterally (angular gyri, inferior parietal lobules), and in subcortical regions (dorsomedial thalami and head of caudate nuclei) (Fig. 2). Contrast analysis of UWS and MCS results revealed stronger brain alterations in UWS in the precuneus, posterior/middle cingulate gyrus, right angular gyrus and inferior parietal lobule, and dorsomedial thalami. Conclusions This meta-analysis provides the most extensive evidence to date on brain alterations in DoC, pointing at a specific set of regions, at cortical and subcortical level, as anatomical basis for DoC, with stronger alterations in UWS compared to MCS.
Disciplines :
Neurology
Author, co-author :
Sala, Arianna  ;  Université de Liège - ULiège > Département des sciences cliniques
Kaan, Baris
Alnagger, Naji ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Abagnale, Simona ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Meys, Michiel  ;  Université de Liège - ULiège > GIGA
Wang, Zhixin
Bardiau, Marjorie  ;  Université de Liège - ULiège > CARE "ULiège Library" > ULiège Library : Sciences de la Santé
Eickhoff, Simon
Tettamanti, Marco
Laureys, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau² ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Annen, Jitka  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
More authors (3 more) Less
Language :
English
Title :
Brain alterations in disorders of consciousness: a coordinate-based metaanalysis
Publication date :
2023
Journal title :
European Journal of Neurology
ISSN :
1351-5101
eISSN :
1468-1331
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
30
Issue :
Supplement 1
Pages :
120-187
Peer reviewed :
Editorial reviewed
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since 05 August 2023

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