Explaining Outcome Differences between Men and Women following Mild Traumatic Brain  Injury.

[en] Men and women differ in outcomes following mild traumatic brain injury (TBI). In the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, we previously found that women had worse 6-month functional outcome (Glasgow Outcome Score Extended [GOSE]), health-related quality of life (HRQoL), and mental health following mild TBI. The aim of this study was to investigate whether those differences were mediated by psychiatric history, gender-related sociodemographic variables, or by care pathways. We analyzed sex/gender differences in 6-month GOSE, generic and TBI-specific HRQoL, and post-concussion and mental health symptoms using three sets of mediators: psychiatric history, sociodemographic variables (living alone, living with children, education and employment status/job category), and care-pathways (referral to study hospital and discharge destination after emergency department); while controlling for a substantial number of potential confounders (pre-injury health and injury-related characteristics). We included 1842 men and 1022 women (16+) with a Glasgow Coma Score 13-15, among whom 83% had GOSE available and about 60% other 6-month outcomes. We used natural effects models to decompose the total effect of sex/gender on the outcomes into indirect effects that passed through the specified mediators and the remaining direct effects. In our study population, women had worse outcomes and these were only partly explained by psychiatric history, and not considerably explained by sociodemographic variables nor by care pathways. Factors other than differences in specified variables seem to underlie observed differences between men and women in outcomes after mild TBI. Future studies should explore more aspects of gender roles and identity and biological factors underpinning sex and gender differences in TBI outcomes.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Mikolic, Ana; Department of Public Health, Erasmus MC-University Medical Center, Rotterdam, the

Groeniger, Joost Oude; Department of Public Health, Erasmus MC-University Medical Center, Rotterdam, the ; Department of Public Administration and Sociology, Erasmus University, Rotterdam,

Zeldovich, Marina; Institute of Medical Psychology and Medical Sociology, Georg-August-University,

Wilson, Lindsay; Division of Psychology, University of Stirling, Stirling, United Kingdom.

van Lennep, Jeanine Roeters; Department of Internal Medicine, Erasmus MC-University Medical Center, Rotterdam,

van Klaveren, David; Department of Public Administration and Sociology, Erasmus University, Rotterdam, ; Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical

Polinder, Suzanne; Department of Public Health, Erasmus MC-University Medical Center, Rotterdam, the

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury

Other collaborator :

Åkerlund, Cecilia

Amrein, Krisztina

Andreassen, Lasse

Anke, Audny

Antoni, Anna

Audibert, Gérard

Azouvi, Philippe

Azzolini, Maria Luisa

Bartels, Ronald

Barzó, Pál

More authors (233 more)

Language :

English

Title :

Explaining Outcome Differences between Men and Women following Mild Traumatic Brain Injury.

Publication date :

December 2021

Journal title :

Journal of Neurotrauma

ISSN :

0897-7151

eISSN :

1557-9042

Volume :

Issue :

Pages :

3315-3331

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 March 2022

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