Neuroimaging after coma.

Brain/pathology/physiopathology; Coma/diagnosis/pathology/physiopathology; Consciousness/physiology; Consciousness Disorders/diagnosis/pathology/physiopathology; Humans; Magnetic Resonance Imaging; Neural Pathways/pathology/physiopathology

Abstract :

[en] Following coma, some patients will recover wakefulness without signs of consciousness (only showing reflex movements, i.e., the vegetative state) or may show non-reflex movements but remain without functional communication (i.e., the minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state (Schnakers et. al. BMC Neurol, 9:35, 8) and the clinical and electrophysiological markers of outcome from the vegetative and minimally conscious states remain unsatisfactory. This should incite clinicians to use multimodal assessment to detect objective signs of consciousness and validate para-clinical prognostic markers in these challenging patients. This review will focus on advanced magnetic resonance imaging (MRI) techniques such as magnetic resonance spectroscopy, diffusion tensor imaging, and functional MRI (fMRI studies in both "activation" and "resting state" conditions) that were recently introduced in the assessment of patients with chronic disorders of consciousness.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Tshibanda, Luaba ; Centre Hospitalier Universitaire de Liège - CHU > Coma Science Group > Imagerie médicale

Vanhaudenhuyse, Audrey ; Université de Liège - ULiège > Coma Science Group > Centre de recherches du cyclotron

Boly, Mélanie ; Université de Liège - ULiège > Centre de Recherches du Cyclotron -Département des sciences cliniques > Coma Group - Neurologie

Soddu, Andrea ; Université de Liège - ULiège > Centre de recherches du cyclotron

Bruno, Marie-Aurélie ; Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science Group

Moonen, Gustave ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Laureys, Steven ; Université de Liège - ULiège > Coma Science group > Centre de recherches du cyclotron - Département des sciences cliniques

Noirhomme, Quentin ; Université de Liège - ULiège > Coma Science Group > Centre de recherches du cyclotron

Language :

English

Title :

Neuroimaging after coma.

Publication date :

2010

Journal title :

Neuroradiology

ISSN :

0028-3940

eISSN :

1432-1920

Publisher :

Springer Science & Business Media B.V., New York, United States - New York

Volume :

Issue :

Pages :

15-24

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
European Commission DISCOS, Mindbridge, DECODER & CATIA
Concerted Research Action
JSMF - James S McDonnell Foundation
MSF - Mind Science Foundation

Available on ORBi :

since 06 February 2011

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