Article (Scientific journals)
Detecting consciousness in a total Locked-in syndrome: an active event related paradigm
Schnakers, Caroline; Perrin, Fabien; Schabus, Manuel et al.
2009In Neurocase: Case Studies in Neuropsychology, Neuropsychiatry and Behavioural Neurology, 25, p. 1-7
Peer Reviewed verified by ORBi
 

Files


Full Text
Schnakers_et_al_(2009).pdf
Publisher postprint (197.58 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Locked-in syndrome; Consciousness; Brain injury; Evoked potentials; Tetraplegia
Abstract :
[en] Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. In this study, consciousness was detected in a 21-year-old woman who presented a total locked-in syndrome after a basilar artery thrombosis (49 days post-injury) using an active event-related paradigm. The patient was presented sequences of names containing the patient's own name and other names. The patient was instructed to count her own name or to count another target name. Similar to 4 age- and gender-matched healthy controls, the P3 response recorded for the voluntarily counted own name was larger than while passively listening. This P3 response was observed 14 days before the first behavioral signs of consciousness. This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose.
Disciplines :
Neurology
Author, co-author :
Schnakers, Caroline ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Perrin, Fabien
Schabus, Manuel
Hustinx, Roland  ;  Université de Liège - ULiège > Médecine nucléaire
Majerus, Steve  ;  Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Moonen, Gustave  ;  Université de Liège - ULiège > Neurologie Sart Tilman
Boly, Mélanie ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bruno, Marie-Aurélie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Neurologie Sart Tilman
Language :
English
Title :
Detecting consciousness in a total Locked-in syndrome: an active event related paradigm
Publication date :
2009
Journal title :
Neurocase: Case Studies in Neuropsychology, Neuropsychiatry and Behavioural Neurology
ISSN :
1355-4794
eISSN :
1465-3656
Publisher :
Psychology Press (UK), Lisse, Netherlands
Volume :
25
Pages :
1-7
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
French Speaking Community of Belgium Concerted Research Action
JSMF - James S McDonnell Foundation [US-MO]
EU - European Commission
MSF - Mind Science Foundation [US-TX]
Available on ORBi :
since 19 February 2010

Statistics


Number of views
297 (21 by ULiège)
Number of downloads
1346 (14 by ULiège)

Scopus citations®
 
114
Scopus citations®
without self-citations
55
OpenCitations
 
91

Bibliography


Similar publications



Contact ORBi