Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy

[en] Background: Impaired consciousness has been associated with impaired cortical signal propagation after transcranial magnetic stimulation (TMS). We hypothesised that the reduced current propagation under propofol-induced unresponsiveness is associated with changes in both feedforward and feedback connectivity across the cortical hierarchy. Methods: Eight subjects underwent left occipital TMS coupled with high-density EEG recordings during wakefulness and propofol-induced unconsciousness. Spectral analysis was applied to responses recorded from sensors overlying six hierarchical cortical sources involved in visual processing. Dynamic causal modelling (DCM) of induced time–frequency responses and evoked response potentials were used to investigate propofol's effects on connectivity between regions. Results: Sensor space analysis demonstrated that propofol reduced both induced and evoked power after TMS in occipital, parietal, and frontal electrodes. Bayesian model selection supported a DCM with hierarchical feedforward and feedback connections. DCM of induced EEG responses revealed that the primary effect of propofol was impaired feedforward responses in cross-frequency theta/alpha–gamma coupling and within frequency theta coupling (F contrast, family-wise error corrected P<0.05). An exploratory analysis (thresholded at uncorrected P<0.001) also suggested that propofol impaired feedforward and feedback beta band coupling. Post hoc analyses showed impairments in all feedforward connections and one feedback connection from parietal to occipital cortex. DCM of the evoked response potential showed impaired feedforward connectivity between left-sided occipital and parietal cortex (T contrast P=0.004, Bonferroni corrected). Conclusions: Propofol-induced loss of consciousness is associated with impaired hierarchical feedforward connectivity assessed by EEG after occipital TMS. © 2018 British Journal of Anaesthesia

Disciplines :

Neurosciences & behavior

Author, co-author :

Sanders, R. D.; Department of Anesthesiology, University of Wisconsin, Madison, WI, United States

Banks, M. I.; Department of Anesthesiology, University of Wisconsin, Madison, WI, United States

Darracq, M.; Department of Anesthesiology, University of Wisconsin, Madison, WI, United States

Moran, R.; Faculty of Engineering, University of Bristol, Bristol, United Kingdom

Sleigh, J.; Department of Anaesthesia, Waikato Hospital, Hamilton, New Zealand

Gosseries, Olivia ; Université de Liège - ULiège > GIGA : Coma Group

BONHOMME, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Brichant, Jean-François ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation

Rosanova, Mario; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy

Raz, A.; Department of Anesthesiology, University of Wisconsin, Madison, WI, United States, Rambam Healthcare Campus, Haifa, Israel

More authors (4 more)

Language :

English

Title :

Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy

Publication date :

2018

Journal title :

British Journal of Anaesthesia

ISSN :

0007-0912

eISSN :

1471-6771

Publisher :

Elsevier Ltd

Volume :

121

Issue :

Pages :

1084-1096

Peer reviewed :

Peer Reviewed verified by ORBi

European Projects :

H2020 - 720270 - HBP SGA1 - Human Brain Project Specific Grant Agreement 1

Name of the research project :

ARC-06/11-340

Funders :

Orion Pharma
Philips Healthcare
University of Wisconsin
NIH - National Institutes of Health
Italian Ministry of Health
JSMF - James S McDonnell Foundation
F.R.S.-FNRS - Fonds de la Recherche Scientifique
MSF - Mind Science Foundation
FWB - Fédération Wallonie-Bruxelles
ULiège - Université de Liège
CHU Liège - Centre Hospitalier Universitaire de Liège
CE - Commission Européenne

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since 04 January 2019

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