[en] The relationship between the Bispectral Index (BIS), an EEG-based monitor of anesthesia, and brain activity is still unclear. This study aimed at investigating the relationship between changes in BIS values during natural sleep and regional cerebral blood flow (rCBF) variations, as measured by Positron Emission Tomography (PET). Data were obtained from six young, healthy, right-handed, male volunteers (20-30 years old) using the H2(15)O infusion method. PET scans were performed both during waking and various stages of sleep. BIS values were monitored continuously and recorded during each PET scan. Positive correlations were detected between BIS and rCBF values in dorsolateral prefontal, parietal, anterior and posterior cingulate, precuneal, mesiofrontal, mesiotemporal and insular cortices. These areas belong to a frontoparietal network known to be related to awareness of self conscious sensory perception, attention and memory. BIS values also positively correlated with activity in brainstem and thalami, both structures known to be involved in arousal and wakefulness. These results show that BIS changes associated with physiological sleep depth co-vary with the activity of specific cortical and subcortical areas. The latter are known to modulate arousal, which in turn allows sustained thalamo-cortical enhancement of activity in a specific frontoparietal network known to be related to the content of consciousness. Thus, although mainly derived from frontal EEG, BIS could represent a wider index of cerebral activity.
Disciplines :
Neurology
Author, co-author :
Noirhomme, Quentin ; Université de Liège - ULiège > Centre de recherches du cyclotron
Boly, Mélanie ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Bonhomme, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Boveroux, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Centre de Recherches du Cyclotron > Anesthésie et réanimation
Phillips, Christophe ; Université de Liège - ULiège > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore)
Soddu, Andrea ; Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Moonen, Gustave ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Maquet, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Centre de Recherches du Cyclotron > Neurologie Sart Tilman
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron - Département des sciences cliniques
Language :
English
Title :
Bispectral index correlates with regional cerebral blood flow during sleep in distinct cortical and subcortical structures in humans.
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