Article (Scientific journals)
Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness.
Panda, Rajanikant; López-González, Ane; Gilson, Matthieu et al.
2023In Human Brain Mapping
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Keywords :
broadcasting of information; disorders of consciousness; in-silico exogenous perturbations; integration of information; Neurology (clinical); Neurology; Radiology, Nuclear Medicine and imaging; Radiological and Ultrasound Technology; Anatomy
Abstract :
[en] The study of the brain's dynamical activity is opening a window to help the clinical assessment of patients with disorders of consciousness. For example, glucose uptake and the dysfunctional spread of naturalistic and synthetic stimuli has proven useful to characterize hampered consciousness. However, understanding of the mechanisms behind loss of consciousness following brain injury is still missing. Here, we study the propagation of endogenous and in-silico exogenous perturbations in patients with disorders of consciousness, based upon directed and causal interactions estimated from resting-state fMRI data, fitted to a linear model of activity propagation. We found that patients with disorders of consciousness suffer decreased capacity for neural propagation and responsiveness to events, and that this can be related to severe reduction of glucose metabolism as measured with [18 F]FDG-PET. In particular, we show that loss of consciousness is related to the malfunctioning of two neural circuits: the posterior cortical regions failing to convey information, in conjunction with reduced broadcasting of information from subcortical, temporal, parietal and frontal regions. These results shed light on the mechanisms behind disorders of consciousness, triangulating network function with basic measures of brain integrity and behavior.
Disciplines :
Neurology
Author, co-author :
Panda, Rajanikant   ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
López-González, Ane ;  Center for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain
Gilson, Matthieu;  Center for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain ; Institut des Neurosciences des Systemes, INSERM-AMU, Marseille, France
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Frasso, Gianluca;  Wageningen Food Safety Research, Wageningen, The Netherlands
Cecconi, Benedetta  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Escrichs, Anira;  Center for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain
Coma Science Group Collaborators
Deco, Gustavo;  Center for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain ; Institució Catalana de la Recerça i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain ; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany ; School of Psychological Sciences, Monash University, Victoria, Australia
Laureys, Steven  ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau² ; CERVO Research Center, Laval University, Québec, Quebec, Canada
Zamora-López, Gorka ;  Center for Brain and Cognition, Department of Information and Communication Technologies, Pompeu Fabra University, Barcelona, Spain
Annen, Jitka   ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
More authors (3 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Whole-brain analyses indicate the impairment of posterior integration and thalamo-frontotemporal broadcasting in disorders of consciousness.
Publication date :
31 May 2023
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
Wiley, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
AstraZeneca [BE]
BELSPO - Belgian Federal Science Policy Office [BE]
ESA - European Space Agency [FR]
Fonds Léon Fredericq [BE]
Fundação BIAL [PT]
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since 02 July 2023

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