Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness

Murovec, Nensi; Heilinger, Alexander; Xu, Ren; Ortner, Rupert; Spataro, Rossella; La Bella, Vincenzo; Miao, Yangyang; Jin, Jing; Chatelle, Camille; Laureys, Steven; Allison, Brendan Z.; Guger, Christoph

doi:10.3389/fnins.2020.00294

Article (Scientific journals)

Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness

Murovec, Nensi; Heilinger, Alexander; Xu, Ren et al.

2020 • In Frontiers in Neuroscience, 14

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/249249

DOI
10.3389/fnins.2020.00294

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Keywords :

BCI performance; CRS-R; P300 event-related potential

Abstract :

[en] Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients’ cognitive functions and command following abilities. 20 DOC patients participated in the study and performed 10 vibro-tactile P300 BCI sessions over 10 days with 8–12 runs each day. Vibrotactile tactors were placed on the each patient’s left and right wrists and one foot. Patients were instructed, via earbuds, to concentrate and silently count vibrotactile pulses on either their left or right wrist that presented a target stimulus and to ignore the others. Changes of the BCI classification accuracy were investigated over the 10 days. In addition, the Coma Recovery Scale-Revised (CRS-R) score was measured before and after the 10 vibro-tactile P300 sessions. In the first run, 10 patients had a classification accuracy above chance level (>12.5%). In the best run, every patient reached an accuracy ≥60%. The grand average accuracy in the first session for all patients was 40%. In the best session, the grand average accuracy was 88% and the median accuracy across all sessions was 21%. The CRS-R scores compared before and after 10 VT3 sessions for all 20 patients, are showing significant improvement (p = 0.024). Twelve of the twenty patients showed an improvement of 1 to 7 points in the CRS-R score after the VT3 BCI sessions (mean: 2.6). Six patients did not show a change of the CRS-R and two patients showed a decline in the score by 1 point. Every patient achieved at least 60% accuracy at least once, which indicates successful command following. This shows the importance of repeated measures when DOC patients are assessed. The improvement of the CRS-R score after the 10 VT3 sessions is an important issue for future experiments to test the possible therapeutic applications of vibro-tactile and related BCIs with a larger patient group. © Copyright © 2020 Murovec, Heilinger, Xu, Ortner, Spataro, La Bella, Miao, Jin, Chatelle, Laureys, Allison and Guger.

Research Center/Unit :

CHU de Liège-Centre du Cerveau² - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Murovec, Nensi; g. tec Medical Engineering GmbH, Schiedlberg, Austria, Guger Technologies OG, Graz, Austria

Heilinger, Alexander; g. tec Medical Engineering GmbH, Schiedlberg, Austria

Xu, Ren; Guger Technologies OG, Graz, Austria

Ortner, Rupert; g. tec Medical Engineering Spain S.L, Barcelona, Spain

Spataro, Rossella; g. tec Medical Engineering GmbH, Schiedlberg, Austria, IRCCS Centro Neurolesi Bonino Pulejo, Palermo, Italy

La Bella, Vincenzo; ALS Clinical Research Center, Bi.N.D, University of Palermo, Palermo, Italy

Miao, Yangyang; Department of Automation, East China University of Science and Technology, Shanghai, China

Jin, Jing; Department of Automation, East China University of Science and Technology, Shanghai, China

Chatelle, Camille ; GIGA Consciousness, Coma Science Group, University of Liège, Liège, Belgium

Laureys, Steven ; Université de Liège - ULiège > GIGA Consciousness-Coma Science Group

Allison, Brendan Z.; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, United States

Guger, Christoph; g. tec Medical Engineering GmbH, Schiedlberg, Austria, Guger Technologies OG, Graz, Austria

Language :

English

Title :

Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness

Publication date :

2020

Journal title :

Frontiers in Neuroscience

ISSN :

1662-4548

eISSN :

1662-453X

Publisher :

Frontiers Media S.A.

Volume :

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

247919 - DECODER; H2020-MSCA-IF-2016-ADOC-752686

Funders :

EC - European Commission
F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

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