Article (Scientific journals)
Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
Cavaliere, Carlo; Aiello, Marco; Di Perri, Carol et al.
2016In Frontiers in Cellular Neuroscience
Peer Reviewed verified by ORBi


Full Text
Publisher postprint (1.17 MB)

All documents in ORBi are protected by a user license.

Send to


Abstract :
[en] Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS.
Disciplines :
Author, co-author :
Cavaliere, Carlo ;  Université de Liège - ULiège > Doct. sc. méd. (paysage)
Aiello, Marco
Di Perri, Carol ;  Université de Liège > GIGA : Coma Group
Amico, Enrico
Martial, Charlotte  ;  Université de Liège > GIGA : Coma Group
Thibaut, Aurore ;  Université de Liège > GIGA : Coma Group
Laureys, Steven  ;  Université de Liège > GIGA : Coma Group
Soddu, Andrea ;  Université de Liège > Centre de recherches du cyclotron
Language :
Title :
Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
Publication date :
November 2016
Journal title :
Frontiers in Cellular Neuroscience
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 March 2017


Number of views
112 (12 by ULiège)
Number of downloads
167 (3 by ULiège)

Scopus citations®
Scopus citations®
without self-citations


Similar publications

Contact ORBi