Article (Scientific journals)
Decreased evoked slow-activity after tDCS in disorders of consciousness
Mensen, Armand; BODART, Olivier; Thibaut, Aurore et al.
2020In Frontiers in Systems Neuroscience, 14 (62)
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Keywords :
Disorders of consciousness; transcranial direct current stimulation; transcranial magnetic stimulation; electroencephalography; bistability; slow activity
Abstract :
[en] Due to life-saving medical advances, the diagnosis and treatment of disorders of consciousness (DOC) has become a more commonly occurring clinical issue. One recently developed intervention option has been non-invasive transcranial direct current stimulation. This dichotomy of patient responders may be better understood by investigating the mechanism behind the transcranial direct current stimulation (tDCS) intervention. The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has been an important diagnostic tool in DOC patients. We therefore examined the neural response using TMS-EEG both before and after tDCS in seven DOC patients (four diagnosed as in a minimally conscious state and three with unresponsive wakefulness syndrome). tDCS was applied over the dorsolateral prefrontal cortex, while TMS pulses were applied to the premotor cortex. None of the seven patients showed relevant behavioral change after tDCS. We did, however, find that the overall evoked slow activity was reduced following tDCS intervention. We also found a positive correlation between the strength of the slow activity and the amount of high-frequency suppression. However, there was no significant pre-post tDCS difference in high frequencies. In the resting-state EEG, we observed that both the incidence of slow waves and the positive slope of the wave were affected by tDCS. Taken together, these results suggest that the tDCS intervention can reduce the slow-wave activity component of bistability, but this may not directly affect high-frequency activity. We hypothesize that while reduced slow activity may be necessary for the recovery of neural function, especially consciousness, this alone is insufficient.
Research center :
CHU de Liège-Centre du Cerveau² - ULiège
Disciplines :
Author, co-author :
Mensen, Armand;  Université de Liège - ULiège > GIGA Consciousness > Coma Science Group
BODART, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de neurologie
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA Consciousness-Coma Science Group
Wannez, Sarah ;  Université de Liège - ULiège > GIGA Consciousness > Coma Science Group
Annen, Jitka  ;  Université de Liège - ULiège > GIGA Consciousness-Coma Science Group
Laureys, Steven  ;  Université de Liège - ULiège > GIGA Consciousness-Coma Science Group
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Language :
Title :
Decreased evoked slow-activity after tDCS in disorders of consciousness
Publication date :
25 September 2020
Journal title :
Frontiers in Systems Neuroscience
Publisher :
Frontiers Media S.A., Switzerland
Volume :
Issue :
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 02 October 2020


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