[en] Despite many calls, functional brain magnetic resonance imaging (fMRI) studies are relatively rare in the domain of entrepreneurship research. This methodological brief presents the brain-imaging method of resting-state fMRI (rs-fMRI) and illustrates its application in neuroentrepreneurship for the first time. In contrast to the traditional task-based fMRI approach, rs-fMRI observes the brain in the absence of cognitive tasks or presentation of stimuli, which offers benefits for improving our understanding of the entrepreneurial mind. Here, we describe the method and provide methodological motivations for performing brain resting-state functional neuroimaging studies on entrepreneurs. In addition, we illustrate the use of seed-based correlation analysis, one of the most common analytical approaches for analyzing rs-fMRI data. In this illustration, we show that habitual entrepreneurs have increased functional connectivity between the insula (a region associated with cognitive flexibility) and the anterior prefrontal cortex (a key region for explorative choice) as compared to managers. This increased connectivity could help promote flexible behavior. Thus in brief, we provide an exemplar of a novel way to expand our understanding of the brain in the domain of entrepreneurship. We discuss possible directions for future research and challenges to be addressed to facilitate the inclusion of re-fMRI studies into neuroentrepreneurship.
Disciplines :
General management, entrepreneurship & organizational theory Neurosciences & behavior
Author, co-author :
Ooms, Frédéric ; Université de Liège - ULiège > HEC Liège : UER > UER Management: Gestion internationale - Entrepreneuriat
Annen, Jitka ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group
Meunier, Paul ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Tshibanda, Luaba ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Laureys, Steven ; Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau² ; CERVO Research Centre, Laval University, Québec, QC, Canada
Pollack, Jeffrey M. ; Poole College of Management, NC State University, Raleigh, NC, USA
Surlemont, Bernard ; Université de Liège - ULiège > HEC Liège : Centres attachés > Centre de recherche PME et d'Entrepreneuriat
Language :
English
Title :
Advancing (Neuro)Entrepreneurship Cognition Research Through Resting-State fMRI: A Methodological Brief
Baldacchino L. (2013). Entrepreneurial experience and opportunity identification: The role of intuition and cognitive versatility. University of Warwick.
Baron R. A. (1998). Cognitive mechanisms in entrepreneurship: Why and when entrepreneurs think differently than other people. Journal of Business Venturing, 13(4), 275–294.
Baron R. A. Hmieleski K. M. Henry R. A. (2012). Entrepreneurs’ dispositional positive affect: The potential benefits—and potential costs—of being “up.” Journal of Business Venturing, 27(3), 310–324.
Baron R. A. Ward T. B. (2004). Expanding entrepreneurial cognition’s toolbox: Potential contributions from the field of cognitive science. Entrepreneurship Theory and Practice, 28(6), 553–573.
Beaty R. E. Benedek M. Wilkins R. W. Jauk E. Fink A. Silvia P. J. Hodges D. A. Koschutnig K. Neubauer A. C. (2014). Creativity and the default network: A functional connectivity analysis of the creative brain at rest. Neuropsychologia, 64, 92–98.
Benjamin C. Lieberman D. A. Chang M. Ofen N. Whitfield-Gabrieli S. Gabrieli J. D. E. Gaab N. (2010). The influence of rest period instructions on the default mode network. Frontiers in Human Neuroscience, 4, 218.
Bernoster I. De Groot K. Wieser M. J. Thurik R. Franken I. H. A. (2019). Birds of a feather flock together: Evidence of prominent correlations within but not between self-report, behavioral, and electrophysiological measures of impulsivity. Biological Psychology, 145, 112–123.
Birn R. M. Molloy E. K. Patriat R. Parker T. Meier T. B. Kirk G. R. Nair V. A. Meyerand M. E. Prabhakaran V. (2013). The effect of scan length on the reliability of resting-state fMRI connectivity estimates. NeuroImage, 83, 550–558.
Biswal B. B. Mennes M. Zuo X. -N. Gohel S. Kelly C. Smith S. M. Beckmann C. F. Adelstein J. S. Buckner R. L. Colcombe S. Dogonowski A. -M. Ernst M. Fair D. Hampson M. Hoptman M. J. Hyde J. S. Kiviniemi V. J. Kötter R. Li S.-J. … Milham P. M. (2010). Toward discovery science of human brain function. PNAS, 107(10), 4734–4739.
Biswal B. Zerrin Yetkin F. Haughton V. M. Hyde J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine, 34(4), 537–541.
Busenitz L. W. Barney J. B. (1997). Differences between entrepreneurs and managers in large organizations: Biases and heuristics in strategic decision-making. Journal of Business Venturing, 12(1), 9–30.
Button K. S. A Ioannidis J. P. Mokrysz C. Nosek B. A. Flint J. Robinson E. S. J. Munafò M. R. (2013). Power failure: Why small sample size undermines the reliability of neuroscience. Nature Reviews, 14, 365–376.
Caballero-Gaudes C. Reynolds R. C. (2017). Methods for cleaning the BOLD fMRI signal. NeuroImage, 154, 128–149.
Cantou P. Platel H. Desgranges B. Groussard M. (2018). How motor, cognitive and musical expertise shapes the brain: Focus on fMRI and EEG resting-state functional connectivity. Journal of Chemical Neuroanatomy, 89, 60–68.
Carland J. C. Carland J. W. Stewart W. H. (2000). The indefatigable entrepreneur: A study of the dispositions of multiple venture founders. Journal of Business and Entrepreneurship, 12(1), 1–18.
Chandler G. N. DeTienne D. R. McKelvie A. Mumford T. V. (2011). Causation and effectuation processes: A validation study. Journal of Business Venturing, 26(3), 375–390.
Cole D. M. Smith S. M. Beckmann C. F. (2010). Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Frontiers in Systems Neuroscience, 4, 1–15.
Crawford G. C. Skorodziyevskiy V. Frid C. J. Nelson T. E. Booyavi Z. Hechavarria D. M. Li X. Reynolds P. D. Teymourian E. (2022). Advancing entrepreneurship theory through replication: A case study on contemporary methodological challenges, future best practices, and an entreaty for communality. Entrepreneurship Theory and Practice, 46(3), 779–799.
Dajani D. R. Uddin L. Q. (2015). Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience. Trends in Neurosciences, 38(9), 571–578.
Daw N. D. O’Doherty J. P. Dayan P. Seymour B. Dolan R. J. (2006). Cortical substrates for exploratory decisions in humans. Nature, 441(15), 876–879.
Deco G. Tononi G. Boly M. Kringelbach M. L. (2015). Rethinking segregation and integration: Contributions of whole-brain modelling. Nature Reviews Neuroscience, 16(7), 430–439.
Dew N. Read S. Sarasvathy S. D. Wiltbank R. (2009). Effectual versus predictive logics in entrepreneurial decision-making: Differences between experts and novices. Journal of Business Venturing, 24(4), 287–309.
Dheer R. J. S. Lenartowicz T. (2019). Cognitive flexibility: Impact on entrepreneurial intentions. Journal of Vocational Behavior, 115, 1–17.
Domenech P. Koechlin E. (2015). Executive control and decision-making in the prefrontal cortex. Current Opinion in Behavioral Sciences, 1, 101–106.
Droutman V. Bechara A. Read S. J. (2015). Roles of the different sub-regions of the insular cortex in various phases of the decision-making process. Frontiers in Behavioral Neuroscience, 9, 1–14.
Dubois J. Adolphs R. (2016). Building a science of individual differences from fMRI. Trends in Cognitive Sciences, 20(6), 425–443.
Eklund A. Nichols T. E. Knutsson H. (2016). Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. PNAS, 113(28), 7900–7905.
Esteban O. Markiewicz C. J. Blair R. W. Moodie C. A. Isik A. I. Erramuzpe A. Kent J. D. Goncalves M. DuPre E. Snyder M. Oya H. Ghosh S. S. Wright J. Durnez J. Poldrack R. A. Gorgolewski K. J. (2019). fMRIPrep: A robust pre-processing pipeline for functional MRI. Nature Methods, 16(1), 111–116.
Fisch C. Franken I. H. A. Thurik R. (2021). Are behavioral and electrophysiological measures of impulsivity useful for predicting entrepreneurship? Journal of Business Venturing Insights, 16(1), e00253. https://doi.org/10.1016/j.jbvi.2021.e00253
Foo M. -D. Uy M. A. Murnieks C. (2015). Beyond affective valence: Untangling valence and activation influences on opportunity identification. Entrepreneurship Theory and Practice, 39(2), 407–431.
Fox M. D. Greicius M. (2010). Clinical applications of resting state functional connectivity. Frontiers in Systems Neuroscience, 4, 19.
Gabrieli J. D. E. Ghosh S. S. Whitfield-Gabrieli S. (2015). Prediction as a humanitarian and pragmatic contribution from human cognitive neuroscience. Neuron, 85(1), 11–26.
Gartner W. B. (1989). “Who is an Entrepreneur?” is the wrong question. Entrepreneurship Theory and Practice, 13(4), 47–67.
Gemmell R. M. Boland R. J. Kolb D. A. (2012). The socio–cognitive dynamics of entrepreneurial ideation. Entrepreneurship Theory and Practice, 36(5), 1053–1073.
Gogolla N. (2017). The insular cortex. Current Biology, 27(12), R580–R586.
Gorgolewski K. J. Alfaro-Almagro F. Auer T. Bellec P. Capotă M. Chakravarty M. M. Churchill N. W. Cohen A. L. Craddock R. C. Devenyi G. A. Eklund A. Esteban O. Flandin G. Ghosh S. S. Guntupalli J. S. Jenkinson M. Keshavan A. Kiar G. Liem F. Poldrack R. A. (2017). BIDS apps: Improving ease of use, accessibility, and reproducibility of neuroimaging data analysis methods. PLOS Computational Biology, 13(3), e1005209.
Grégoire D. A. Corbett A. C. McMullen J. S. (2011). The cognitive perspective in entrepreneurship: An agenda for future research: The cognitive perspective in entrepreneurship. Journal of Management Studies, 48(6), 1443–1477.
Griffa A. Amico E. Liégeois R. Van De Ville D. Preti M. G. (2022). Brain structure-function coupling provides signatures for task decoding and individual fingerprinting. NeuroImage, 250, 118970.
Griffanti L. Douaud G. Bijsterbosch J. Evangelisti S. Alfaro-Almagro F. Glasser M. F. Duff E. P. Fitzgibbon S. Westphal R. Carone D. Beckmann C. F. Smith S. M. (2017). Hand classification of fMRI ICA noise components. NeuroImage, 154, 188–205.
Guerra-Carrillo B. MacKey A. P. Bunge S. A. (2014). Resting-state fMRI: A window into human brain plasticity. Neuroscientist, 20(5), 522–533.
Halko M. -L. Lahti T. Hytönen K. Jääskeläinen I. P. (2017). Entrepreneurial and parental love-are they the same? Human Brain Mapping, 38(6), 2923–2938.
Hodgson T. Chamberlain M. Parris B. James M. Gutowski N. Husain M. Kennard C. (2007). The role of the ventrolateral frontal cortex in inhibitory oculomotor control. Brain, 130(6), 1525–1537.
Holbrook A. L. Green M. C. Krosnick J. A. (2003). Telephone versus face-to-face interviewing of national probability samples with long questionnaires comparisons of respondent satisficing and social desirability response bias. Public Opinion Quarterly, 67(1), 79–125.
Jiatong W. Murad M. Li C. Gill S. A. Ashraf S. F. (2021). Linking cognitive flexibility to entrepreneurial alertness and entrepreneurial intention among medical students with the moderating role of entrepreneurial self-efficacy: A second-order moderated mediation model. PloS One, 16(9), e0256420.
Kaffka G. Krueger N. (2018). The entrepreneurial ‘mindset’: Entrepreneurial intentions from the entrepreneurial event to neuroentrepreneurship. In Javadian G. Gupta V. Dutta D. Guo G. Osorio A. Ozkazanc-Pan B.. (Eds) Foundational Research in Entrepreneurship Studies (pp. 203–224). Palgrave Macmillan. https://doi.org/10.1007/978-3-319-73528-3_10
Kerr S. P. Kerr W. R. Xu T. (2018). Personality traits of entrepreneurs: A review of recent literature. Foundations and Trends in Entrepreneurship, 14(3), 279–356.
Koechlin E. (2011). Frontal pole function: What is specifically human? Trends in Cognitive Sciences, 15(6), 241.
Lahti T. Halko M. -L. Karagozoglu N. Wincent J. (2019). Why and how do founding entrepreneurs bond with their ventures? Neural correlates of entrepreneurial and parental bonding. Journal of Business Venturing, 34(2), 368–388.
Laureiro-Martínez D. Brusoni S. (2018). Cognitive flexibility and adaptive decision-making: Evidence from a laboratory study of expert decision makers. Strategic Management Journal, 39(4), 1031–1058.
Laureiro-Martínez D. Canessa N. Brusoni S. Zollo M. Hare T. Alemanno F. Cappa S. F. (2014). Frontopolar cortex and decision-making efficiency: Comparing brain activity of experts with different professional background during an exploration-exploitation task. Frontiers in Human Neuroscience, 7, 1–10.
Lawrence A. Clark L. Labuzetta J. N. Sahakian B. Vyakarnum S. (2008). The innovative brain. Nature, 456(13), 168–169.
Lenka A. Bhalsing K. S. Panda R. Jhunjhunwala K. Naduthota R. M. Saini J. Bharath R. D. Yadav R. Pal P. K. (2017). Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor. Neuroradiology, 59(2), 157–168.
Loued-Khenissi L. Pfeuffer A. Einhäuser W. Preuschoff K. (2020). Anterior insula reflects surprise in value-based decision-making and perception. NeuroImage, 210, 1–13.
Martin de Holan P. (2014). It’s all in your head: Why we need neuroentrepreneurship. Journal of Management Inquiry, 23(1), 93–97.
Martin de Holan P. Couffe C. (2017). Unpacking neuroentrepreneurship: Conducting entrepreneurship research with EEG technologies. In Day M. Boardman M. C. Krueger N. F. (Eds.), Handbook of Research Methodologies and Design in Neuroentrepreneurship (pp. 94–119). Edward Elgar Publishing.
Massaro S. Drover W. Cerf M. Hmieleski K. M. (2020). Using functional neuroimaging to advance entrepreneurial cognition research. Journal of Small Business Management, 61(2), 938–966.
McGrath R. G. MacMillan I. C. Scheinberg S. (1992). Elitists, risk-takers, and rugged individualists? An exploratory analysis of cultural differences between entrepreneurs and non-entrepreneurs. Journal of Business Venturing, 7(2), 115–135.
McMullen J. S. Wood M. S. Palich L. E. (2014). Entrepreneurial cognition and social cognitive neuroscience. In Mitchell J. R. Mitchell R. K. Randolph-Seng B. (Eds.), Handbook of Entrepreneurial Cognition (pp. 316–363). Edward Elgar Publishing.
Menon V. Uddin L. Q. (2010). Saliency, switching, attention and control: A network model of insula function. Brain Structure and Function, 214(5–6), 655–667.
Mitchell J. R. Israelsen T. Mitchell R. K. (2020). Entrepreneurial cognition research–an update. In Gielnik M. M. Cardon M. S. Frese M. (Eds.), The Psychology of Entrepreneurship (1st ed., pp. 5–25). Routledge.
Mitchell R. K. Busenitz L. Lant T. McDougall P. P. Morse E. A. Smith J. B. (2002). Toward a theory of entrepreneurial cognition: Rethinking the people side of entrepreneurship research. Entrepreneurship Theory and Practice, 27(2), 93–104.
Molnar-Szakacs I. Uddin L. Q. (2022). Anterior insula as a gatekeeper of executive control. Neuroscience & Biobehavioral Reviews, 139, 104736.
Murphy K. Birn R. M. Bandettini P. A. (2013). Resting-state fMRI confounds and clean-up. NeuroImage, 80, 349–359.
Nicolaou N. Shane S. (2014). Biology, neuroscience, and entrepreneurship. Journal of Management Inquiry, 23(1), 98–100.
Nofal A. M. Nicolaou N. Symeonidou N. Shane S. (2018). Biology and management: A review, critique, and research agenda. Journal of Management, 44(1), 7–31.
O’Connor E. E. Zeffiro T. A. (2019). Why is clinical fMRI in a resting state? Frontiers in Neurology, 10, 420.
Pang Y. Cui Q. Wang Y. Chen Y. Wang X. Han S. Zhang Z. Lu G. Chen H. (2016). Extraversion and neuroticism related to the resting-state effective connectivity of amygdala. Nature Scientific Reports, 6(1), 35484.
Parkes L. Fulcher B. Yücel M. Fornito A. (2018). An evaluation of the efficacy, reliability, and sensitivity of motion correction strategies for resting-state functional MRI. NeuroImage, 171, 415–436.
Poldrack R. A. Baker C. I. Durnez J. Gorgolewski K. J. Matthews P. M. Munafò M. R. Nichols T. E. Poline J. -B. Vul E. Yarkoni T. (2017). Scanning the horizon: Towards transparent and reproducible neuroimaging research. Nature Reviews Neuroscience, 18(2), 115–126.
Poldrack R. A. Mumford J. A. Nichols T. E. (2011). Handbook of functional MRI data analysis. Cambridge University Press.
Raichle M. E. Mintun M. A. (2006). Brain work and brain imaging. Annual Review of Neuroscience, 29(1), 449–476.
Ramoglou S. Gartner W. B. Tsang E. W. K. (2020). “Who is an entrepreneur?” is (still) the wrong question. Journal of Business Venturing Insights, 13, 1–7.
Sarasvathy S. D. (2001). Effectual reasoning in entrepreneurial decision making: Existence and bounds. Academy of Management Proceedings, 2001(1), D1–D6.
Sarasvathy S. D. (2008). Effectuation: Elements of entrepreneurial expertise new horizons in entrepreneurship series. Edward Elgar Publishing.
Savoy R. L. (2012). Evolution and current challenges in the teaching of functional MRI and functional brain imaging. NeuroImage, 62(2), 1201–1207.
Shane S. Drover W. Clingingsmith D. Cerf M. (2020). Founder passion, neural engagement and informal investor interest in startup pitches: An fMRI study. Journal of Business Venturing 35(4). https://doi.org/10.1016/j.jbusvent.2019.105949
Shehzad Z. Kelly A. M. C. Reiss P. T. Gee D. G. Gotimer K. Uddin L. Q. Lee S. H. Margulies D. S. Roy A. K. Biswal B. B. Petkova E. Castellanos F. X. Milham M. P. (2009). The resting brain: Unconstrained yet reliable. Cerebral Cortex, 19(10), 2209–2229.
Shepherd D. A. Gruber M. (2021). The lean startup framework: Closing the academic–practitioner divide. Entrepreneurship Theory and Practice, 45(5), 967–998.
Shepherd D. A. Williams T. A. Patzelt H. (2015). Thinking about entrepreneurial decision making: Review and research agenda. Journal of Management, 41(1), 11–46.
Siebenthal Z. von Boucher O. Lazzouni L. Taylor V. Martinu K. Roy M. Rainville P. Lepore F. Nguyen D. K. (2020). Expected value and sensitivity to punishment modulate insular cortex activity during risky decision-making. Nature Scientific Reports, 10, 11920.
Singer T. Critchley H. D. Preuschoff K. (2009). A common role of insula in feelings, empathy and uncertainty. Trends in Cognitive Sciences, 13(8), 334–340.
Smolka K. M. Verheul I. Burmeister–Lamp K. Heugens P. P. M. A. R. (2018). Get it together! Synergistic effects of causal and effectual decision–making logics on venture performance. Entrepreneurship Theory and Practice, 42(4), 571–604.
Speer S. P. H. Smidts A. Boksem M. A. S. (2022). Individual differences in (dis)honesty are represented in the brain’s functional connectivity at rest. NeuroImage, 246, 118761.
Sridharan D. Levitin D. J. Menon V. (2008). A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. PNAS, 105(34), 12569–12574.
Tong L. C. P. Ye K. J. Asai K. Ertac S. List J. A. Nusbaum H. C. Hortaçsu A. (2016). Trading experience modulates anterior insula to reduce the endowment effect. PNAS, 113(33), 9238–9243.
Trapnell P. D. Campbell J. D. (1999). Private self-consciousness and the five-factor model of personality: Distinguishing rumination from reflection. Journal of Personality and Social Psychology, 76(2), 284–304.
Turcan R. V. Fraser N. M. (2018). Cognitive neuroscience perspective on entrepreneurship. In Turcan R. V. Fraser N. M. (Eds.), The Palgrave Handbook of Multidisciplinary Perspectives on Entrepreneurship (pp. 43–58). Palgrave Macmillan.
Uddin L. Q. (2021). Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations. Nature Reviews Neuroscience, 22(3), 167–179.
van den Heuvel M. P. Hulshoff Pol H. E. (2010). Exploring the brain network: A review on resting-state fMRI functional connectivity. European Neuropsychopharmacology, 20(8), 519–534.
Van De Ville D. Farouj Y. Preti M. G. Liégeois R. Amico E. (2021). When makes you unique: Temporality of the human brain fingerprint. Science Advances, 7(42), eabj0751.
Van Dijk K. R. A. Hedden T. Venkataraman A. Evans K. C. Lazar S. W. Buckner R. L. (2010). Intrinsic functional connectivity as a tool for human connectomics: Theory, properties, and optimization. Journal of Neurophysiology, 103(1), 297–321.
van Praag C. M. Versloot P. H. (2007). What is the value of entrepreneurship? A review of recent research. Small Business Economics, 29(4), 351–382.
van Witteloostuijn A. Dejardin M. Pollack J. M. (2021). Replication in entrepreneurship. Journal of Business Venturing Insights, 16, e00271.
Ward M. K. Reeck C. Becker W. (2017). A brief primer on using functional magnetic resonance imaging (fMRI) in entrepreneurship research. In Day M. Boardman M. C. Krueger N. F. (Eds.), Handbook of Research Methodologies and Design in Neuroentrepreneurship (pp. 120–149). Edward Elgar Publishing.
Whitfield-Gabrieli S. Nieto-Castanon A. (2012). Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connectivity, 2(3), 125–141.
Yang X. Sun S. L. Zhao X. (2019). Search and execution: Examining the entrepreneurial cognitions behind the lean startup model. Small Business Economics, 52(3), 667–679.
Zaro A. M. Fagundes L. Rocha F. Nunes W. (2016). Cognitive brain mapping used in the study of entrepreneurial behavior—Pilot test with the use of electroencephalogram - EEG during the process of identification of business opportunities. American Journal of Educational Research, 4(6), 472–478.
Zhao H. Seibert S. E. (2006). The big five personality dimensions and entrepreneurial status: A meta-analytical review. Journal of Applied Psychology, 91(2), 259–271.
