Article (Scientific journals)
Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls.
TSHIBANDA, Luaba; Vanhaudenhuyse, Audrey; Galanaud, Damien et al.
2009In Progress in Brain Research, 177, p. 215-29
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Keywords :
Anisotropy; Aspartic Acid/analogs & derivatives/metabolism; Brain Mapping; Choline/metabolism; Coma/diagnosis/metabolism/physiopathology; Creatine/metabolism; Databases, Factual/statistics & numerical data; Diffusion Magnetic Resonance Imaging/methods; Humans; Image Processing, Computer-Assisted/methods; Magnetic Resonance Spectroscopy/methods; Protons/diagnostic use; Recovery of Function/physiology; Severity of Illness Index; Survivors/statistics & numerical data
Abstract :
[en] The status of comatose patient is currently established on the basis of the patient-exhibited behaviors. Clinical assessment is subjective and, in 40% of patients, fails to distinguish vegetative state (VS) from minimally conscious states (MCS). The technologic advances of magnetic resonance imaging (MRI) have dramatically improved our understanding of these altered states of consciousness. The role of neuroimaging in coma survivors has increased beyond the simple evaluation of morphological abnormalities. The development of 1H-MR spectroscopy (MRS) and diffusion tensor imaging (DTI) provide opportunity to evaluate processes that cannot be approached by current morphologic MRI sequences. They offer potentially unique insights into the histopathology of VS and MCS. The MRS is a powerful noninvasive imaging technique that enables the in vivo quantification of certain chemical compound or metabolites as N-acetylaspartate (NAA), Choline (Cho), and Creatine (Cr). These biomarkers explore neuronal integrity (NAA), cell membrane turnover (Cho), and cell energetic function (Cr). DTI is an effective and proved quantitative method for evaluating tissue integrity at microscopic level. It provides information about the microstructure and the architecture of tissues, especially the white matter. Various physical parameters can be extracted from this sequence: the fractional anisotropy (FA), a marker of white matter integrity; mean diffusivity (MD); and the apparent diffusion coefficient (ADC) which can differentiate cytotoxic and vasogenic edema. The most prominent findings with MRS and DTI performed in traumatic brain-injured (TBI) patients in subacute phase are the reduction of the NAA/Cr ratio in posterior pons and the decrease of mean infratentorial and supratentorial FA except in posterior pons that enables to predict unfavorable outcome at 1 year from TBI with up to 86% sensitivity and 97% specificity. This review will focus on the interest of comatose patients MRI multimodal assessment with MRS and DTI. It will emphasize the advantages and pitfalls of these techniques in particular in predicting the coma survivors' outcome.
Disciplines :
Author, co-author :
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Imagerie médicale
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Galanaud, Damien
Boly, Mélanie ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Puybasset, Louis
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Title :
Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls.
Publication date :
Journal title :
Progress in Brain Research
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
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