[en] Background: This review discusses the advantages of transcranial magnetic stimulation combined with high-density electroencephalography (TMS-hdEEG) over other current techniques of brain imaging. Methods and results: Its application was reviewed, focusing particularly on disorders of consciousness, in the perspective of recent theories of consciousness. Assessment of non-communicative patients with disorders of consciousness remains a clinical challenge and objective measures of the level of consciousness are still needed. Current theories suggest that a key requirement for consciousness is the brain’s capacity to rapidly integrate information across different specialized cortical areas. TMS-EEG allows the stimulation of any given cortical area and the recording of the immediate electrical cortical response. This technique has recently been successfully employed to measure changes in brain complexity under physiological, pharmacological and pathological conditions.
Conclusions: This suggests that TMS-EEG is a reliable tool to discriminate between conscious and unconscious patients at the single subject level. Future works are needed to validate and implement this technique as a clinical tool.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Napolitani, Martino ✱; Università degli Studi di Milano
Bodart, Olivier ✱; Université de Liège - ULiège > Centre de recherches du cyclotron
Canali, P.
Seregni, F.
Rosanova, Mario; Università degli Studi di Milano
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Massimini, Marcello; Università degli Studi di Milano
Gosseries, Olivia ; Université de Liège - ULiège > Centre de recherches du cyclotron
✱ These authors have contributed equally to this work.
Language :
English
Title :
Transcranial magnetic stimulation combined with high density EEG in altered states of consciousness
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