Article (Scientific journals)
Baseline brain activity fluctuations predict somatosensory perception in humans
Boly, Mélanie; Balteau, Evelyne; Schnakers, Caroline et al.
2007In Proceedings of the National Academy of Sciences of the United States of America, 104 (29), p. 12187-12192
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Keywords :
consciousness; functional MRI; pain
Abstract :
[en] In perceptual experiments, within-individual fluctuations in perception are observed across multiple presentations of the same stimuli, a phenomenon that remains only partially understood. Here, by means of thulium-yttrium/aluminum- garnet laser and event-related functional MRI, we tested whether variability in perception of identical stimuli relates to differences in prestimulus, baseline brain activity. Results indicate a positive relationship between conscious perception of low-intensity somatosensory stimuli and immediately preceding levels of baseline activity in medial thalamus and the lateral frontoparietal network, respectively, which are thought to relate to vigilance and "external monitoring." Conversely, there was a negative correlation between subsequent reporting of conscious perception and baseline activity in a set of regions encompassing posterior cingulate/ precuneus and temporoparietal cortices, possibly relating to introspection and self-oriented processes. At nociceptive levels of stimulation, pain-intensity ratings positively correlated with baseline fluctuations in anterior cingulate cortex in an area known to be involved in the affective dimension of pain. These results suggest that baseline brain-activity fluctuations may profoundly modify our conscious perception of the external world.
Disciplines :
Neurology
Author, co-author :
Boly, Mélanie ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron - Comagroup > Neurologie
Balteau, Evelyne ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Schnakers, Caroline ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Peigneux, Philippe ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Baseline brain activity fluctuations predict somatosensory perception in humans
Publication date :
17 July 2007
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
Natl Acad Sciences, Washington, United States - Washington
Volume :
104
Issue :
29
Pages :
12187-12192
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
FMRE - Fondation Médicale Reine Elisabeth
MSF - Mind Science Foundation
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