Consciousness in the Locked-In Syndrome

[en] Patients in a locked-in syndrome (LIS) are selectively de-efferented (i.e., they have no means of producing speech, limb, or face movements). Usually the anatomy of the responsible lesion in the brainstem is such that locked-in patients are left with the capacity to use vertical eye movements and blinking to communicate with the external world. The syndrome is subdivided as: (i) classical LIS, which is characterized by total immobility except for vertical eye movements or blinking; (ii) incomplete LIS, which allows remnants of voluntary motion such as head or finger movements; and (iii) total LIS, which is a complete immobility including all eye movements. In all three cases, consciousness is usually fully preserved. Eye-controlled computer-based communication and brain-computer interface technology currently allows these patients to control their environment, use a word processor coupled to a speech synthesizer and access the world wide net. Available literature raises important ethical considerations in terms of quality of life and end-of-life decisions in such challenging patients. © 2016 Elsevier Ltd All rights reserved.

Disciplines :

Neurologie

Auteur, co-auteur :

Bruno, Marie-Aurélie ; Coma Science Group, Neurology Department and GIGA, University of Liège, Liège, Belgium

Nizzi, Marie-Christine; Psychology Department, Harvard University, Cambridge, MA, United States

Laureys, Steven ; Université de Liège - ULiège > Consciousness-Coma Science Group

Gosseries, Olivia ; Université de Liège - ULiège > Consciousness-Coma Science Group

Langue du document :

Anglais

Titre :

Consciousness in the Locked-In Syndrome

Date de publication/diffusion :

2015

Titre de l'ouvrage principal :

The Neurology of Consciousness

Auteur, co-auteur :

Laureys, S.

Gosseries, O. ; Université de Liège - ULiège > Département des sciences cliniques

Tononi, G.

Maison d'édition :

Elsevier

Pagination :

187-202

Peer reviewed :

Peer reviewed

Commentaire :

9780128011751; 9780128009482

Disponible sur ORBi :

depuis le 01 janvier 2020

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137 (dont 3 ULiège)

Nombre de téléchargements

5 (dont 3 ULiège)

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Bibliographie

Albrecht G.L., Devlieger P.J. The disability paradox: high quality of life against all odds. Soc. Sci. Med. 1999, 48(8):977-988.
Allain P., Joseph P.A., Isambert J.L., Le Gal D., Emile J. Cognitive functions in chronic locked-in syndrome: a report of two cases. Cortex 1998, 34(4):629-634.
American Congress of Rehabilitation Medicine Recommendations for use of uniform nomenclature pertinent to patients with severe alterations of consciousness. Arch. Phys. Med. Rehabil. 1995, 76:205-209.
Anderson C., Dillon C., Burns R. Life-sustaining treatment and locked-in syndrome. Lancet 1993, 342(8875):867-868.
Anonymous Awareness during anaesthesia. Lancet 1973, 2(7841):1305.
Azad C., Mahajan V., Jat K.R. Locked-in syndrome as a presentation of snakebite. Indian Pediatr. 2013, 50(7):695-697.
Bach J.R. Threats to "informed" advance directives for the severely physically challenged?. Arch. Phys. Med. Rehabil. 2003, 84(4 Suppl. 2):S23-S28.
Bakshi N., Maselli R.A., Gospe S.M., Ellis Jr., W.G., McDonald C., et al. Fulminant demyelinating neuropathy mimicking cerebral death. Muscle Nerve 1997, 20(12):1595-1597.
Barbic D., Levine Z., Tampieri D., Teitelbau J. Locked-in syndrome: a critical and time-dependent diagnosis. CJEM 2012, 14(5):317-320.
Bassetti C., Mathis J., Hess C.W. Multimodal electrophysiological studies including motor evoked potentials in patients with locked-in syndrome: report of six patients. J. Neurol. Neurosurg. Psychiatry 1994, 57(11):1403-1406.
Bauby, J.-D., 1997. The Diving Bell and the Butterfly (original title: Le scaphandre et le papillon). In: Laffont, E.R. (Ed.).
Bauer G., Gerstenbrand F., Rumpl E. Varieties of the locked-in syndrome. J. Neurol. 1979, 221(2):77-91.
Bernheim J.L. How to get serious answers to the serious question: "How have you been?": subjective quality of life (QOL) as an individual experiential emergent construct. Bioethics 1999, 13(3-4):272-287.
Birbaumer N., Ghanayim N., Hinterberger T., Iversen I., Kotchoubey B., Kubler A., et al. A spelling device for the paralysed. Nature 1999, 398(6725):297-298.
Boly M., Coleman M.R., Davis M.H., Hampshire A., Bor D., Moonen G., et al. When thoughts become action: an fMRI paradigm to study volitional brain activity in non-communicative brain injured patients. Neuroimage 2007, 36(3):979-992.
Boly M., Faymonville M.E., Schnakers C., Peigneux P., Lambermont B., Phillips C., et al. Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol. 2008, 7(11):1013-1020.
Brighouse D., Norman J. To wake in fright. BMJ 1992, 304(6838):1327-1328.
Britt R.H., Herrick M.K., Hamilton R.D. Traumatic locked-in syndrome. Ann. Neurol. 1977, 1(6):590-592.
Bruno M., Bernheim J.L., Schnakers C., Laureys S. Locked-in: don't judge a book by its cover. J. Neurol. Neurosurg. Psychiatry 2008, 79(1):2.
Bruno M., Schnakers C., Damas F., Pellas F., Lutte I., Bernheim J., et al. Locked-in syndrome in children: report of five cases and review of the literature. Pediatr. Neurol. 2009, 41(4):237-246.
Bruno M.A., et al. Life with locked-in syndrome. Rev. Med. Liege 2008, 63(5-6):445-451.
Bruno M.A., Pellas F., Laureys S. Quality of life in locked-in syndrome. 2008 Yearbook of Intensive Care and Emergency Medicine 2008, 881-890. Springer-Verlag, Berlin. J.L. Vincent (Ed.).
Bruno M.-A., Bernheim J.L., Ledoux D., Pellas F., Demertzi A., Laureys S. A survey on self-assessed well-being in a cohort of chronic locked-in syndrome patients: happy majority, miserable minority. BMJ Open 2011, 1-9.
Calder A.J., Lawrence A.D., Young A.W. Neuropsychology of fear and loathing. Nat. Rev. Neurosci. 2001, 2(5):352-363.
Calmels P., Bethoux F., Roche G., Fayolle-Minon I., Picano-Gonard C. Evaluation of the handicap and the quality of life in spinal cord injuries: study in a population of 58 patients living at home. Ann. Readapt. Med. Phys. 2003, 46(5):233-240.
Cappa S.F., Vignolo L.A. Locked-in syndrome for 12 years with preserved intelligence. Ann. Neurol. 1982, 11(5):545.
Cappa S.F., Pirovano C., Vignolo L.A. Chronic "locked-in" syndrome: psychological study of a case. Eur. Neurol. 1985, 24(2):107-111.
Carroll W.M., Mastaglia F.L. "Locked-in coma" in postinfective polyneuropathy. Arch. Neurol. 1979, 36(1):46-47.
Casali A.G., Gosseries O., Rosanova M., Boly M., Sarasso S., Casali K.R., et al. A theoretically based index of consciousness independent of sensory processing and behavior. Sci. Transl. Med. 2013, 5(198):198ra105.
Casanova E., Lazzari R.E., Lotta S., Mazzucchi A. Locked-in syndrome: improvement in the prognosis after an early intensive multidisciplinary rehabilitation. Arch. Phys. Med. Rehabil. 2003, 84(6):862-867.
Chang B., Morariu M.A. Transient traumatic "locked-in" syndrome. Eur. Neurol. 1979, 18(6):391-394.
Chia L.G. Locked-in syndrome with bilateral ventral midbrain infarcts. Neurology 1991, 41(3):445-446.
Christakis N.A., Asch D.A. Biases in how physicians choose to withdraw life support. Lancet 1993, 342(8872):642-646.
Combaz A., Chatelle C., Robben A., Vanhoof G., Goeleven A., Thijs V., et al. A comparison of two spelling brain-computer interfaces based on visual P3 and SSVEP in locked-in syndrome. PLoS One 2013, 8(9):e73691.
Cummins R. Normative life satisfaction: measurement issues and a homeostatic model. Soc. Indic. Res. 2003, 64(2):225-256.
Daneski K., Coshall C., Tilling K., Wolfe C.D. Reliability and validity of a postal version of the Reintegration to Normal Living Index, modified for use with stroke patients. Clin. Rehabil. 2003, 17(8):835-839.
De Massari D., Ruf C.A., Furdea A., Matuz T., van der Heiden L., Halder S., et al. Brain communication in the locked-in state. Brain 2013, 136(Pt 6):1989-2000.
Demertzi A., Jox R.J., Racine E., Laureys S. A European survey on attitudes towards pain and end-of-life issues in locked-in syndrome. Brain Inj. 2014, 28(9):1209-1215.
Doble J.E., Haig A.J., Anderson C., Katz R. Impairment, activity, participation, life satisfaction, and survival in persons with locked-in syndrome for over a decade: follow-up on a previously reported cohort. J. Head Trauma Rehabil. 2003, 18(5):435-444.
Dumas A. The Count of Monte Cristo 1997, Wordworth Editions Limited, London.
Ebinger G., Huyghens L., Corne L., Aelbrecht W. Reversible "locked-in" syndromes. Intensive Care Med. 1985, 11(4):218-219.
Ethics and Humanities Subcommittee of the AAN Position statement: certain aspects of the care and management of profoundly and irreversibly paralyzed patients with retained consciousness and cognition. Report of the Ethics and Humanities Subcommittee of the American Academy of Neurology. Neurology 1993, 43(1):222-223.
Feldman M.H. Physiological observations in a chronic case of "locked-in" syndrome. Neurology 1971, 21(5):459-478.
Fitzgerald L.F., Simpson R.K., Trask T. Locked-in syndrome resulting from cervical spine gunshot wound. J. Trauma 1997, 42(1):147-149.
Fred H.L. Helen. South Med. J. 1986, 79(9):1135-1136.
Gallegos-Ayala G., Furdea A., Takano K., Ruf C.A., Flor H., Birbaumer N. Brain communication in a completely locked-in patient using bedside near-infrared spectroscopy. Neurology 2014, 82(21):1930-1932.
Gallo U.E., Fontanarosa P.B. Locked-in syndrome: report of a case. Am. J. Emerg. Med. 1989, 7(6):581-583.
Gayraud F., Martinie B., Bentot E., Lepilliez A., Tell L., Cotton F., et al. Written production in a case of locked-in syndrome with bilateral corticopontic degeneration. Neuropsychol. Rehabil. 2014, 1-18.
Ghorbel S. Statut fonctionnel et qualité de vie chez le locked-in syndrome a domicile. DEA Motricité Humaine et Handicap, Laboratory of Biostatistics, Epidemiology and Clinical Research 2002, Université Jean Monnet Saint-Etienne, Montpellier, France.
Golubovic V., Muhvic D., Golubovic S. Posttraumatic locked-in syndrome with an unusual three day delay in the appearance. Coll. Antropol. 2004, 28(2):923-926.
Gutling E., Isenmann S., Wichmann W. Electrophysiology in the locked-in-syndrome. Neurology 1996, 46(4):1092-1101.
Haig A.J., Katz R.T., Sahgal V. Locked-in syndrome: a review. Curr. Concepts Rehabil. Med. 1986, 3:12-16.
Haig A.J., Katz R.T., Sahgal V. Mortality and complications of the locked-in syndrome. Arch. Phys. Med. Rehabil. 1987, 68(1):24-27.
Hayashi H., Kato S. Total manifestations of amyotrophic lateral sclerosis. ALS in the totally locked-in state. J. Neurol. Sci. 1989, 93(1):19-35.
Heine L., Demertzi A., Laureys S., Gosseries O. Brain mapping: an encyclopedic reference. Consciousness and Disorders of Consciousness 2015, 1067-1073. Academic Press, Elsevier. W. Arthur (Ed.).
Holz E.M., Botrel L., Kaufmann T., Kubler A. Long-term independent brain-computer interface home use improves quality of life of a patient in the locked-in state: a case study. Arch. Phys. Med. Rehabil. 2015, 96(3 Suppl.):S16-S26.
Jacome D.E., Morilla-Pastor D. Unreactive EEG: pattern in locked-in syndrome. Clin. Electroencephalogr. 1990, 21(1):31-36.
Katz R.T., Haig A.J., Clark B.B., DiPaola R.J. Long-term survival, prognosis, and life-care planning for 29 patients with chronic locked-in syndrome. Arch. Phys. Med. Rehabil. 1992, 73(5):403-408.
Kaufmann T., Holz E.M., Kubler A. Comparison of tactile, auditory, and visual modality for brain-computer interface use: a case study with a patient in the locked-in state. Front. Neurosci. 2013, 7:129.
Keane J.R. Locked-in syndrome with deafness. Neurology 1985, 35(9):1395.
Keane J.R. Locked-in syndrome after head and neck trauma. Neurology 1986, 36(1):80-82.
Kennedy P.R., Bakay R.A. Restoration of neural output from a paralyzed patient by a direct brain connection. Neuroreport 1998, 9(8):1707-1711.
Kompanje E.J. End-of-life decision-making in patients with locked-in syndrome. Intern. Med. J. 2010, 40(8):607-608.
Kopsky D.J., Winninghoff Y., Winninghoff A.C., Stolwijk-Swuste J.M. A novel spelling system for locked-in syndrome patients using only eye contact. Disabil. Rehabil. 2014, 36(20):1723-1727.
Kotchoubey B., Lang S., Winter S., Birbaumer N. Cognitive processing in completely paralyzed patients with amyotrophic lateral sclerosis. Eur. J. Neurol. 2003, 10(5):551-558.
Kubler A., Neumann N. Brain-computer interfaces-the key for the conscious brain locked into a paralyzed body. Prog. Brain Res. 2005, 150:513-525.
Kubler A., Winter S., Ludoplh A.C., Hautzinger M., Birbaumer N. Severity of depressive symptoms and quality of life in patients with amyotrophic lateral sclerosis. Neurorehabil. Neural Repair 2005, 19(3):182-193.
Lacroix G., Couret D., Combaz X., Prunet B., Girard N., Bruder N. Transient locked-in syndrome and basilar artery vasospasm. Neurocrit. Care 2012, 16(1):145-147.
Landrieu P., Fromentin C., Tardieu M., Menget A., Laget P. Locked in syndrome with a favourable outcome. Eur. J. Pediatr. 1984, 142(2):144-145.
Laureys, S., van Eeckhout, P., Ferring, M., Faymonville, M., Mavroudakis, N., Berre, J., et al. 2003. Brain function in acute and chronic locked-in syndrome. Presented at the Ninth Annual Meeting of the Organisation for Human Brain Mapping (OHBM), June 18-22, 2003, NY, USA, NeuroImage CD ROM 19 (2 Suppl. 1).
Laureys S., Perrin F., Faymonville M.E., Schnakers C., Boly M., Bartsch V., et al. Cerebral processing in the minimally conscious state. Neurology 2004, 14:916-918.
Laureys S., Owen A.M., Schiff N.D. Brain function in coma, vegetative state, and related disorders. Lancet Neurol. 2004, 3(9):537-546.
Laureys S., Pellas F., van Eeckhout P., Ghorbel S., Schnakers C., Perrin F., et al. The locked-in syndrome: what is it like to be conscious but paralyzed and voiceless?. Prog. Brain Res. 2005, 150:495-511.
Leon-Carrion J., et al. The locked-in syndrome: a syndrome looking for a therapy. Brain Inj. 2002, 16(7):571-582.
Leon-Carrion J., van Eeckhout P., Dominguez-Morales Mdel R., Perez-Santamaria F.J. The locked-in syndrome: a syndrome looking for a therapy. Brain Inj. 2002, 16(7):555-569.
Lesenfants D., Habbal D., Lugo Z., Lebeau M., Horki P., Amico E. An independent SSVEP-based brain-computer interface in locked-in syndrome. J. Neural Eng. 2014, 11(3):035002.
Levy D.E., Sidtis J.J., Rottenberg D.A., Jarden J.O., Strother S.C., Dhawan V., et al. Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients. Ann. Neurol. 1987, 22(6):673-682.
Loeb C., Mancardi G.L., Tabaton M. Locked-in syndrome in acute inflammatory polyradiculoneuropathy. Eur. Neurol. 1984, 23(2):137-140.
Lugo Z.R., Rodriguez J., Lechner A., Ortner R., Gantner I.S., Laureys S., et al. A vibrotactile p300-based brain-computer interface for consciousness detection and communication. Clin. EEG Neurosci. 2014, 45(1):14-21.
Lugo Z.-R., Bruno M.A., Gosseries O., Demertzi A., Heine L., Thonnard M., et al. Beyond the gaze: communicating in chronic locked-in syndrome. Brain Inj. 2015.
Lule D., Zickler C., Hacker S., Bruno M.A., Demertzi A., Pellas F., et al. Life can be worth living in locked-in syndrome. Prog. Brain Res. 2009, 177:339-351.
Majerus S., Gill-Thwaites H., Andrews K., Laureys S. Behavioral evaluation of consciousness in severe brain damage. Prog. Brain Res. 2005, 150:397-413.
Markand O.N. Electroencephalogram in "locked-in" syndrome. Electroencephalogr. Clin. Neurophysiol. 1976, 40(5):529-534.
May L.A., Warren S. Measuring quality of life of persons with spinal cord injury: external and structural validity. Spinal Cord 2002, 40(7):341-350.
McCusker E.A., Rudick R.A., Honch G.W., Griggs R.C. Recovery from the "locked-in" syndrome. Arch. Neurol. 1982, 39(3):145-147.
Meienberg O., Mumenthaler M., Karbowski K. Quadriparesis and nuclear oculomotor palsy with total bilateral ptosis mimicking coma: a mesencephalic "locked-in syndrome"?. Arch. Neurol. 1979, 36(11):708-710.
Murrell R. Quality of life and neurological illness: a review of the literature. Neuropsychol. Rev. 1999, 9(4):209-229.
New P.W., Thomas S.J. Cognitive impairments in the locked-in syndrome: a case report. Arch. Phys. Med. Rehabil. 2005, 86(2):338-343.
Nijboer F. Technology transfer of brain-computer interfaces as assistive technology: barriers and opportunities. Ann. Phys. Rehabil. Med. 2015, 58(1):35-38.
Nikic P.M., Jovanovic D., Paspalj D., Georgievski-Brkic B., Savic M. Clinical characteristics and outcome in the acute phase of ischemic locked-in syndrome: case series of twenty patients with ischemic LIS. Eur. Neurol. 2013, 69(4):207-212.
Nizzi M.C., Demertzi A., Gosseries O., Bruno M.A., Jouen F., Laureys S. From armchair to wheelchair: how patients with a locked-in syndrome integrate bodily changes in experienced identity. Conscious Cogn. 2012, 21(1):431-437.
O'Donnell P.P. "Locked-in syndrome" in postinfective polyneuropathy. Arch. Neurol. 1979, 36(13):860.
Ohry A. The locked-in syndrome and related states. Paraplegia 1990, 28(2):73-75.
Oken B.S., Orhan U., Roark B., Erdogmus D., Fowler A., Mooney A., et al. Brain-computer interface with language model-electroencephalography fusion for locked-in syndrome. Neurorehabil. Neural Repair 2014, 28(4):387-394.
Onofrj M., Thomas A., Paci C., Scesi M., Tombari R. Event related potentials recorded in patients with locked-in syndrome. J. Neurol. Neurosurg. Psychiatry 1997, 63(6):759-764.
Ovadia-Caro S., Nir Y., Soddu A., Ramot M., Hesselmann G., Vanhaudenhuyse A., et al. Reduction in inter-hemispheric connectivity in disorders of consciousness. PLoS One 2012, 7(5):e37238.
Patterson J.R., Grabois M. Locked-in syndrome: a review of 139 cases. Stroke 1986, 17(4):758-764.
Peduto V.A., Silvetti L., Piga M. An anesthetized anesthesiologist tells his experience of waking up accidentally during the operation. Minerva Anestesiol. 1994, 60(1-2):1-5.
Perrin F., García-Larrea L., Mauguiere F., Bastuji H. A differential brain response to the subject's own name persists during sleep. Clin. Neurophysiol. 1999, 110(12):2153-2164.
Perrin F., Schnakers C., Schabus M., Degueldre C., Goldman S., Bredart S., et al. Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome. Arch. Neurol. 2006, 63(4):562-569.
Pistoia F., Conson M., Trojano L., Grossi D., Ponari M., Colonnese C., et al. Impaired conscious recognition of negative facial expressions in patients with locked-in syndrome. J. Neurosci. 2010, 30(23):7838-7844.
Plotkin A., Sela L., Weissbrod A., Kahana R., Haviv L., Yeshurun Y., et al. Sniffing enables communication and environmental control for the severely disabled. Proc. Natl. Acad. Sci. USA. 2010, 107(32):14413-14418.
Plum F., Posner J.B. The Diagnosis of Stupor and Coma 1983, 363-364. Philadelphia, PA. F.A. Davis (Ed.).
Rae-Grant A.D., Lin F., Yaeger B.A., Barbour P., Levitt L.P., Castaldo J.E., et al. Post traumatic extracranial vertebral artery dissection with locked-in syndrome: a case with MRI documentation and unusually favourable outcome. J. Neurol. Neurosurg. Psychiatry 1989, 52(10):1191-1193.
Ragazzoni A., Grippo A., Tozzi F., Zaccara G. Event-related potentials in patients with total locked-in state due to fulminant Guillain-Barre syndrome. Int. J. Psychophysiol. 2000, 37(1):99-109.
Richard I., Pereon Y., Guiheneu P., Nogues B., Perrouin-Verbe B., Mathe J.F. Persistence of distal motor control in the locked in syndrome. Review of 11 patients. Paraplegia 1995, 33(11):640-646.
Rosanova M., Gosseries O., Casarotto S., Boly M., Casali A.G., Bruno M.A., et al. Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients. Brain 2012, 135(Pt 4):1308-1320.
Rousseau M.C., Pietra S., Nadji M., de Villemeur T.B. Evaluation of quality of life in complete locked-in syndrome patients. J. Palliat. Med. 2013, 16(11):1455-1458.
Sandin R.H., Enlund G., Samuelsson P., Lennmarken C. Awareness during anaesthesia: a prospective case study. Lancet 2000, 355(9205):707-711.
Schnakers C., Majerus S., Goldman S., Boly M., van Eeckhout P., Gay S., et al. Cognitive function in the locked-in syndrome. J. Neurol. 2008, 255(3):323-330.
Schnakers C., Perrin F., Schabus M., Hustinx R., Majerus S., Moonen G., et al. Detecting consciousness in a total locked-in syndrome: an active event-related paradigm. Neurocase 2009, 15(4):271-277.
Sellers E.W., Ryan D.B., Hauser C.K. Noninvasive brain-computer interface enables communication after brainstem stroke. Sci. Transl. Med. 2014, 6(257):257re7.
Sharpless B.A., Barber J.P. Lifetime prevalence rates of sleep paralysis: a systematic review. Sleep Med. Rev. 2011, 15(5):311-315.
Sigalovsky N. Awareness under general anesthesia. AANA J. 2003, 71(5):373-379.
Smart C.M., Giacino J.T., Cullen T., Moreno D.R., Hirsch J., Schiff N.D., et al. A case of locked-in syndrome complicated by central deafness. Nat. Clin. Pract. Neurol. 2008, 4(8):448-453.
Snoeys L., Vanhoof G., Manders E. Living with locked-in syndrome: an explorative study on health care situation, communication and quality of life. Disabil. Rehabil. 2013, 35(9):713-718.
Soddu A., Vanhaudenhuyse A., Bahri M.A., Bruno M.A., Boly M., Demertzi A., et al. Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness. Hum. Brain Mapp. 2012, 33(4):778-796.
Steffen G.E., Franklin C. Who speaks for the patient with the locked-in syndrome?. Hastings Cent. Rep. 1985, 15(6):13-15.
Stoll J., Chatelle C., Carter O., Koch C., Laureys S., Einhauser W. Pupil responses allow communication in locked-in syndrome patients. Curr. Biol. 2013, 23(15):R647-R648.
Stumpf S.E. A comment on "Helen". South Med. J. 1986, 79(9):1057-1058.
Tavalaro J., Tayson R. Look up for yes 1997, Kodansha America, Inc, New York, NY.
Thibaut A., Bruno M.A., Chatelle C., Gosseries O., Vanhaudenhuyse A., Demertzi A., et al. Metabolic activity in external and internal awareness networks in severely brain-damaged patients. J. Rehabil. Med. 2012, 44(6):487-494.
Tonack M., Hitzig S.L., Craven B.C., Campbell K.A., Boschen K.A., McGillivray C.F. Predicting life satisfaction after spinal cord injury in a Canadian sample. Spinal Cord 2008, 46(5):380-385.
Towle V.L., Maselli R., Bernstein L.P., Spire J.P. Electrophysiologic studies on locked-in patients: heterogeneity of findings. Electroencephalogr. Clin. Neurophysiol. 1989, 73(5):419-426.
Trail M., Nelson N.D., Van J.N., Appel S.H., Lai E.C. A study comparing patients with amyotrophic lateral sclerosis and their caregivers on measures of quality of life, depression, and their attitudes toward treatment options. J. Neurol. Sci. 2003, 209(1-2):79-85.
Trojano L., Moretta P., Estraneo A., Santoro L. Neuropsychologic assessment and cognitive rehabilitation in a patient with locked-in syndrome and left neglect. Arch. Phys. Med. Rehabil. 2010, 91(3):498-502.
Vanhaudenhuyse A., Noirhomme Q., Tshibanda L.J., Bruno M.A., Boveroux P., Schnakers C., et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010, 133(Pt 1):161-171.
Vigand P. Promenades Immobiles 2002, Le Livre de Poche.
Vigand P., Vigand S. Only the Eyes Say Yes (original title: Putain de silence) 2000, Arcade Publishing.
Wang X.K., Zhu J. Locked-in syndrome in three children with Guillain-Barre syndrome. Pediatr. Neurol. 2012, 46(4):264. (author reply 264-265).
Ware J.E., Snow K.K., Kosinski M. SF-36 Health Survey Manual and Interpretation Guide 1993, The Health Institute, New England Medical Center, Boston, MA.
Wilhelm B., Jordan M., Birbaumer N. Communication in locked-in syndrome: effects of imagery on salivary pH. Neurology 2006, 67(3):534-535.
Wilson B.A., Hinchcliffe A., Okines T., Florschutz G., Fish J. A case study of locked-in-syndrome: psychological and personal perspectives. Brain Inj. 2011, 25(5):526-538.
Wood-Dauphinee S., Williams J.I. Reintegration to Normal Living as a proxy to quality of life. J. Chronic Dis. 1987, 40(6):491-502.
Zickler C., Halder S., Kleih S.C., Herbert C., Kubler A. Brain Painting: usability testing according to the user-centered design in end users with severe motor paralysis. Artif. Intell. Med. 2013, 59(2):99-110.
Zola E. Thérère Raquin 1979, Ed. Gallimard, Paris, p. 352.