Article (Scientific journals)
Disorders of consciousness: Moving from passive to resting state and active paradigms
Bruno, Marie-Aurélie; Soddu, Andrea; Demertzi, Athina et al.
2010In Cognitive Neuroscience, 1 (1), p. 193–203
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Keywords :
Consciousness; Vegetative state; Resting state; fMRI; Active paradigms
Abstract :
[en] Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e., minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state. The increasing use of fMRI and EEG tools permits the clinical characterization of these patients to be improved. We first discuss “resting metabolism” and “passive activation” paradigms, used in neuroimaging and evoked potential studies, which merely identify neural activation reflecting “automatic” processing—that is, occurring without the patient’s willful intervention. Secondly, we present an alternative approach consisting of instructing subjects to imagine well-defined sensorymotor or cognitive-mental actions. This strategy reflects volitional neural activation and, hence, witnesses awareness. Finally, we present results on blood-oxgen-level-dependent “default mode network”/resting state studies that might be a promising tool in the diagnosis of these challenging patients.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Bruno, Marie-Aurélie  ;  Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science group
Soddu, Andrea  ;  Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science group
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron - Département des sciences cliniques > Coma Science Group
Gosseries, Olivia  ;  Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science Group
Schnakers, Caroline ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Boly, Mélanie ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron - Coma Science Group > Département des sciences cliniques - Neurologie
Noirhomme, Quentin ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Thonnard, Marie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Chatelle, Camille ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science Group
 These authors have contributed equally to this work.
Language :
English
Title :
Disorders of consciousness: Moving from passive to resting state and active paradigms
Publication date :
2010
Journal title :
Cognitive Neuroscience
ISSN :
1758-8928
eISSN :
1758-8936
Publisher :
Taylor & Francis, Cambridge, United Kingdom
Volume :
1
Issue :
1
Pages :
193–203
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
EU - European Commission
Concerted Research Action (ARC-06/11-340)
JSMF - James S McDonnell Foundation [US-MO]
MSF - Mind Science Foundation [US-TX]
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