Coma; Curing Coma Campaign; Disorders of consciousness; National Institute of Health; Proceedings; Critical Care and Intensive Care Medicine; Neurology (clinical)
Abstract :
[en] This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we summarize the background, research priorities, panel discussions, and deliverables discussed during the symposium across six major domains related to disorders of consciousness. The six domains include (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, and (6) Long-term Recovery. Following the 1st Curing Coma NIH virtual symposium held on September 9 to September 10, 2020, six workgroups, each consisting of field experts in respective domains, were formed and tasked with identifying gaps and developing key priorities and deliverables to advance the mission of the Curing Coma Campaign. The highly interactive and inspiring presentations and panel discussions during the 3-day virtual NIH symposium identified several action items for the Curing Coma Campaign mission, which we summarize in this article.
Disciplines :
Neurology
Author, co-author :
Mainali, Shraddha ; Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. shraddha.mainali@vcuhealth.org
Aiyagari, Venkatesh; Neurological Surgery and Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Alexander, Sheila; School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA
Bodien, Yelena; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Charlestown, MA, USA
Boerwinkle, Varina; Division of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA
Boly, Mélanie ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie ; Departments of Neurology and Psychiatry, Wisconsin Institute for Sleep and Consciousness, University of Wisconsin, Madison, WI, USA
Brown, Emery; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Brown, Jeremy; Office of Emergency Care Research, Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
Claassen, Jan; Department of Neurology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA
Edlow, Brian L; Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, USA ; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA
Fink, Ericka L; Department of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Fins, Joseph J; Division of Medical Ethics, Weill Cornell Medical College, New York, NY, USA ; Yale Law School, New Haven, CT, USA
Foreman, Brandon; Division of Neurocritical Care, Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA
Frontera, Jennifer; Department of Neurology, New York University School of Medicine, New York, NY, USA
Geocadin, Romergryko G; Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Giacino, Joseph; Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA
Gilmore, Emily J; Comprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, CT, USA
Gosseries, Olivia ; Université de Liège - ULiège > Département des sciences cliniques
Hammond, Flora; Indiana University Department of Physical Medicine and Rehabilitation, University of Indiana School of Medicine, Indianapolis, IN, USA
Helbok, Raimund; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Claude Hemphill, J; Department of Neurology, University of California, San Francisco, CA, USA
Hirsch, Karen; Division of Neurocritical Care, Department of Neurology, Stanford University, Stanford, CA, USA
Kim, Keri; College of Pharmacy, University of Illinois, Chicago, IL, USA
LAUREYS, Steven ; Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau²
Lewis, Ariane; Department of Neurology and Neurosurgery, New York University Langone Health, New York, NY, USA
Ling, Geoffrey; Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Livesay, Sarah L; Department of Adult Health and Gerontological Nursing, College of Nursing, Rush University, Chicago, IL, USA
McCredie, Victoria; Interdepartmental Division of Critical Care, Department of Respirology, University of Toronto, Toronto, ON, Canada
McNett, Molly; College of Nursing, Ohio State University, Columbus, OH, USA
Menon, David; Division of Anaesthesia, University of Cambridge, Cambridge, UK
Molteni, Erika; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK
Olson, DaiWai; Neuroscience Intensive Care Unit, O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA
O'Phelan, Kristine; Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
Park, Soojin; Department of Neurology and Neurocritical Care, Columbia University, New York, NY, USA
Polizzotto, Len; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA
Javier Provencio, Jose; Department of Neurology and Neuroscience, University of Virginia, Charlottesville, VA, USA
Puybasset, Louis; Department of Neuroradiology, University of Paris VI, Pierre et Marie Curie, Pitié-Salpêtrière Hospital, Paris, France
Venkatasubba Rao, Chethan P; Division of Vascular Neurology and Neurocritical Care, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Baylor College of Medicine, Houston, TX, USA
Robertson, Courtney; Departments of Anesthesiology and Critical Care Medicine, and Pediatrics, Johns Hopkins Children's Center, The Johns Hopkins University School of Medcine, Baltimore, MD, USA
Rohaut, Benjamin; Neuroscience Intensive Care Unit, Department of Neurology, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France
Rubin, Michael; Neurological Surgery and Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Sharshar, Tarek; Department of Intensive Care, Paris Descartes University, Paris, France
Shutter, Lori; University of Pittsburgh, Pittsburgh, PA, USA
Sampaio Silva, Gisele; Hospital Israelita Albert Einstein, Academic Research Organization and Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil
Smith, Wade; Department of Neurology, University of California, San Francisco, CA, USA
Stevens, Robert D; Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Thibaut, Aurore ; Université de Liège - ULiège > Département des sciences cliniques
Vespa, Paul; Ronald Reagan UCLA Medical Center, UCLA Santa Monica Medical Center, Santa Monica, CA, USA
Wagner, Amy K; Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Ziai, Wendy C; Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Zink, Elizabeth; Department of Neuroscience Nursing, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD, USA
I Suarez, Jose; Division of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
This work is supported by the Neurocritical Care Society/Curing Coma Campaign.Except for the authors listed below, others declare no conflict of interest related to this article: JC: NIH R01 NS106014 and R03 NS112760; DANA Foundation, McDonnell Foundation. SL: Belgian National Funds for Scientific Research (FRS-FNRS), Human Brain Project (EU-H2020-fetflagship-hbp-sga1-ga720270), National Natural Science Foundation of China (Joint Research Project 81471100), Mind Science Foundation, European Foundation of Biomedical Research FERB Onlus, BIAL Foundation, fund Generet of King Baudouin.
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