Article (Scientific journals)
Decreased integration of EEG source-space networks in disorders of consciousness
Rizkallah, Jennifer; Annen, Jitka; Modolo, Julien et al.
2019In NeuroImage: Clinical, 23, p. 1-9
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Keywords :
Disorders of consciousness; High-density electroencephalography; Functional brain networks; Unresponsive wakefulness syndrome; Minimally conscious state
Abstract :
[en] Increasing evidence links disorders of consciousness (DOC) with disruptions in functional connectivity between distant brain areas. However, to which extent the balance of brain network segregation and integration is modified in DOC patients remains unclear. Using high-density electroencephalography (EEG), the objective of our study was to characterize the local and global topological changes of DOC patients' functional brain networks. Resting state high-density-EEG data were collected and analyzed from 82 participants: 61 DOC patients recovering from coma with various levels of consciousness (EMCS (n=6), MCS+ (n=29), MCS- (n=17) and UWS (n=9)), and 21 healthy subjects (i.e., controls). Functional brain networks in five different EEG frequency bands and the broadband signal were estimated using an EEG connectivity approach at the source level. Graph theory-based analyses were used to evaluate their relationship with decreasing levels of consciousness as well as group differences between healthy volunteers and DOC patient groups. Results showed that networks in DOC patients are characterized by impaired global information processing (network integration) and increased local information processing (network segregation) as compared to controls. The large-scale functional brain networks had integration decreasing with lower level of consciousness.
Disciplines :
Neurology
Author, co-author :
Rizkallah, Jennifer;  Université de Rennes > Laboratoire Traitement du Signal et de l'Image
Annen, Jitka  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Modolo, Julien;  Université de Rennes > Laboratoire Traitement du Signal et de l'Image
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Benquet, Pascal;  Université de Rennes > Laboratoire Traitement du Signal et de l'Image
Mortaheb, Sepehr  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Amoud, Hassan;  Lebanese University > Azm Center for Research in Biotechnology and its Applications
Cassol, Helena ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Mheich, Ahmad;  Université de Rennes > Laboratoire Traitement du Signal et de l'Image
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Chatelle, Camille ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Hassan, Mahmoud;  Université de Rennes > Laboratoire Traitement du Signal et de l'Image
Panda, Rajanikant  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Wendling, Fabrice;  Université de Rennes > Laboratoire Traitement du Signal et de l'Image
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
More authors (5 more) Less
Language :
English
Title :
Decreased integration of EEG source-space networks in disorders of consciousness
Publication date :
2019
Journal title :
NeuroImage: Clinical
eISSN :
2213-1582
Publisher :
Elsevier, Netherlands
Volume :
23
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 686764 - LUMINOUS - Studying, Measuring and Altering Consciousness through information theory in the electrical brain
Funders :
CE - Commission Européenne [BE]
Available on ORBi :
since 11 July 2019

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