Article (Scientific journals)
Diagnostic accuracy of the CRS-R index in patients with disorders of consciousness
Annen, Jitka; Filippini, Maria Maddalena; Bonin, Estelle et al.
2019In Brain Injury, 33 (11), p. 1409-1412
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Keywords :
CRS-R; CRS-R index; CSR-R modified score; disorders of consciousness; unresponsive wakefulness syndrome; minimally conscious state
Abstract :
[en] Objective: To obtain a CRS-R index suitable for diagnosis of patients with disorders of consciousness (DOC) and compare it to other CRS-R based scores to evaluate its potential for clinics and research. Design: We evaluated the diagnostic accuracy of several CRS-R-based scores in 124 patients with DOC. ROC analysis of the CRS-R total score, the Rasch-based CRS-R score, CRS-R-MS and the CRS-R index evaluated the diagnostic accuracy for patients with the Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS). Correlations were computed between the CRS-R-MS, CRS-R index, the Rasch-based score and the CRS-R total score. Results: Both the CRS-R-MS and CRS-R index ranged from 0 to 100, with a cut-off of 8.315 that perfectly distinguishes between patients with UWS and MCS. The CRS-R total score and Rasch-based score did not provide a cut-off score for patients with UWS and MCS. The proposed CRS-R index correlated with the CRS-R total score, Rasch-based score and the CRS-R-MS. Conclusion: The CRS-R index is reliable to diagnose patients with UWS and MCS and can be used in compliance with the CRS-R scoring guidelines. The obtained index offers the opportunity to improve the interpretation of clinical assessment and can be used in (longitudinal) research protocols.
Research center :
Coma Science Group - GIGA Consciousness
Disciplines :
Neurology
Author, co-author :
Annen, Jitka  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Filippini, Maria Maddalena
Bonin, Estelle  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Cassol, Helena ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Aubinet, Charlène  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Carrière, Manon ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Barra, Alice  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Wolff, Audrey ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Sanz, Leandro  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Martial, Charlotte  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Chatelle, Camille ;  Université de Liège - ULiège > Consciousness-Coma Science Group
More authors (4 more) Less
Language :
English
Title :
Diagnostic accuracy of the CRS-R index in patients with disorders of consciousness
Publication date :
18 July 2019
Journal title :
Brain Injury
ISSN :
0269-9052
eISSN :
1362-301X
Publisher :
Taylor and Francis, London, United Kingdom
Volume :
33
Issue :
11
Pages :
1409-1412
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 785907 - HBP SGA2 - Human Brain Project Specific Grant Agreement 2
Name of the research project :
Luminous project (EU-H2020-fetopenga686764); Center-TBI project (FP7-HEALTH- 602150)
Funders :
ULiège - Université de Liège [BE]
CHU Liège - Centre Hospitalier Universitaire de Liège [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
UE - Union Européenne [BE]
UET - Université Européenne du Travail [BE]
FERB - Fondazione Europea Ricerca Biomedica [IT]
Laboratórios Bial [PT]
MSF - Mind Science Foundation [US-TX] [US-TX]
ASE - Agence Spatiale Européenne [FR]
BELSPO - Politique scientifique fédérale [BE]
CE - Commission Européenne [BE]
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