Abstract :
[en] Objective: To obtain a CRS-R index suitable for diagnosis of patients with disorders of consciousness (DOC) and compare it to other CRS-R based scores to evaluate its potential for clinics and research.
Design: We evaluated the diagnostic accuracy of several CRS-R-based scores in 124 patients with DOC. ROC analysis of the CRS-R total score, the Rasch-based CRS-R score, CRS-R-MS and the CRS-R index evaluated the diagnostic accuracy for patients with the Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS). Correlations were computed between the CRS-R-MS, CRS-R index, the Rasch-based score and the CRS-R total score.
Results: Both the CRS-R-MS and CRS-R index ranged from 0 to 100, with a cut-off of 8.315 that perfectly distinguishes between patients with UWS and MCS. The CRS-R total score and Rasch-based score did not provide a cut-off score for patients with UWS and MCS. The proposed CRS-R index correlated with the CRS-R total score, Rasch-based score and the CRS-R-MS.
Conclusion: The CRS-R index is reliable to diagnose patients with UWS and MCS and can be used in compliance with the CRS-R scoring guidelines. The obtained index offers the opportunity to improve the interpretation of clinical assessment and can be used in (longitudinal) research protocols.
Name of the research project :
Luminous project (EU-H2020-fetopenga686764); Center-TBI project (FP7-HEALTH- 602150)
Funders :
ULiège - Université de Liège [BE]
CHU Liège - Centre Hospitalier Universitaire de Liège [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
UE - Union Européenne [BE]
UET - Université Européenne du Travail [BE]
FERB - Fondazione Europea Ricerca Biomedica [IT]
Laboratórios Bial [PT]
MSF - Mind Science Foundation [US-TX] [US-TX]
ASE - Agence Spatiale Européenne [FR]
BELSPO - Politique scientifique fédérale [BE]
CE - Commission Européenne [BE]
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