Article (Scientific journals)
Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
Peigneux, Philippe; Laureys, Steven; Fuchs, Sonia et al.
2003In NeuroImage, 20 (1), p. 125-134
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Abstract :
[en] We have previously shown that several brain areas are activated both during sequence learning at wake and during subsequent rapid-eye-movements (REM) sleep (Nat. Neurosci. 3 (2000) 831-836), suggesting that REM sleep participates in the reprocessing of recent memory traces in humans. However, the nature of the reprocessed information remains open. Here, we show that regional cerebral reactivation during posttraining REM sleep is not merely related to the acquisition of basic visuomotor skills during prior practice of the serial reaction time task, but rather to the implicit acquisition of the probabilistic rules that defined stimulus sequences. Moreover, functional connections between the reactivated cuneus and the striatum-the latter being critical for implicit sequence learning-are reinforced during REM sleep after practice on a probabilistic rather than on a random sequence of stimuli. Our results therefore support the hypothesis that REM sleep is deeply involved in the reprocessing and optimization of the high-order information contained in the material to be learned. In addition, we show that the level of acquisition of probabilistic rules attained prior to sleep is correlated to the increase in regional cerebral blood flow during subsequent REM sleep. This suggests that posttraining cerebral reactivation is modulated by the strength of the memory traces developed during the learning episode. Our data provide the first experimental evidence for a link between behavioral performance and cerebral reactivation during REM sleep. (C) 2003 Elsevier Inc. All rights reserved.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Peigneux, Philippe ;  Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Fuchs, Sonia
Destrebecqz, Arnaud
Collette, Fabienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Delbeuck, Xavier
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Del Fiore, Guy
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Cleeremans, Axel
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
More authors (3 more) Less
Language :
English
Title :
Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep
Publication date :
September 2003
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Academic Press Inc Elsevier Science, San Diego, United States - California
Volume :
20
Issue :
1
Pages :
125-134
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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