Article (Scientific journals)
Transcutaneous Auricular Vagal Nerve Stimulation and Disorders of Consciousness: A Hypothesis for Mechanisms of Action
Briand, Marie-Michèle; Gosseries, Olivia; Staumont, Bernard et al.
2020In Frontiers in Neurology, 11
Peer Reviewed verified by ORBi
 

Files


Full Text
Briand2020_taVNShypothesis.pdf
Publisher postprint (1.37 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
coma; vagus nerve; consciousness
Abstract :
[en] Disorders of consciousness (DoC) are the hallmark of severe acquired brain injuries characterized by abnormal activity in important brain areas and disruption within and between brain networks. As DoC's therapeutic arsenal is limited, new potential therapies such as transcutaneous auricular vagal nerve stimulation (taVNS) have recently been explored. The potential of taVNS in the process of consciousness recovery has been highlighted in recent studies with DoC patients. However, it is not clear how taVNS plays a role in the recovery of consciousness. In this article, we first describe the neural correlates of consciousness, the vagus nerve anatomy and functions, along with the results of functional magnetic resonance imaging studies using taVNS. Based on consciousness recovery and taVNS mechanisms, we propose the Vagal Cortical Pathways model. This model highlights four consecutive pathways (A. Lower brainstem activation, B. Upper brainstem activation, C. Norepinephrine pathway, and D. Serotonin pathway) likely to have an impact on patients with a brain injury and DoC. Additionally, we suggest six different mechanisms of action: (1) Activation of the ascending reticular activating system; (2) Activation of the thalamus; (3) Re-establishment of the cortico-striatal-thalamic-cortical loop; (4) Promotion of negative connectivity between external and default mode networks by the activation of the salience network; (5) Increase in activity and connectivity within the external network through the norepinephrine pathway; and (6) Increase in activity within the default mode network through the serotonin pathway. This model aims to explain the potential therapeutic effects that taVNS has on brain activity in the process of consciousness recovery. © Copyright © 2020 Briand, Gosseries, Staumont, Laureys and Thibaut.
Disciplines :
Neurology
Author, co-author :
Briand, Marie-Michèle ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Gosseries, Olivia  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Staumont, Bernard ;  Université de Liège - ULiège > In silico medecine-Biomechanics Research Unit
Laureys, Steven  ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Thibaut, Aurore ;  Université de Liège - ULiège > Consciousness-Coma Science Group
Language :
English
Title :
Transcutaneous Auricular Vagal Nerve Stimulation and Disorders of Consciousness: A Hypothesis for Mechanisms of Action
Publication date :
2020
Journal title :
Frontiers in Neurology
eISSN :
1664-2295
Publisher :
Frontiers Media S.A.
Volume :
11
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2021

Statistics


Number of views
53 (5 by ULiège)
Number of downloads
171 (3 by ULiège)

Scopus citations®
 
27
Scopus citations®
without self-citations
25
OpenCitations
 
8

Bibliography


Similar publications



Contact ORBi