Article (Scientific journals)
Amantadine, Apomorphine and Zolpidem in the Treatment of Disorders of Consciousness
Gosseries, Olivia; Charland-Verville, Vanessa; Thonnard, Marie et al.
2014In Current Pharmaceutical Design, 20
Peer Reviewed verified by ORBi
 

Files


Full Text
Gosseries-MSPROOFS.pdf
Publisher postprint (1.99 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Survivors of severe brain injuries may end up in a state of 'wakeful unresponsiveness' or in a minimally conscious state. Pharmacological treatments of patients with disorders of consciousness aim to improve arousal levels and recovery of consciousness. We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from coma. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, leading sometimes to dramatic improvements. These findings are discussed in the context of current hypotheses of these agents' therapeutic mechanisms on cerebral function. In order to enhance our understanding of the underlying pathophysiological mechanisms of these drugs, we suggest combining sensitive and specific behavioral tools with neuroimaging and electrophysiological measures in large randomized, double-blind, placebo-controlled experimental designs. We conclude that the pharmacokinetics and pharmacodynamics of amantadine, apomorphine and zolpidem need further exploration to determine which treatment would provide a better neurological outcome regarding the patient's etiology, diagnosis, time since injury and overall condition.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Gosseries, Olivia   ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Charland-Verville, Vanessa  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Thonnard, Marie ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bodart, Olivier  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
 These authors have contributed equally to this work.
Language :
English
Title :
Amantadine, Apomorphine and Zolpidem in the Treatment of Disorders of Consciousness
Publication date :
2014
Journal title :
Current Pharmaceutical Design
ISSN :
1381-6128
eISSN :
1873-4286
Publisher :
Bentham Science Publishers Ltd., Hilversum, Netherlands
Volume :
20
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 22 October 2013

Statistics


Number of views
316 (34 by ULiège)
Number of downloads
37 (14 by ULiège)

Scopus citations®
 
38
Scopus citations®
without self-citations
23

Bibliography


Similar publications



Contact ORBi