Article (Scientific journals)
A novel closed-loop EEG-tDCS approach to promote responsiveness of patients in minimally conscious state: a study protocol.
Martens, Géraldine; Ibáñez-Soria, David; Barra, Alice et al.
2021In Behavioural Brain Research, p. 113311
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Keywords :
EEG; minimally conscious state; spectral entropy; transcranial direct current stimulation; vigilance
Abstract :
[en] Transcranial direct current stimulation (tDCS) applied over the prefrontal cortex has been shown to improve behavioral responsiveness in patients with disorders of consciousness following severe brain injury, especially those in minimally conscious state (MCS). However, one potential barrier of clinical response to tDCS is the timing of stimulation with regard to the fluctuations of vigilance that characterize this population. Indeed, a previous study showed that the vigilance of MCS patients has periodic average cycles of 70 minutes (range 57-80 minutes), potentially preventing them to be in an optimal neural state to benefit from tDCS when applied randomly. To tackle this issue, we propose a new protocol to optimize the application of tDCS by selectively stimulating at high and low vigilance states. Electroencephalography (EEG) real-time spectral entropy will be used as a marker of vigilance and to trigger tDCS, in a closed-loop fashion. We will conduct a randomized controlled crossover clinical trial on 16 patients in prolonged MCS who will undergo three EEG-tDCS sessions 5 days apart (1. tDCS applied at high vigilance; 2. tDCS applied at low vigilance; 3. tDCS applied at a random moment). Behavioral effects will be assessed using the Coma Recovery Scale-Revised at baseline and right after the stimulations. EEG will be recorded throughout the session and for 30 minutes after the end of the stimulation. This unique and novel approach will provide patients' tailored treatment options, currently lacking in the field of disorders of consciousness.
Research center :
CHU de Liège-Centre du Cerveau² - ULiège
Disciplines :
Neurology
Author, co-author :
Martens, Géraldine  ;  Université de Liège - ULiège > GIGA
Ibáñez-Soria, David
Barra, Alice  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Soria-Frisch, Aureli
Piarulli, Andrea
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Salvador, Ricardo
Rojas, Andrés
Nitsche, Michael A.
Kroupi, Eleni
Laureys, Steven  ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
Ruffini, Giulio
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA Consciousness - Coma Science Group
More authors (3 more) Less
Language :
English
Title :
A novel closed-loop EEG-tDCS approach to promote responsiveness of patients in minimally conscious state: a study protocol.
Publication date :
2021
Journal title :
Behavioural Brain Research
ISSN :
0166-4328
eISSN :
1872-7549
Publisher :
Elsevier, Netherlands
Pages :
113311
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 686764 - LUMINOUS - Studying, Measuring and Altering Consciousness through information theory in the electrical brain
Funders :
CE - Commission Européenne [BE]
Commentary :
Copyright © 2021. Published by Elsevier B.V.
Available on ORBi :
since 04 May 2021

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