Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

Andelic, N.; Røe, C.; Brunborg, C.; Zeldovich, M.; Løvstad, M.; Løke, D.; Borgen, I. M.; Voormolen, D. C.; Howe, E. I.; Forslund, M. V.; Dahl, H. M.; von Steinbuechel, N.; Åkerlund, C.; Amrein, K.; Andelic, N.; Andreassen, L.; Anke, A.; Antoni, A.; Audibert, G.; Azouvi, P.; Azzolini, M. L.; Bartels, R.; Barzó, P.; Beauvais, R.; Beer, R.; Bellander, B.-M.; Belli, A.; Benali, H.; Berardino, M.; Beretta, L.; Blaabjerg, M.; Bragge, P.; Brazinova, A.; Brinck, V.; Brooker, J.; Brorsson, C.; Buki, A.; Bullinger, M.; Cabeleira, M.; Caccioppola, A.; Calappi, E.; Calvi, M. R.; Cameron, P.; Lozano, G. C.; Carbonara, M.; Cavallo, S.; Chevallard, G.; Chieregato, A.; Citerio, G.; Ceyisakar, I.; Clusmann, H.; Coburn, M.; Coles, J.; Cooper, J. D.; Correia, M.; Čović, A.; Curry, N.; Czeiter, E.; Czosnyka, M.; Dahyot-Fizelier, C.; Dark, P.; Dawes, H.; Keyser, V.; Degos, V.; Corte, F. D.; Boogert, H.; Depreitere, B.; Đilvesi, Đ.; Dixit, A.; Donoghue, E.; Dreier, J.; Dulière, G.-L.; Ercole, A.; Esser, P.; Ezer, E.; Fabricius, M.; Feigin, V. L.; Foks, K.; Frisvold, S.; Furmanov, A.; Gagliardo, P.; Galanaud, D.; Gantner, D.; Gao, G.; George, P; Ghuysen, Alexandre; Giga, L.; Glocker, B.; Golubovic, J.; Gomez, P. A.; Gratz, J.; Gravesteijn, B.; Grossi, F.; Gruen, R. L.; Gupta, D.; Haagsma, J. A.; Haitsma, I.; Helbok, R.; Helseth, E.; Horton, L.; Huijben, J.; Hutchinson, P. J.; Jacobs, B.; Jankowski, S.; Jarrett, M.; Jiang, J.-Y.; Johnson, F.; Jones, K.; Karan, M.; Kolias, A. G.; Kompanje, E.; Kondziella, D.; Koraropoulos, E.; Koskinen, L.-O.; Kovács, N.; Kowark, A.; Lagares, A.; Lanyon, L.; Laureys, Steven; Lecky, F.; LEDOUX, Didier; Lefering, R.; Legrand, Victor; Lejeune, Aurélie; Levi, L.; Lightfoot, R.; Lingsma, H.; Maas, A. I. R.; Castaño-León, A. M.; Maegele, M.; Majdan, M.; Manara, A.; Manley, G.; Martino, C.; Maréchal, H.; Mattern, J.; McMahon, C.; Melegh, B.; Menon, D.; Menovsky, T.; Mikolic, A.; Misset, Benoît; Muraleedharan, V.; Murray, L.; Negru, A.; Nelson, D.; Newcombe, V.; Nieboer, D.; Nyirádi, J.; Olubukola, O.; Oresic, M.; Ortolano, F.; Palotie, A.; Parizel, P. M.; Payen, J.-F.; Perera, N.; Perlbarg, V.; Persona, P.; Peul, W.; Piippo-Karjalainen, A.; Pirinen, M.; Ples, H.; Polinder, S.; Pomposo, I.; Posti, J. P.; Puybasset, L.; Radoi, A.; Ragauskas, A.; Raj, R.; Rambadagalla, M.; Rhodes, J.; Richardson, S.; Richter, S.; Ripatti, S.; Rocka, S.; Roe, C.; Roise, O.; Rosand, J.; Rosenfeld, J. V.; Rosenlund, C.; Rosenthal, G.; Rossaint, R.; Rossi, S.; Rueckert, D.; Rusnák, M.; Sahuquillo, J.; Sakowitz, O.; Sanchez-Porras, R.; Sandor, J.; Schäfer, N.; Schmidt, S.; Schoechl, H.; Schoonman, G.; Schou, R. F.; Schwendenwein, E.; Sewalt, C.; Skandsen, T.; Smielewski, P.; Sorinola, A.; Stamatakis, E.; Stanworth, S.; Stevens, R.; Stewart, W.; Steyerberg, E. W.; Stocchetti, N.; Sundström, N.; Synnot, A.; Takala, R.; Tamás, V.; Tamosuitis, T.; Taylor, M. S.; Ao, B. T.; Tenovuo, O.; Theadom, A.; Thomas, M.; Tibboel, D.; Timmers, M.; Tolias, C.; Trapani, T.; Maria Tudora, C.; Vajkoczy, P.; Vallance, S.; Valeinis, E.; Vámos, Z.; Jagt, M.; Steen, G.; Naalt, J.; Jeroen, T. J. M. D.; Essen, T. A.; Hecke, W.; Heugten, C.; Praag, D.; Vyvere, T.; RoelWijk, P. J.; Vargiolu, A.; Vega, E.; Velt, K.; Verheyden, J.; Vespa, P. M.; Vik, A.; Vilcinis, R.; Volovici, V.; Steinbüchel, N.; Voormolen, D.; Vulekovic, P.; Wang, K. K. W.; Wiegers, E.; Williams, G.; Wilson, L.; Winzeck, S.; Wolf, S.; Yang, Z.; Ylén, P.; Younsi, A.; Zeiler, F. A.; Zelinkova, V.; Ziverte, A.; Zoerle, T.; CENTER-TBI participants investigators

doi:10.1007/s00415-020-10022-2

Article (Scientific journals)

Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

Andelic, N.; Røe, C.; Brunborg, C. et al.

2020 • In Journal of Neurology

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/257703

DOI
10.1007/s00415-020-10022-2

PubMed
32676767

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Keywords :

Head injury; Longitudinal studies; Neurological disorders; Post-traumatic fatigue

Abstract :

[en] Background: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. Methods: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. Results: Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. Conclusion: A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study. © 2020, The Author(s).

Research Center/Unit :

CHU de Liège-Centre du Cerveau² - ULiège

Disciplines :

Public health, health care sciences & services

Author, co-author :

Andelic, N.; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway, Faculty of Medicine, Institute of Health and Society, Research Centre for Habilitation and Rehabilitation Models and Services (CHARM), University of Oslo, Oslo, Norway

Røe, C.; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Brunborg, C.; Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway

Zeldovich, M.; Institute of Medical Psychology and Medical Sociology, University Medical Center, Göttingen, Germany

Løvstad, M.; Research Department, Sunnaas Rehabilitation Hospital, Bjørnemyr, Norway, Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway

Løke, D.; Research Department, Sunnaas Rehabilitation Hospital, Bjørnemyr, Norway, Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway

Borgen, I. M.; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway, Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway

Voormolen, D. C.; Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands

Howe, E. I.; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Forslund, M. V.; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway

More authors (249 more)

Language :

English

Title :

Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

Publication date :

2020

Journal title :

Journal of Neurology

ISSN :

0340-5354

eISSN :

1432-1459

Publisher :

Springer

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

EC - European Commission

Available on ORBi :

since 07 March 2021

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