Article (Scientific journals)
Neural mechanisms of antinociceptive effects of hypnosis.
Faymonville, Marie; Laureys, Steven; Degueldre, Christian et al.
2000In Anesthesiology, 92 (5), p. 1257-67
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Keywords :
Adult; Cerebrovascular Circulation; Eidetic Imagery; Female; Hot Temperature; Humans; Hypnosis; Magnetic Resonance Imaging; Male; Middle Aged; Pain Measurement; Pain Threshold; Regression Analysis; Rest; Tomography, Emission-Computed
Abstract :
[en] BACKGROUND: The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS: The protocol used a factorial design with two factors: state (hypnotic state, resting state, mental imagery) and stimulation (warm non-noxious vs. hot noxious stimuli applied to right thenar eminence). Two cerebral blood flow scans were obtained with the 15O-water technique during each condition. After each scan, the subject was asked to rate pain sensation and unpleasantness. Statistical parametric mapping was used to determine the main effects of noxious stimulation and hypnotic state as well as state-by-stimulation interactions (i.e., brain areas that would be more or less activated in hypnosis than in control conditions, under noxious stimulation). RESULTS: Hypnosis decreased both pain sensation and the unpleasantness of noxious stimuli. Noxious stimulation caused an increase in regional cerebral blood flow in the thalamic nuclei and anterior cingulate and insular cortices. The hypnotic state induced a significant activation of a right-sided extrastriate area and the anterior cingulate cortex. The interaction analysis showed that the activity in the anterior (mid-)cingulate cortex was related to pain perception and unpleasantness differently in the hypnotic state than in control situations. CONCLUSIONS: Both intensity and unpleasantness of the noxious stimuli are reduced during the hypnotic state. In addition, hypnotic modulation of pain is mediated by the anterior cingulate cortex.
Disciplines :
Anesthesia & intensive care
Neurology
Alternative medicine
Author, co-author :
Faymonville, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
DelFiore, Guy
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Franck, Georges ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Maquet, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Language :
English
Title :
Neural mechanisms of antinociceptive effects of hypnosis.
Publication date :
2000
Journal title :
Anesthesiology
ISSN :
0003-3022
eISSN :
1528-1175
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
92
Issue :
5
Pages :
1257-67
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 March 2009

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