[en] The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of debate. Recent electrophysiological reports suggest that while initial propofol infusion provokes an increase in fast rhythms (from beta to gamma range), slow activity (from delta to alpha range) rises selectively during loss of consciousness. Dynamic causal modeling was used to investigate the neural mechanisms mediating these changes in spectral power in humans. We analyzed source-reconstructed data from frontal and parietal cortices during normal wakefulness, propofol-induced mild sedation, and loss of consciousness. Bayesian model selection revealed that the best model for explaining spectral changes across the three states involved changes in corticothalamic interactions. Compared with wakefulness, mild sedation was accounted for by an increase in thalamic excitability, which did not further increase during loss of consciousness. In contrast, loss of consciousness per se was accompanied by a decrease in backward corticocortical connectivity from frontal to parietal cortices, while thalamocortical connectivity remained unchanged. These results emphasize the importance of recurrent corticocortical communication in the maintenance of consciousness and suggest a direct effect of propofol on cortical dynamics.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Boly, Mélanie ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Moran, Rosalyn
Murphy, Michael
BOVEROUX, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Bruno, Marie-Aurélie ; Université de Liège - ULiège > Centre de recherches du cyclotron
Noirhomme, Quentin ; Université de Liège - ULiège > Centre de recherches du cyclotron
LEDOUX, Didier ; Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
BONHOMME, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
BRICHANT, Jean-François ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Tononi, Giulio
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Friston, Karl
Language :
English
Title :
Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness.
Publication date :
2012
Journal title :
Journal of Neuroscience
ISSN :
0270-6474
eISSN :
1529-2401
Publisher :
Society for Neuroscience, Washington, United States - District of Columbia
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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