Article (Scientific journals)
Recovery of Acute Leukoencephalopathy Documented by Neuroimaging: A Case Report.
Szymkowicz, Emilie; Neumann, Olga; Sanz, Leandro et al.
2023In Neurology: Clinical Practice, 13 (6), p. 200203
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Keywords :
Neurology (clinical); Leukoencephalopathy; Multimodal assessments; Consciousness disorders; Neurological recovery; Case report
Abstract :
[en] OBJECTIVES: We describe an atypical delayed neurologic recovery from coma and unresponsive wakefulness syndrome (i.e., persistent vegetative state) in a patient with severe drug-induced toxic leukoencephalopathy (presumably due to synthetic cannabinoid intake). METHODS: The patient underwent standardized behavioral and multimodal neuroimaging assessments to monitor clinical evolution and brain function over a 5-month period after presumed intoxication. RESULTS: A progressive clinical recovery was observed, from an initial state of coma to emergence from a minimally conscious state after 2 months. Despite the stability of extensive white matter lesions documented by CT and structural MRI, fluorodeoxyglucose PET showed partial recovery of cortical metabolism after 5 months. DISCUSSION: This case report illustrates that the temporal dynamics of recovery from toxic acute leukoencephalopathy may be atypical and delayed. Multimodal monitoring with repeated behavioral and functional neuroimaging assessments tends to improve the prognosis reliability, while early prognosis based on structural damage may result in misleading statements.
Disciplines :
Neurology
Author, co-author :
Szymkowicz, Emilie   ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Centre Hospitalier Universitaire de Liège [BE] > Centre du Cerveau2
Neumann, Olga  ;  Kliniken Schmieder
Sanz, Leandro   ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Centre Hospitalier Universitaire de Liège [BE] > Centre du Cerveau2
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Centre Hospitalier Universitaire de Liège [BE] > Centre du Cerveau2
Thibaut, Aurore  ;  Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; CHU Liège - Centre Hospitalier Universitaire de Liège [BE] > Centre du Cerveau2
Cavaliere, Carlo ;  IRCCS SYNLAB SDN
Laureys, Steven   ;  Centre Hospitalier Universitaire de Liège - CHU > > Centre du Cerveau² ; Université de Liège - ULiège > GIGA > GIGA Consciousness
Liepert, Joachim  ;  Kliniken Schmieder
 These authors have contributed equally to this work.
Language :
English
Title :
Recovery of Acute Leukoencephalopathy Documented by Neuroimaging: A Case Report.
Publication date :
December 2023
Journal title :
Neurology: Clinical Practice
ISSN :
2163-0402
eISSN :
2163-0933
Publisher :
Ovid Technologies (Wolters Kluwer Health), United States
Volume :
13
Issue :
6
Pages :
e200203
Peer reviewed :
Peer reviewed
Available on ORBi :
since 09 October 2023

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