Article (Scientific journals)
Conscious while being considered in an unresponsive wakefulness syndrome for 20 years
VANHAUDENHUYSE, Audrey; Charland-Verville, Vanessa; Thibaut, Aurore et al.
2018In Frontiers in Neurology, 9 (AUG)
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Keywords :
Disorders of consciousness; EEG; Locked-in syndrome; Misdiagnosis; MRI; PET; Unresponsive wakefulness syndrome; Vegetative state; Article; Babinski reflex; Coma Recovery Scale Revised; Glasgow coma scale
Abstract :
[en] Despite recent advances in our understanding of consciousness disorders, accurate diagnosis of severely brain-damaged patients is still a major clinical challenge. We here present the case of a patient who was considered in an unresponsive wakefulness syndrome/vegetative state for 20 years. Repeated standardized behavioral examinations combined to neuroimaging assessments allowed us to show that this patient was in fact fully conscious and was able to functionally communicate. We thus revised the diagnosis into an incomplete locked-in syndrome, notably because the main brain lesion was located in the brainstem. Clinical examinations of severe brain injured patients suffering from serious motor impairment should systematically include repeated standardized behavioral assessments and, when possible, neuroimaging evaluations encompassing magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography. © 2018 Vanhaudenhuyse, Charland-Verville, Thibaut, Chatelle, Tshibanda, Maudoux, Faymonville, Laureys and Gosseries.
Disciplines :
Neurosciences & behavior
Author, co-author :
VANHAUDENHUYSE, Audrey  ;  Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Centre interdisciplinaire d'algologie
Charland-Verville, Vanessa ;  Université de Liège - ULiège > GIGA : Coma Group
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA : Coma Group
Chatelle, Camille ;  Université de Liège - ULiège > GIGA : Coma Group
Tshibanda, J.-F. L.;  GIGA-Consciousness, Coma Science Group and Neurology Department, University Hospital of Liege, Liege, Belgium, Department of Radiology, University Hospital of Liege and University of Liege, Liege, Belgium
Maudoux, Audrey ;  Université de Liège - ULiège > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie
Faymonville, Marie-Elisabeth ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Laureys, Steven  ;  Université de Liège - ULiège > GIGA : Coma Group
Gosseries, Olivia  ;  Université de Liège - ULiège > GIGA : Coma Group
Language :
English
Title :
Conscious while being considered in an unresponsive wakefulness syndrome for 20 years
Publication date :
2018
Journal title :
Frontiers in Neurology
eISSN :
1664-2295
Publisher :
Frontiers Media S.A.
Volume :
9
Issue :
AUG
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2019

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