Article (Scientific journals)
Striatum forever, despite sequence learning variability : A random effect analysis of PET data
Peigneux, Philippe; Maquet, Pierre; Meulemans, Thierry et al.
2000In Human Brain Mapping, 10 (4), p. 179-194
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Keywords :
implicit learning; serial reaction time; individual variability; PET; statistical parametric mapping; striatum; caudate nucleus
Abstract :
[en] This PET study is concerned with the what, where, and how of implicit sequence learning. In contrast with previous studies imaging the serial reaction time (SRT) task, the sequence of successive locations was determined by a probabilistic finite-state grammar. The implicit acquisition of statistical relationships between serially ordered elements (i.e., what) was studied scan by scan, aiming to evidence the brain areas (i.e., where) specifically involved in the implicit processing of this core component of sequential higher-order knowledge. As behavioural results demonstrate between- and within-subjects variability in the implicit acquisition of sequential knowledge through practice, functional PET data were modelled using a random-effect model analysis (i.e., how) to account for both sources of behavioural variability. First, two mean condition images were created per subject depending on the presence or not of implicit sequential knowledge at the time of each of the 12 scans. Next, direct comparison of these mean condition images provided the brain areas involved in sequential knowledge processing. Using this approach, we have shown that the striatum is involved in more than simple pairwise associations and that it has the capacity to process higher-order knowledge. We suggest that the striatum is not only involved in the implicit automatization of serial information through prefrontal cortex-caudate nucleus networks, but also that it plays a significant role for the selection of the most appropriate responses in the context created by both the current and previous stimuli, thus contributing to better efficiency and faster response preparation in the SRT task. Hum. Brain Mapping 10:179-194, 2000. © 2000 Wiley-Liss, Inc.
Disciplines :
Neurosciences & behavior
Author, co-author :
Peigneux, Philippe ;  Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Meulemans, Thierry ;  Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Destrebecqz, Arnaud
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Delfiore, Guy
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Franck, Georges ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Van der Linden, Martial ;  Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Cleeremans, Axel
Language :
English
Title :
Striatum forever, despite sequence learning variability : A random effect analysis of PET data
Publication date :
August 2000
Journal title :
Human Brain Mapping
ISSN :
1065-9471
eISSN :
1097-0193
Publisher :
John Wiley & Sons
Volume :
10
Issue :
4
Pages :
179-194
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 February 2013

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