Article (Scientific journals)
Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity
Demertzi, Athina; Soddu, Andrea; FAYMONVILLE, Marie-Elisabeth et al.
2011In Progress in Brain Research, 193, p. 309-322
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Keywords :
consciousness; hypnotic state; awareness; fMRI; default mode network; functional connectivity.
Abstract :
[en] Resting state fMRI (functional magnetic resonance imaging) acquisitions are characterized by low-frequency spontaneous activity in a default mode network (encompassing medial brain areas and linked to self-related processes) and an anticorrelated “extrinsic” system (encompassing lateral frontoparietal areas and modulated via external sensory stimulation). In order to better determine the functional contribution of these networks to conscious awareness, we here sought to transiently modulate their relationship by means of hypnosis. We used independent component analysis (ICA) on resting state fMRI acquisitions during normal wakefulness, under hypnotic state, and during a control condition of autobiographical mental imagery. As compared to mental imagery, hypnosis-induced modulation of resting state fMRI networks resulted in a reduced “extrinsic” lateral frontoparietal cortical connectivity, possibly reflecting a decreased sensory awareness. The default mode network showed an increased connectivity in bilateral angular and middle frontal gyri, whereas its posterior midline and parahippocampal structures decreased their connectivity during hypnosis, supposedly related to an altered “self” awareness and posthypnotic amnesia. In our view, fMRI resting state studies of physiological (e.g., sleep or hypnosis), pharmacological (e.g., sedation or anesthesia), and pathological modulation (e.g., coma or related states) of “intrinsic” default mode and anticorrelated “extrinsic” sensory networks, and their interaction with other cerebral networks, will further improve our understanding of the neural correlates of subjective awareness.
Disciplines :
Neurosciences & behavior
Author, co-author :
Demertzi, Athina  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Soddu, Andrea ;  Université de Liège - ULiège > Centre de recherches du cyclotron
FAYMONVILLE, Marie-Elisabeth ;  Centre Hospitalier Universitaire de Liège - CHU > Algologie - soins palliatifs
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Gosseries, Olivia  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Vanhaudenhuyse, Audrey  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Phillips, Christophe  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity
Publication date :
23 August 2011
Journal title :
Progress in Brain Research
ISSN :
0079-6123
eISSN :
1875-7855
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
193
Pages :
309-322
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 September 2011

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