Article (Scientific journals)
Functional neuroanatomy of disorders of consciousness
Di Perri, Carol; Stender, Johan; Laureys, Steven et al.
2014In Epilepsy and Behavior
Peer Reviewed verified by ORBi
 

Files


Full Text
YEBEH3596.pdf
Publisher postprint (622.67 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
consciousness; Neuroimaging techniques; Brain connectivity; Vegetative/unresponsive wakefulness; syndrome; Minimally conscious rate; General anesthesia; Coma
Abstract :
[en] Our understanding of the mechanisms of loss and recovery of consciousness, following severe brain injury or during anesthesia, is changing rapidly. Recent neuroimaging studies have shown that patients with chronic disorders of consciousness and subjects undergoing general anesthesia present a complex dysfunctionality in the architecture of brain connectivity. At present, the global hallmark of impaired consciousness appears to be amultifaceted dysfunctional connectivity pattern with both within-network loss of connectivity in awidespread frontoparietal network and between-network hyperconnectivity involving other regions such as the insula and ventral tegmental area. Despite ongoing efforts, the mechanisms underlying the emergence of consciousness after severe brain injury are not thoroughly understood. Important questions remain unanswered:What triggers the connectivity impairment leading to disorders of consciousness? Why do some patients recover from coma, while others with apparently similar brain injuries do not? Understanding these mechanisms could lead to a better comprehension of brain function and, hopefully, lead to new therapeutic strategies in this challenging patient population.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Di Perri, Carol 
Stender, Johan
Laureys, Steven  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Gosseries, Olivia  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Functional neuroanatomy of disorders of consciousness
Publication date :
2014
Journal title :
Epilepsy and Behavior
ISSN :
1525-5050
eISSN :
1525-5069
Publisher :
Elsevier, Atlanta, United States - California
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2014

Statistics


Number of views
754 (10 by ULiège)
Number of downloads
1347 (7 by ULiège)

Scopus citations®
 
80
Scopus citations®
without self-citations
74
OpenCitations
 
68

Bibliography


Similar publications



Contact ORBi