Article (Scientific journals)
BCI performance and brain metabolism profile in severely brain-injured patients without response to command at bedside
Annen, Jitka; Blandiaux, Séverine; Lejeune, Nicolas et al.
2018In Frontiers in Neuroscience
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Abstract :
[en] Detection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish "covert command following." These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed "covert command following" (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without "covert command-following" but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe "covert command following" in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC.
Disciplines :
Neurology
Author, co-author :
Annen, Jitka  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Blandiaux, Séverine ;  Université de Liège - ULiège > GIGA : Coma Group
Lejeune, Nicolas  ;  N.Lejeune@student.uliege.be
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA : Coma Group
Cho, Woosang
Guger, Christophe
Chatelle, Camille  ;  Université de Liège - ULiège > GIGA : Coma Group
Laureys, Steven   ;  Université de Liège - ULiège > GIGA : Coma Group
 These authors have contributed equally to this work.
Language :
English
Title :
BCI performance and brain metabolism profile in severely brain-injured patients without response to command at bedside
Publication date :
2018
Journal title :
Frontiers in Neuroscience
ISSN :
1662-4548
eISSN :
1662-453X
Publisher :
Frontiers Research Foundation
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 June 2018

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