BCI performance and brain metabolism profile in severely brain-injured patients without response to command at bedside

[en] Detection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish "covert command following." These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed "covert command following" (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without "covert command-following" but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe "covert command following" in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC.

Disciplines :

Neurology

Author, co-author :

Annen, Jitka ; Université de Liège - ULiège > Centre de recherches du cyclotron

Blandiaux, Séverine ; Université de Liège - ULiège > GIGA : Coma Group

Lejeune, Nicolas ; N.Lejeune@student.uliege.be

Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron

Thibaut, Aurore ; Université de Liège - ULiège > GIGA : Coma Group

Cho, Woosang

Guger, Christophe

Chatelle, Camille ^✱; Université de Liège - ULiège > GIGA : Coma Group

Laureys, Steven ^✱; Université de Liège - ULiège > GIGA : Coma Group

^✱ These authors have contributed equally to this work.

Language :

English

Title :

BCI performance and brain metabolism profile in severely brain-injured patients without response to command at bedside

Publication date :

2018

Journal title :

Frontiers in Neuroscience

ISSN :

1662-4548

eISSN :

1662-453X

Publisher :

Frontiers Research Foundation

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 June 2018

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Bibliography

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