[en] Event-related potentials (ERP) have been proposed to improve the differential diagnosis of non-responsive patients. We investigated the potential of the P300 as a reliable marker of conscious processing in patients with locked-in syndrome (LIS). Eleven chronic LIS patients and 10 healthy subjects (HS) listened to a complex-tone auditory oddball paradigm, first in a passive condition (listen to the sounds) and then in an active condition (counting the deviant tones). Seven out of nine HS displayed a P300 waveform in the passive condition and all in the active condition. HS showed statistically significant changes in peak and area amplitude between conditions. Three out of seven LIS patients showed the P3 waveform in the passive condition and five of seven in the active condition. No changes in peak amplitude and only a significant difference at one electrode in area amplitude were observed in this group between conditions. We conclude that, in spite of keeping full consciousness and intact or nearly intact cortical functions, compared to HS, LIS patients present less reliable results when testing with ERP, specifically in the passive condition. We thus strongly recommend applying ERP paradigms in an active condition when evaluating consciousness in non-responsive patients.
Disciplines :
Neurology
Author, co-author :
Lugo, Zulay R.; Coma Science Group, University and University Hospital of Liège, GIGA, Liège, Belgium, Institute of Psychology, University of Würzburg, Würzburg, Germany, French Association of Locked-in Syndrome (ALIS), Paris, France
Quitadamo, Lucia R.; Neuroelectrical Imaging and BCI Laboratory, Fondazione Santa Lucia, IRCCS, Rome, Italy, School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, United Kingdom
Bianchi, Luigi; Department of Civil Engineering and Computer Science, University of Rome Tor Vergata, Rome, Italy
Pellas, Fréderic; French Association of Locked-in Syndrome (ALIS), Paris, France, Coma Arousal Unit-PMR Department, Nîmes University Hospital, Nîmes, France
Veser, Sandra; Institute for Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
Lesenfants, Damien; Coma Science Group, University and University Hospital of Liège, GIGA, Liège, Belgium
Real, Ruben G. L.; Institute of Psychology, University of Würzburg, Würzburg, Germany
Herbert, Cornelia; Institute of Psychology, University of Würzburg, Würzburg, Germany, Department of Psychiatry, University of Tübingen, Tübingen, Germany, Department of Biomedical Resonance, University of Tübingen, Tübingen, Germany
Guger, Christoph; G.Tec Medical Engineering GmbH/Guger Technologies OG, Graz, Austria
Kotchoubey, Boris; Institute for Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
Mattia, Donatella; Neuroelectrical Imaging and BCI Laboratory, Fondazione Santa Lucia, IRCCS, Rome, Italy
Kübler, Andrea; Institute of Psychology, University of Würzburg, Würzburg, Germany
Laureys, Steven ; Université de Liège - ULiège > GIGA Consciousness: Coma Science Group
Noirhomme, Quentin ; Université de Liège - ULiège > GIGA Consciousness: Coma Science Group
Cognitive processing in non-communicative patients: What can event-related potentials tell us?
Publication date :
2016
Journal title :
Frontiers in Human Neuroscience
eISSN :
1662-5161
Publisher :
Frontiers Media S. A
Volume :
10
Issue :
NOV2016
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 247919 - DECODER - Deployment of Brain-Computer Interfaces for the Detection of Consciousness in Non-Responsive Patients
Funders :
ALIS - Association du Locked-In Syndrome [FR] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] FEDER - Fonds Européen de Développement Régional [BE] Fonds Léon Fredericq [BE] JSMF - James S McDonnell Foundation [US-MO] [US-MO] MSF - Mind Science Foundation [US-TX] [US-TX] the French Speaking Community Concerted Research Action (ARC06/11-340) University of Würzburg ULiège - Université de Liège [BE] CHU Liège - Centre Hospitalier Universitaire de Liège [BE] CE - Commission Européenne [BE]
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