Hypnosis modulates behavioural measures and subjective ratings about external and internal awareness

[en] In altered subjective states, the behavioural quantification of external and internal awareness remains challenging due to the need for reports on the subjects’ behalf. With the aim to characterize the behavioural counterpart of external and internal awareness in a modified subjective condition, we used hypnosis during which subjects remain fully responsive. Eleven right-handed subjects reached a satisfactory level of hypnotisability as evidenced by subjective reports on arousal, absorption and dissociation. Compared to normal wakefulness, in hypnosis (a) participants’ self-ratings for internal awareness increased and self-ratings for external awareness decreased, (b) the two awareness components tended to anticorrelate less and the switches between external and internal awareness self-ratings were less frequent, and (c) participants’ reaction times were higher and lapses in key presses were more frequent. The identified imbalance between the two components of awareness is considered as of functional relevance to subjective (meta)cognition, possibly mediated by allocated attentional properties brought about by hypnosis. Our results highlight the presence of a cognitive counterpart in resting state, indicate that the modified contents of awareness are measurable behaviourally, and provide leverage for investigations of more challenging altered conscious states, such as anaesthesia, sleep and disorders of consciousness.

Disciplines :

Alternative medicine

Author, co-author :

Demertzi, Athina ; Université de Liège > Centre de recherches du cyclotron

VANHAUDENHUYSE, Audrey ; Centre Hospitalier Universitaire de Liège - CHU > Algologie - soins palliatifs

Noirhomme, Quentin ; Université de Liège > Centre de recherches du cyclotron

FAYMONVILLE, Marie-Elisabeth ; Centre Hospitalier Universitaire de Liège - CHU > Algologie - soins palliatifs

LAUREYS, Steven ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie

Language :

English

Title :

Hypnosis modulates behavioural measures and subjective ratings about external and internal awareness

Publication date :

2015

Journal title :

Journal of Physiology - Paris

ISSN :

0928-4257

Publisher :

Elsevier Science, Paris, France

Volume :

109

Issue :

Pages :

173-179

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 March 2016

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Bibliography

Akerstedt, T., Gillberg, M., Subjective and objective sleepiness in the active individual. Int. J. Neurosci. 52 (1990), 29–37.
Arieli, A., Sterkin, A., Grinvald, A., Aertsen, A., Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses. Science 273 (1996), 1868–1871.
Axelrod, V., Rees, G., Lavidor, M., Bar, M., Increasing propensity to mind-wander with transcranial direct current stimulation. Proc. Natl. Acad. Sci. USA 112 (2015), 3314–3319.
Barttfeld, P., Uhrig, L., Sitt, J.D., Sigman, M., Jarraya, B., Dehaene, S., Signature of consciousness in the dynamics of resting-state brain activity. Proc. Natl. Acad. Sci. USA 112 (2015), 887–892.
Boly, M., Balteau, E., Schnakers, C., Degueldre, C., Moonen, G., Luxen, A., Phillips, C., Peigneux, P., Maquet, P., Laureys, S., Baseline brain activity fluctuations predict somatosensory perception in humans. Proc. Natl. Acad. Sci. USA 104 (2007), 12187–12192.
Boly, M., Tshibanda, L., Vanhaudenhuyse, A., Noirhomme, Q., Schnakers, C., Ledoux, D., Boveroux, P., Garweg, C., Lambermont, B., Phillips, C., Luxen, A., Moonen, G., Bassetti, C., Maquet, P., Laureys, S., Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum. Brain Mapp. 30 (2009), 2393–2400.
Boveroux, P., Vanhaudenhuyse, A., Bruno, M.-A., Noirhomme, Q., Lauwick, S., Luxen, A., Degueldre, C., Plenevaux, A., Schnakers, C., Phillips, C., Brichant, J.F., Bonhomme, V., Maquet, P., Greicius, M.D., Laureys, S., Boly, M., Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness. Anesthesiology 113 (2010), 1038–1053.
Buchel, C., Bornhovd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C., Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study. J. Neurosci. 22 (2002), 970–976.
Chai, X.J., Ofen, N., Gabrieli, J.D., Whitfield-Gabrieli, S., Selective development of anticorrelated networks in the intrinsic functional organization of the human brain. J. Cogn. Neurosci. 26 (2014), 501–513.
Christoff, K., Gordon, A.M., Smallwood, J., Smith, R., Schooler, J.W., Experience sampling during fMRI reveals default network and executive system contributions to mind wandering. Proc. Natl. Acad. Sci. USA 106 (2009), 8719–8724.
Dahl, C.J., Lutz, A., Davidson, R.J., Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice. Trends Cogn. Sci. 19 (2015), 515–523.
Demertzi, A., Soddu, A., Faymonville, M.-E., Bahri, M.-A., Gosseries, O., Vanhaudenhuyse, A., Phillips, C., Maquet, P., Noirhomme, Q., Luxen, A., Laureys, S., Hypnotic modulation of resting state fMRI default mode and extrinsic network connectivity. Prog. Brain Res. 193 (2011), 309–322.
Demertzi, A., Soddu, A., Laureys, S., Consciousness supporting networks. Curr. Opin. Neurobiol. 23 (2013), 239–244.
Demertzi, A., Vanhaudenhuyse, A., Bredart, S., Heine, L., Di Perri, C., Laureys, S., Looking for the self in pathological unconsciousness. Front. Hum. Neurosci. 7 (2013), 1–6.
Faymonville, M.-E., Fissette, J., Mambourg, P.H., Roediger, L., Joris, J., Lamy, M., Hypnosis as adjunct therapy in conscious sedation for plastic surgery. Reg. Anesth. 20 (1995), 145–151.
Faymonville, M.-E., Laureys, S., Degueldre, C., DelFiore, G., Luxen, A., Franck, G., Lamy, M., Maquet, P., Neural mechanisms of antinociceptive effects of hypnosis. Anesthesiology 92 (2000), 1257–1267.
Faymonville, M.-E., Mambourg, P.H., Joris, J., Vrijens, B., Fissette, J., Albert, A., Lamy, M., Psychological approaches during conscious sedation. Hypnosis versus stress reducing strategies: a prospective randomized study. Pain 73 (1997), 361–367.
Faymonville, M.-E., Meurisse, M., Fissette, J., Hypnosedation: a valuable alternative to traditional anaesthetic techniques. Acta Chir. Belg. 99 (1999), 141–146.
Faymonville, M.-E., Roediger, L., Del Fiore, G., Delgueldre, C., Phillips, C., Lamy, M., Luxen, A., Maquet, P., Laureys, S., Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Cogn. Brain Res. 17 (2003), 255–262.
Fox, K.C., Christoff, K., Transcranial direct current stimulation to lateral prefrontal cortex could increase meta-awareness of mind wandering. Proc. Natl. Acad. Sci. USA, 112, 2015, E2414.
Fox, M.D., Snyder, A.Z., Vincent, J.L., Corbetta, M., Van Essen, D.C., Raichle, M.E., The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. USA 102 (2005), 9673–9678.
Fox, M.D., Snyder, A.Z., Vincent, J.L., Raichle, M.E., Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior. Neuron 56 (2007), 171–184.
Fransson, P., Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Hum. Brain Mapp. 26 (2005), 15–29.
Frischholz, E.J., Braun, B.G., Sachs, R.G., Schwartz, D.R., Lewis, J., Shaeffer, D., Westergaard, C., Pasquotto, J., Construct validity of the dissociative experiences scale: II. Its relationship to hypnotizability. Am. J. Clin. Hypn. 35 (1992), 145–152.
Frischholz, E.J., Spiegel, D., Trentalange, M.J., Spiegel, H., The hypnotic induction profile and absorption. Am. J. Clin. Hypn. 30 (1987), 87–93.
Fuhrmann, A., Hein, G., Tsai, N., Naumer, M.J., Knight, R.T., Temporal characteristics of audiovisual information processing. J. Neurosci. 28 (2008), 5344–5349.
Goldberg, I.I., Harel, M., Malach, R., When the brain loses its self: prefrontal inactivation during sensorimotor processing. Neuron 50 (2006), 329–339.
Golland, Y., Bentin, S., Gelbard, H., Benjamini, Y., Heller, R., Nir, Y., Hasson, U., Malach, R., Extrinsic and intrinsic systems in the posterior cortex of the human brain revealed during natural sensory stimulation. Cereb. Cortex 17 (2007), 766–777.
Grady, C.L., Protzner, A.B., Kovacevic, N., Strother, S.C., Afshin-Pour, B., Wojtowicz, M., Anderson, J.A., Churchill, N., McIntosh, A.R., A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains. Cereb. Cortex 20 (2009), 1432–1447.
Hampson, M., Driesen, N., Roth, J.K., Gore, J.C., Constable, R.T., Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance. Magn. Reson. Imaging 28 (2010), 1051–1057.
Heine, L., Soddu, A., Gomez, F., Vanhaudenhuyse, A., Tshibanda, L., Thonnard, M., Charland-Verville, V., Kirsch, M., Laureys, S., Demertzi, A., Resting state networks and consciousness. Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states. Front. Psychol. 3 (2012), 1–12.
James, W., Attention the Principles of Psychology, vol. 1, 1890, Dover Publications, New York, 402–458.
Keller, J.B., Hedden, T., Thompson, T.W., Anteraper, S.A., Gabrieli, J.D., Whitfield-Gabrieli, S., Resting-state anticorrelations between medial and lateral prefrontal cortex: association with working memory, aging, and individual differences. Cortex 64 (2015), 271–280.
Kelly, A.M., Uddin, L.Q., Biswal, B.B., Castellanos, F.X., Milham, M.P., Competition between functional brain networks mediates behavioral variability. Neuroimage 39 (2008), 527–537.
Knauff, M., Fangmeier, T., Ruff, C.C., Johnson-Laird, P.N., Reasoning, models, and images: behavioral measures and cortical activity. J. Cogn. Neurosci. 15 (2003), 559–573.
Landry, M., Appourchaux, K., Raz, A., Elucidating unconscious processing with instrumental hypnosis. Front. Psychol., 5, 2014, 785.
Laureys, S., The neural correlate of (un)awareness: lessons from the vegetative state. Trends Cogn. Sci. 9 (2005), 556–559.
Lifshitz, M., Cusumano, E.P., Raz, A., Hypnosis as neurophenomenology. Front. Hum. Neurosci., 7, 2013, 469.
Lomb, N., Least-squares frequency analysis of unequally spaced data. Astrophys. Space Sci. 39 (1976), 447–462.
Lou, H.C., Luber, B., Crupain, M., Keenan, J.P., Nowak, M., Kjaer, T.W., Sackeim, H.A., Lisanby, S.H., Parietal cortex and representation of the mental self. Proc. Natl. Acad. Sci. USA 101 (2004), 6827–6832.
Maquet, P., Faymonville, M.E., Degueldre, C., Delfiore, G., Franck, G., Luxen, A., Lamy, M., Functional neuroanatomy of hypnotic state. Biol. Psychiatry 45 (1999), 327–333.
Mason, M.F., Norton, M.I., Van Horn, J.D., Wegner, D.M., Grafton, S.T., Macrae, C.N., Wandering minds: the default network and stimulus-independent thought. Science 315 (2007), 393–395.
McGeown, W.J., Mazzoni, G., Venneri, A., Kirsch, I., Hypnotic induction decreases anterior default mode activity. Conscious. Cogn. 18 (2009), 848–855.
McKiernan, K.A., D'Angelo, B.R., Kaufman, J.N., Binder, J.R., Interrupting the “stream of consciousness”: an fMRI investigation. Neuroimage 29 (2006), 1185–1191.
Morin, A., Michaud, J., Self-awareness and the left inferior frontal gyrus: inner speech use during self-related processing. Brain Res. Bull. 74 (2007), 387–396.
Nir, Y., Hasson, U., Levy, I., Yeshurun, Y., Malach, R., Widespread functional connectivity and fMRI fluctuations in human visual cortex in the absence of visual stimulation. Neuroimage 30 (2006), 1313–1324.
Oakley, D.A., Halligan, P.W., Hypnotic suggestion and cognitive neuroscience. Trends Cogn. Sci. 13 (2009), 264–270.
Press, W.H., Teukolsky, S.A., Vetterling, W.T., Flannery, B.P., Spectral analysis of unevenly sampled data. Press, W.H., Teukolsky, S.A., Vetterling, W.T., Flannery, B.P., (eds.) Numerical Recipes in C, second ed., 1992, Cambridge University Press, Cambridge, 575–584.
Rainville, P., Hofbauer, R.K., Bushnell, M.C., Duncan, G.H., Price, D.D., Hypnosis modulates activity in brain structures involved in the regulation of consciousness. J. Cogn. Neurosci. 14 (2002), 887–901.
Rainville, P., Price, D.D., Hypnosis phenomenology and the neurobiology of consciousness. Int. J. Clin. Exp. Hypn. 51 (2003), 105–129.
Raz, A., Hypnosis as a lens to the development of attention. Conscious. Cogn. 21 (2012), 1595–1598.
Raz, A., Buhle, J., Typologies of attentional networks. Nat. Rev. Neurosci. 7 (2006), 367–379.
Rees, G., Neural correlates of the contents of visual awareness in humans. Philos. Trans. R. Soc. Lond. B Biol. Sci. 362 (2007), 877–886.
Samann, P.G., Wehrle, R., Hoehn, D., Spoormaker, V.I., Peters, H., Tully, C., Holsboer, F., Czisch, M., Development of the brain's default mode network from wakefulness to slow wave sleep. Cereb. Cortex 21 (2011), 2082–2093.
Sapir, A., d'Avossa, G., McAvoy, M., Shulman, G.L., Corbetta, M., Brain signals for spatial attention predict performance in a motion discrimination task. Proc. Natl. Acad. Sci. USA 102 (2005), 17810–17815.
Schooler, J.W., Smallwood, J., Christoff, K., Handy, T.C., Reichle, E.D., Sayette, M.A., Meta-awareness, perceptual decoupling and the wandering mind. Trends Cogn. Sci. 15 (2011), 319–326.
Smallwood, J., Fishman, D.J., Schooler, J.W., Counting the cost of an absent mind: mind wandering as an underrecognized influence on educational performance. Psychon. Bull. Rev. 14 (2007), 230–236.
Smallwood, J., McSpadden, M., Luus, B., Schooler, J., Segmenting the stream of consciousness: the psychological correlates of temporal structures in the time series data of a continuous performance task. Brain Cogn. 66 (2008), 50–56.
Smallwood, J., McSpadden, M., Luus, B., Schooler, J.W., Segmenting the stream of consciousness: the psychological correlates of temporal structures in the time series data of a continuous performance task. Brain Cogn. 66 (2008), 50–56.
Smallwood, J., McSpadden, M., Schooler, J.W., The lights are on but no one's home: meta-awareness and the decoupling of attention when the mind wanders. Psychon. Bull. Rev. 14 (2007), 527–533.
Smallwood, J., Schooler, J.W., The restless mind. Psychol. Bull. 132 (2006), 946–958.
Soddu, A., Boly, M., Nir, Y., Noirhomme, Q., Vanhaudenhuyse, A., Demertzi, A., Arzi, A., Ovadia, S., Stanziano, M., Papa, M., Laureys, S., Malach, R., Reaching across the abyss: recent advances in functional magnetic resonance imaging and their potential relevance to disorders of consciousness. Prog. Brain Res. 177 (2009), 261–274.
The Executive Committee of the American Psychological Association – Division of Psychological Hypnosis, Definition and description of hypnosis. Contemp. Hypn. 11 (1994), 142–162.
Vanhaudenhuyse, A., Boly, M., Balteau, E., Schnakers, C., Moonen, G., Luxen, A., Lamy, M., Degueldre, C., Brichant, J.F., Maquet, P., Laureys, S., Faymonville, M.-E., Pain and non-pain processing during hypnosis: a thulium-YAG event-related fMRI study. Neuroimage 47 (2009), 1047–1054.
Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., Phillips, C., Soddu, A., Luxen, A., Moonen, G., Laureys, S., Two distinct neuronal networks mediate the awareness of environment and of self. J. Cogn. Neurosci. 23 (2011), 570–578.
Wagstaff, G.F., High hypnotizability in a sociocognitive framework. Heap, M., Brown, R.J., Oakley, D.A., (eds.) The Highly Hypnotizable Person: Theoretical, Experimental, and Clinical Issues, 2004, Brunner-Routledge, New York, 85–114.
Wang, K., Jiang, T., Yu, C., Tian, L., Li, J., Liu, Y., Zhou, Y., Xu, L., Song, M., Li, K., Spontaneous activity associated with primary visual cortex: a resting-state FMRI study. Cereb. Cortex 18 (2008), 697–704.
Weissman, D.H., Roberts, K., Visscher, K., Woldorff, M.G., The neural bases of momentary lapses in attention. Nat. Neurosci. 9 (2006), 971–978.
Whitfield-Gabrieli, S., Thermenos, H.W., Milanovic, S., Tsuang, M.T., Faraone, S.V., McCarley, R.W., Shenton, M.E., Green, A.I., Nieto-Castanon, A., LaViolette, P., Wojcik, J., Gabrieli, J.D., Seidman, L.J., Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc. Natl. Acad. Sci. USA 106 (2009), 1279–1284.
Zeman, A., Consciousness. Brain 124 (2001), 1263–1289.