Brain function; Cognitive function; Consciousness; Neuroimaging; Vegetative state
Abstract :
[en] The assessment of patients in the vegetative state is extremely complex and depends frequently on subjective interpretations of the observed spontaneous and volitional behavior. In recent years, a number of studies have demonstrated an important role for functional neuroimaging in the identification of residual cognitive function, and even conscious awareness, in some patients fulfilling the clinical criteria for vegetative state. Such studies, when successful, may be particularly useful where there is concern about the accuracy of the diagnosis and the possibility that residual cognitive function has remained undetected. However, use of these techniques in severely brain-injured persons is methodologically complex and requires careful quantitative analysis and interpretation.
Disciplines :
Neurology
Author, co-author :
Owen, Adrian M.; The Brain and Mind Institute, The University of Western Ontario, London, ON, Canada
Schiff, Nicholas D.; Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, United States
Laureys, Steven ; Université de Liège - ULiège > Consciousness-Coma Science Group
Language :
English
Title :
The Assessment of Conscious Awareness in the Vegetative State
Publication date :
2016
Main work title :
The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology
Editor :
LAUREYS, Steven ; Centre Hospitalier Universitaire de Liège - CHU > Centre du Cerveau²
Gosseries, Olivia ; Université de Liège - ULiège > Département des sciences cliniques
Tononi, Giulio
Publisher :
Elsevier Inc.
Edition :
2nd edition
ISBN/EAN :
978-0-12-800948-2
Pages :
155-166
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique S02172,NS434 Charles A. Dana Foundation Canada Excellence Research Chairs (CERC) program JSMF - James S McDonnell Foundation National Sciences andEngineering Research Council of Canada (NSERC) CIHR - Canadian Institutes of Health Research
Agardh C.D., Rosen I., Ryding E. Persistent vegetative state with high cerebral blood flow following profound hypoglycemia. Ann. Neurol. 1983, 14(4):482-486.
Aguirre G.K., Detre J.A., Alsop D.C., D'Esposito M. The parahippocampus subserves topographical learning in man. Cereb. Cortex 1996, 6(6):823-829.
Andrews K., Murphy L., Munday R., Littlewood C. Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit. BMJ 1996, 313(7048):13-16.
Baars B.J., Ramsoy T.Z., Laureys S. Brain, conscious experience and the observing self. Trends Neurosci. 2003, 26(12):671-675.
Bardin J.C., Fins J.J., Katz D.I., Hersh J., Heier L.A., Tabelow K., et al. Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 2011, 134(Pt 3):769-782.
Bardin J.C., Schiff N.D., Voss H.U. Pattern classification of volitional functional magnetic resonance imaging responses in patients with severe brain injury. Arch. Neurol. 2012, 69(2):176-181.
Bergsneider M., Hovda D.A., McArthur D.L., Etchepare M., Huang S.C., Sehati N., et al. Metabolic recovery following human traumatic brain injury based on FDG-PET: time course and relationship to neurological disability. J. Head Trauma Rehabil. 2001, 16(2):135-148.
Beuthien-Baumann B., Handrick W., Schmidt T., Burchert W., Oehme L., Kropp J., et al. Persistent vegetative state: evaluation of brain metabolism and brain perfusion with PET and SPECT. Nucl. Med. Commun. 2003, 24(6):643-649.
Bidet-Caulet A., Fischer C., Besle J., Aguera P.E., Giard M.H., Bertrand O. Effects of selective attention on the electrophysiological representation of concurrent sounds in the human auditory cortex. J. Neurosci. 2007, 27(35):9252-9261.
Boly M., Faymonville M.E., Peigneux P., Lambermont B., Damas P., Del Fiore G., et al. Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state. Arch. Neurol. 2004, 61(2):233-238.
Boly M., Coleman M.R., Davis M.H., Hampshire A., Bor D., Moonen G., et al. When thoughts become action: an fMRI paradigm to study volitional brain activity in non-communicative brain injured patients. Neuroimage 2007, 36(3):979-992.
Childs N.L., Mercer W.N., Childs H.W. Accuracy of diagnosis of persistent vegetative state. Neurology 1993, 43(8):1465-1467.
de Jong B.M., Willemsen A.T., Paans A.M. Regional cerebral blood flow changes related to affective speech presentation in persistent vegetative state. Clin. Neurol. Neurosurg. 1997, 99(3):213-216.
DeVolder A.G., Goffinet A.M., Bol A., Michel C., de Barsy T., Laterre C. Brain glucose metabolism in postanoxic syndrome. Positron emission tomographic study. Arch. Neurol. 1990, 47(2):197-204.
Edgren E., Enblad P., Grenvik A., Lilja A., Valind S., Wiklund L., et al. Cerebral blood flow and metabolism after cardiopulmonary resuscitation. A pathophysiologic and prognostic positron emission tomography pilot study. Resuscitation 2003, 57(2):161-170.
Fernandez-Espejo D., Owen A.M. Detecting awareness after severe brain injury. Nat. Rev. Neurosci. 2013, 14(11):801-809.
Fernandez-Espejo D., Norton L., Owen A.M. The clinical utility of fMRI for identifying covert awareness in the vegetative state: a comparison of sensitivity between 3T and 1.5T. PLoS One 2014, 9(4):e95082.
Giacino J.T., Kalmar K., Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch. Phys. Med. Rehabil. 2004, 85(12):2020-2029.
Goodman J.C., Valadka A.B., Gopinath S.P., Uzura M., Robertson C.S. Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit. Care Med. 1999, 27(9):1965-1973.
Gould E., Reeves A.J., Graziano M.S., Gross C.G. Neurogenesis in the neocortex of adult primates. Science 1999, 286(5439):548-552.
Greenberg D.L. Comment on "Detecting awareness in the vegetative state". Science 2007, 315(5816):1221.
Gsell W., De Sadeleer C., Marchalant Y., MacKenzie E.T., Schumann P., Dauphin F. The use of cerebral blood flow as an index of neuronal activity in functional neuroimaging: experimental and pathophysiological considerations. J. Chem. Neuroanat. 2000, 20(3-4):215-224.
Hamlin G.P., Cernak I., Wixey J.A., Vink R. Increased expression of neuronal glucose transporter 3 but not glial glucose transporter 1 following severe diffuse traumatic brain injury in rats. J. Neurotrauma 2001, 18(10):1011-1018.
Hampshire A., Parkin B.L., Cusack R., Espejo D.F., Allanson J., Kamau E., et al. Assessing residual reasoning ability in overtly non-communicative patients using fMRI. Neuroimage Clin. 2012, 2:174-183.
Hamzei F., Knab R., Weiller C., Rother J. The influence of extra- and intracranial artery disease on the BOLD signal in FMRI. Neuroimage 2003, 20(2):1393-1399.
Haxby J.V., Grady C.L., Horwitz B., Ungerleider L.G., Mishkin M., Carson R.E., et al. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proc. Natl. Acad. Sci. USA. 1991, 88(5):1621-1625.
Haxby J.V., Horwitz B., Ungerleider L.G., Maisog J.M., Pietrini P., Grady C.L. The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations. J. Neurosci. 1994, 14(11 Pt 1):6336-6353.
Herscovitch P., Auchus A.P., Gado M., Chi D., Raichle M.E. Correction of positron emission tomography data for cerebral atrophy. J. Cereb. Blood Flow Metab. 1986, 6(1):120-124.
Hovda D.A., Becker D.P., Katayama Y. Secondary injury and acidosis. J. Neurotrauma 1992, 9(Suppl. 1):S47-S60.
Jeannerod M., Frak V. Mental imaging of motor activity in humans. Curr. Opin. Neurobiol. 1999, 9(6):735-739.
Jennett B. The vegetative state. J. Neurol. Neurosurg. Psychiatry 2002, 73(4):355-357.
Jennett B., Plum F. Persistent vegetative state after brain damage. A syndrome in search of a name. Lancet 1972, 1(7753):734-737.
Laureys S., Goldman S., Phillips C., Van Bogaert P., Aerts J., Luxen A., et al. Impaired effective cortical connectivity in vegetative state: preliminary investigation using PET. Neuroimage 1999, 9(4):377-382.
Laureys S., Lemaire C., Maquet P., Phillips C., Franck G. Cerebral metabolism during vegetative state and after recovery to consciousness. J. Neurol. Neurosurg. Psychiatry 1999, 67(1):121.
Laureys S., Faymonville M.E., Degueldre C., Fiore G.D., Damas P., Lambermont B., et al. Auditory processing in the vegetative state. Brain 2000, 123(Pt 8):1589-1601.
Laureys S., Faymonville M.E., Goldman S. Impaired cerebral connectivity in vegetative state. Physiological Imaging of the Brain with PET 2000, 329-334. Academic Press, San Diego, CA. A. Gjedde, S.B. Hansen, G.M. Knudsen, O.B. Paulson (Eds.).
Laureys S., Faymonville M.E., Luxen A., Lamy M., Franck G., Maquet P. Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 2000, 355(9217):1790-1791.
Laureys S., Faymonville M.E., Moonen G., Luxen A., Maquet P. PET scanning and neuronal loss in acute vegetative state. Lancet 2000, 355(9217):1825-1827.
Laureys S., Faymonville M.E., Peigneux P., Damas P., Lambermont B., Del Fiore G., et al. Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. Neuroimage 2002, 17(2):732-741.
Levy D.E., Sidtis J.J., Rottenberg D.A., Jarden J.O., Strother S.C., Dhawan V., et al. Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients. Ann. Neurol. 1987, 22(6):673-682.
Medical aspects of the persistent vegetative state (1). The Multi-Society Task Force on PVS. 1994. N. Engl. J. Med. 330 (21), 1499-1508.
Menon D.K., Owen A.M., Williams E.J., Minhas P.S., Allen C.M., Boniface S.J., et al. Cortical processing in persistent vegetative state. Wolfson Brain Imaging Centre Team. Lancet 1998, 352(9123):200.
Momose T., Matsui T., Kosaka N., Ohtake T., Watanabe T., Nishikawa J., et al. Effect of cervical spinal cord stimulation (cSCS) on cerebral glucose metabolism and blood flow in a vegetative patient assessed by positron emission tomography (PET) and single photon emission computed tomography (SPECT). Radiat. Med. 1989, 7(5):243-246.
Monti M.M., Coleman M.R., Owen A.M. Executive functions in the absence of behavior: functional imaging of the minimally conscious state. Prog. Brain Res. 2009, 177:249-260.
Monti M.M., Vanhaudenhuyse A., Coleman M.R., Boly M., Pickard J.D., Tshibanda L., et al. Willful modulation of brain activity in disorders of consciousness. N. Engl. J. Med. 2010, 362(7):579-589.
Monti M.M., Pickard J.D., Owen A.M. Visual cognition in disorders of consciousness: from V1 to top-down attention. Hum. Brain Mapp. 2013, 34(6):1245-1253.
Nachev P., Husain M. Comment on "Detecting awareness in the vegetative state". Science 2007, 315(5816):1221.
Naci L., Owen A.M. Making every word count for nonresponsive patients. JAMA Neurol. 2013, 70(10):1235-1241.
Naci L., Cusack R., Jia V.Z., Owen A.M. The brain's silent messenger: using selective attention to decode human thought for brain-based communication. J. Neurosci. 2013, 33(22):9385-9393.
Owen A.M., Coleman M.R. Detecting awareness in the vegetative state. Ann. N.Y. Acad. Sci. 2008, 1129:130-138.
Owen A.M., Coleman M.R., Boly M., Davis M.H., Laureys S., Pickard J.D. Detecting awareness in the vegetative state. Science 2006, 313(5792):1402.
Owen A.M., Coleman M.R., Boly M., Davis M.H., Laureys S., Jolles D., et al. Response to comments on "Detecting awareness in the vegetative state". Science 2007, 315(5816):1221.
Rossini P.M., Altamura C., Ferretti A., Vernieri F., Zappasodi F., Caulo M., et al. Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics?. Brain 2004, 127(Pt 1):99-110.
Rudolf J., Ghaemi M., Ghaemi M., Haupt W.F., Szelies B., Heiss W.D. Cerebral glucose metabolism in acute and persistent vegetative state. J. Neurosurg. Anesthesiol. 1999, 11(1):17-24.
Rudolf J., Sobesky J., Grond M., Heiss W.D. Identification by positron emission tomography of neuronal loss in acute vegetative state. Lancet 2000, 355(9198):115-116.
Rudolf J., Sobesky J., Ghaemi M., Heiss W.D. The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state. Eur. J. Neurol. 2002, 9(6):671-677.
Sakatani K., Murata Y., Fukaya C., Yamamoto T., Katayama Y. BOLD functional MRI may overlook activation areas in the damaged brain. Acta Neurochir. Suppl. 2003, 87:59-62.
Schiff N., Ribary U., Plum F., Llinas R. Words without mind. J. Cogn. Neurosci. 1999, 11(6):650-656.
Schiff N., Ribary U., Moreno D.R., Beattie B., Kronberg E., Blasberg R., et al. Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. Brain 2002, 125(Pt 6):1210-1234.
Tommasino C., Grana C., Lucignani G., Torri G., Fazio F. Regional cerebral metabolism of glucose in comatose and vegetative state patients. J. Neurosurg. Anesthesiol. 1995, 7(2):109-116.
Videen T.O., Perlmutter J.S., Mintun M.A., Raichle M.E. Regional correction of positron emission tomography data for the effects of cerebral atrophy. J. Cereb. Blood Flow Metab. 1988, 8(5):662-670.
Wade D.T., Johnston C. The permanent vegetative state: practical guidance on diagnosis and management. BMJ 1999, 319(7213):841-844.
Weiskopf N., Mathiak K., Bock S.W., Scharnowski F., Veit R., Grodd W., et al. Principles of a brain-computer interface (BCI) based on real-time functional magnetic resonance imaging (fMRI). IEEE Trans. Biomed. Eng. 2004, 51(6):966-970.
Wilson B.A., Gracey F., Bainbridge K. Cognitive recovery from "persistent vegetative state": psychological and personal perspectives. Brain Inj. 2001, 15(12):1083-1092.
Wu H.M., Huang S.C., Hattori N., Glenn T.C., Vespa P.M., Yu C.L., et al. Selective metabolic reduction in gray matter acutely following human traumatic brain injury. J. Neurotrauma 2004, 21(2):149-161.
Zeman A. The problem of unreportable awareness. Prog. Brain Res. 2009, 177:1-9.