Article (Scientific journals)
Randomized controlled trial of home-based 4-week tDCS in chronic minimally conscious state
Martens, Géraldine; Lejeune, Nicolas; O'Brien, Anthony et al.
2018In Brain Stimulation
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Keywords :
transcranial direct current stimulation (tDCS); traumatic brain injury; minimally conscious state
Abstract :
[en] Background Patients with chronic disorders of consciousness face a significant lack of treatment options. Objective We aimed at investigating the feasibility and the behavioral effects of home-based transcranial direct current stimulation (tDCS), applied by relatives or caregivers, in chronic patients in minimally conscious state (MCS). Methods Each participant received, in a randomized order, 20 sessions of active and 20 sessions of sham tDCS applied over the prefrontal cortex for 4 weeks; separated by 8 weeks of washout. Level of consciousness was assessed using the Coma Recovery Scale-Revised before the first stimulation (baseline), after the end of the 20 tDCS sessions (direct effects) and 8 weeks after the end of each stimulation period (long-term effects). Reported adverse events and data relative to the adherence (i.e., amount of sessions effectively received) were collected as well. Results Twenty-seven patients completed the study and 22 patients received at least 80% of the stimulation sessions. All patients tolerated tDCS well, no severe adverse events were noticed after real stimulation and the overall adherence (i.e., total duration of stimulation) was good. A moderate effect size (0.47 and 0.53, for modified intention to treat and per protocol analysis, respectively) was observed at the end of the 4 weeks of tDCS in favor of the active treatment. Conclusions We demonstrated that home-based tDCS can be used adequately outside a research facility or hospital by patients’ relatives or caregivers. In addition, 4 weeks of tDCS moderately improved the recovery of signs of consciousness in chronic MCS patients.
Disciplines :
Author, co-author :
Martens, Géraldine  ;  Université de Liège - ULiège > GIGA : Coma Group
Lejeune, Nicolas  ;  Université de Liège - ULiège > Form. doct. sc. méd. (paysage)
O'Brien, Anthony
Fregni, Felipe
Martial, Charlotte  ;  Université de Liège - ULiège > GIGA : Coma Group
Wannez, Sarah ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Laureys, Steven  ;  Université de Liège - ULiège > GIGA : Coma Group
Thibaut, Aurore ;  Université de Liège - ULiège > GIGA : Coma Group
Language :
Title :
Randomized controlled trial of home-based 4-week tDCS in chronic minimally conscious state
Publication date :
May 2018
Journal title :
Brain Stimulation
Publisher :
Elsevier, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 686764 - LUMINOUS - Studying, Measuring and Altering Consciousness through information theory in the electrical brain
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
ASE - Agence Spatiale Européenne [FR]
CE - Commission Européenne [BE]
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