[en] STUDY OBJECTIVES: The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep. DESIGN: 256-channel EEG recordings in humans during propofol anesthesia. SETTING: Hospital operating room. PATIENTS OR PARTICIPANTS: 8 healthy subjects (4 males) INTERVENTIONS: N/A MEASUREMENTS AND RESULTS: Initially, propofol induced increases in EEG power from 12-25 Hz. Loss of consciousness (LOC) was accompanied by the appearance of EEG slow waves that resembled the slow waves of NREM sleep. We compared slow waves in propofol to slow waves recorded during natural sleep and found that both populations of waves share similar cortical origins and preferentially propagate along the mesial components of the default network. However, propofol slow waves were spatially blurred compared to sleep slow waves and failed to effectively entrain spindle activity. Propofol also caused an increase in gamma (25-40 Hz) power that persisted throughout LOC. Source modeling analysis showed that this increase in gamma power originated from the anterior and posterior cingulate cortices. During LOC, we found increased gamma functional connectivity between these regions compared to the wakefulness. CONCLUSIONS: Propofol anesthesia is a sleep-like state and slow waves are associated with diminished consciousness even in the presence of high gamma activity. CITATION: Murphy M; Bruno MA; Riedner BA; Boveroux P; Noirhomme Q; Landsness EC; Brichant JF; Phillips C; Massimini M; Laureys S; Tononi G; Boly M. Propofol anesthesia and sleep: a high-density EEG study. SLEEP 2011;34(3):283-291.
Disciplines :
Neurology Anesthesia & intensive care
Author, co-author :
Murphy, Michael
Bruno, Marie-Aurélie ; Université de Liège - ULiège > Centre de recherches du cyclotron
Riedner, Brady A
BOVEROUX, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Noirhomme, Quentin ; Université de Liège - ULiège > Centre de recherches du cyclotron
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Shafer A. Metaphor and anesthesia. Anesthesiology 1995;83:1331-42.
Franks NP. General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal. Nat Rev Neurosci 2008;9:370-86. (Pubitemid 351556044)
Lydic R, Baghdoyan HA. Sleep, anesthesiology, and the neurobiology of arousal state control. Anesthesiology 2005;103:1268-95. (Pubitemid 41692513)
Kaisti KK, Metsahonkala L, Teras M, et al. Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology 2002;96:1358-70. (Pubitemid 34587204)
Maquet P. Functional neuroimaging of normal human sleep by positron emission tomography. J Sleep Res 2000;9:207-31.
Tung A, Bergmann BM, Herrera S, Cao D, Mendelson WB. Recovery from sleep deprivation occurs during propofol anesthesia. Anesthesiology 2004;100:1419-26. (Pubitemid 38679311)
Tung A, Lynch JP, Mendelson WB. Prolonged sedation with propofol in the rat does not result in sleep deprivation. Anesth Analg 2001;92:1232-6. (Pubitemid 32385948)
Steriade M, Nunez A, Amzica F. A novel slow (<1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J Neurosci 1993;13:3252-65.
Volgushev M, Chauvette S, Mukovski M, Timofeev I. Precise long-range synchronization of activity and silence in neocortical neurons during slow-wave oscillations [corrected]. J Neurosci 2006;26:5665-72. (Pubitemid 44315258)
Landsness EC, Crupi D, Hulse BK, et al. Sleep-dependent improvement in visuomotor learning: a causal role for slow waves. Sleep 2009;32:1273-84.
Maquet P. The role of sleep in learning and memory. Science 2001;294:1048-52. (Pubitemid 33041853)
Tononi G, Cirelli C. Sleep function and synaptic homeostasis. Sleep Med Rev 2006;10:49-62. (Pubitemid 43106851)
Gugino LD, Chabot RJ, Prichep LS, John ER, Formanek V, Aglio LS. Quantitative EEG changes associated with loss and return of consciousness in healthy adult volunteers anaesthetized with propofol or sevoflurane. Br J Anaesth 2001;87:421-8. (Pubitemid 32827478)
John ER, Prichep LS. The anesthetic cascade: a theory of how anesthesia suppresses consciousness. Anesthesiology 2005;102:447-71. (Pubitemid 40189096)
Stickgold R, Malia A, Fosse R, Propper R, Hobson JA. Brain-mind states: I. Longitudinal field study of sleep/wake factors influencing mentation report length. Sleep 2001;24:171-9.
Tucker DM, Brown M, Luu P, Holmes MD. Discharges in ventromedial frontal cortex during absence spells. Epilepsy Behav 2007;11:546-5.
Engel AK, Fries P, Konig P, Brecht M, Singer W. Temporal binding, binocular rivalry, and consciousness. Conscious Cogn 1999;8:128-51.
Llinas R, Ribary U, Contreras D, Pedroarena C. The neuronal basis for consciousness. Philos Trans R Soc Lond B Biol Sci 1998;353:1841-9. (Pubitemid 28537291)
Klimesch W, Doppelmayr M, Yonelinas A, et al. Theta synchronization during episodic retrieval: neural correlates of conscious awareness. Brain Res Cogn Brain Res 2001;12:33-8. (Pubitemid 32728278)
Vanderwolf CH. Are neocortical gamma waves related to consciousness? Brain Res 2000;855:217-24.
Nunez PL, Srinivasan R, Westdorp AF, et al. EEG coherency. I: Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales. Electroencephalogr Clin Neurophysiol 1997;103:499-515.
Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J 1974;2:656-9.
Marsh B, White M, Morton N, Kenny GN. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth 1991;67:41-8.
Murphy M, Riedner BA, Huber R, Massimini M, Ferrarelli F, Tononi G. Source modeling sleep slow waves. Proc Natl Acad Sci U S A 2009;106:1608-13.
Riedner BA, Vyazovskiy VV, Huber R, et al. Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 2007;30:1643-57.
Nichols TE, Holmes AP. Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 2002;15:1-25. (Pubitemid 34020610)
Grave de Peralta Menendez R, Gonzalez Andino S, Lantz G, Michel CM, Landis T. Noninvasive localization of electromagnetic epileptic activity. I. Method descriptions and simulations. Brain Topogr 2001;14:131-7.
Kirschstein T, Kohling R. What is the source of the EEG? Clin EEG Neurosci 2009;40:146-9.
Pockett S, Bold GE, Freeman WJ. EEG synchrony during a perceptual-cognitive task: widespread phase synchrony at all frequencies. Clin Neurophysiol 2009;120:695-708.
Lachaux JP, Rodriguez E, Martinerie J, Varela FJ. Measuring phase synchrony in brain signals. Hum Brain Mapp 1999;8:194-208.
Whitham EM, Pope KJ, Fitzgibbon SP, et al. Scalp electrical recording during paralysis: quantitative evidence that EEG frequencies above 20 Hz are contaminated by EMG. Clin Neurophysiol 2007;118:1877-88. (Pubitemid 47031703)
Yuval-Greenberg S, Tomer O, Keren AS, Nelken I, Deouell LY. Transient induced gamma-band response in EEG as a manifestation of miniature saccades. Neuron 2008;58:429-41. (Pubitemid 351615190)
Gao F, Mapleson WW, Vickers MD. Effect of sub-anaesthetic infusions of propofol on peak velocity of saccadic eye movements. Eur J Anaesthesiol 1991;8:267-76.
Heaney M, Kevin LG, Manara AR, et al. Ocular microtremor during general anesthesia: results of a multicenter trial using automated signal analysis. Anesth Analg 2004;99:775-80. (Pubitemid 39100368)
Struys M, Versichelen L, Mortier E, et al. Comparison of spontaneous frontal EMG, EEG power spectrum and bispectral index to monitor propofol drug effect and emergence. Acta Anaesthesiol Scand 1998;42:628-36.
Dimigen O, Valsecchi M, Sommer W, Kliegl R. Human microsaccade-related visual brain responses. J Neurosci 2009;29:12321-31.
Molle M, Marshall L, Gais S, Born J. Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep. J Neurosci 2002;22:10941-7. (Pubitemid 36005170)
Tung A, Mendelson WB. Anesthesia and sleep. Sleep Med Rev 2004;8:213-25. (Pubitemid 38715679)
Clement EA, Richard A, Thwaites M, Ailon J, Peters S, Dickson CT. Cyclic and sleep-like spontaneous alternations of brain state under urethane anaesthesia. PLoS One 2008;3:e2004.
Sleigh JW, Andrzejowski J, Steyn-Ross A, Steyn-Ross M. The bispectral index: a measure of depth of sleep? Anesth Analg 1999;88:659-61.
Tung A, Szafran MJ, Bluhm B, Mendelson WB. Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane. Anesthesiology 2002;97:906-11.
Hagmann P, Cammoun L, Gigandet X, et al. Mapping the structural core of human cerebral cortex. PLoS Biol 2008;6:e159.
Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A 2001;98:676-82. (Pubitemid 32105102)
Gath I, Bar-On E. Classical sleep stages and the spectral content of the EEG signal. Int J Neurosci 1983;22:147-55.
Veselis RA, Feshchenko VA, Reinsel RA, Dnistrian AM, Beattie B, Akhurst TJ. Thiopental and propofol affect different regions of the brain at similar pharmacologic effects. Anesth Analg 2004;99:399-408. (Pubitemid 38970409)
Born J, Rasch B, Gais S. Sleep to remember. Neuroscientist 2006;12:410-24. (Pubitemid 44316320)
MacIver MB, Mandema JW, Stanski DR, Bland BH. Thiopental uncouples hippocampal and cortical synchronized electroencephalographic activity. Anesthesiology 1996;84:1411-24. (Pubitemid 26192050)
Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G. Breakdown of cortical effective connectivity during sleep. Science 2005;309:2228-32. (Pubitemid 41396075)
Tononi G. Consciousness as integrated information: a provisional manifesto. Biol Bull 2008;215:216-42.
Ferrarelli F, Massimini M, Sarasso S, et al. Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc Natl Acad Sci U S A 2010;107:2681-6.
Vyazovskiy VV, Tobler I, Winsky-Sommerer R. Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization. Neuroscience 2007;147:833-41. (Pubitemid 46990658)
Wikler A. Pharmacologic dissociation of behavior and EEG «sleep patterns » in dogs; morphine, n-allylnormorphine, and atropine. Proc Soc Exp Biol Med 1952;79:261-5.
Itil T, Fink M. EEG and behavioral aspects of the interaction of anticholinergic hallucinogens with centrally active compounds. Prog Brain Res 1968;28:149-68.
Kikuchi M, Wada Y, Nanbu Y, et al. EEG changes following scopolamine administration in healthy subjects. Quantitative analysis during rest and photic stimulation. Neuropsychobiology 1999;39:219-26.
Crick F, Koch C. Towards a neurobiological theory of consciousness. In: Seminars in the neurosciences. Academic Press; 1990: 201.
Cantero JL, Atienza M, Madsen JR, Stickgold R. Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep. Neuroimage 2004;22:1271-80. (Pubitemid 38829216)
John ER, Prichep LS, Kox W, et al. Invariant reversible QEEG effects of anesthetics. Conscious Cogn 2001;10:165-83. (Pubitemid 32701719)
Perez-Garci E, del-Rio-Portilla Y, Guevara MA, Arce C, Corsi-Cabrera M. Paradoxical sleep is characterized by uncoupled gamma activity between frontal and perceptual cortical regions. Sleep 2001;24:118-26.
Lee U, Mashour GA, Kim S, Noh G-J, Choi B-M. Propofol induction reduces the capacity for neural information integration: Implications for the mechanism of consciousness and general anesthesia. Consc Cogn 2009;18:56-64.
Dehaene S, Changeux JP. Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness. PLoS Biol 2005;3:e141.
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