Cerebral correlates of explicit sequence learning

[en] Using positron emission tomography (PET) and regional cerebral blood flow (rCBF) measurements, we investigated the cerebral correlates of consciousness in a sequence learning task through a novel application of the Process Dissociation Procedure, a behavioral paradigm that makes it possible to separately assess conscious and unconscious contributions to performance. Results show that the metabolic response in the anterior cingulate/mesial prefrontal cortex (ACC/MPFC) is exclusively and specifically correlated with the explicit component of performance during recollection of a learned sequence. This suggests a significant role for the ACC/MPFC in the explicit processing of sequential material. © 2003 Elsevier Science B.V. All rights reserved.

Disciplines :

Neurosciences & behavior

Author, co-author :

Destrebecqz, Arnaud; Cognitive Science Research Unit, Université Libre de Bruxelles, Bruxelles, Belgium, Université Libre de Bruxelles, 50 Av. FD Roosevelt, 1050 Bruxelles, Belgium

Peigneux, Philippe ; Université de Liège - ULiège > GIGA CRC In vivo Imaging

Laureys, Steven ; Université de Liège - ULiège > Consciousness-Coma Science Group

Degueldre, Christian ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Del Fiore, Guy; Cyclotron Research Center, University of Liège, Liège, Belgium

Aerts, Joël ; Cyclotron Research Center, University of Liège, Liège, Belgium

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse

Van Der Linden, Martial

Cleeremans, Axel; Cognitive Science Research Unit, Université Libre de Bruxelles, Bruxelles, Belgium

Maquet, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Language :

English

Title :

Cerebral correlates of explicit sequence learning

Publication date :

2003

Journal title :

Cognitive Brain Research

ISSN :

0926-6410

Publisher :

Elsevier

Volume :

Issue :

Pages :

391-398

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

ULiège - Université de Liège
CE - Commission Européenne
F.R.S.-FNRS - Fonds de la Recherche Scientifique
ULB - Université Libre de Bruxelles

Available on ORBi :

since 30 May 2020

Statistics

Number of views

85 (7 by ULiège)

Number of downloads

140 (6 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Aizenstein H.J., MacDonald A.W., Stenger V.A., Nebes R.D., Larson J.K., Ursu S., Carter C.S. Complementary category learning systems identified using event-related functional MRI. J. Cogn. Neurosci. 12:2000;977-987.
Barch D.M., Braver T.S., Akbudak E., Conturo T., Ollinger J., Snyder A. Anterior cingulate cortex and response conflict: effects of response modality and processing domain. Cereb. Cortex. 11:2001;837-848.
Berman K.F., Randolph C., Gold J.M., Ostrem J.M., Coppola R., Carson R.E., Herscovitch P., Weinberger D.R. Activation of a cortical network during performance of the Wisconsin Card Sorting Test: a positron emission tomography study. Neuropsychologia. 33:1995;1027-1046.
Botvinick M., Nystrom L.E., Fissell K., Carter C.S., Cohen J.D. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature. 402:1999;179-181.
Buge A., Escourolle R., Rancurel G., Poisson M. Akinetic mutism and bicingular softening: three anatomo-clinical cases. Rev. Neurol. (Paris). 131:1975;121-131.
Burgess P.W., Veitch E., de Lacy Costello A., Shallice T. The cognitive and neuroanatomical correlates of multitasking. Neuropsychologia. 38:2000;848-863.
Bush G., Luu P., Posner M.I. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 4:2000;215-222.
Cleeremans A., Destrebecqz A., Boyer M. Implicit learning: news from the front. Trends Cogn. Sci. 2:1998;406-416.
Cleeremans A., McClelland J.L. Learning the structure of event sequences. J. Exp. Psychol. Gen. 120:1991;235-253.
Clegg B.A., DiGirolamo G.J., Keele S.W. Sequence learning. Trends Cogn. Sci. 2:1998;275-281.
Dehaene S., Naccache L. Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework. Cognition. 79:2001;1-37.
Destrebecqz A., Cleeremans A. Can sequence learning be implicit? New evidence with the process dissociation procedure. Psychon. Bull. Rev. 8:2001;343-350.
Frith C.D., Frith U. Interacting minds - A biological basis. Science. 286:1999;1692-1695.
Frith C., Perry R., Lumer E. The neural correlates of conscious experience: an experimental framework. Trends Cogn. Sci. 3:1999;105-114.
Grafton S.T., Hazeltine E., Ivry R. Functional mapping of sequence learning in normal humans. J. Cogn. Neurosci. 7:1995;497-510.
Grèzes J., Costes N., Decety J. The effects of learning and memory on the neural network involved in the perception of meaningless action. Brain. 122:1999;1875-1887.
Ikeda A., Luders H.O., Collura T.F., Burgess R.C., Morris H.H., Hamano T., Shibasaki H. Subdural potentials at orbitofrontal and mesial prefrontal areas accompanying anticipation and decision making in humans: a comparison with Bereitschaftspotential. Electroencephalogr. Clin. Neurophysiol. 98:1996;206-212.
Jacoby L.L. A process dissociation framework: separating automatic from intentional uses of memory. J. Mem. Lang. 30:1991;513-541.
Jacoby L.L., Woloshyn V., Kelley C. Becoming famous without being recognized: unconscious influence of memory produced by divided attention. J. Exp. Psychol. Gen. 118:1989;115-125.
Jueptner M., Weiller C. Does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI. Neuroimage. 2:1995;148-156.
Koechlin E., Corrado G., Pietrini P., Grafman J. Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning. Proc. Natl. Acad. Sci. USA. 97:2000;7651-7656.
Lane R.D. Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J. Cogn. Neurosci. 10:1998;525-535.
Llinas R., Ribary U., Contreras D., Pedroarena C. The neuronal basis for consciousness. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 353:1998;1841-1849.
Luu P., Flaisch T., Tucker D.M. Medial frontal cortex in action monitoring. J. Neurosci. 20:2000;464-469.
MacDonald A.W., Cohen J.D., Stenger V.A., Carter C.S. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science. 288:2001;1835-1838.
Mega M.S., Cohenour R.C. Akinetic mutism: disconnection of frontal-subcortical circuits. Neuropsychiatry Neuropsychol. Behav. Neurol. 10:1997;254-259.
Menon V., Adleman N.E., White C.D., Glover G.H., Reiss A.L. Error-related brain activation during a Go/No Go response inhibition task. Hum. Brain Mapp. 12:2001;131-143.
Németh G., Hegedüs K., Molnar L. Akinetic mutism associated with bicingular lesions. Clinicopathological and functional anatomical correlates. Eur. Arch. Psychiatry Clin. Neurosci. 237:1998;218-222.
Paus T., Tomaiuolo F., Otaky N., MacDonald D., Petrides M., Atlas J., Morris R., Evans A.C. Human cingulate and paracingulate sulci: pattern, variability, asymmetry, and probabilistic map. Cereb. Cortex. 6:1996;207-214.
Rauch S.L., Savage C.R., Brown H.D., Curran T., Alpert N.M., Kendrick A., Fischman A.J., Kosslyn S.M. A PET investigation of implicit and explicit sequence learning. Hum. Brain Mapp. 3:1995;271-286.
Reed J., Johnson P. Assessing implicit learning with indirect tests: determining what is learned about sequence structure. J. Exp. Psychol. Learn. Mem. Cogn. 20:1994;585-594.
Richardson-Klavehn A., Gardiner J.M., Java R.I. Memory: task dissociations, process dissociations, and dissociation of consciousness. Underwood G. Implicit Cognition. 1996;85-158 Oxford University Press, Oxford.
Rubia K., Overmeyer S., Taylor E., Brammer M., Williams S., Simmons A., Andrew C., Bullmore E.T. Prefrontal involvement in temporal bridging and timing movement. Neuropsychologia. 36:1998;1283-1293.
Sewards T.V., Sewards M.A. On the neural correlates of object recognition awareness: relationship to computational activities and activities mediating perceptual awareness. Conscious. Cogn. 11:2002;51-77.
Shanks D.R., Johnstone T. Implicit knowledge in sequential learning tasks. Stadler M.A., Frensch P.A. Handbook of Implicit Learning. 1998;533-572 Sage Publications.
Shanks D.R., Johnstone T. Evaluating the relationship between explicit and implicit knowledge in a serial reaction time task. J. Exp. Psychol. Learn. Mem. Cogn. 25:1999;1435-1451.
Shanks D.R., St. John M.F. Characteristics of dissociable human learning systems. Behav. Brain Sci. 17:1994;367-447.
Singer W. Consciousness and the structure of neuronal representation. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 353:1998;1829-1840.
Tononi G., Edelman G.M. Consciousness and complexity. Science. 282:1998;1846-1851.